iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000282954.1	ENST00000634982.1	ENSP00000488997.1
ENSG00000282954.1	ENST00000634720.1	ENSP00000489074.1
ENSG00000282954.1	ENST00000634917.1	ENSP00000489012.1
ENSG00000282954.1	ENST00000635016.1	ENSP00000489291.1

Annotation

Cancer Mutation
TCGA	COSMIC	CGAP	IntOGen
mRNA Expression
TCGA	ICGC	COSMIC	HPM
DNA & RNA Element
UTRdb	CircNet	RepTar	SomamiR
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	Mentha
InWeb_IM
Disease-associated Information
ClinVar	GWASdb
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/SCF/F-box	F-box	18203720

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/SCF/F-box	0.0025	19.5	17	59

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/SCF/F-box

   S: 102  lldrlpeeilveilklldkee.llraarvcrrwqelasqkalw 143
            ld lp e+lv++l+++++++ + r++ vcr w+ + + +++w
   Q: 17   ALDALPPELLVQVLSHVPPRSlVTRCRPVCRAWRDIVDGPTVW 59
           5689*************9999799**********888878877 PP

Organism

Homo sapiens

Functional Description
(View)

Part of a SCF (SKP1-cullin-F-box) protein ligase complex. Interacts with SKP1 and CUL1.

Protein Sequence
(Fasta)

MGARLSRRRL PADPSLALDA LPPELLVQVL SHVPPRSLVT RCRPVCRAWR DIVDGPTVWL 60
LQLARDRSAE GRALYAVAQR CLPSNEDKEE FPLCALARYC LRAPFGRNLI FNSCGEQGFR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCGCTCCCCG CTGGCCTCGC GGCAACTGGG CCTCCCCCTC GCTGCACGCA GCCCTCCAAG 60
CTCCCCCGCC CGCCCGCCCT CGCTCCCGCT GGGCCCCGCA GCCGGAGGAG GGGCGGCCTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR007397--F-box-assoc_dom
IPR001810--F-box_dom
IPR008979--Galactose-bd-like

PROSITE

PS51114--FBA
PS50181--FBOX

Pfam

PF12937--F-box-like
PF04300--FBA

SMART

SM01198--FBA
SM00256--FBOX

Gene Ontology

GO:0005829--C:cytosol
GO:0019005--C:SCF ubiquitin ligase complex
GO:0001948--F:glycoprotein binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0000209--P:protein polyubiquitination

KEGG

hsa:115290

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000348	Aegilops tauschii	62.86	1.00e-05	44.70
IUUC-Aml-002175	Ailuropoda melanoleuca	92.46	2.00e-137	481.00
IUUC-Atr-002476	Amborella trichopoda	27.66	1.90e-01	31.20
IUUC-Aca-005289	Anolis carolinensis	49.58	4.00e-63	234.00
IUUC-Aly-006011	Arabidopsis lyrata	34.33	7.00e-05	41.20
IUUC-Ath-007566	Arabidopsis thaliana	32.84	1.00e-02	34.70
IUUC-Bta-012403	Bos taurus	91.04	5.00e-139	486.00
IUUC-Bdi-014683	Brachypodium distachyon	46.81	1.10e-02	36.20
IUUC-Bra-016666	Brassica rapa	41.67	5.00e-04	38.50
IUUC-Cja-019664	Callithrix jacchus	87.86	1.00e-141	495.00
IUUC-Cfa-020507	Canis familiaris	89.57	2.00e-132	464.00
IUUC-Cpo-021692	Cavia porcellus	87.64	3.00e-138	484.00
IUUC-Csa-023237	Chlorocebus sabaeus	98.56	4.00e-161	560.00
IUUC-Dno-030010	Dasypus novemcinctus	87.65	6.00e-127	446.00
IUUC-Dor-030171	Dipodomys ordii	87.77	8.00e-145	506.00
IUUC-Eca-034121	Equus caballus	94.24	2.00e-74	270.00
IUUC-Eeu-034490	Erinaceus europaeus	80.22	1.00e-131	462.00
IUUC-Fca-036454	Felis catus	72.79	6.00e-107	380.00
IUUC-Gma-044203	Glycine max	28.57	2.00e-03	37.40
IUUC-Itr-048913	Ictidomys tridecemlineatus	91.36	4.00e-87	313.00
IUUC-Lpe-051277	Leersia perrieri	68.75	5.00e-03	32.00
IUUC-Laf-054235	Loxodonta africana	94.74	2.00e-72	263.00
IUUC-Mcc-054716	Macaca mulatta	88.85	5.00e-126	443.00
IUUC-Mpo-057547	Magnaporthe poae	33.33	1.60e-02	31.20
IUUC-Mtr-057739	Medicago truncatula	34.69	5.00e-04	38.90
IUUC-Mla-059161	Melampsora laricipopulina	37.78	1.20e-01	30.40
IUUC-Mmr-061741	Microcebus murinus	92.06	4.00e-138	483.00
IUUC-Mmu-063186	Mus musculus	83.57	1.00e-139	489.00
IUUC-Mac-064951	Musa acuminata	27.95	6.00e-05	42.00
IUUC-Mpu-066676	Mustela putorius furo	92.09	6.00e-139	486.00
IUUC-Mlu-067553	Myotis lucifugus	93.21	3.00e-88	317.00
IUUC-Nle-069434	Nomascus leucogenys	98.92	4.00e-150	523.00
IUUC-Opr-070811	Ochotona princeps	83.70	2.00e-66	245.00
IUUC-Ocu-074614	Oryctolagus cuniculus	86.61	8.00e-125	439.00
IUUC-Ogu-078768	Oryza glumaepatula	40.43	1.00e-04	41.20
IUUC-Oin-079568	Oryza indica	42.22	2.00e-04	38.90
IUUC-Olo-080883	Oryza longistaminata	47.62	5.00e-06	43.90
IUUC-Ome-081576	Oryza meridionalis	37.74	2.00e-05	44.30
IUUC-Oni-082669	Oryza nivara	32.20	4.00e-06	46.20
IUUC-Opu-083853	Oryza punctata	40.48	2.00e-03	37.40
IUUC-Oru-084840	Oryza rufipogon	32.20	5.00e-06	46.20
IUUC-Osa-085304	Oryza sativa	35.56	1.00e-02	34.70
IUUC-Oga-088143	Otolemur garnettii	89.21	2.00e-147	514.00
IUUC-Oar-089201	Ovis aries	91.98	7.00e-87	312.00
IUUC-Pan-092112	Papio anubis	99.28	1.00e-150	525.00
IUUC-Pno-094803	Phaeosphaeria nodorum	36.67	3.00e-03	36.20
IUUC-Pab-098059	Pongo abelii	98.56	1.00e-161	561.00
IUUC-Pop-100065	Populus trichocarpa	32.84	6.00e-06	45.10
IUUC-Pca-100353	Procavia capensis	77.42	7.00e-125	439.00
IUUC-Ppe-101505	Prunus persica	30.43	4.00e-05	42.70
IUUC-Pva-102310	Pteropus vampyrus	88.85	2.00e-135	475.00
IUUC-Rno-105558	Rattus norvegicus	81.55	1.00e-105	375.00
IUUC-Sha-106875	Sarcophilus harrisii	44.84	4.00e-65	241.00
IUUC-Sit-109871	Setaria italica	33.33	2.00e-03	38.10
IUUC-Sly-111384	Solanum lycopersicum	37.04	8.00e-05	42.00
IUUC-Sar-113465	Sorex araneus	73.17	3.00e-84	304.00
IUUC-Sbi-114018	Sorghum bicolor	52.78	1.00e-03	38.10
IUUC-Ssc-115935	Sus scrofa	67.73	2.00e-102	365.00
IUUC-Tca-121064	Theobroma cacao	41.03	7.00e-05	42.00
IUUC-Tae-122782	Triticum aestivum	64.71	9.00e-06	45.10
IUUC-Tur-126828	Triticum urartu	64.71	8.00e-06	45.40
IUUC-Tbe-128039	Tupaia belangeri	90.71	1.00e-71	261.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence