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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046484
UUCD1 version UUC-HoS-00445
Ensembl Protein ID ENSP00000443824.2
UniProt Accession Q9ULT6; B3KU18; Q6ICH1; Q6NTF8; Q8WU18; ZNRF3_HUMAN
Genbank Protein ID BAG53280.1; CAI17901.1; CAI17901.1; CAI17992.1; CAI17992.1; BAB33319.1; CAG30283.1; AAH21570.1; AAH69019.1; AAH94857.1
Protein Name E3 ubiquitin-protein ligase ZNRF3; RING finger protein 203; RING-type E3 ubiquitin transferase ZNRF3; Zinc/RING finger protein 3
Genbank Nucleotide ID AK096397; Z95113; AL021393; AL021393; Z95113; AL031596; CR456397; BC021570; BC069019; BC094857
Gene Name ZNRF3; KIAA1133; RNF203
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000183579.15 ENST00000544604.6 ENSP00000443824.2
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDPINAHINTMentha
InWeb_IM
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosSNPPhosphositePlus
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 18511420
Classification
Family E-value Score Start End
E3 activity/RING/RING 3.50e-05 25.9 293 334
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledf..kdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           CaiCle +   ++++v pC H fh++C+  w        ++ +CP Cr
   Q: 293  CAICLEKYidGEELRVIPCTHRFHRKCVDPW------LLQHHTCPHCR 334
           ********66334******************......9999******8 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone.
 E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone.
Protein Sequence
(Fasta)
MRPRSGGRPG ATGRRRRRLR RRPRGLRCSR LPPPPPLPLL LGLLLAAAGP GAARAKETAF 60
VEVVLFESSP SGDYTTYTTG LTGRFSRAGA TLSAEGEIVQ MHPLGLCNNN DEEDLYEYGW 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046484|E3,RING|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGATGAAAGG GCCGCGGCGC GACGGCCGGG GGAGCCGAGC TGAGCCTGCG ACCCACAAAG 60
CCGCCGCCGC CGCCGCCGTG ATGGGGCTGT GAGGCGTCCG CCCGCGTTCG GTCCTCAGCC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046484|E3,RING|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0472--Membrane
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0732--Signal
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway
KW-0879--Wnt signaling pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50089--ZF_RING_2
Pfam

PF13639--zf-RING_2
SMART

SM00184--RING
Gene Ontology

GO:0005887--C:integral component of plasma membrane
GO:0005886--C:plasma membrane
GO:0005109--F:frizzled binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0060070--P:canonical Wnt signaling pathway
GO:0090090--P:negative regulation of canonical Wnt signaling pathway
GO:2000051--P:negative regulation of non-canonical Wnt signaling pathway
GO:0016567--P:protein ubiquitination
GO:0072089--P:stem cell proliferation
GO:0006511--P:ubiquitin-dependent protein catabolic process
GO:0038018--P:Wnt receptor catabolic process
GO:0060071--P:Wnt signaling pathway, planar cell polarity pathway
KEGG hsa:84133
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001916 Ailuropoda melanoleuca 87.03 0.00e+00 1234.00
IUUC-Apl-004188 Anas platyrhynchos 71.48 0.00e+00 1049.00
IUUC-Aca-004606 Anolis carolinensis 36.78 2.00e-27 116.00
IUUC-Aly-005850 Arabidopsis lyrata 42.68 5.00e-15 73.60
IUUC-Ath-007372 Arabidopsis thaliana 42.68 2.00e-14 71.60
IUUC-Ame-011764 Astyanax mexicanus 62.19 0.00e+00 730.00
IUUC-Bta-012478 Bos taurus 66.22 0.00e+00 653.00
IUUC-Bol-016217 Brassica oleracea 56.25 3.00e-14 70.90
IUUC-Bra-017407 Brassica rapa 56.25 3.00e-14 70.90
IUUC-Cja-019504 Callithrix jacchus 95.69 0.00e+00 1460.00
IUUC-Cfa-020048 Canis familiaris 89.32 0.00e+00 1338.00
IUUC-Cpo-021725 Cavia porcellus 82.99 0.00e+00 1268.00
IUUC-Csa-023586 Chlorocebus sabaeus 96.56 0.00e+00 1430.00
IUUC-Cho-024867 Choloepus hoffmanni 92.44 0.00e+00 691.00
IUUC-Cin-025569 Ciona intestinalis 47.33 3.00e-56 213.00
IUUC-Csv-025869 Ciona savignyi 45.33 2.00e-57 216.00
IUUC-Dre-027553 Danio rerio 66.33 0.00e+00 857.00
IUUC-Dno-029370 Dasypus novemcinctus 85.01 0.00e+00 1220.00
IUUC-Dor-030816 Dipodomys ordii 81.61 0.00e+00 1138.00
IUUC-Ete-033060 Echinops telfairi 74.80 0.00e+00 850.00
IUUC-Eca-034044 Equus caballus 88.83 0.00e+00 1324.00
IUUC-Eeu-034591 Erinaceus europaeus 67.89 1.00e-138 487.00
IUUC-Fca-036000 Felis catus 87.96 0.00e+00 1329.00
IUUC-Fal-037147 Ficedula albicollis 71.04 0.00e+00 1063.00
IUUC-Gmo-039099 Gadus morhua 50.43 1.00e-119 423.00
IUUC-Gga-041243 Gallus gallus 67.86 0.00e+00 836.00
IUUC-Gac-041340 Gasterosteus aculeatus 49.57 2.00e-114 406.00
IUUC-Gma-044387 Glycine max 41.98 5.00e-15 74.30
IUUC-Ggo-044953 Gorilla gorilla 98.93 0.00e+00 1475.00
IUUC-Itr-048470 Ictidomys tridecemlineatus 89.10 0.00e+00 1310.00
IUUC-Lch-050004 Latimeria chalumnae 59.12 0.00e+00 675.00
IUUC-Loc-051830 Lepisosteus oculatus 65.31 0.00e+00 839.00
IUUC-Laf-053975 Loxodonta africana 86.32 0.00e+00 1269.00
IUUC-Mcc-055302 Macaca mulatta 96.09 0.00e+00 1393.00
IUUC-Meu-056263 Macropus eugenii 75.39 0.00e+00 798.00
IUUC-Mtr-058744 Medicago truncatula 54.17 2.00e-13 68.60
IUUC-Mga-059706 Meleagris gallopavo 71.23 0.00e+00 1069.00
IUUC-Mmr-061372 Microcebus murinus 89.33 0.00e+00 1281.00
IUUC-Mdo-062651 Monodelphis domestica 65.55 0.00e+00 872.00
IUUC-Mmu-064339 Mus musculus 85.00 0.00e+00 1314.00
IUUC-Mac-065356 Musa acuminata 50.00 1.00e-12 67.80
IUUC-Mpu-066211 Mustela putorius furo 86.89 0.00e+00 1275.00
IUUC-Mlu-067058 Myotis lucifugus 88.32 0.00e+00 1251.00
IUUC-Nle-069886 Nomascus leucogenys 98.42 0.00e+00 1448.00
IUUC-Opr-070218 Ochotona princeps 82.54 0.00e+00 1109.00
IUUC-Ont-072483 Oreochromis niloticus 62.71 0.00e+00 830.00
IUUC-Oan-073718 Ornithorhynchus anatinus 71.16 0.00e+00 922.00
IUUC-Ocu-073847 Oryctolagus cuniculus 80.76 0.00e+00 1066.00
IUUC-Oba-075528 Oryza barthii 43.64 4.00e-12 66.20
IUUC-Obr-076184 Oryza brachyantha 53.33 2.00e-12 67.00
IUUC-Opu-083306 Oryza punctata 67.44 6.00e-13 67.40
IUUC-Ola-087358 Oryzias latipes 62.03 0.00e+00 766.00
IUUC-Oga-088362 Otolemur garnettii 88.16 0.00e+00 1339.00
IUUC-Oar-090197 Ovis aries 99.49 9.00e-97 347.00
IUUC-Ptr-091350 Pan troglodytes 99.43 0.00e+00 1552.00
IUUC-Pan-091700 Papio anubis 96.28 0.00e+00 1450.00
IUUC-Psi-093301 Pelodiscus sinensis 69.25 0.00e+00 990.00
IUUC-Pfo-096917 Poecilia formosa 63.46 0.00e+00 767.00
IUUC-Pab-097932 Pongo abelii 97.50 0.00e+00 1489.00
IUUC-Pop-099640 Populus trichocarpa 57.14 1.00e-14 72.80
IUUC-Pca-101054 Procavia capensis 93.72 0.00e+00 969.00
IUUC-Pva-102879 Pteropus vampyrus 89.73 0.00e+00 1349.00
IUUC-Pgr-103476 Puccinia graminis 41.27 3.00e-09 55.80
IUUC-Sha-106507 Sarcophilus harrisii 54.10 9.00e-165 573.00
IUUC-Sit-110656 Setaria italica 67.44 6.00e-13 67.40
IUUC-Stu-112500 Solanum tuberosum 62.79 9.00e-13 66.60
IUUC-Sar-113182 Sorex araneus 87.89 2.00e-111 397.00
IUUC-Sbi-114414 Sorghum bicolor 40.00 1.00e-12 65.90
IUUC-Ssc-115966 Sus scrofa 82.04 0.00e+00 1079.00
IUUC-Tgu-116864 Taeniopygia guttata 63.49 0.00e+00 684.00
IUUC-Tru-118502 Takifugu rubripes 63.05 0.00e+00 800.00
IUUC-Tsy-119210 Tarsius syrichta 89.71 0.00e+00 1300.00
IUUC-Tni-120344 Tetraodon nigroviridis 52.74 3.00e-123 435.00
IUUC-Tca-120966 Theobroma cacao 48.39 3.00e-13 69.30
IUUC-Tur-125977 Triticum urartu 50.00 2.00e-13 70.10
IUUC-Tbe-127735 Tupaia belangeri 88.07 3.00e-137 482.00
IUUC-Ttr-128714 Tursiops truncatus 75.83 0.00e+00 1003.00
IUUC-Vvi-131280 Vitis vinifera 31.50 3.00e-13 69.30
IUUC-Xtr-132280 Xenopus tropicalis 59.60 0.00e+00 758.00
Created Date 25-Jun-2017

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