iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000018750.14	ENSMUST00000108640.7	ENSMUSP00000104280.1
ENSMUSG00000018750.14	ENSMUST00000108642.7	ENSMUSP00000104282.1
ENSMUSG00000018750.14	ENSMUST00000156932.7	ENSMUSP00000115687.1
ENSMUSG00000018750.14	ENSMUST00000108638.1	ENSMUSP00000104278.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	miRTarBase	microRNA	TRANSFAC
RepTar	RAID2
Protein-protein Interaction
IID	Mentha
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	PHOSIDA
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB	1.30e-10	42.6	30	129

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_Other: BTB

   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmelees.................................ksklmveikdvqpevfral 56
           +Dv+l+ g+++f+ah++vLaasS++F+  +l   +                                    +    e+ +v + +f+++
   Q: 30   CDVTLIAGDTKFPAHRSVLAASSPFFREALLASAPLPlppvtggsapspatttaasssssspppasphssSPPRVLELPGVPAAAFSDV 118
           9*****************************998885569*****************************976566778889********* PP
   S: 57   lkFlYtgklde 67
           l+F+Y+ +l +
   Q: 119  LNFIYSARLAL 129
           ******99975 PP

Organism

Mus musculus

Functional Description
(View)

Transcriptional repressor with bimodal DNA-binding specificity. Represses transcription in a methyl-CpG-dependent manner. Binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to the non-methylated consensus sequence 5'-CTGCNA-3' also known as the consensus kaiso binding site (KBS). Can also bind specifically to a single methyl-CpG pair and can bind hemimethylated DNA but with a lower affinity compared to methylated DNA.

Protein Sequence
(Fasta)

MPPPAEVTDP SHAPAVLHQL NEQRLRGLFC DVTLIAGDTK FPAHRSVLAA SSPFFREALL 60
ASAPLPLPPV TGGSAPSPAT TTAASSSSSS PPPASPHSSS PPRVLELPGV PAAAFSDVLN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GATGATGTCA GCGGCGGCGG CGGCGGCGGT GGGGCTGGGC CGGGGCCGGG CGCTGGGGGG 60
GGCCGGGGCC GGGGCCGGAG CCGGAGCCGG AGCTGGAGGA GAGCGAAACC CAAGCGGCCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0158--Chromosome
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR000210--BTB/POZ_dom
IPR011333--SKP1/BTB/POZ
IPR013087--Znf_C2H2_type
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50097--BTB
PS00028--ZINC_FINGER_C2H2_1
PS50157--ZINC_FINGER_C2H2_2

Pfam

PF00651--BTB

SMART

SM00225--BTB
SM00355--ZnF_C2H2

Gene Ontology

GO:0005694--C:chromosome
GO:0005829--C:cytosol
GO:0016604--C:nuclear body
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0046872--F:metal ion binding
GO:0008327--F:methyl-CpG binding
GO:0010428--F:methyl-CpNpG binding
GO:0042803--F:protein homodimerization activity
GO:0019901--F:protein kinase binding
GO:0000977--F:RNA polymerase II regulatory region sequence-specific DNA binding
GO:0043565--F:sequence-specific DNA binding
GO:0001227--F:transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
GO:0006974--P:cellular response to DNA damage stimulus
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated

KEGG

mmu:75580

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aca-004385	Anolis carolinensis	41.18	2.00e-163	570.00
IUUC-Bta-012689	Bos taurus	80.10	0.00e+00	976.00
IUUC-Cja-019922	Callithrix jacchus	79.19	0.00e+00	828.00
IUUC-Cfa-020348	Canis familiaris	80.61	0.00e+00	950.00
IUUC-Cpo-021824	Cavia porcellus	78.82	0.00e+00	1006.00
IUUC-Csa-024023	Chlorocebus sabaeus	84.36	0.00e+00	906.00
IUUC-Dno-029721	Dasypus novemcinctus	82.07	0.00e+00	986.00
IUUC-Dor-030987	Dipodomys ordii	84.42	1.00e-164	574.00
IUUC-Ete-032788	Echinops telfairi	80.52	4.00e-172	598.00
IUUC-Eca-034199	Equus caballus	84.59	0.00e+00	915.00
IUUC-Eeu-034887	Erinaceus europaeus	80.95	1.00e-120	427.00
IUUC-Fca-036123	Felis catus	90.14	9.00e-163	567.00
IUUC-Ggo-044792	Gorilla gorilla	84.48	0.00e+00	944.00
IUUC-Hsa-045806	Homo sapiens	84.72	0.00e+00	942.00
IUUC-Itr-048293	Ictidomys tridecemlineatus	87.27	0.00e+00	1053.00
IUUC-Lch-049633	Latimeria chalumnae	39.61	5.00e-150	525.00
IUUC-Laf-053666	Loxodonta africana	80.86	0.00e+00	969.00
IUUC-Mcc-055380	Macaca mulatta	84.36	0.00e+00	911.00
IUUC-Meu-056434	Macropus eugenii	66.40	0.00e+00	721.00
IUUC-Mdo-062151	Monodelphis domestica	70.71	2.00e-106	379.00
IUUC-Mpu-065808	Mustela putorius furo	81.59	0.00e+00	964.00
IUUC-Mlu-068025	Myotis lucifugus	82.21	0.00e+00	1040.00
IUUC-Opr-070749	Ochotona princeps	76.92	0.00e+00	815.00
IUUC-Ocu-074809	Oryctolagus cuniculus	81.57	0.00e+00	969.00
IUUC-Oga-088975	Otolemur garnettii	82.12	0.00e+00	1006.00
IUUC-Oar-090000	Ovis aries	80.19	3.00e-140	492.00
IUUC-Ptr-090835	Pan troglodytes	83.01	0.00e+00	921.00
IUUC-Pan-092409	Papio anubis	84.25	0.00e+00	911.00
IUUC-Pab-097964	Pongo abelii	83.01	0.00e+00	885.00
IUUC-Pca-100651	Procavia capensis	75.80	0.00e+00	887.00
IUUC-Pva-102379	Pteropus vampyrus	80.08	0.00e+00	914.00
IUUC-Rno-104928	Rattus norvegicus	93.92	0.00e+00	1120.00
IUUC-Sha-106756	Sarcophilus harrisii	63.66	0.00e+00	777.00
IUUC-Sar-113009	Sorex araneus	79.34	0.00e+00	885.00
IUUC-Ssc-115587	Sus scrofa	82.61	0.00e+00	935.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence