iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Xtr-132291

Ensembl Protein ID

ENSXETP00000037721.3

UniProt Accession

F7DXH6; F7DXH6_XENTR

Genbank Protein ID

ENSXETP00000037721

Protein Name

Tyrosine-protein kinase

Genbank Nucleotide ID

AAMC01016610

Gene Name

src

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXETG00000017318.3	ENSXETT00000037721.3	ENSXETP00000037721.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	2.90e-13	49.8	84	138

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 5    kvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvek 61
           ++ +lydye+ ++ +L++kkG+ ++++  ++++++W+ + +  +g+ G +P+n+v+ 
   Q: 84   TFVALYDYESRTETDLSFKKGERLQIV--NNTEGDWWLARSLSSGQTGYIPSNYVAP 138
           5789***********************..8999*********************975 PP

Organism

Xenopus tropicalis

Protein Sequence
(Fasta)

MGATKSKPRE GGPRSRSLDI AEGSHQPFTS LSASQTPSKS LDSHRQPAQP FGGNCDLTPF 60
GGVNFSDTIT SPQRIGPLAG GVTTFVALYD YESRTETDLS FKKGERLQIV NNTEGDWWLA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACCGTACGCT GAGTAGATCC CCAAACTTCC CGGCCCAGGA GGAATCTGAT GTGTGGGGAG 60
AGGCACCGGG AGATAGTGGG TACGAGAAGA GCGCTCTTGC CCCCCTCTGT GTGAGGGGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0005524--F:ATP binding
GO:0070851--F:growth factor receptor binding
GO:0051427--F:hormone receptor binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0045453--P:bone resorption
GO:0007155--P:cell adhesion
GO:0016477--P:cell migration
GO:0007417--P:central nervous system development
GO:0007173--P:epidermal growth factor receptor signaling pathway
GO:0045087--P:innate immune response
GO:0030520--P:intracellular estrogen receptor signaling pathway
GO:2001237--P:negative regulation of extrinsic apoptotic signaling pathway
GO:2001243--P:negative regulation of intrinsic apoptotic signaling pathway
GO:0036035--P:osteoclast development
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:0048008--P:platelet-derived growth factor receptor signaling pathway
GO:0048920--P:posterior lateral line neuromast primordium migration
GO:0050847--P:progesterone receptor signaling pathway
GO:0051726--P:regulation of cell cycle
GO:0042127--P:regulation of cell proliferation
GO:0071801--P:regulation of podosome assembly
GO:0043114--P:regulation of vascular permeability
GO:0001878--P:response to yeast

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001713	Ailuropoda melanoleuca	86.76	0.00e+00	963.00
IUUC-Aca-004237	Anolis carolinensis	86.67	0.00e+00	963.00
IUUC-Aly-005712	Arabidopsis lyrata	33.19	3.00e-19	90.50
IUUC-Ame-011887	Astyanax mexicanus	78.12	0.00e+00	854.00
IUUC-Bta-012982	Bos taurus	86.76	0.00e+00	973.00
IUUC-Bdi-014324	Brachypodium distachyon	36.07	4.00e-23	103.00
IUUC-Cja-019995	Callithrix jacchus	86.95	0.00e+00	964.00
IUUC-Cfa-020060	Canis familiaris	87.92	0.00e+00	974.00
IUUC-Cpo-021557	Cavia porcellus	87.85	0.00e+00	965.00
IUUC-Csa-023711	Chlorocebus sabaeus	87.13	0.00e+00	962.00
IUUC-Dre-028491	Danio rerio	82.68	0.00e+00	881.00
IUUC-Dno-029651	Dasypus novemcinctus	84.42	0.00e+00	947.00
IUUC-Ete-033170	Echinops telfairi	91.52	0.00e+00	874.00
IUUC-Eca-033970	Equus caballus	84.76	0.00e+00	919.00
IUUC-Fca-036113	Felis catus	87.92	0.00e+00	974.00
IUUC-Fal-036785	Ficedula albicollis	86.74	0.00e+00	966.00
IUUC-Gga-040899	Gallus gallus	87.90	0.00e+00	973.00
IUUC-Gac-042332	Gasterosteus aculeatus	80.26	0.00e+00	891.00
IUUC-Gma-043938	Glycine max	34.16	2.00e-22	101.00
IUUC-Ggo-044829	Gorilla gorilla	73.53	0.00e+00	773.00
IUUC-Hsa-046192	Homo sapiens	87.13	0.00e+00	963.00
IUUC-Itr-049014	Ictidomys tridecemlineatus	87.11	0.00e+00	964.00
IUUC-Lch-049892	Latimeria chalumnae	83.70	0.00e+00	927.00
IUUC-Lpe-051166	Leersia perrieri	34.70	2.00e-23	104.00
IUUC-Loc-052812	Lepisosteus oculatus	80.88	0.00e+00	886.00
IUUC-Laf-053977	Loxodonta africana	86.00	0.00e+00	963.00
IUUC-Mcc-055159	Macaca mulatta	85.41	0.00e+00	958.00
IUUC-Mga-060135	Meleagris gallopavo	86.56	0.00e+00	964.00
IUUC-Mmr-061168	Microcebus murinus	85.20	0.00e+00	965.00
IUUC-Mdo-063030	Monodelphis domestica	84.84	0.00e+00	960.00
IUUC-Mmu-063893	Mus musculus	86.74	0.00e+00	968.00
IUUC-Mpu-066411	Mustela putorius furo	87.92	0.00e+00	974.00
IUUC-Mlu-068139	Myotis lucifugus	85.48	0.00e+00	961.00
IUUC-Nle-070178	Nomascus leucogenys	84.93	0.00e+00	913.00
IUUC-Ont-072666	Oreochromis niloticus	80.96	0.00e+00	866.00
IUUC-Ocu-074403	Oryctolagus cuniculus	86.45	0.00e+00	958.00
IUUC-Ogl-077331	Oryza glaberrima	34.70	2.00e-23	104.00
IUUC-Ogu-078962	Oryza glumaepatula	35.16	8.00e-24	105.00
IUUC-Oin-079172	Oryza indica	35.16	7.00e-24	105.00
IUUC-Olo-080286	Oryza longistaminata	35.16	7.00e-24	105.00
IUUC-Ome-081400	Oryza meridionalis	35.16	5.00e-24	106.00
IUUC-Oni-082734	Oryza nivara	34.70	1.00e-23	104.00
IUUC-Oru-084741	Oryza rufipogon	35.16	6.00e-24	106.00
IUUC-Osa-085779	Oryza sativa	36.07	1.00e-23	105.00
IUUC-Ola-086527	Oryzias latipes	79.68	0.00e+00	889.00
IUUC-Oga-088493	Otolemur garnettii	86.76	0.00e+00	961.00
IUUC-Oar-090279	Ovis aries	87.11	0.00e+00	976.00
IUUC-Ptr-091050	Pan troglodytes	87.13	0.00e+00	963.00
IUUC-Pan-091862	Papio anubis	88.10	0.00e+00	969.00
IUUC-Psi-093071	Pelodiscus sinensis	87.71	0.00e+00	974.00
IUUC-Pfo-096578	Poecilia formosa	79.50	0.00e+00	891.00
IUUC-Pab-097902	Pongo abelii	85.23	0.00e+00	956.00
IUUC-Pop-099554	Populus trichocarpa	31.40	2.00e-23	104.00
IUUC-Ppe-102072	Prunus persica	34.77	3.00e-26	114.00
IUUC-Rno-105847	Rattus norvegicus	86.95	0.00e+00	971.00
IUUC-Sha-107539	Sarcophilus harrisii	87.71	0.00e+00	972.00
IUUC-Stu-112331	Solanum tuberosum	32.40	6.00e-23	102.00
IUUC-Sbi-114480	Sorghum bicolor	35.04	3.00e-24	107.00
IUUC-Ssc-115762	Sus scrofa	86.00	0.00e+00	968.00
IUUC-Tru-117849	Takifugu rubripes	80.44	0.00e+00	865.00
IUUC-Tni-120843	Tetraodon nigroviridis	80.99	0.00e+00	891.00
IUUC-Tca-121389	Theobroma cacao	31.23	1.00e-22	102.00
IUUC-Ttr-128702	Tursiops truncatus	81.25	0.00e+00	886.00
IUUC-Xma-133134	Xiphophorus maculatus	79.14	0.00e+00	888.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence