iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSRNOG00000000999.7	ENSRNOT00000031901.6	ENSRNOP00000031927.4
ENSRNOG00000000999.7	ENSRNOT00000084577.1	ENSRNOP00000073635.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
TRANSFAC	RAID2
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.80e-127	425.8	395	730

Active Site

Position(s)	Description	Evidence
699	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dlkkrl+v+f+gEegld+gGv+re+l+ll++e+ np++glf+ys ++ +tlq+npds + np+hl++F+f+Gr++g+a+++g++++ 
   Q: 395  PKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYTLQINPDSSI-NPDHLSYFHFVGRIMGLAVFHGHYING 482
           689*********************************************************9.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            ++ +fyk+llgk+++l+dle+vdpel+ksl +i+en   di+   ld tf+v+++ +g + ++eLkp+G+n+pVt+eNk+eYv+l+v+
   Q: 483  GFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILEN---DITPV-LDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVN 567
           ***********************************99...9***8.******************************************* PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+ +gi+ q+ a+++Gfne+ip++ll+ F+++elel+i G ++id++d+k++t+ k+ + +ds+ ++wFw+++e f++e r+++LqFv
   Q: 568  WRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKH-CVADSNIVRWFWQAVETFDEERRARLLQFV 655
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk.......prlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tgs r+Pl+Gf++l+       prlf+i+  da++d+lP+++TCfn++++P+Y+s+e+l+ekLl+A+eet gF +
   Q: 656  TGSTRVPLQGFKALQgstgaagPRLFTIHLiDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGFAV 730
           ******************************99999**************************************76 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MSNPGTRRNG SSIKIRLTVL CAKNLAKKDF FRLPDPFAKI VVDGSGQCHS TDTVKNTLDP 60
KWNQHYDLYV GKTDSITISV WNHKKIHKKQ GAGFLGCVRL LSNAISRLKD TGYQRLDLCK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCCGGCCGGC CGCTGGCGGG AGATGTCGAA CCCCGGGACC CGTAGGAACG GCTCCAGCAT 60
CAAGATCCGT CTGACAGGTA GGCACGACAG GCCGCGGCCC TCGCGCCCAA GCGGTCCCGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0030424--C:axon
GO:0070062--C:extracellular exosome
GO:0005739--C:mitochondrion
GO:0043025--C:neuronal cell body
GO:0005886--C:plasma membrane
GO:0061630--F:ubiquitin protein ligase activity
GO:0030509--P:BMP signaling pathway
GO:0061736--P:engulfment of target by autophagosome
GO:0030279--P:negative regulation of ossification
GO:0030512--P:negative regulation of transforming growth factor beta receptor signaling pathway
GO:0061734--P:parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization
GO:1903861--P:positive regulation of dendrite extension
GO:2000060--P:positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0006611--P:protein export from nucleus
GO:0034394--P:protein localization to cell surface
GO:0000209--P:protein polyubiquitination
GO:0071211--P:protein targeting to vacuole involved in autophagy
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0032801--P:receptor catabolic process
GO:0030516--P:regulation of axon extension
GO:0061753--P:substrate localization to autophagosome
GO:0030579--P:ubiquitin-dependent SMAD protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001459	Ailuropoda melanoleuca	92.28	0.00e+00	1404.00
IUUC-Apl-004155	Anas platyrhynchos	92.68	0.00e+00	1413.00
IUUC-Aca-005238	Anolis carolinensis	94.82	0.00e+00	1410.00
IUUC-Ame-010901	Astyanax mexicanus	90.72	0.00e+00	1368.00
IUUC-Bta-013221	Bos taurus	90.67	0.00e+00	1332.00
IUUC-Cja-018985	Callithrix jacchus	95.51	0.00e+00	1472.00
IUUC-Cfa-020568	Canis familiaris	93.50	0.00e+00	1434.00
IUUC-Cpo-022531	Cavia porcellus	95.11	0.00e+00	1464.00
IUUC-Csa-024145	Chlorocebus sabaeus	98.22	0.00e+00	1472.00
IUUC-Cho-024963	Choloepus hoffmanni	83.65	0.00e+00	774.00
IUUC-Cin-025126	Ciona intestinalis	63.50	0.00e+00	928.00
IUUC-Csv-026339	Ciona savignyi	63.25	0.00e+00	947.00
IUUC-Dre-028341	Danio rerio	91.13	0.00e+00	1378.00
IUUC-Dno-029705	Dasypus novemcinctus	93.61	0.00e+00	1422.00
IUUC-Dme-031740	Drosophila melanogaster	72.54	1.00e-175	610.00
IUUC-Eca-034125	Equus caballus	95.13	0.00e+00	1431.00
IUUC-Fca-035905	Felis catus	97.10	0.00e+00	1442.00
IUUC-Fal-037336	Ficedula albicollis	95.82	0.00e+00	1405.00
IUUC-Gmo-039486	Gadus morhua	80.92	0.00e+00	867.00
IUUC-Gga-040218	Gallus gallus	95.69	0.00e+00	1451.00
IUUC-Gac-041707	Gasterosteus aculeatus	84.71	0.00e+00	1268.00
IUUC-Ggo-045408	Gorilla gorilla	89.04	0.00e+00	1322.00
IUUC-Hsa-045878	Homo sapiens	95.38	0.00e+00	1471.00
IUUC-Itr-048317	Ictidomys tridecemlineatus	95.39	0.00e+00	1433.00
IUUC-Loc-052628	Lepisosteus oculatus	85.53	0.00e+00	1352.00
IUUC-Laf-053644	Loxodonta africana	92.73	0.00e+00	1390.00
IUUC-Mcc-055479	Macaca mulatta	90.42	0.00e+00	1324.00
IUUC-Mga-059723	Meleagris gallopavo	92.30	0.00e+00	1384.00
IUUC-Mdo-063005	Monodelphis domestica	97.40	0.00e+00	1469.00
IUUC-Mmu-063634	Mus musculus	99.86	0.00e+00	1496.00
IUUC-Mpu-065898	Mustela putorius furo	97.63	0.00e+00	1446.00
IUUC-Mlu-067584	Myotis lucifugus	94.10	0.00e+00	1428.00
IUUC-Nle-069033	Nomascus leucogenys	95.26	0.00e+00	1434.00
IUUC-Ont-072265	Oreochromis niloticus	83.05	0.00e+00	1281.00
IUUC-Oan-073621	Ornithorhynchus anatinus	90.81	0.00e+00	1409.00
IUUC-Ocu-073960	Oryctolagus cuniculus	93.93	0.00e+00	1419.00
IUUC-Ola-086597	Oryzias latipes	72.64	0.00e+00	1128.00
IUUC-Oga-088579	Otolemur garnettii	95.38	0.00e+00	1469.00
IUUC-Oar-090396	Ovis aries	92.87	0.00e+00	1337.00
IUUC-Ptr-091624	Pan troglodytes	95.38	0.00e+00	1471.00
IUUC-Pan-092479	Papio anubis	95.13	0.00e+00	1435.00
IUUC-Pfo-097203	Poecilia formosa	84.59	0.00e+00	1276.00
IUUC-Pab-097540	Pongo abelii	95.17	0.00e+00	1401.00
IUUC-Pca-100379	Procavia capensis	73.16	0.00e+00	644.00
IUUC-Pva-102456	Pteropus vampyrus	85.50	0.00e+00	1233.00
IUUC-Sha-107216	Sarcophilus harrisii	93.35	0.00e+00	1434.00
IUUC-Ssc-116413	Sus scrofa	95.75	0.00e+00	1400.00
IUUC-Tgu-116723	Taeniopygia guttata	92.72	0.00e+00	1400.00
IUUC-Tru-117843	Takifugu rubripes	82.61	0.00e+00	1263.00
IUUC-Tsy-119455	Tarsius syrichta	95.04	0.00e+00	1359.00
IUUC-Tni-120037	Tetraodon nigroviridis	81.79	0.00e+00	1207.00
IUUC-Tbe-127879	Tupaia belangeri	81.59	0.00e+00	1174.00
IUUC-Ttr-128423	Tursiops truncatus	93.77	0.00e+00	1367.00
IUUC-Xtr-132237	Xenopus tropicalis	87.30	0.00e+00	1355.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence