iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Csa-024145

Ensembl Protein ID

ENSCSAP00000013793.1

UniProt Accession

A0A0D9RYV4; A0A0D9RYV4_CHLSB

Genbank Protein ID

ENSCSAP00000013793

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AQIB01149737

Gene Name

SMURF1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCSAG00000017771.1	ENSCSAT00000015865.1	ENSCSAP00000013793.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.00e-127	426.1	395	727

Active Site

Position(s)	Description	Evidence
696	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dlkkrl+v+f+gEegld+gGv+re+l+ll++e+ np++glf+ys ++ ++lq+npds + np+hl++F+f+Gr++g+a+++g++++ 
   Q: 395  PKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSSI-NPDHLSYFHFVGRIMGLAVFHGHYING 482
           689*********************************************************9.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            ++ +fyk+llgk+++l+dle+vdpel+ksl +i+en   di+   ld tf+v+++ +g + ++eLkp+G+n+pVt+eNk+eYv+l+v+
   Q: 483  GFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILEN---DITPV-LDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVN 567
           ***********************************99...9***8.******************************************* PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+ +gi+ q+ a+++Gfne+ip++ll+ F+++elel+i G ++id++d+k++t+ k+ + +ds+ ++wFw+++e f++e r+++LqFv
   Q: 568  WRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKH-CVADSNIVRWFWQAVETFDEERRARLLQFV 655
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tgs r+Pl+Gf++l+    prlf+i+  da++d+lP+++TCfn++++P+Y+s+e+l+ekLl+A+eet gF +
   Q: 656  TGSTRVPLQGFKALQgaagPRLFTIHLiDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGFAV 727
           ***************************99999**************************************76 PP

Organism

Chlorocebus sabaeus

Protein Sequence
(Fasta)

MSNPGTRRNG SSIKIRLTVL CAKNLAKKDF FRLPDPFAKI VVDGSGQCHS TDTVKNTLDP 60
KWNQHYDLYV GKTDSITISV WNHKKIHKKQ GAGFLGCVRL LSNAISRLKD TGYQRLDLCK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGCGCTGGAT CCGCGGCTGT CCGATCGTTG GCGGGAGATG TCGAACCCCG GGACACGCAG 60
GAACGGCTCC AGCATCAAGA TCCGTCTGAC AGGTACGGCC GGCGGGAGGC CCACCCGCGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0005739--C:mitochondrion
GO:0005886--C:plasma membrane
GO:0061630--F:ubiquitin protein ligase activity
GO:0030509--P:BMP signaling pathway
GO:0061736--P:engulfment of target by autophagosome
GO:0030279--P:negative regulation of ossification
GO:0030512--P:negative regulation of transforming growth factor beta receptor signaling pathway
GO:0061734--P:parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization
GO:1903861--P:positive regulation of dendrite extension
GO:2000060--P:positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0006611--P:protein export from nucleus
GO:0034394--P:protein localization to cell surface
GO:0000209--P:protein polyubiquitination
GO:0071211--P:protein targeting to vacuole involved in autophagy
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0032801--P:receptor catabolic process
GO:0061753--P:substrate localization to autophagosome
GO:0030579--P:ubiquitin-dependent SMAD protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001459	Ailuropoda melanoleuca	93.18	0.00e+00	1425.00
IUUC-Apl-004155	Anas platyrhynchos	93.08	0.00e+00	1432.00
IUUC-Aca-005238	Anolis carolinensis	96.03	0.00e+00	1448.00
IUUC-Ame-010901	Astyanax mexicanus	90.71	0.00e+00	1382.00
IUUC-Bta-013221	Bos taurus	91.29	0.00e+00	1362.00
IUUC-Cja-018985	Callithrix jacchus	95.90	0.00e+00	1496.00
IUUC-Cfa-020568	Canis familiaris	93.63	0.00e+00	1439.00
IUUC-Cpo-022531	Cavia porcellus	95.38	0.00e+00	1486.00
IUUC-Cho-024963	Choloepus hoffmanni	77.31	0.00e+00	925.00
IUUC-Cin-025126	Ciona intestinalis	62.97	0.00e+00	918.00
IUUC-Csv-026339	Ciona savignyi	62.72	0.00e+00	937.00
IUUC-Dre-028341	Danio rerio	91.41	0.00e+00	1395.00
IUUC-Dno-029705	Dasypus novemcinctus	93.74	0.00e+00	1425.00
IUUC-Dme-031740	Drosophila melanogaster	70.35	3.00e-172	599.00
IUUC-Ete-032715	Echinops telfairi	70.26	0.00e+00	1055.00
IUUC-Eca-034125	Equus caballus	95.26	0.00e+00	1453.00
IUUC-Eeu-034945	Erinaceus europaeus	72.39	0.00e+00	1038.00
IUUC-Fca-035905	Felis catus	97.24	0.00e+00	1447.00
IUUC-Fal-037336	Ficedula albicollis	96.92	0.00e+00	1427.00
IUUC-Gmo-039486	Gadus morhua	79.92	0.00e+00	862.00
IUUC-Gga-040218	Gallus gallus	95.83	0.00e+00	1470.00
IUUC-Gac-041707	Gasterosteus aculeatus	84.71	0.00e+00	1280.00
IUUC-Ggo-045408	Gorilla gorilla	89.72	0.00e+00	1348.00
IUUC-Hsa-045878	Homo sapiens	96.04	0.00e+00	1497.00
IUUC-Itr-048317	Ictidomys tridecemlineatus	95.26	0.00e+00	1451.00
IUUC-Lch-050026	Latimeria chalumnae	73.31	0.00e+00	1146.00
IUUC-Loc-052628	Lepisosteus oculatus	85.41	0.00e+00	1366.00
IUUC-Laf-053644	Loxodonta africana	93.51	0.00e+00	1408.00
IUUC-Mcc-055479	Macaca mulatta	91.38	0.00e+00	1352.00
IUUC-Meu-056436	Macropus eugenii	58.80	0.00e+00	854.00
IUUC-Mga-059723	Meleagris gallopavo	93.22	0.00e+00	1410.00
IUUC-Mmr-060806	Microcebus murinus	74.13	0.00e+00	1139.00
IUUC-Mdo-063005	Monodelphis domestica	97.81	0.00e+00	1487.00
IUUC-Mmu-063634	Mus musculus	98.08	0.00e+00	1470.00
IUUC-Mpu-065898	Mustela putorius furo	97.77	0.00e+00	1449.00
IUUC-Mlu-067584	Myotis lucifugus	94.24	0.00e+00	1448.00
IUUC-Nle-069033	Nomascus leucogenys	95.94	0.00e+00	1460.00
IUUC-Opr-070591	Ochotona princeps	70.30	0.00e+00	1048.00
IUUC-Ont-072265	Oreochromis niloticus	83.31	0.00e+00	1293.00
IUUC-Oan-073621	Ornithorhynchus anatinus	91.83	0.00e+00	1445.00
IUUC-Ocu-073960	Oryctolagus cuniculus	93.79	0.00e+00	1418.00
IUUC-Ola-086597	Oryzias latipes	72.64	0.00e+00	1126.00
IUUC-Oga-088579	Otolemur garnettii	95.77	0.00e+00	1493.00
IUUC-Oar-090396	Ovis aries	92.73	0.00e+00	1350.00
IUUC-Ptr-091624	Pan troglodytes	96.04	0.00e+00	1497.00
IUUC-Pan-092479	Papio anubis	96.08	0.00e+00	1462.00
IUUC-Psi-093298	Pelodiscus sinensis	74.56	0.00e+00	1136.00
IUUC-Pma-094354	Petromyzon marinus	67.76	0.00e+00	1006.00
IUUC-Pfo-097203	Poecilia formosa	85.35	0.00e+00	1308.00
IUUC-Pab-097540	Pongo abelii	95.72	0.00e+00	1425.00
IUUC-Pca-100379	Procavia capensis	73.38	0.00e+00	642.00
IUUC-Pva-102754	Pteropus vampyrus	73.35	0.00e+00	1102.00
IUUC-Rno-105396	Rattus norvegicus	98.22	0.00e+00	1472.00
IUUC-Sha-107216	Sarcophilus harrisii	93.75	0.00e+00	1452.00
IUUC-Sar-113122	Sorex araneus	64.33	0.00e+00	934.00
IUUC-Ssc-116413	Sus scrofa	95.61	0.00e+00	1418.00
IUUC-Tgu-116723	Taeniopygia guttata	92.99	0.00e+00	1402.00
IUUC-Tru-117843	Takifugu rubripes	83.07	0.00e+00	1289.00
IUUC-Tsy-119455	Tarsius syrichta	94.90	0.00e+00	1359.00
IUUC-Tni-120037	Tetraodon nigroviridis	81.79	0.00e+00	1218.00
IUUC-Tbe-127879	Tupaia belangeri	81.72	0.00e+00	1194.00
IUUC-Ttr-128423	Tursiops truncatus	93.63	0.00e+00	1368.00
IUUC-Vpa-130591	Vicugna pacos	68.56	0.00e+00	1016.00
IUUC-Xtr-132237	Xenopus tropicalis	87.43	0.00e+00	1372.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence