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Tag Content
iUUCD ID IUUC-Dre-028423
Ensembl Protein ID ENSDARP00000007140.7
UniProt Accession P0CH95; PHF8_DANRE
Genbank Protein ID ENSDARP00000007140
Protein Name Histone lysine demethylase PHF8; PHD finger protein 8
Genbank Nucleotide ID CR352210
Gene Name phf8
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSDARG00000006584.9 ENSDART00000026314.7 ENSDARP00000007140.7
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/PHD 5.00e-09 37.1 6 54
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/PHD
   S: 2    kvClvCgeggedekslveCekCrewfHpaClklsveeelpnsekwiCpkCr 52
           ++C +C+ +++ ++ ++eC+ C++wfH  C++ + e++  + + + Cp+C+
   Q: 6    VYC-LCRLPYDVTRFMIECDVCQDWFHGSCVGVE-EDKAAEIDLYHCPNCQ 54
           69*.******************************.*******99******7 PP
   
Organism Danio rerio
Functional Description
(View)

Functional Description


     Histone lysine demethylase with selectivity for the di- and monomethyl states that plays a key role cell cycle progression, rDNA transcription and brain development. Demethylates mono- and dimethylated histone H3 'Lys-9' residue (H3K9Me1 and H3K9Me2), dimethylated H3 'Lys-27' (H3K27Me2) and monomethylated histone H4 'Lys-20' residue (H4K20Me1). Acts as a transcription activator as H3K9Me1, H3K9Me2, H3K27Me2 and H4K20Me1 are epigenetic repressive marks. Involved in cell cycle progression by being required to control G1-S transition. Acts as a coactivator of rDNA transcription, by activating polymerase I (pol I) mediated transcription of rRNA genes. Has activity toward H4K20Me1 only when nucleosome is used as a substrate and when not histone octamer is used as substrate (By similarity). Required for brain development, probably by regulating expression of neuron-specific genes.
 Histone lysine demethylase with selectivity for the di- and monomethyl states that plays a key role cell cycle progression, rDNA transcription and brain development. Demethylates mono- and dimethylated histone H3 'Lys-9' residue (H3K9Me1 and H3K9Me2), dimethylated H3 'Lys-27' (H3K27Me2) and monomethylated histone H4 'Lys-20' residue (H4K20Me1). Acts as a transcription activator as H3K9Me1, H3K9Me2, H3K27Me2 and H4K20Me1 are epigenetic repressive marks. Involved in cell cycle progression by being required to control G1-S transition. Acts as a coactivator of rDNA transcription, by activating polymerase I (pol I) mediated transcription of rRNA genes. Has activity toward H4K20Me1 only when nucleosome is used as a substrate and when not histone octamer is used as substrate (By similarity). Required for brain development, probably by regulating expression of neuron-specific genes.
Protein Sequence
(Fasta)
MASVPVYCLC RLPYDVTRFM IECDVCQDWF HGSCVGVEED KAAEIDLYHC PNCQVTHGPS 60
VMRKRRGAVK HADVGLGRDS GRPVKTGSAQ FVRELRCRTF PSADEVLLKP TGAQLTVEFL 120
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Protein Fasta Sequence


>IUUC-Dre-028423|E3,PHD|Danio rerio
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Nucleotide Sequence
(Fasta)
GCTGCACGGG CGGATTGGGA TGGATTTATA GCACGGGAAA TCGCTGCGTT ATGAATTTCA 60
TAAAATCTAT GATTCTCAGC TGTGGACTGT ATTCCCTCGA GATCTTGCAA GATTTGTTTA 120
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Nucleotide Fasta Sequence


>IUUC-Dre-028423|E3,PHD|Danio rerio
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0010--Activator
KW-0131--Cell cycle
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0223--Dioxygenase
KW-0408--Iron
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0560--Oxidoreductase
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR003347--JmjC_dom
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS51184--JMJC
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
Pfam

PF02373--JmjC
PF00628--PHD
SMART

SM00558--JmjC
SM00249--PHD
Gene Ontology

GO:0005730--C:nucleolus
GO:0003682--F:chromatin binding
GO:0071558--F:histone demethylase activity (H3-K27 specific)
GO:0051864--F:histone demethylase activity (H3-K36 specific)
GO:0032454--F:histone demethylase activity (H3-K9 specific)
GO:0035575--F:histone demethylase activity (H4-K20 specific)
GO:0035064--F:methylated histone binding
GO:0008270--F:zinc ion binding
GO:0007420--P:brain development
GO:0000082--P:G1/S transition of mitotic cell cycle
GO:0071557--P:histone H3-K27 demethylation
GO:0070544--P:histone H3-K36 demethylation
GO:0033169--P:histone H3-K9 demethylation
GO:0035574--P:histone H4-K20 demethylation
GO:0061188--P:negative regulation of chromatin silencing at rDNA
GO:0045943--P:positive regulation of transcription from RNA polymerase I promoter
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
KEGG dre:566534
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002427 Ailuropoda melanoleuca 62.06 0.00e+00 995.00
IUUC-Aca-004346 Anolis carolinensis 64.29 0.00e+00 1073.00
IUUC-Acl-008303 Aspergillus clavatus 32.98 2.00e-66 248.00
IUUC-Afl-008579 Aspergillus flavus 29.47 8.00e-30 125.00
IUUC-Afu-008903 Aspergillus fumigatus 32.64 4.00e-67 250.00
IUUC-Ang-009645 Aspergillus niger 31.91 8.00e-64 239.00
IUUC-Aor-010233 Aspergillus oryzae 32.34 6.00e-66 246.00
IUUC-Ate-010345 Aspergillus terreus 33.26 2.00e-68 254.00
IUUC-Ame-010945 Astyanax mexicanus 86.52 0.00e+00 1431.00
IUUC-Cfa-021156 Canis familiaris 61.44 0.00e+00 1039.00
IUUC-Cpo-022284 Cavia porcellus 59.57 0.00e+00 1113.00
IUUC-Cre-022934 Chlamydomonas reinhardtii 41.54 1.00e-10 59.30
IUUC-Csa-023515 Chlorocebus sabaeus 60.41 0.00e+00 1126.00
IUUC-Cme-027118 Cyanidioschyzon merolae 30.72 2.00e-55 210.00
IUUC-Dno-029446 Dasypus novemcinctus 66.03 0.00e+00 859.00
IUUC-Ete-032380 Echinops telfairi 69.27 0.00e+00 832.00
IUUC-Eca-034302 Equus caballus 59.79 0.00e+00 1105.00
IUUC-Fca-035578 Felis catus 62.85 0.00e+00 1053.00
IUUC-Ggr-039960 Gaeumannomyces graminis 56.00 5.00e-11 63.20
IUUC-Gac-041666 Gasterosteus aculeatus 78.63 0.00e+00 1237.00
IUUC-Ggo-044712 Gorilla gorilla 60.13 0.00e+00 1119.00
IUUC-Hsa-045724 Homo sapiens 60.43 0.00e+00 1129.00
IUUC-Kpa-049384 Komagataella pastoris 35.73 1.00e-60 227.00
IUUC-Lch-049793 Latimeria chalumnae 82.44 0.00e+00 847.00
IUUC-Laf-053656 Loxodonta africana 63.21 0.00e+00 1060.00
IUUC-Mcc-055658 Macaca mulatta 60.41 0.00e+00 1126.00
IUUC-Mor-057044 Magnaporthe oryzae 38.14 3.00e-10 60.50
IUUC-Mpo-057588 Magnaporthe poae 56.00 5.00e-11 62.80
IUUC-Mtr-057679 Medicago truncatula 38.46 1.00e-10 59.70
IUUC-Mla-058890 Melampsora laricipopulina 46.76 8.00e-74 270.00
IUUC-Mvi-060481 Microbotryum violaceum 39.84 1.00e-77 285.00
IUUC-Mmr-060993 Microcebus murinus 62.99 0.00e+00 1055.00
IUUC-Mdo-062097 Monodelphis domestica 57.72 0.00e+00 983.00
IUUC-Mmu-063909 Mus musculus 63.49 0.00e+00 1060.00
IUUC-Mpu-066429 Mustela putorius furo 62.96 0.00e+00 1051.00
IUUC-Mlu-067746 Myotis lucifugus 59.83 0.00e+00 1114.00
IUUC-Nfi-068537 Neosartorya fischeri 32.85 4.00e-67 250.00
IUUC-Nle-070143 Nomascus leucogenys 60.24 0.00e+00 1140.00
IUUC-Ont-072257 Oreochromis niloticus 80.00 0.00e+00 1292.00
IUUC-Oan-073654 Ornithorhynchus anatinus 76.56 0.00e+00 789.00
IUUC-Ocu-074417 Oryctolagus cuniculus 60.53 0.00e+00 1085.00
IUUC-Ola-087502 Oryzias latipes 78.50 0.00e+00 1297.00
IUUC-Olu-087802 Ostreococcus lucimarinus 47.17 6.00e-15 73.60
IUUC-Oga-088662 Otolemur garnettii 62.46 0.00e+00 957.00
IUUC-Oar-090332 Ovis aries 61.54 0.00e+00 1049.00
IUUC-Ptr-091646 Pan troglodytes 62.47 0.00e+00 962.00
IUUC-Pan-092122 Papio anubis 60.41 0.00e+00 1126.00
IUUC-Pma-094621 Petromyzon marinus 69.87 0.00e+00 679.00
IUUC-Pfo-096107 Poecilia formosa 80.57 0.00e+00 1238.00
IUUC-Pab-097635 Pongo abelii 52.32 0.00e+00 893.00
IUUC-Pca-100779 Procavia capensis 54.92 5.00e-157 548.00
IUUC-Pva-102839 Pteropus vampyrus 70.24 0.00e+00 681.00
IUUC-Ptt-103859 Puccinia triticina 40.38 1.00e-80 294.00
IUUC-Rno-105933 Rattus norvegicus 63.28 0.00e+00 1070.00
IUUC-Ssc-115645 Sus scrofa 62.54 0.00e+00 1019.00
IUUC-Tru-118403 Takifugu rubripes 70.29 0.00e+00 1221.00
IUUC-Tsy-119214 Tarsius syrichta 59.74 0.00e+00 840.00
IUUC-Tni-119736 Tetraodon nigroviridis 75.17 0.00e+00 1161.00
IUUC-Tme-127054 Tuber melanosporum 33.09 3.00e-56 214.00
IUUC-Tbe-128138 Tupaia belangeri 57.81 0.00e+00 937.00
IUUC-Vpa-130595 Vicugna pacos 56.70 3.00e-136 479.00
IUUC-Xtr-132307 Xenopus tropicalis 63.38 0.00e+00 1064.00
IUUC-Xma-134323 Xiphophorus maculatus 80.69 0.00e+00 1211.00
Created Date 25-Jun-2017

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