iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Aml-002395

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

ACTA01176080

Gene Name

USP49

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAMEG00000013061.1	ENSAMET00000014328.1	ENSAMEP00000013756.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	3.20e-92	309.4	197	593

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 9    tCYmNSvLQcLsnipelrelllekkkeklneenp....................................................... 42
            CYmNS+LQ+Ls+++++re++l+ +++++++  p                                                       
   Q: 197  RCYMNSILQVLSHLQKFRECFLNLDPSQTQQLFPkapngkaplsgrpagssatelsarsdgaeacereglcfnggasisrsleliqnke 285
           6**********************888888877777788999999999999999999999999999999999999999999999999999 PP
   S: 43   .kepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdea 130
            ++++ +l+++l++lf+ +w++k+  vsp ++l++++++ + f+gy+qqDaqEfl+ ll+++++el         e+e+++++ l   +
   Q: 286  pSSKHISLCHELHTLFRVMWSGKWALVSPFAMLHSVWSLIPAFRGYDQQDAQEFLCELLHKVQQEL---------ESEGTARRILIPFS 365
           888899************************************************************.........6788999999999* PP
   S: 131  eekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke..........slqdcLesftkeeelegenkyyce 209
           ++k +k+  ++++++F+gql sq++c +c+ +s++ epf+dlsl++p++ ++ ++           l+++L++ft++e leg+  y c+
   Q: 366  QRKLTKQVLKVVNTIFHGQLLSQVTCVSCNYKSNTIEPFWDLSLEFPERYHCIEKgfvplnqtecLLTEMLAKFTETEALEGRI-YACD 453
           **************************************************998879*************************965.**** PP
   S: 210  kckkkqe...........aekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspeekqke..kkkYeLiavvv 285
           +c++k++           a+k+l++ +lP+vL lhLkRf++s + ++reki  +v f + L+++p+c+++  ++ +  +  Y+L+avv+
   Q: 454  QCNSKRRksnpkplvlseARKQLMIYRLPQVLRLHLKRFRWSGR-NHREKIGVHVVFDQVLTMEPYCCRDMLSSLDkeTFAYDLSAVVM 541
           ***9999999*******************************997.8889********************876654433999******** PP
   S: 286  HsG.slssGHYvayvknekgk.WllfdDskVtevkeeevleetgstaYvlfYkrr 338
           H+G +++sGHY+ay++n++g+ W++++Dsk ++++ eev++   ++aY+lfY++r
   Q: 542  HHGkGFGSGHYTAYCYNTEGGfWVHCNDSKLNVCSVEEVCK---TQAYILFYTQR 593
           *****************9999********************...********985 PP

Organism

Ailuropoda melanoleuca

Protein Sequence
(Fasta)

MDRCKHVGRL RLAQDHSILN PQKWCCRECA TTESVWACLK CSHVACGRYI EDHALKHFEE 60
TGHPLAMEVR DLYVFCYLCK DYVLNDNPEG DLKLLRSSLL AVRGQTQKQD PPLRRGRTLR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGATAGAT GCAAACATGT CGGGCGGTTG CGGCTCGCCC AGGACCACTC CATCCTGAAC 60
CCGCAGAAGT GGTGCTGCAG GGAGTGCGCC ACCACCGAGT CCGTGTGGGC TTGTCTCAAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0035616--P:histone H2B conserved C-terminal lysine deubiquitination
GO:0000398--P:mRNA splicing, via spliceosome
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Bta-012911	Bos taurus	96.03	0.00e+00	840.00
IUUC-Cja-019171	Callithrix jacchus	94.84	0.00e+00	842.00
IUUC-Cfa-020408	Canis familiaris	97.89	0.00e+00	864.00
IUUC-Cpo-022233	Cavia porcellus	88.29	0.00e+00	782.00
IUUC-Cho-025051	Choloepus hoffmanni	90.57	0.00e+00	658.00
IUUC-Dno-029856	Dasypus novemcinctus	94.38	0.00e+00	843.00
IUUC-Eca-033851	Equus caballus	86.36	0.00e+00	695.00
IUUC-Fca-035919	Felis catus	98.25	0.00e+00	816.00
IUUC-Gmo-039249	Gadus morhua	77.67	9.00e-146	510.00
IUUC-Gga-040383	Gallus gallus	84.38	0.00e+00	728.00
IUUC-Ggo-044979	Gorilla gorilla	95.31	0.00e+00	848.00
IUUC-Hsa-046743	Homo sapiens	95.07	0.00e+00	846.00
IUUC-Itr-048251	Ictidomys tridecemlineatus	96.02	0.00e+00	858.00
IUUC-Loc-051961	Lepisosteus oculatus	76.53	3.00e-178	618.00
IUUC-Laf-053819	Loxodonta africana	94.85	0.00e+00	852.00
IUUC-Mcc-055048	Macaca mulatta	95.54	0.00e+00	850.00
IUUC-Meu-055971	Macropus eugenii	94.61	9.00e-94	337.00
IUUC-Mga-059720	Meleagris gallopavo	84.35	0.00e+00	726.00
IUUC-Mmr-061253	Microcebus murinus	86.98	5.00e-156	544.00
IUUC-Mmu-064095	Mus musculus	91.10	0.00e+00	813.00
IUUC-Mpu-066318	Mustela putorius furo	97.89	0.00e+00	872.00
IUUC-Mlu-067090	Myotis lucifugus	92.74	0.00e+00	828.00
IUUC-Nle-069486	Nomascus leucogenys	95.54	0.00e+00	850.00
IUUC-Opr-070563	Ochotona princeps	91.82	0.00e+00	818.00
IUUC-Oan-073245	Ornithorhynchus anatinus	89.71	0.00e+00	627.00
IUUC-Ocu-074851	Oryctolagus cuniculus	95.54	2.00e-179	622.00
IUUC-Ola-086413	Oryzias latipes	59.87	0.00e+00	686.00
IUUC-Oga-088862	Otolemur garnettii	95.78	0.00e+00	828.00
IUUC-Oar-089462	Ovis aries	87.60	0.00e+00	1090.00
IUUC-Ptr-091525	Pan troglodytes	95.07	0.00e+00	725.00
IUUC-Pan-092363	Papio anubis	96.01	0.00e+00	806.00
IUUC-Pma-094155	Petromyzon marinus	59.39	4.00e-82	297.00
IUUC-Pca-100449	Procavia capensis	92.99	0.00e+00	809.00
IUUC-Pva-102868	Pteropus vampyrus	95.78	0.00e+00	854.00
IUUC-Rno-105190	Rattus norvegicus	88.99	0.00e+00	798.00
IUUC-Sar-113561	Sorex araneus	95.81	4.00e-95	341.00
IUUC-Ssc-115735	Sus scrofa	96.02	0.00e+00	859.00
IUUC-Tsy-118814	Tarsius syrichta	94.61	0.00e+00	823.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence