iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oar-089447

Ensembl Protein ID

ENSOARP00000005352.1

UniProt Accession

W5P4J9; W5P4J9_SHEEP

Genbank Protein ID

ENSOARP00000005352

Protein Name

Histone-lysine N-methyltransferase

Genbank Nucleotide ID

AMGL01028722

Gene Name

KMT2B

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOARG00000004987.1	ENSOART00000005439.1	ENSOARP00000005352.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	5.50e-30	103.5	1245	1298

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 2    kvClvCgeggedekslveCekCrewfHpaClklsveeelpnsek..wiCpkCrsk 54
           k+C+vCg++g+++k+l+eCe+Cr+++HpaCl++s ++++ ++++  wiC+ C ++
   Q: 1245 KFCHVCGRKGRGSKHLLECERCRHAYHPACLGPS-YPTRATRKRrhWICSACVRC 1298
           58********************************.88888877777******876 PP

Organism

Ovis aries

Protein Sequence
(Fasta)

FTQTSDGDAL PCPHRSPAGR EPGALSQTAS GRGPGPESPC GVRAVNPVAA PGGSTWRPPP 60
PSPGASDPSL EAAGRENNRR SLGREPHLPA GPGKARGAGX GRGWGLSRGC LLEEESSDGE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTCACTCAAA CATCAGATGG AGACGCACTA CCGTGTCCAC ACAGGTACGG GCGTCCTGCC 60
CTGTGCAAAC TGCTTCCTTC CAAACTCCAG TGGGCCCGCT CCTAAGTCCC TCTGTGAGTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0489--Methyltransferase
KW-1185--Reference proteome
KW-0949--S-adenosyl-L-methionine
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001487--Bromodomain
IPR034732--EPHD
IPR003889--FYrich_C
IPR003888--FYrich_N
IPR003616--Post-SET_dom
IPR001214--SET_dom
IPR002857--Znf_CXXC
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51805--EPHD
PS51543--FYRC
PS51542--FYRN
PS50868--POST_SET
PS50280--SET
PS51058--ZF_CXXC
PS50016--ZF_PHD_2

Pfam

PF05965--FYRC
PF05964--FYRN
PF00628--PHD
PF00856--SET
PF02008--zf-CXXC

SMART

SM00542--FYRC
SM00541--FYRN
SM00249--PHD
SM00508--PostSET
SM00317--SET

Gene Ontology

GO:0035097--C:histone methyltransferase complex
GO:0003677--F:DNA binding
GO:0042800--F:histone methyltransferase activity (H3-K4 specific)
GO:0008270--F:zinc ion binding
GO:0016458--P:gene silencing
GO:0080182--P:histone H3-K4 trimethylation
GO:0007613--P:memory
GO:0009994--P:oocyte differentiation
GO:0001541--P:ovarian follicle development
GO:0030728--P:ovulation
GO:0051569--P:regulation of histone H3-K4 methylation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002367	Ailuropoda melanoleuca	90.99	0.00e+00	2260.00
IUUC-Aca-004718	Anolis carolinensis	56.41	0.00e+00	1441.00
IUUC-Ame-010705	Astyanax mexicanus	47.29	0.00e+00	781.00
IUUC-Bta-013578	Bos taurus	97.73	0.00e+00	2338.00
IUUC-Bdi-014882	Brachypodium distachyon	33.83	1.00e-27	118.00
IUUC-Bra-017422	Brassica rapa	33.98	8.00e-28	119.00
IUUC-Cja-019138	Callithrix jacchus	87.69	0.00e+00	2204.00
IUUC-Cfa-020020	Canis familiaris	93.58	0.00e+00	2205.00
IUUC-Cpo-021552	Cavia porcellus	87.33	0.00e+00	2125.00
IUUC-Csa-024216	Chlorocebus sabaeus	90.99	0.00e+00	2193.00
IUUC-Dre-027700	Danio rerio	47.52	0.00e+00	727.00
IUUC-Dno-029583	Dasypus novemcinctus	92.08	0.00e+00	2046.00
IUUC-Dor-030903	Dipodomys ordii	86.38	0.00e+00	2137.00
IUUC-Dme-032023	Drosophila melanogaster	47.28	2.00e-92	336.00
IUUC-Eca-034026	Equus caballus	95.09	0.00e+00	1800.00
IUUC-Eeu-034687	Erinaceus europaeus	91.11	0.00e+00	1139.00
IUUC-Fca-036311	Felis catus	91.82	0.00e+00	2300.00
IUUC-Gmo-039265	Gadus morhua	44.53	0.00e+00	804.00
IUUC-Gac-041840	Gasterosteus aculeatus	48.94	0.00e+00	698.00
IUUC-Ggo-044791	Gorilla gorilla	91.38	0.00e+00	1874.00
IUUC-Hsa-046988	Homo sapiens	90.08	0.00e+00	2130.00
IUUC-Hvu-047762	Hordeum vulgare	37.31	1.00e-20	94.40
IUUC-Itr-048907	Ictidomys tridecemlineatus	90.69	0.00e+00	2267.00
IUUC-Lpe-051476	Leersia perrieri	31.96	2.00e-24	107.00
IUUC-Loc-052252	Lepisosteus oculatus	54.03	0.00e+00	781.00
IUUC-Laf-053703	Loxodonta africana	91.94	0.00e+00	1997.00
IUUC-Mcc-054782	Macaca mulatta	89.85	0.00e+00	2179.00
IUUC-Meu-056046	Macropus eugenii	78.70	0.00e+00	1852.00
IUUC-Mmr-061316	Microcebus murinus	91.48	0.00e+00	1897.00
IUUC-Mdo-062648	Monodelphis domestica	79.56	0.00e+00	1861.00
IUUC-Mmu-063579	Mus musculus	88.41	0.00e+00	2184.00
IUUC-Mac-064935	Musa acuminata	33.80	4.00e-30	126.00
IUUC-Mpu-066710	Mustela putorius furo	93.53	0.00e+00	2286.00
IUUC-Mlu-067559	Myotis lucifugus	88.95	0.00e+00	2255.00
IUUC-Nle-070085	Nomascus leucogenys	88.05	0.00e+00	2065.00
IUUC-Opr-071148	Ochotona princeps	86.34	0.00e+00	2158.00
IUUC-Ont-071626	Oreochromis niloticus	46.18	0.00e+00	890.00
IUUC-Ocu-074475	Oryctolagus cuniculus	87.67	0.00e+00	2158.00
IUUC-Obr-076458	Oryza brachyantha	34.98	2.00e-28	120.00
IUUC-Ogl-077851	Oryza glaberrima	36.81	2.00e-28	120.00
IUUC-Ogu-078706	Oryza glumaepatula	36.81	1.00e-28	121.00
IUUC-Oin-079802	Oryza indica	31.90	2.00e-23	104.00
IUUC-Osa-085421	Oryza sativa	36.81	3.00e-28	120.00
IUUC-Ola-086609	Oryzias latipes	51.32	0.00e+00	754.00
IUUC-Oga-088140	Otolemur garnettii	90.60	0.00e+00	2193.00
IUUC-Ptr-090902	Pan troglodytes	89.95	0.00e+00	2136.00
IUUC-Pan-091930	Papio anubis	90.99	0.00e+00	2194.00
IUUC-Ppa-095221	Physcomitrella patens	36.49	4.00e-31	129.00
IUUC-Pfo-096884	Poecilia formosa	46.77	0.00e+00	893.00
IUUC-Pab-098404	Pongo abelii	91.82	0.00e+00	883.00
IUUC-Pop-099620	Populus trichocarpa	32.35	9.00e-27	115.00
IUUC-Pca-100949	Procavia capensis	82.96	0.00e+00	1246.00
IUUC-Ppe-101920	Prunus persica	33.01	5.00e-28	119.00
IUUC-Pva-102634	Pteropus vampyrus	91.55	0.00e+00	2288.00
IUUC-Rno-105870	Rattus norvegicus	88.14	0.00e+00	2236.00
IUUC-Sit-110552	Setaria italica	34.83	4.00e-29	122.00
IUUC-Sar-113289	Sorex araneus	88.03	0.00e+00	1605.00
IUUC-Ssc-115509	Sus scrofa	93.09	0.00e+00	2310.00
IUUC-Tru-117736	Takifugu rubripes	45.27	0.00e+00	827.00
IUUC-Tca-121624	Theobroma cacao	33.33	5.00e-28	119.00
IUUC-Tae-125629	Triticum aestivum	37.31	1.00e-20	94.40
IUUC-Tbe-127825	Tupaia belangeri	86.99	0.00e+00	1430.00
IUUC-Ttr-128754	Tursiops truncatus	91.36	0.00e+00	1253.00
IUUC-Xtr-132838	Xenopus tropicalis	48.96	0.00e+00	982.00
IUUC-Xma-133119	Xiphophorus maculatus	48.38	0.00e+00	927.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence