iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mpu-065691

Ensembl Protein ID

ENSMPUP00000018872.1

UniProt Accession

M3Z5L0; M3Z5L0_MUSPF

Genbank Protein ID

ENSMPUP00000018872

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AEYP01039537

Gene Name

TRIM59

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMPUG00000018992.1	ENSMPUT00000019144.1	ENSMPUP00000018872.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/U-box	3.00e-06	27.2	6	89
E3 activity/RING/RING	1.40e-09	38.3	10	60

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 4    eeflCpIslelMrdPvvlpsGitydrssIekwlasggk...........tcPvtrqpl.....teedlvPnltlrrliqawcee 71
           +e+ CpI + +++dP vlp+ +t+ r+++e  l+ +g+           +cP +r+ +       e+l  n +lr++i+++ +e
   Q: 6    DELTCPICYSIFEDPRVLPCSHTFCRNCLENVLQASGNfyiwrplriplKCPNCRSIIeiaptGIESLPVNFALRAIIEKYQQE 89
           7899*****************************999999**********99999986533321456777799999999999776 PP

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefr..........CPlCr 46
           C+iC++ f+d p+vlpC H+f+++Cl+++     ++s++f+          CP Cr
   Q: 10   CPICYSIFED-PRVLPCSHTFCRNCLENV----LQASGNFYiwrplriplkCPNCR 60
           **********.***************999....667777766667777777****8 PP

Organism

Mustela putorius furo

Protein Sequence
(Fasta)

MHNFEDELTC PICYSIFEDP RVLPCSHTFC RNCLENVLQA SGNFYIWRPL RIPLKCPNCR 60
SIIEIAPTGI ESLPVNFALR AIIEKYQQED HPDIVTCPEH YRQPLNVYCL LDKKLVCGHC 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGCACAATT TTGAGGACGA GTTAACATGT CCCATTTGTT ACAGTATTTT TGAAGATCCT 60
CGTGTACTAC CATGCTCTCA TACATTTTGT AGAAATTGCT TGGAAAACGT TCTTCAGGCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0472--Membrane
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR027370--Znf-RING_LisH
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00643--zf-B_box
PF13445--zf-RING_UBOX

SMART

SM00184--RING

Gene Ontology

GO:0005783--C:endoplasmic reticulum
GO:0016021--C:integral component of membrane
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0045087--P:innate immune response
GO:0043124--P:negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0046597--P:negative regulation of viral entry into host cell

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002249	Ailuropoda melanoleuca	95.77	0.00e+00	789.00
IUUC-Apl-003996	Anas platyrhynchos	57.78	5.00e-123	434.00
IUUC-Aca-005141	Anolis carolinensis	58.02	1.00e-132	466.00
IUUC-Ame-011353	Astyanax mexicanus	52.09	2.00e-100	359.00
IUUC-Bta-013440	Bos taurus	94.20	0.00e+00	700.00
IUUC-Cfa-021168	Canis familiaris	96.76	0.00e+00	796.00
IUUC-Cpo-021702	Cavia porcellus	78.61	0.00e+00	631.00
IUUC-Csa-024141	Chlorocebus sabaeus	90.82	0.00e+00	691.00
IUUC-Dre-028408	Danio rerio	47.44	4.00e-89	321.00
IUUC-Dno-029180	Dasypus novemcinctus	91.81	0.00e+00	756.00
IUUC-Ete-033028	Echinops telfairi	89.03	2.00e-171	595.00
IUUC-Eca-034357	Equus caballus	93.30	0.00e+00	740.00
IUUC-Fca-036287	Felis catus	97.52	0.00e+00	800.00
IUUC-Gga-040739	Gallus gallus	58.13	2.00e-136	479.00
IUUC-Ggo-045307	Gorilla gorilla	89.83	0.00e+00	725.00
IUUC-Hsa-045690	Homo sapiens	90.57	0.00e+00	726.00
IUUC-Itr-048230	Ictidomys tridecemlineatus	94.29	0.00e+00	786.00
IUUC-Laf-054522	Loxodonta africana	88.59	0.00e+00	740.00
IUUC-Mcc-055145	Macaca mulatta	91.56	0.00e+00	733.00
IUUC-Meu-056214	Macropus eugenii	48.37	3.00e-63	235.00
IUUC-Mmr-061197	Microcebus murinus	95.53	0.00e+00	795.00
IUUC-Mdo-062631	Monodelphis domestica	60.74	6.00e-137	480.00
IUUC-Mmu-064217	Mus musculus	87.56	0.00e+00	700.00
IUUC-Mlu-067742	Myotis lucifugus	91.52	0.00e+00	725.00
IUUC-Nle-069722	Nomascus leucogenys	91.07	0.00e+00	760.00
IUUC-Oan-073382	Ornithorhynchus anatinus	59.70	6.00e-137	480.00
IUUC-Oar-089206	Ovis aries	93.05	0.00e+00	775.00
IUUC-Pan-092189	Papio anubis	91.81	0.00e+00	735.00
IUUC-Psi-093523	Pelodiscus sinensis	62.32	4.00e-144	504.00
IUUC-Pma-094162	Petromyzon marinus	33.75	2.00e-48	185.00
IUUC-Pfo-096032	Poecilia formosa	46.62	5.00e-89	321.00
IUUC-Pva-103089	Pteropus vampyrus	93.52	0.00e+00	744.00
IUUC-Pgr-103338	Puccinia graminis	38.10	1.00e-06	46.60
IUUC-Rno-105440	Rattus norvegicus	89.80	0.00e+00	718.00
IUUC-Ssc-115809	Sus scrofa	92.56	0.00e+00	738.00
IUUC-Tru-118402	Takifugu rubripes	44.63	1.00e-94	339.00
IUUC-Tni-119737	Tetraodon nigroviridis	45.34	4.00e-86	311.00
IUUC-Ttr-128921	Tursiops truncatus	92.27	0.00e+00	741.00
IUUC-Vpa-130397	Vicugna pacos	93.80	0.00e+00	780.00
IUUC-Xtr-132752	Xenopus tropicalis	43.63	8.00e-85	307.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence