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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046940
UUCD1 version UUC-HoS-00381
Ensembl Protein ID ENSP00000311827.2
UniProt Accession Q9HCI7; B4DYL4; G5E9I1; Q0D2P1; Q8NDB4; Q9NVS4; MSL2_HUMAN
Genbank Protein ID BAB13411.1; BAA91673.1; BAG63776.1; CAD38963.2; EAW79119.1; EAW79120.1; AAH32719.1; AAH93764.1; AAH93790.1
Protein Name E3 ubiquitin-protein ligase MSL2; Male-specific lethal 2-like 1; Male-specific lethal-2 homolog; Male-specific lethal-2 homolog 1; RING finger protein 184
Genbank Nucleotide ID AB046805; AK001408; AK302491; AL834289; AC092991; CH471052; BC032719; BC093764; BC093790
Gene Name MSL2; KIAA1585; MSL2L1; RNF184
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000174579.3 ENST00000309993.2 ENSP00000311827.2
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPMSZDB
DNA & RNA Element
UTRdbAREsiteCircNetmiRTarBase
microRNATRANSFACTargetScanRepTar
miRNAMapSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexHINTMentha
InWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDUniProtBioGRID
DNA Methylation
TCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 19651615; 21726816; 23874665
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at lysine 16 which is implicated in the formation of higher-order chromatin structure. Acts as an E3 ubiquitin ligase that promotes monoubiquitination of histone H2B at 'Lys-35' (H2BK34Ub), but not that of H2A. This activity is greatly enhanced by heterodimerization with MSL1. H2B ubiquitination in turn stimulates histine H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1.
 Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at lysine 16 which is implicated in the formation of higher-order chromatin structure. Acts as an E3 ubiquitin ligase that promotes monoubiquitination of histone H2B at 'Lys-35' (H2BK34Ub), but not that of H2A. This activity is greatly enhanced by heterodimerization with MSL1. H2B ubiquitination in turn stimulates histine H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1.
Protein Sequence
(Fasta)
MNPVNATALY ISASRLVLNY DPGDPKAFTE INRLLPYFRQ SLSCCVCGHL LQDPIAPTNS 60
TCQHYVCKTC KGKKMMMKPS CSWCKDYEQF EENKQLSILV NCYKKLCEYI TQTTLARDII 120
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Protein Fasta Sequence


>IUUC-Hsa-046940|E3,RING|Homo sapiens
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Nucleotide Sequence
(Fasta)
AGCTCGGTGA AGTCCTGATC GGCACCCATG AAGGTGAGGC CGCACGAGTC CAAGGGCCAG 60
AGGCCGTGGG AACAGCGCGG GTCCGACGGG TAGGAGGGGG CAGTGGGTTC GAGCCTCCAC 120
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Nucleotide Fasta Sequence


>IUUC-Hsa-046940|E3,RING|Homo sapiens
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Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-1017--Isopeptide bond
KW-0436--Ligase
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR032049--Msl2-CXC
IPR032043--Msl2_Znf-RING
IPR033467--Tesmin/TSO1-like_CXC
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50089--ZF_RING_2
Pfam

PF16682--MSL2-CXC
PF16685--zf-RING_10
SMART

SM01114--CXC
Gene Ontology

GO:0072487--C:MSL complex
GO:0005654--C:nucleoplasm
GO:0016874--F:ligase activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0043984--P:histone H4-K16 acetylation
KEGG hsa:55167
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002110 Ailuropoda melanoleuca 99.13 0.00e+00 1025.00
IUUC-Apl-003940 Anas platyrhynchos 82.71 0.00e+00 767.00
IUUC-Acl-008267 Aspergillus clavatus 33.93 1.70e-01 31.20
IUUC-Ame-010946 Astyanax mexicanus 57.72 1.00e-162 566.00
IUUC-Bta-012906 Bos taurus 98.79 0.00e+00 1019.00
IUUC-Cja-019438 Callithrix jacchus 99.83 0.00e+00 1055.00
IUUC-Cfa-020717 Canis familiaris 98.96 0.00e+00 1023.00
IUUC-Cpo-021407 Cavia porcellus 99.65 0.00e+00 1052.00
IUUC-Csa-023801 Chlorocebus sabaeus 100.00 0.00e+00 1055.00
IUUC-Cho-024478 Choloepus hoffmanni 98.05 0.00e+00 970.00
IUUC-Cin-025751 Ciona intestinalis 44.63 1.00e-30 125.00
IUUC-Csv-026353 Ciona savignyi 42.74 2.00e-29 122.00
IUUC-Dre-027439 Danio rerio 57.83 1.00e-156 546.00
IUUC-Dno-029323 Dasypus novemcinctus 93.24 0.00e+00 1048.00
IUUC-Dme-032080 Drosophila melanogaster 38.81 3.00e-09 57.80
IUUC-Ete-032763 Echinops telfairi 98.33 0.00e+00 843.00
IUUC-Eca-033874 Equus caballus 99.31 0.00e+00 1056.00
IUUC-Fca-035538 Felis catus 99.13 0.00e+00 1025.00
IUUC-Fal-037168 Ficedula albicollis 81.31 0.00e+00 830.00
IUUC-Gmo-039463 Gadus morhua 66.18 1.00e-52 199.00
IUUC-Gga-040838 Gallus gallus 83.25 0.00e+00 884.00
IUUC-Gac-041568 Gasterosteus aculeatus 54.95 3.00e-49 187.00
IUUC-Ggo-045165 Gorilla gorilla 100.00 0.00e+00 1055.00
IUUC-Itr-048075 Ictidomys tridecemlineatus 99.06 0.00e+00 949.00
IUUC-Lch-049993 Latimeria chalumnae 72.93 0.00e+00 762.00
IUUC-Loc-052104 Lepisosteus oculatus 63.99 1.00e-174 606.00
IUUC-Laf-054282 Loxodonta africana 98.96 0.00e+00 1048.00
IUUC-Mcc-054618 Macaca mulatta 100.00 0.00e+00 914.00
IUUC-Meu-056240 Macropus eugenii 90.31 0.00e+00 885.00
IUUC-Mga-059313 Meleagris gallopavo 81.10 0.00e+00 793.00
IUUC-Mmr-060641 Microcebus murinus 99.60 0.00e+00 919.00
IUUC-Mmu-063468 Mus musculus 98.96 0.00e+00 1048.00
IUUC-Mpu-066403 Mustela putorius furo 99.06 0.00e+00 927.00
IUUC-Mlu-067092 Myotis lucifugus 97.58 0.00e+00 1022.00
IUUC-Nle-069656 Nomascus leucogenys 99.83 0.00e+00 1052.00
IUUC-Opr-070922 Ochotona princeps 98.44 0.00e+00 1037.00
IUUC-Ont-071492 Oreochromis niloticus 48.64 1.00e-126 447.00
IUUC-Oan-072851 Ornithorhynchus anatinus 80.30 0.00e+00 798.00
IUUC-Ocu-073895 Oryctolagus cuniculus 99.65 0.00e+00 1053.00
IUUC-Ola-087132 Oryzias latipes 49.10 2.00e-118 419.00
IUUC-Oga-088381 Otolemur garnettii 99.31 0.00e+00 1051.00
IUUC-Oar-089727 Ovis aries 98.79 0.00e+00 1021.00
IUUC-Ptr-090506 Pan troglodytes 100.00 0.00e+00 1055.00
IUUC-Pan-091684 Papio anubis 100.00 0.00e+00 1055.00
IUUC-Psi-093464 Pelodiscus sinensis 82.38 0.00e+00 745.00
IUUC-Pno-094894 Phaeosphaeria nodorum 36.07 2.20e-02 33.90
IUUC-Pfo-096951 Poecilia formosa 50.75 3.00e-48 186.00
IUUC-Pab-097981 Pongo abelii 94.10 5.00e-152 530.00
IUUC-Pca-100212 Procavia capensis 98.97 0.00e+00 701.00
IUUC-Pva-102132 Pteropus vampyrus 98.96 0.00e+00 1043.00
IUUC-Pte-104312 Pyrenophora teres 35.14 1.70e-02 33.90
IUUC-Rno-105868 Rattus norvegicus 98.61 0.00e+00 1021.00
IUUC-Sha-107624 Sarcophilus harrisii 91.38 0.00e+00 989.00
IUUC-Ssl-108482 Sclerotinia sclerotiorum 26.83 5.00e-03 32.30
IUUC-Sar-113641 Sorex araneus 98.27 0.00e+00 1051.00
IUUC-Ssc-116207 Sus scrofa 99.13 0.00e+00 1023.00
IUUC-Tru-117652 Takifugu rubripes 49.11 1.00e-132 467.00
IUUC-Tsy-119274 Tarsius syrichta 97.35 0.00e+00 941.00
IUUC-Tni-120021 Tetraodon nigroviridis 47.05 2.00e-130 459.00
IUUC-Tvi-122401 Trichoderma virens 23.73 2.30e-01 31.20
IUUC-Ttr-128251 Tursiops truncatus 99.06 0.00e+00 714.00
IUUC-Vpa-130513 Vicugna pacos 98.96 0.00e+00 1023.00
IUUC-Vvi-131498 Vitis vinifera 24.69 7.00e-03 33.10
IUUC-Xtr-132490 Xenopus tropicalis 71.21 0.00e+00 743.00
Created Date 25-Jun-2017

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