iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mdo-061926

Ensembl Protein ID

ENSMODP00000032525.2

UniProt Accession

F7A3L2; F7A3L2_MONDO

Protein Name

Uncharacterized protein

Gene Name

VAV1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMODG00000002314.4	ENSMODT00000034109.2	ENSMODP00000032525.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	1.10e-20	73.5	708	759

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 7    qvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvek 61
           ++ yd+ a +  eL+lk+Gd++++i  ++ ++gW++g  e  g+ G fP+n+ve+
   Q: 708  KARYDFCARDRTELSLKEGDIIKII-SKKGNQGWWRG--EIYGRIGWFPSNYVEE 759
           688**********************.999********..9*************86 PP

Organism

Monodelphis domestica

Protein Sequence
(Fasta)

MVLMLGGGYM AGPILVPISK SIFHVQVIYT LSALSWTTIA QDKGIVPFPT DEDSLGDDDI 60
YSGLSDQIDD TVEEDEDLYD CVENEEAEGD EIYEDLMRTE PTPMLPKMTE LDKRACCLRE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGAACCTCAA AAATTCAGAA TCTTAAGAGT TTTTGAACTG AAGGCTCCTT CAATCTTAGA 60
AGTCTAGACT TCTAGGATCT CAGGGTTCTA GACTTTAAGG GACCTAAATT CTGGAAATGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0344--Guanine-nucleotide releasing factor
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0727--SH2 domain
KW-0728--SH3 domain
KW-0862--Zinc

Interpro

IPR001715--CH-domain
IPR000219--DH-domain
IPR001331--GDS_CDC24_CS
IPR002219--PE/DAG-bd
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR000980--SH2
IPR001452--SH3_domain
IPR028530--Vav

PROSITE

PS00741--DH_1
PS50010--DH_2
PS50003--PH_DOMAIN
PS50001--SH2
PS50002--SH3
PS00479--ZF_DAG_PE_1
PS50081--ZF_DAG_PE_2

Pfam

PF00130--C1_1
PF00169--PH
PF00621--RhoGEF
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN

SMART

SM00109--C1
SM00233--PH
SM00325--RhoGEF
SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0005911--C:cell-cell junction
GO:0005622--C:intracellular
GO:0046872--F:metal ion binding
GO:0030676--F:Rac guanyl-nucleotide exchange factor activity
GO:0007186--P:G-protein coupled receptor signaling pathway
GO:0006955--P:immune response
GO:0007229--P:integrin-mediated signaling pathway
GO:0030593--P:neutrophil chemotaxis
GO:0006909--P:phagocytosis
GO:0045785--P:positive regulation of cell adhesion
GO:0045954--P:positive regulation of natural killer cell mediated cytotoxicity
GO:0072593--P:reactive oxygen species metabolic process
GO:0008361--P:regulation of cell size
GO:0035023--P:regulation of Rho protein signal transduction
GO:0007264--P:small GTPase mediated signal transduction
GO:0030217--P:T cell differentiation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Bta-013049	Bos taurus	73.35	0.00e+00	1049.00
IUUC-Cja-020009	Callithrix jacchus	86.23	0.00e+00	1316.00
IUUC-Cfa-020768	Canis familiaris	87.83	0.00e+00	1315.00
IUUC-Dno-029602	Dasypus novemcinctus	86.10	0.00e+00	1305.00
IUUC-Eca-033682	Equus caballus	87.30	0.00e+00	1324.00
IUUC-Fca-035629	Felis catus	86.11	0.00e+00	1338.00
IUUC-Gmo-039693	Gadus morhua	57.41	0.00e+00	802.00
IUUC-Gac-041567	Gasterosteus aculeatus	62.65	0.00e+00	860.00
IUUC-Hsa-045886	Homo sapiens	86.36	0.00e+00	1312.00
IUUC-Itr-048730	Ictidomys tridecemlineatus	82.51	0.00e+00	1230.00
IUUC-Loc-051761	Lepisosteus oculatus	70.16	0.00e+00	1017.00
IUUC-Laf-054537	Loxodonta africana	86.50	0.00e+00	1321.00
IUUC-Mcc-054726	Macaca mulatta	86.23	0.00e+00	1312.00
IUUC-Mmr-060980	Microcebus murinus	84.84	0.00e+00	1296.00
IUUC-Mmu-063942	Mus musculus	85.70	0.00e+00	1302.00
IUUC-Mpu-066000	Mustela putorius furo	87.30	0.00e+00	1310.00
IUUC-Mlu-067818	Myotis lucifugus	84.71	0.00e+00	1252.00
IUUC-Ont-072213	Oreochromis niloticus	65.24	0.00e+00	946.00
IUUC-Ocu-074830	Oryctolagus cuniculus	71.77	0.00e+00	1034.00
IUUC-Ola-087345	Oryzias latipes	61.61	0.00e+00	882.00
IUUC-Oga-089104	Otolemur garnettii	86.90	0.00e+00	1322.00
IUUC-Oar-089459	Ovis aries	85.56	0.00e+00	1289.00
IUUC-Ptr-090766	Pan troglodytes	86.36	0.00e+00	1315.00
IUUC-Pan-091994	Papio anubis	85.05	0.00e+00	1289.00
IUUC-Psi-093595	Pelodiscus sinensis	76.48	0.00e+00	1083.00
IUUC-Pfo-097210	Poecilia formosa	64.03	0.00e+00	906.00
IUUC-Pab-098630	Pongo abelii	86.20	0.00e+00	1277.00
IUUC-Pva-102406	Pteropus vampyrus	85.70	0.00e+00	1257.00
IUUC-Pte-104123	Pyrenophora teres	51.67	5.00e-11	63.90
IUUC-Pyt-104567	Pyrenophora triticirepentis	57.14	5.00e-11	63.90
IUUC-Rno-105763	Rattus norvegicus	83.02	0.00e+00	1245.00
IUUC-Sha-106683	Sarcophilus harrisii	93.45	0.00e+00	1413.00
IUUC-Sly-111123	Solanum lycopersicum	46.97	2.00e-09	56.60
IUUC-Sar-113457	Sorex araneus	73.49	0.00e+00	786.00
IUUC-Ssc-115338	Sus scrofa	87.03	0.00e+00	1323.00
IUUC-Tru-118199	Takifugu rubripes	61.75	0.00e+00	845.00
IUUC-Tni-120548	Tetraodon nigroviridis	62.35	0.00e+00	876.00
IUUC-Tbe-127235	Tupaia belangeri	63.82	1.00e-124	440.00
IUUC-Ttr-128916	Tursiops truncatus	82.31	0.00e+00	883.00
IUUC-Vpa-130066	Vicugna pacos	65.55	1.00e-69	257.00
IUUC-Xtr-132410	Xenopus tropicalis	69.88	0.00e+00	1073.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence