iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB	3.80e-21	75.3	90	156
E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box	7.00e-09	34.9	189	220

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB

   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgklden 68
           +Dv+l+v++e f+ahk+vL+a+S++F+a+f+++l+es+  ++v++++v p++++ +l F+Ytg+++ +
   Q: 90   TDVVLEVKKELFPAHKVVLSAASPYFKAMFTGGLKESE-MSRVQLQGVCPTAMSRILYFMYTGQIRVT 156
           7************************************8.*************************9876 PP

E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box

   S: 1    leNclgilrfAdlydcpdLkdaaldfilkhFk 32
           + N++gi +fA++++c +L ++a+ fi+++F+
   Q: 189  PTNAIGIAHFAEQHGCVELQKKANVFIERNFT 220
           78*****************************7 PP

Organism

Drosophila melanogaster

Protein Sequence
(Fasta)

MQTQMHSPMQ YETHISDMPN HKGYPCRPEE AEMSNTSESC SISCGGRFGS AHSTLDDHDA 60
TDDDMTFCMS NYAKEALKMM YMMRSHGMLT DVVLEVKKEL FPAHKVVLSA ASPYFKAMFT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCACTTGCAT GTTTACCTTA AGAAGAAGAG TAGAAAAAAT CGTTGTGTAG TGGCAAAATA 60
AATAAATACA GATGTGAGTA GCAGTAAATA AAACATACAA AGTGCAAAAA AGGCATAAAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0880--Kelch repeat
KW-1185--Reference proteome
KW-0677--Repeat

Interpro

IPR011705--BACK
IPR000210--BTB/POZ_dom
IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR011333--SKP1/BTB/POZ

PROSITE

PS50097--BTB

Pfam

PF07707--BACK
PF00651--BTB
PF01344--Kelch_1

SMART

SM00875--BACK
SM00225--BTB
SM00612--Kelch

Gene Ontology

GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0005634--C:nucleus
GO:0005703--C:polytene chromosome puff
GO:0003779--F:actin binding
GO:0042803--F:protein homodimerization activity
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0006979--P:response to oxidative stress

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001377	Ailuropoda melanoleuca	49.73	1.00e-165	575.00
IUUC-Aca-005389	Anolis carolinensis	48.94	2.00e-167	582.00
IUUC-Ate-010500	Aspergillus terreus	27.34	2.00e-19	89.40
IUUC-Ame-010749	Astyanax mexicanus	50.27	2.00e-164	571.00
IUUC-Bta-013505	Bos taurus	49.38	7.00e-164	569.00
IUUC-Bci-013875	Botrytis cinerea	25.74	6.00e-16	77.40
IUUC-Cja-018823	Callithrix jacchus	49.55	1.00e-164	572.00
IUUC-Cfa-021202	Canis familiaris	49.55	4.00e-165	573.00
IUUC-Cpo-021830	Cavia porcellus	51.87	9.00e-125	439.00
IUUC-Csa-023728	Chlorocebus sabaeus	49.55	5.00e-164	570.00
IUUC-Cin-025195	Ciona intestinalis	47.76	4.00e-159	553.00
IUUC-Csv-026155	Ciona savignyi	45.39	8.00e-147	513.00
IUUC-Dre-027388	Danio rerio	49.29	1.00e-161	562.00
IUUC-Dno-029066	Dasypus novemcinctus	44.64	3.00e-139	487.00
IUUC-Dor-030674	Dipodomys ordii	52.00	2.00e-123	435.00
IUUC-Eca-034381	Equus caballus	48.48	5.00e-163	566.00
IUUC-Fca-036067	Felis catus	49.73	2.00e-165	575.00
IUUC-Gmo-039691	Gadus morhua	50.09	7.00e-164	569.00
IUUC-Gga-040266	Gallus gallus	48.49	2.00e-158	551.00
IUUC-Gac-041866	Gasterosteus aculeatus	50.36	2.00e-166	578.00
IUUC-Ggo-044719	Gorilla gorilla	49.73	2.00e-165	574.00
IUUC-Hsa-046255	Homo sapiens	49.73	2.00e-165	574.00
IUUC-Itr-048457	Ictidomys tridecemlineatus	49.38	3.00e-165	574.00
IUUC-Lch-049646	Latimeria chalumnae	49.65	1.00e-166	578.00
IUUC-Loc-052296	Lepisosteus oculatus	44.64	3.00e-134	471.00
IUUC-Laf-054579	Loxodonta africana	49.20	1.00e-164	572.00
IUUC-Mcc-055315	Macaca mulatta	49.55	5.00e-164	570.00
IUUC-Meu-056288	Macropus eugenii	46.61	3.00e-147	514.00
IUUC-Mmr-061639	Microcebus murinus	49.38	8.00e-165	572.00
IUUC-Mdo-062072	Monodelphis domestica	50.27	4.00e-167	580.00
IUUC-Mmu-063622	Mus musculus	49.02	2.00e-162	565.00
IUUC-Mpu-066737	Mustela putorius furo	49.82	6.00e-164	570.00
IUUC-Mlu-068173	Myotis lucifugus	49.20	4.00e-164	570.00
IUUC-Opr-070432	Ochotona princeps	49.02	2.00e-163	568.00
IUUC-Ont-072160	Oreochromis niloticus	50.44	9.00e-161	559.00
IUUC-Oan-072691	Ornithorhynchus anatinus	45.02	4.00e-141	493.00
IUUC-Ocu-073798	Oryctolagus cuniculus	49.91	7.00e-166	576.00
IUUC-Ola-086367	Oryzias latipes	47.61	2.00e-153	535.00
IUUC-Oga-088231	Otolemur garnettii	49.73	8.00e-166	576.00
IUUC-Oar-089227	Ovis aries	48.48	2.00e-158	551.00
IUUC-Ptr-091460	Pan troglodytes	49.73	2.00e-165	574.00
IUUC-Pan-092713	Papio anubis	49.55	5.00e-164	570.00
IUUC-Pfo-096468	Poecilia formosa	51.34	9.00e-167	579.00
IUUC-Pab-098357	Pongo abelii	49.73	2.00e-165	574.00
IUUC-Pca-100837	Procavia capensis	48.93	7.00e-164	569.00
IUUC-Pva-103249	Pteropus vampyrus	47.24	2.00e-152	531.00
IUUC-Rno-106086	Rattus norvegicus	49.02	5.00e-160	556.00
IUUC-Sha-107245	Sarcophilus harrisii	50.62	4.00e-168	583.00
IUUC-Sar-112985	Sorex araneus	49.20	3.00e-164	570.00
IUUC-Ssc-115756	Sus scrofa	49.73	9.00e-166	576.00
IUUC-Tru-117644	Takifugu rubripes	49.91	4.00e-165	573.00
IUUC-Tni-120245	Tetraodon nigroviridis	50.09	7.00e-164	569.00
IUUC-Uma-129413	Ustilago maydis	32.00	2.90e-01	30.40
IUUC-Vpa-130683	Vicugna pacos	49.03	2.00e-147	514.00
IUUC-Xtr-132827	Xenopus tropicalis	47.49	2.00e-154	538.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence