iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000128923.10	ENST00000316848.9	ENSP00000326194.5
ENSG00000128923.10	ENST00000560289.5	ENSP00000453425.1
ENSG00000128923.10	ENST00000559228.5	ENSP00000452885.1
ENSG00000128923.10	ENST00000450403.3	ENSP00000393231.2

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
RepTar	SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
InWeb_IM
Disease-associated Information
GWASdb
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	UniProt	BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM

Status

Reviewed

Details

Family	Domain	References (PMIDs)
DUB/MINDY	MINDY	27292798
UBD/Alpha-Helix/MIU	MIU	27292798

Classification

Family	E-value	Score	Start	End
DUB/MINDY	4.20e-66	222.3	273	395

Active Site

Position(s)	Description	Evidence
266	Nucleophile	{ECO:0000250\|UniProtKB:Q8N5J2}
448	Proton acceptor	{ECO:0000250\|UniProtKB:Q8N5J2}

Domain Profile

DUB/MINDY

   S: 1    nilllswkvklvpkkevitleelievlgdilldvkdkekseiselnyeqnvddalsllpklaeGldvnvrftGvrsfeytkecsvfdlldid 92
           n+lll+wkvkl+p++e+it+e+l+e+lgd++ld+k+ke+sei++lnyeqn++da+++l+kl++GldvnvrftGvr+feyt+ec+vfdlldi+
   Q: 273  NVLLLAWKVKLPPMMEIITAEQLMEYLGDYMLDAKPKEISEIQRLNYEQNMSDAMAILHKLQTGLDVNVRFTGVRVFEYTPECIVFDLLDIP 364
           9******************************************************************************************* PP
   S: 93   lyhGWlvdsqideavkavgklsyeqlveril 123
           lyhGWlvd+qid++vkavg++sy+qlve+i+
   Q: 365  LYHGWLVDPQIDDIVKAVGNCSYNQLVEKII 395
           ******************************8 PP

Organism

Homo sapiens

Functional Description
(View)

Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins (PubMed:27292798). Binds to polyubiquitin chains of different linkage types, including 'Lys-6', 'Lys-11', 'Lys-29', 'Lys-33', 'Lys-48' and 'Lys-63' (PubMed:28082312). May play a regulatory role at the level of protein turnover (PubMed:27292798).

Protein Sequence
(Fasta)

MESSPESLQP LEHGVAAGPA SGTGSSQEGL QETRLAAGDG PGVWAAETSG GNGLGAAAAR 60
RSLPDSASPA GSPEVPGPCS SSAGLDLKDS GLESPAAAEA PLRGQYKVTA SPETAVAGVG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCAGTCAGGC GGAGGCAAGC TCAGAGCGCA CGGACAGAGC GGTAGCGCGC GCCCGCGCGC 60
GTTCTTAGTA CTCTCCCCGG TGACGTGCCT GACCGAGGCC GCGCCAGGGC GCTGTTGCTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR007518--MINDY
IPR033979--MINDY_domain

Pfam

PF04424--MINDY_DUB

Gene Ontology

GO:0005654--C:nucleoplasm
GO:0016807--F:cysteine-type carboxypeptidase activity
GO:0071795--F:K11-linked polyubiquitin binding
GO:0036435--F:K48-linked polyubiquitin binding
GO:0071796--F:K6-linked polyubiquitin binding
GO:0070530--F:K63-linked polyubiquitin binding
GO:1990380--F:Lys48-specific deubiquitinase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity

KEGG

hsa:54629

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-136382	Ailuropoda melanoleuca	89.96	0.00e+00	631.00
IUUC-Apl-136387	Anas platyrhynchos	97.13	8.00e-154	536.00
IUUC-Aca-136392	Anolis carolinensis	93.44	1.00e-168	586.00
IUUC-Ate-136406	Aspergillus terreus	30.23	9.00e-23	102.00
IUUC-Bta-136414	Bos taurus	91.38	0.00e+00	831.00
IUUC-Cja-136427	Callithrix jacchus	96.21	0.00e+00	649.00
IUUC-Cfa-136430	Canis familiaris	97.67	0.00e+00	642.00
IUUC-Cpo-136434	Cavia porcellus	89.81	1.00e-178	619.00
IUUC-Csa-136441	Chlorocebus sabaeus	98.07	0.00e+00	975.00
IUUC-Cho-136445	Choloepus hoffmanni	77.97	5.00e-75	275.00
IUUC-Csv-136449	Ciona savignyi	55.29	4.00e-79	287.00
IUUC-Cgl-136450	Colletotrichum gloeosporioides	29.15	2.00e-23	104.00
IUUC-Dre-136454	Danio rerio	82.95	4.00e-179	621.00
IUUC-Dno-136459	Dasypus novemcinctus	88.26	0.00e+00	766.00
IUUC-Dor-136463	Dipodomys ordii	76.00	2.00e-107	382.00
IUUC-Ete-136469	Echinops telfairi	95.02	7.00e-160	557.00
IUUC-Eca-136473	Equus caballus	95.86	0.00e+00	649.00
IUUC-Fca-136479	Felis catus	96.63	0.00e+00	660.00
IUUC-Fal-136483	Ficedula albicollis	96.75	2.00e-152	531.00
IUUC-Fox-136484	Fusarium oxysporum	29.74	8.00e-25	108.00
IUUC-Gmo-136489	Gadus morhua	79.54	3.00e-173	601.00
IUUC-Ggr-136490	Gaeumannomyces graminis	26.32	2.00e-23	105.00
IUUC-Gga-136493	Gallus gallus	87.31	0.00e+00	635.00
IUUC-Gac-136497	Gasterosteus aculeatus	82.10	1.00e-173	602.00
IUUC-Ggo-136505	Gorilla gorilla	95.95	0.00e+00	891.00
IUUC-Lch-136517	Latimeria chalumnae	85.79	2.00e-177	615.00
IUUC-Lpe-136520	Leersia perrieri	33.46	2.00e-30	128.00
IUUC-Loc-136524	Lepisosteus oculatus	85.79	0.00e+00	646.00
IUUC-Lma-136525	Leptosphaeria maculans	33.80	4.00e-31	130.00
IUUC-Laf-136528	Loxodonta africana	97.76	3.00e-172	597.00
IUUC-Mcc-136532	Macaca mulatta	97.80	0.00e+00	686.00
IUUC-Mpo-136538	Magnaporthe poae	26.85	1.00e-21	99.00
IUUC-Mga-136545	Meleagris gallopavo	96.35	2.00e-178	618.00
IUUC-Mmr-136549	Microcebus murinus	92.81	0.00e+00	829.00
IUUC-Mdo-136553	Monodelphis domestica	73.06	0.00e+00	679.00
IUUC-Mmu-136558	Mus musculus	76.12	0.00e+00	691.00
IUUC-Mpu-136563	Mustela putorius furo	86.23	4.00e-156	545.00
IUUC-Mlu-136568	Myotis lucifugus	80.17	0.00e+00	676.00
IUUC-Ncr-136571	Neurospora crassa	28.66	3.00e-25	111.00
IUUC-Nle-136575	Nomascus leucogenys	98.71	0.00e+00	948.00
IUUC-Oan-136584	Ornithorhynchus anatinus	92.44	1.00e-109	389.00
IUUC-Ocu-136588	Oryctolagus cuniculus	87.60	0.00e+00	776.00
IUUC-Ola-136611	Oryzias latipes	80.05	6.00e-169	587.00
IUUC-Olu-136613	Ostreococcus lucimarinus	51.72	8.00e-20	91.70
IUUC-Oga-136616	Otolemur garnettii	90.00	0.00e+00	742.00
IUUC-Oar-136622	Ovis aries	96.71	0.00e+00	681.00
IUUC-Ptr-136626	Pan troglodytes	99.84	0.00e+00	987.00
IUUC-Pan-136629	Papio anubis	98.07	0.00e+00	969.00
IUUC-Psi-136633	Pelodiscus sinensis	90.10	0.00e+00	637.00
IUUC-Pma-136636	Petromyzon marinus	70.98	3.00e-137	482.00
IUUC-Pno-136637	Phaeosphaeria nodorum	32.65	2.00e-29	124.00
IUUC-Pfo-136644	Poecilia formosa	81.59	7.00e-176	610.00
IUUC-Pab-136647	Pongo abelii	99.36	0.00e+00	969.00
IUUC-Pca-136655	Procavia capensis	96.76	2.00e-156	545.00
IUUC-Pva-136659	Pteropus vampyrus	82.73	0.00e+00	660.00
IUUC-Pte-136663	Pyrenophora teres	31.03	6.00e-28	119.00
IUUC-Pyt-136664	Pyrenophora triticirepentis	30.60	1.00e-27	118.00
IUUC-Rno-136667	Rattus norvegicus	74.33	0.00e+00	686.00
IUUC-Sce-136670	Saccharomyces cerevisiae	33.09	6.00e-28	118.00
IUUC-Sha-136674	Sarcophilus harrisii	96.18	6.00e-146	509.00
IUUC-Tgu-136696	Taeniopygia guttata	86.11	0.00e+00	635.00
IUUC-Tru-136700	Takifugu rubripes	82.35	2.00e-174	605.00
IUUC-Tsy-136704	Tarsius syrichta	91.73	0.00e+00	791.00
IUUC-Tni-136709	Tetraodon nigroviridis	81.75	3.00e-171	594.00
IUUC-Tre-136712	Trichoderma reesei	32.62	1.00e-26	113.00
IUUC-Tvi-136713	Trichoderma virens	29.35	5.00e-27	116.00
IUUC-Tbe-136721	Tupaia belangeri	97.82	2.00e-161	561.00
IUUC-Ttr-136724	Tursiops truncatus	91.49	0.00e+00	816.00
IUUC-Vda-136728	Verticillium dahliae	31.49	3.00e-24	107.00
IUUC-Vpa-136731	Vicugna pacos	93.69	0.00e+00	641.00
IUUC-Xtr-136736	Xenopus tropicalis	79.90	1.00e-175	609.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence