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Tag Content
UUCD2 ID IUUC-Nle-069033
UUCD1 version UUC-NoL-00557
Ensembl Protein ID ENSNLEP00000013148.1
UniProt Accession G1RIU2; G1RIU2_NOMLE
Genbank Protein ID ENSNLEP00000013148
Protein Name Uncharacterized protein
Genbank Nucleotide ID ADFV01105144
Gene Name SMURF1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSNLEG00000010717.2 ENSNLET00000013791.2 ENSNLEP00000013148.1
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/HECT 1.70e-127 425.4 403 738
Active Site
Position(s) Description Evidence
707 Glycyl thioester intermediate {ECO:0000256|PIRSR:PIRSR001569-1,
ECO:0000256|PROSITE-ProRule:PRU00104}
Domain Profile

   E3 activity/HECT
   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dlkkrl+v+f+gEegld+gGv+re+l+ll++e+ np++glf+ys ++ ++lq+npds + np+hl++F+f+Gr++g+a+++g++++ 
   Q: 403  PKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSSI-NPDHLSYFHFVGRIMGLAVFHGHYING 490
           689*********************************************************9.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            ++ +fyk+llgk+++l+dle+vdpel+ksl +i+en   di+   ld tf+v+++ +g + ++eLkp+G+n+pVt+eNk+eYv+l+v+
   Q: 491  GFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILEN---DITPV-LDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVN 575
           ***********************************99...9***8.******************************************* PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+ +gi+ q+ a+++Gfne+ip++ll+ F+++elel+i G ++id++d+k++t+ k+ + +ds+ ++wFw+++e f++e r+++LqFv
   Q: 576  WRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKH-CVADSNIVRWFWQAVETFDEERRARLLQFV 663
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk.......prlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tgs r+Pl+Gf++l+       prlf+i+  da++d+lP+++TCfn++++P+Y+s+e+l+ekLl+A+eet gF +
   Q: 664  TGSTRVPLQGFKALQgstgaagPRLFTIHLiDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGFAV 738
           ******************************99999**************************************76 PP
   
Organism Nomascus leucogenys
Protein Sequence
(Fasta)
VLCAKNLAKK DFFRLPDPFA KIVVDGSGQC HSTDTVKNTL DPKWNQHYDL YVGKTDSITI 60
SVWNHKKIHK KQGAGFLGCV RLLSNAISRL KDTGYQRLDL CKLNPSDTDA VRGQIVVSLQ 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Nle-069033|E3,HECT|Nomascus leucogenys
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGTGTTATGT GCCAAGAACC TTGCAAAGAA AGACTTTTTC AGTAAGTAAA CACTTATTTT 60
TTTCCCTCTT ATAATGTTAT GCATGTATTT CTGAAATTTT AAACTTTAAA AAAAGATTGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Nle-069033|E3,HECT|Nomascus leucogenys
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom
PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2
Pfam

PF00168--C2
PF00632--HECT
PF00397--WW
SMART

SM00239--C2
SM00119--HECTc
SM00456--WW
Gene Ontology

GO:0070062--C:extracellular exosome
GO:0005739--C:mitochondrion
GO:0005886--C:plasma membrane
GO:0061630--F:ubiquitin protein ligase activity
GO:0030509--P:BMP signaling pathway
GO:0061736--P:engulfment of target by autophagosome
GO:0030512--P:negative regulation of transforming growth factor beta receptor signaling pathway
GO:1903861--P:positive regulation of dendrite extension
GO:2000060--P:positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0006611--P:protein export from nucleus
GO:0034394--P:protein localization to cell surface
GO:0000209--P:protein polyubiquitination
GO:0071211--P:protein targeting to vacuole involved in autophagy
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0032801--P:receptor catabolic process
GO:0061753--P:substrate localization to autophagosome
GO:0030579--P:ubiquitin-dependent SMAD protein catabolic process
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001459 Ailuropoda melanoleuca 90.40 0.00e+00 1402.00
IUUC-Apl-004155 Anas platyrhynchos 95.02 0.00e+00 1450.00
IUUC-Aca-005238 Anolis carolinensis 92.72 0.00e+00 1415.00
IUUC-Ame-010901 Astyanax mexicanus 87.70 0.00e+00 1342.00
IUUC-Bta-013221 Bos taurus 89.50 0.00e+00 1341.00
IUUC-Cja-018985 Callithrix jacchus 99.59 0.00e+00 1535.00
IUUC-Cfa-020568 Canis familiaris 97.83 0.00e+00 1488.00
IUUC-Cpo-022531 Cavia porcellus 98.65 0.00e+00 1523.00
IUUC-Csa-024145 Chlorocebus sabaeus 95.94 0.00e+00 1460.00
IUUC-Cho-024963 Choloepus hoffmanni 80.85 0.00e+00 981.00
IUUC-Dre-028341 Danio rerio 88.39 0.00e+00 1355.00
IUUC-Dno-029705 Dasypus novemcinctus 98.51 0.00e+00 1498.00
IUUC-Dme-031740 Drosophila melanogaster 71.11 2.00e-175 609.00
IUUC-Eca-034125 Equus caballus 98.92 0.00e+00 1525.00
IUUC-Fca-035905 Felis catus 95.40 0.00e+00 1443.00
IUUC-Fal-037336 Ficedula albicollis 93.52 0.00e+00 1407.00
IUUC-Gmo-039486 Gadus morhua 76.71 0.00e+00 858.00
IUUC-Gga-040218 Gallus gallus 95.01 0.00e+00 1449.00
IUUC-Gac-041707 Gasterosteus aculeatus 81.79 0.00e+00 1241.00
IUUC-Ggo-045408 Gorilla gorilla 93.78 0.00e+00 1428.00
IUUC-Hsa-045878 Homo sapiens 100.00 0.00e+00 1540.00
IUUC-Itr-048317 Ictidomys tridecemlineatus 98.11 0.00e+00 1509.00
IUUC-Loc-052628 Lepisosteus oculatus 82.79 0.00e+00 1328.00
IUUC-Laf-053644 Loxodonta africana 89.99 0.00e+00 1388.00
IUUC-Mcc-055479 Macaca mulatta 88.23 0.00e+00 1311.00
IUUC-Mga-059723 Meleagris gallopavo 89.92 0.00e+00 1387.00
IUUC-Mdo-063005 Monodelphis domestica 94.99 0.00e+00 1451.00
IUUC-Mmu-063634 Mus musculus 95.13 0.00e+00 1431.00
IUUC-Mpu-065898 Mustela putorius furo 95.40 0.00e+00 1444.00
IUUC-Mlu-067584 Myotis lucifugus 98.38 0.00e+00 1516.00
IUUC-Ont-072265 Oreochromis niloticus 84.66 0.00e+00 1294.00
IUUC-Oan-073621 Ornithorhynchus anatinus 89.70 0.00e+00 1419.00
IUUC-Ocu-073960 Oryctolagus cuniculus 97.70 0.00e+00 1491.00
IUUC-Oga-088579 Otolemur garnettii 99.46 0.00e+00 1533.00
IUUC-Oar-090396 Ovis aries 95.94 0.00e+00 1406.00
IUUC-Ptr-091624 Pan troglodytes 100.00 0.00e+00 1540.00
IUUC-Pan-092479 Papio anubis 99.73 0.00e+00 1536.00
IUUC-Pfo-097203 Poecilia formosa 81.95 0.00e+00 1253.00
IUUC-Pab-097540 Pongo abelii 99.86 0.00e+00 1471.00
IUUC-Pca-100379 Procavia capensis 73.81 0.00e+00 651.00
IUUC-Rno-105396 Rattus norvegicus 95.26 0.00e+00 1434.00
IUUC-Sha-107216 Sarcophilus harrisii 95.67 0.00e+00 1468.00
IUUC-Sar-113250 Sorex araneus 96.85 0.00e+00 832.00
IUUC-Ssc-116413 Sus scrofa 94.45 0.00e+00 1411.00
IUUC-Tgu-116723 Taeniopygia guttata 93.80 0.00e+00 1422.00
IUUC-Tru-117843 Takifugu rubripes 79.92 0.00e+00 1236.00
IUUC-Tsy-119455 Tarsius syrichta 98.87 0.00e+00 1433.00
IUUC-Tni-120037 Tetraodon nigroviridis 81.71 0.00e+00 1211.00
IUUC-Tbe-127879 Tupaia belangeri 84.96 0.00e+00 1255.00
IUUC-Ttr-128423 Tursiops truncatus 97.15 0.00e+00 1438.00
IUUC-Xtr-132237 Xenopus tropicalis 88.51 0.00e+00 1366.00
Created Date 25-Jun-2017

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