iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Bta-012735

UUCD1 version

UUC-BoT-00069

Ensembl Protein ID

ENSBTAP00000013121.5

UniProt Accession

A6QLA8; F1MTX8; A6QLA8_BOVIN

Genbank Protein ID

AAI47899.1

Protein Name

TRIM25 protein

Genbank Nucleotide ID

DAAA02048261

Gene Name

TRIM25

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000009948.5	ENSBTAT00000013121.5	ENSBTAP00000013121.5

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	4.90e-08	33.5	13	54

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadCl.qkwpglknssskefrCPlCr 46
           C+iCle+fk  p+++pCgH f+  Cl + w     ++    +CP Cr
   Q: 13   CSICLEPFKG-PVTTPCGHNFCGACLdETW----AVQGAPYLCPQCR 54
           ********77.*******************....8999999*****8 PP

Organism

Bos taurus

Protein Sequence
(Fasta)

MAELCPLAEE LSCSICLEPF KGPVTTPCGH NFCGACLDET WAVQGAPYLC PQCRTGFAAR 60
PQLRKNTVLC AVVEQFLQAE QARPALAADD WTPPTRAAAP SAAGQVACDH CLQATAVKTC 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACGTCCCGTC GGGCGCCCAC GACACACCAT GGCGGAGCTG TGCCCGCTGG CCGAGGAGCT 60
GTCGTGCTCC ATCTGCCTGG AGCCCTTCAA GGGCCCGGTC ACCACGCCGT GCGGCCACAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001870--B30.2/SPRY
IPR003879--Butyrophylin
IPR013320--ConA-like_dom
IPR006574--PRY
IPR003877--SPRY_dom
IPR018957--Znf_C3HC4_RING-type
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50188--B302_SPRY
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF13765--PRY
PF00622--SPRY
PF00097--zf-C3HC4

PRINTS

PR01407--BUTYPHLNCDUF

SMART

SM00589--PRY
SM00184--RING
SM00449--SPRY

Gene Ontology

GO:0005829--C:cytosol
GO:0016604--C:nuclear body
GO:0003723--F:RNA binding
GO:1904264--F:ubiquitin protein ligase activity involved in ERAD pathway
GO:0008270--F:zinc ion binding
GO:0045087--P:innate immune response
GO:0046597--P:negative regulation of viral entry into host cell
GO:1902187--P:negative regulation of viral release from host cell
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:0006513--P:protein monoubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043627--P:response to estrogen

KEGG

bta:510923

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002424	Ailuropoda melanoleuca	74.29	0.00e+00	936.00
IUUC-Apl-004101	Anas platyrhynchos	49.13	8.00e-173	600.00
IUUC-Aca-005025	Anolis carolinensis	48.03	1.00e-173	602.00
IUUC-Cja-019996	Callithrix jacchus	65.29	1.00e-171	595.00
IUUC-Cfa-020466	Canis familiaris	72.88	0.00e+00	931.00
IUUC-Cpo-021737	Cavia porcellus	66.00	0.00e+00	876.00
IUUC-Csa-023217	Chlorocebus sabaeus	73.54	0.00e+00	948.00
IUUC-Cho-024346	Choloepus hoffmanni	51.00	7.00e-73	267.00
IUUC-Dno-030082	Dasypus novemcinctus	70.73	0.00e+00	926.00
IUUC-Dor-030335	Dipodomys ordii	50.39	6.00e-121	427.00
IUUC-Ete-032923	Echinops telfairi	69.40	0.00e+00	808.00
IUUC-Eca-033411	Equus caballus	72.98	0.00e+00	930.00
IUUC-Eeu-034656	Erinaceus europaeus	72.85	4.00e-161	561.00
IUUC-Fca-035371	Felis catus	74.41	0.00e+00	939.00
IUUC-Fal-037008	Ficedula albicollis	46.70	4.00e-164	571.00
IUUC-Gmo-038668	Gadus morhua	34.51	2.00e-104	372.00
IUUC-Gga-040608	Gallus gallus	51.27	9.00e-169	587.00
IUUC-Gac-041409	Gasterosteus aculeatus	36.35	6.00e-118	417.00
IUUC-Ggo-044518	Gorilla gorilla	74.29	0.00e+00	929.00
IUUC-Hsa-045828	Homo sapiens	74.65	0.00e+00	951.00
IUUC-Itr-049070	Ictidomys tridecemlineatus	58.27	0.00e+00	704.00
IUUC-Lch-050478	Latimeria chalumnae	39.00	4.00e-71	262.00
IUUC-Loc-052864	Lepisosteus oculatus	37.35	6.00e-115	408.00
IUUC-Laf-054325	Loxodonta africana	76.69	7.00e-177	612.00
IUUC-Mcc-054920	Macaca mulatta	73.86	0.00e+00	950.00
IUUC-Meu-056367	Macropus eugenii	73.41	3.00e-74	273.00
IUUC-Mga-059975	Meleagris gallopavo	50.00	4.00e-168	584.00
IUUC-Mmr-060748	Microcebus murinus	74.48	0.00e+00	933.00
IUUC-Mdo-062904	Monodelphis domestica	58.78	0.00e+00	707.00
IUUC-Mmu-063891	Mus musculus	69.34	0.00e+00	915.00
IUUC-Mpu-066473	Mustela putorius furo	73.60	0.00e+00	974.00
IUUC-Mlu-068185	Myotis lucifugus	74.41	0.00e+00	954.00
IUUC-Nle-070177	Nomascus leucogenys	74.49	0.00e+00	952.00
IUUC-Opr-070558	Ochotona princeps	60.31	4.00e-147	514.00
IUUC-Ont-071368	Oreochromis niloticus	35.62	1.00e-110	394.00
IUUC-Ocu-074461	Oryctolagus cuniculus	70.71	4.00e-157	548.00
IUUC-Ola-086993	Oryzias latipes	26.62	2.00e-58	220.00
IUUC-Oga-088937	Otolemur garnettii	69.76	0.00e+00	874.00
IUUC-Oar-089781	Ovis aries	92.73	0.00e+00	797.00
IUUC-Ptr-090771	Pan troglodytes	74.65	0.00e+00	937.00
IUUC-Pan-092830	Papio anubis	73.86	0.00e+00	951.00
IUUC-Psi-093664	Pelodiscus sinensis	50.42	1.00e-99	357.00
IUUC-Pma-094147	Petromyzon marinus	27.53	9.00e-58	218.00
IUUC-Pfo-096528	Poecilia formosa	35.49	3.00e-116	412.00
IUUC-Pab-097588	Pongo abelii	74.17	0.00e+00	937.00
IUUC-Pca-100890	Procavia capensis	72.63	2.00e-161	562.00
IUUC-Pva-102314	Pteropus vampyrus	77.52	0.00e+00	934.00
IUUC-Pgr-103377	Puccinia graminis	37.50	1.00e-05	44.70
IUUC-Rno-105234	Rattus norvegicus	67.99	0.00e+00	894.00
IUUC-Sce-106362	Saccharomyces cerevisiae	43.48	7.00e-09	55.10
IUUC-Sha-106807	Sarcophilus harrisii	54.61	0.00e+00	673.00
IUUC-Sar-113283	Sorex araneus	54.29	8.00e-125	440.00
IUUC-Ssc-115878	Sus scrofa	88.41	2.00e-118	418.00
IUUC-Tgu-117026	Taeniopygia guttata	43.76	1.00e-130	460.00
IUUC-Tru-117794	Takifugu rubripes	32.98	2.00e-52	200.00
IUUC-Tni-120778	Tetraodon nigroviridis	27.97	2.00e-61	229.00
IUUC-Tbe-127580	Tupaia belangeri	68.63	4.00e-145	507.00
IUUC-Ttr-128648	Tursiops truncatus	75.52	0.00e+00	681.00
IUUC-Vpa-130254	Vicugna pacos	88.57	3.00e-96	345.00
IUUC-Xtr-132892	Xenopus tropicalis	42.61	2.00e-74	272.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence