iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Tni-120468

UUCD1 version

UUC-TeN-00446

Ensembl Protein ID

ENSTNIP00000021840.1

UniProt Accession

H3DMU2; H3DMU2_TETNG

Protein Name

Uncharacterized protein

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTNIG00000018665.1	ENSTNIT00000022076.1	ENSTNIP00000021840.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.10e-60	199.0	480	513
UBD/Beta-Prp	1.20e-102	343.3	231	513

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    HtdsvtclafsdtllvsGsdDgtikvWDlrtgvl 35
           H++ vtcl+f+ ++++++sdDgt+k+WDl+tg  
   Q: 480  HQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEF 513
           9*********449******************976 PP

UBD/Beta-Prp

   S: 3    ktlkghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlk 91
           k+lkgh+++vitc++f   ++ +++gs+d+t+kvw++ tgk+lr+l gh+++v++ ++ ++  i+++gs+Drt+kvw+ +tg+c+htl 
   Q: 231  KVLKGHDDHVITCLQF--CGNRIVSGSDDNTLKVWSAITGKCLRTLVGHTGGVWSSQMRDN--IIISGSTDRTLKVWNAETGECIHTLY 315
           6799************..*******************************************..************************** PP
   S: 92   ghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgght 180
           gh+++v+++++++  +++vsGs+d t+rvwd+e+gqcl+ +l gh ++v+cv++++  + +vsG++D +v++Wd +t+++l+tl+g ht
   Q: 316  GHTSTVRCMHLHE--KRVVSGSRDATLRVWDIESGQCLH-VLMGHVAAVRCVQYDG--RRVVSGAYDFMVKVWDPETETCLHTLQG-HT 398
           *************..************************.****************..***************************9.** PP
   S: 181  dsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlhnssvis 269
           ++vysl+fd    ++vsgsld+++++wd++tg+c++tl+gh++ ++ +++   d++lvsg++D +++iWd+++g++l+tlq+++++ ++
   Q: 399  NRVYSLQFDG--IHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELK--DNILVSGNADSTVKIWDIKTGQCLQTLQGPHKHQSA 483
           *********9..9**************************************..************************************ PP
   S: 270  vavlsfgdnvlvlgsedskvniwklkknep 299
           v++l+f++n +++ s+d++v++w+lk+ e+
   Q: 484  VTCLQFNKNFVITSSDDGTVKLWDLKTGEF 513
           *************************98776 PP

Organism

Tetraodon nigroviridis

Protein Sequence
(Fasta)

EEEKGKHRLS RMGFYGTLKM IFYKMKRKLD HGPEVRSFPS GKKPYKGPEY CSPTGIVPCP 60
ATPTTFGHIR TANGQGQQRR RITSIQPPTG LQEWLRTFQS WTGPEKLLAL DELIDSCEPT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAAGAGGAGA AGGGAAAACA CCGGCTTTCA AGGATGGGGT TCTACGGCAC TTTAAAGATG 60
ATTTTCTACA AAGTAAGTAG GATCCGCGCT GGCGACCATC CGCCCGTGTC ACCTCCAGCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR001810--F-box_dom
IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50181--FBOX
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12937--F-box-like
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00256--FBOX
SM00320--WD40

Gene Ontology

GO:0001525--P:angiogenesis
GO:0031642--P:negative regulation of myelination
GO:0045746--P:negative regulation of Notch signaling pathway
GO:0032006--P:regulation of TOR signaling

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002406	Ailuropoda melanoleuca	94.45	0.00e+00	1048.00
IUUC-Apl-003489	Anas platyrhynchos	93.47	0.00e+00	1049.00
IUUC-Aca-005318	Anolis carolinensis	93.44	0.00e+00	1073.00
IUUC-Ago-007794	Ashbya gossypii	31.07	1.00e-61	230.00
IUUC-Acl-008123	Aspergillus clavatus	32.20	1.00e-74	273.00
IUUC-Afl-008730	Aspergillus flavus	31.95	2.00e-72	267.00
IUUC-Afu-009014	Aspergillus fumigatus	31.93	8.00e-73	268.00
IUUC-Ani-009332	Aspergillus nidulans	32.41	9.00e-79	287.00
IUUC-Ang-009529	Aspergillus niger	33.40	3.00e-73	270.00
IUUC-Aor-010215	Aspergillus oryzae	30.91	2.00e-73	269.00
IUUC-Ate-010535	Aspergillus terreus	37.25	1.00e-66	247.00
IUUC-Ame-010898	Astyanax mexicanus	94.82	0.00e+00	1041.00
IUUC-Bgr-012075	Blumeria graminis	33.01	2.00e-78	286.00
IUUC-Bta-012391	Bos taurus	93.79	0.00e+00	1074.00
IUUC-Bci-013725	Botrytis cinerea	32.81	6.00e-77	281.00
IUUC-Cel-018495	Caenorhabditis elegans	48.14	7.00e-130	457.00
IUUC-Cja-018902	Callithrix jacchus	94.82	0.00e+00	1050.00
IUUC-Cfa-020237	Canis familiaris	93.65	0.00e+00	1049.00
IUUC-Cpo-022234	Cavia porcellus	93.79	0.00e+00	1077.00
IUUC-Cre-022837	Chlamydomonas reinhardtii	37.09	2.00e-48	186.00
IUUC-Csa-023532	Chlorocebus sabaeus	94.82	0.00e+00	1050.00
IUUC-Cho-025026	Choloepus hoffmanni	78.32	0.00e+00	691.00
IUUC-Cin-025516	Ciona intestinalis	70.64	7.00e-140	489.00
IUUC-Csv-026312	Ciona savignyi	70.90	0.00e+00	745.00
IUUC-Cgl-026492	Colletotrichum gloeosporioides	34.41	5.00e-84	305.00
IUUC-Cne-027018	Cryptococcus neoformans	32.89	3.00e-72	266.00
IUUC-Cme-027168	Cyanidioschyzon merolae	31.10	2.00e-30	127.00
IUUC-Dre-028303	Danio rerio	93.16	0.00e+00	1035.00
IUUC-Dno-029576	Dasypus novemcinctus	92.14	0.00e+00	1032.00
IUUC-Dor-030196	Dipodomys ordii	92.20	0.00e+00	1026.00
IUUC-Dme-031702	Drosophila melanogaster	72.80	0.00e+00	793.00
IUUC-Ete-032791	Echinops telfairi	87.41	0.00e+00	962.00
IUUC-Eca-033424	Equus caballus	93.79	0.00e+00	1075.00
IUUC-Eeu-034996	Erinaceus europaeus	92.05	0.00e+00	1016.00
IUUC-Fca-036422	Felis catus	94.82	0.00e+00	1051.00
IUUC-Fal-037267	Ficedula albicollis	93.42	0.00e+00	1044.00
IUUC-Fox-037800	Fusarium oxysporum	33.67	4.00e-83	302.00
IUUC-Fso-038258	Fusarium solani	33.81	1.00e-82	300.00
IUUC-Gmo-039119	Gadus morhua	85.97	0.00e+00	945.00
IUUC-Ggr-039781	Gaeumannomyces graminis	34.86	4.00e-85	308.00
IUUC-Gga-040667	Gallus gallus	94.14	0.00e+00	1051.00
IUUC-Ggo-044422	Gorilla gorilla	94.82	0.00e+00	1051.00
IUUC-Hsa-045898	Homo sapiens	94.82	0.00e+00	1051.00
IUUC-Itr-048241	Ictidomys tridecemlineatus	97.22	0.00e+00	944.00
IUUC-Kpa-049097	Komagataella pastoris	31.92	4.00e-75	275.00
IUUC-Lch-050414	Latimeria chalumnae	95.19	0.00e+00	1055.00
IUUC-Loc-052348	Lepisosteus oculatus	95.72	0.00e+00	1096.00
IUUC-Lma-053185	Leptosphaeria maculans	31.00	1.00e-68	254.00
IUUC-Laf-054054	Loxodonta africana	94.64	0.00e+00	1050.00
IUUC-Mcc-055056	Macaca mulatta	94.82	0.00e+00	1050.00
IUUC-Meu-056778	Macropus eugenii	89.91	7.00e-167	580.00
IUUC-Mor-057076	Magnaporthe oryzae	34.72	3.00e-84	305.00
IUUC-Mla-059081	Melampsora laricipopulina	33.90	1.00e-79	290.00
IUUC-Mga-059255	Meleagris gallopavo	94.64	0.00e+00	1050.00
IUUC-Mvi-060490	Microbotryum violaceum	38.75	6.00e-66	246.00
IUUC-Mmr-061292	Microcebus murinus	94.82	0.00e+00	1050.00
IUUC-Mdo-062304	Monodelphis domestica	95.19	0.00e+00	1057.00
IUUC-Mmu-063610	Mus musculus	93.65	0.00e+00	1051.00
IUUC-Mpu-065931	Mustela putorius furo	94.82	0.00e+00	1049.00
IUUC-Mlu-066976	Myotis lucifugus	93.47	0.00e+00	1052.00
IUUC-Nfi-068428	Neosartorya fischeri	31.27	3.00e-73	269.00
IUUC-Ncr-068688	Neurospora crassa	36.17	1.00e-87	317.00
IUUC-Nle-070174	Nomascus leucogenys	94.82	0.00e+00	1050.00
IUUC-Opr-070851	Ochotona princeps	79.74	4.00e-174	603.00
IUUC-Ont-071997	Oreochromis niloticus	98.55	0.00e+00	1127.00
IUUC-Oan-072936	Ornithorhynchus anatinus	94.33	0.00e+00	1055.00
IUUC-Ocu-074742	Oryctolagus cuniculus	93.65	0.00e+00	1052.00
IUUC-Obr-076806	Oryza brachyantha	31.16	3.00e-29	124.00
IUUC-Oin-079809	Oryza indica	31.16	3.00e-29	124.00
IUUC-Ola-087098	Oryzias latipes	96.33	0.00e+00	1086.00
IUUC-Olu-087837	Ostreococcus lucimarinus	35.23	4.00e-39	154.00
IUUC-Oga-088884	Otolemur garnettii	97.10	0.00e+00	761.00
IUUC-Oar-090220	Ovis aries	94.13	0.00e+00	1046.00
IUUC-Ptr-090492	Pan troglodytes	94.82	0.00e+00	1051.00
IUUC-Pan-091770	Papio anubis	94.82	0.00e+00	1050.00
IUUC-Psi-093207	Pelodiscus sinensis	93.79	0.00e+00	1076.00
IUUC-Pma-094749	Petromyzon marinus	81.93	0.00e+00	950.00
IUUC-Pno-095026	Phaeosphaeria nodorum	38.83	2.00e-70	261.00
IUUC-Pfo-096493	Poecilia formosa	97.97	0.00e+00	1079.00
IUUC-Pab-098141	Pongo abelii	93.79	0.00e+00	1075.00
IUUC-Pca-100571	Procavia capensis	92.67	0.00e+00	731.00
IUUC-Pva-102988	Pteropus vampyrus	93.82	0.00e+00	1051.00
IUUC-Pgr-103612	Puccinia graminis	35.73	8.00e-62	231.00
IUUC-Pte-104275	Pyrenophora teres	31.79	6.00e-73	268.00
IUUC-Pyt-104438	Pyrenophora triticirepentis	31.87	2.00e-72	266.00
IUUC-Rno-105706	Rattus norvegicus	93.97	0.00e+00	1050.00
IUUC-Sce-106314	Saccharomyces cerevisiae	29.98	1.00e-61	231.00
IUUC-Sha-107653	Sarcophilus harrisii	95.19	0.00e+00	1052.00
IUUC-Sja-107840	Schizosaccharomyces japonicus	33.83	2.00e-78	286.00
IUUC-Spo-108115	Schizosaccharomyces pombe	32.08	3.00e-63	236.00
IUUC-Sar-113600	Sorex araneus	88.17	0.00e+00	956.00
IUUC-Sre-114901	Sporisorium reilianum	47.72	2.00e-66	248.00
IUUC-Ssc-115787	Sus scrofa	91.83	0.00e+00	1021.00
IUUC-Tgu-117510	Taeniopygia guttata	93.96	0.00e+00	1048.00
IUUC-Tru-117819	Takifugu rubripes	99.26	0.00e+00	1117.00
IUUC-Tsy-118828	Tarsius syrichta	93.65	0.00e+00	1050.00
IUUC-Tre-122193	Trichoderma reesei	35.55	2.00e-84	306.00
IUUC-Tvi-122615	Trichoderma virens	34.42	8.00e-82	297.00
IUUC-Tme-127021	Tuber melanosporum	34.89	7.00e-84	304.00
IUUC-Tbe-127925	Tupaia belangeri	92.29	0.00e+00	1049.00
IUUC-Ttr-128899	Tursiops truncatus	93.28	0.00e+00	1047.00
IUUC-Uma-129449	Ustilago maydis	46.47	1.00e-65	245.00
IUUC-Vda-129802	Verticillium dahliae	35.99	8.00e-87	314.00
IUUC-Vpa-130082	Vicugna pacos	92.64	0.00e+00	872.00
IUUC-Xtr-132213	Xenopus tropicalis	95.19	0.00e+00	1053.00
IUUC-Xma-133646	Xiphophorus maculatus	97.83	0.00e+00	1101.00
IUUC-Yli-134429	Yarrowia lipolytica	34.00	1.00e-86	313.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence