iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Oga-089124

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAQR03036054

Gene Name

VHL

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOGAG00000007587.2	ENSOGAT00000007590.2	ENSOGAP00000006788.2

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	27.43	3.00e-03	38.90	IUUC-Dme-031988
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	94.97	5.00e-83	304.00	IUUC-Hsa-046547

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Otolemur garnettii

Protein Sequence
(Fasta)

MPWRAGNGVE AEGGAEEGGA EEYGPEEYGH EESGAEESGP EESDPEESGT EEEMDAGRPR 60
PVLRSVNSRE PSQVIFCNRS PRVVLPVWLN FDGEPQPYPT LQPGTGRRIH SYRGHLWLFR 120

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Nucleotide Sequence
(Fasta)

ATGCCCTGGA GGGCTGGGAA CGGAGTAGAG GCTGAGGGCG GCGCCGAGGA GGGCGGCGCC 60
GAAGAATACG GCCCTGAAGA GTACGGCCAC GAGGAGTCGG GCGCTGAAGA GTCTGGCCCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR002714--VHL
IPR024048--VHL_alpha_dom
IPR024053--VHL_beta_dom
IPR022772--VHL_tumour_suppress_b/a_dom

Pfam

PF01847--VHL
PF17211--VHL_C

Gene Ontology

GO:0005929--C:cilium
GO:0031462--C:Cul2-RING ubiquitin ligase complex
GO:0005737--C:cytoplasm
GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0001525--P:angiogenesis
GO:0043534--P:blood vessel endothelial cell migration
GO:0061073--P:ciliary body morphogenesis
GO:0030198--P:extracellular matrix organization
GO:0048069--P:eye pigmentation
GO:0048877--P:homeostasis of number of retina cells
GO:0061072--P:iris morphogenesis
GO:0006582--P:melanin metabolic process
GO:0045602--P:negative regulation of endothelial cell differentiation
GO:0010629--P:negative regulation of gene expression
GO:1902072--P:negative regulation of hypoxia-inducible factor-1alpha signaling pathway
GO:0070244--P:negative regulation of thymocyte apoptotic process
GO:0006607--P:NLS-bearing protein import into nucleus
GO:0003310--P:pancreatic A cell differentiation
GO:0050679--P:positive regulation of epithelial cell proliferation
GO:0010498--P:proteasomal protein catabolic process
GO:2001233--P:regulation of apoptotic signaling pathway
GO:1903827--P:regulation of cellular protein localization
GO:0003309--P:type B pancreatic cell differentiation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002327	Ailuropoda melanoleuca	84.66	9.00e-75	272.00
IUUC-Apl-003580	Anas platyrhynchos	65.48	2.00e-24	103.00
IUUC-Aca-004492	Anolis carolinensis	76.74	1.00e-55	208.00
IUUC-Ang-009806	Aspergillus niger	40.62	6.50e-02	28.50
IUUC-Ame-011818	Astyanax mexicanus	50.29	2.00e-44	172.00
IUUC-Bta-013459	Bos taurus	92.17	5.00e-86	310.00
IUUC-Cel-018173	Caenorhabditis elegans	30.33	2.00e-04	38.90
IUUC-Cja-019826	Callithrix jacchus	91.57	3.00e-85	307.00
IUUC-Cfa-021280	Canis familiaris	92.07	5.00e-84	303.00
IUUC-Cpo-022544	Cavia porcellus	86.52	6.00e-86	309.00
IUUC-Cre-022809	Chlamydomonas reinhardtii	41.67	4.00e-07	48.90
IUUC-Csa-023644	Chlorocebus sabaeus	94.34	2.00e-84	304.00
IUUC-Cho-024479	Choloepus hoffmanni	63.16	3.00e-39	153.00
IUUC-Cin-025505	Ciona intestinalis	28.33	3.00e-05	41.20
IUUC-Cme-027232	Cyanidioschyzon merolae	33.78	9.00e-06	43.50
IUUC-Dre-028350	Danio rerio	51.61	2.00e-32	131.00
IUUC-Dno-029207	Dasypus novemcinctus	85.59	3.00e-54	204.00
IUUC-Dor-030912	Dipodomys ordii	65.58	3.00e-49	187.00
IUUC-Dme-031988	Drosophila melanogaster	27.43	2.00e-04	38.90
IUUC-Eca-034007	Equus caballus	100.00	1.00e-20	90.50
IUUC-Fca-036350	Felis catus	96.15	2.00e-85	308.00
IUUC-Fal-037192	Ficedula albicollis	67.52	4.00e-55	206.00
IUUC-Gmo-038921	Gadus morhua	58.55	2.00e-44	171.00
IUUC-Gga-041016	Gallus gallus	68.75	1.00e-53	201.00
IUUC-Gac-042560	Gasterosteus aculeatus	51.72	3.00e-35	141.00
IUUC-Ggo-045419	Gorilla gorilla	94.90	5.00e-83	300.00
IUUC-Hsa-046547	Homo sapiens	94.90	5.00e-83	300.00
IUUC-Itr-048225	Ictidomys tridecemlineatus	94.44	2.00e-86	310.00
IUUC-Lch-050463	Latimeria chalumnae	62.18	3.00e-52	197.00
IUUC-Loc-052053	Lepisosteus oculatus	55.06	2.00e-47	181.00
IUUC-Laf-053893	Loxodonta africana	89.29	1.00e-84	305.00
IUUC-Mcc-055347	Macaca mulatta	64.48	1.00e-55	209.00
IUUC-Mtr-058490	Medicago truncatula	46.88	3.00e-02	32.00
IUUC-Mdo-062169	Monodelphis domestica	75.53	3.00e-38	149.00
IUUC-Mmu-064366	Mus musculus	91.49	2.00e-72	264.00
IUUC-Mpu-066593	Mustela putorius furo	89.47	5.00e-86	310.00
IUUC-Mlu-066926	Myotis lucifugus	87.56	4.00e-89	320.00
IUUC-Nle-069724	Nomascus leucogenys	95.54	5.00e-84	303.00
IUUC-Opr-070679	Ochotona princeps	76.40	6.00e-76	276.00
IUUC-Ont-071332	Oreochromis niloticus	52.20	5.00e-42	163.00
IUUC-Ola-086869	Oryzias latipes	47.85	1.00e-38	152.00
IUUC-Oar-089799	Ovis aries	90.10	5.00e-49	185.00
IUUC-Ptr-091186	Pan troglodytes	92.16	2.00e-49	187.00
IUUC-Pan-092150	Papio anubis	94.27	1.00e-82	298.00
IUUC-Psi-094039	Pelodiscus sinensis	66.20	2.00e-50	191.00
IUUC-Pma-094129	Petromyzon marinus	41.96	3.00e-26	111.00
IUUC-Pfo-096892	Poecilia formosa	50.31	5.00e-38	149.00
IUUC-Pab-097822	Pongo abelii	95.54	5.00e-84	303.00
IUUC-Pca-101058	Procavia capensis	88.34	9.00e-77	279.00
IUUC-Pva-102932	Pteropus vampyrus	95.65	6.00e-87	313.00
IUUC-Rno-105050	Rattus norvegicus	83.33	4.00e-87	313.00
IUUC-Sha-106738	Sarcophilus harrisii	76.24	5.00e-41	158.00
IUUC-Ssc-115973	Sus scrofa	87.71	1.00e-86	312.00
IUUC-Tgu-116663	Taeniopygia guttata	67.65	4.00e-32	128.00
IUUC-Tru-118654	Takifugu rubripes	57.24	2.00e-42	164.00
IUUC-Tca-121306	Theobroma cacao	38.89	3.50e-02	29.60
IUUC-Ttr-128418	Tursiops truncatus	89.53	9.00e-87	312.00
IUUC-Vpa-130268	Vicugna pacos	89.11	4.00e-48	183.00
IUUC-Xtr-132506	Xenopus tropicalis	60.62	2.00e-52	197.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence