iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Xtr-132222

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

HECT domain-containing E3 ubiquitin protein ligase 4

Genbank Nucleotide ID

AAMC01099892

Gene Name

hectd4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXETG00000004302.3	ENSXETT00000009363.3	ENSXETP00000009363.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.90e-78	264.4	3584	3944

Active Site

Position(s)	Description	Evidence
3918	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 4    dlkkrlevefvgEegldlgGvtreflallskelqnpdlglf.......lysendketlqpnpdsglknpehlklFeflGrllgkalq 83
           d ++ ++++f+gEe+++++G++r+fl++++kelq+++l+l+       ++++++k+ l+p+p ++     +++l +f+G+llg+a++
   Q: 3584 DPTYAFNIRFTGEEVHGTSGSFRHFLWQVCKELQSSSLSLLllcpssaVNKNKGKYLLTPSPITY----AEEQLLHFFGQLLGIAIR 3666
           5667788*********************************9999999888888***********9....589*************** PP
   S: 84   dgrlldlplsksfyklllgkklsl.edleevdpelykslkeik.enaesdieelgldltfs..vseei.............lgetke 153
            + +l+l+l ++f+k+l+g++l+   dl e d  +++++k+ +  n+es++e+l+++++++  ++e+                + +e
   Q: 3667 ADVPLPLDLLPCFWKMLVGEPLDPeTDLYEADILTHNYIKKFEnVNDESELEALCAEIASQhlPTESPdsphkpackftylTMTGEE 3753
           ************************99************6666515568899999999999865444448999*******65555566 PP
   S: 154  eeLkpgGenipVtneNkeeYvklvveyrlke.gikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggy 239
           +eL+p+G++i+V +eNk+ Y   + ++r++e + +e++ a+r+G+ ++ipl+ll+ +++ e+el +cG ++i++e lk++t+y+ g+
   Q: 3754 VELCPKGRHISVVWENKDIYAMGIRNLRIRElKNQECMSAVRAGLGSIIPLQLLTTLNALEMELRTCGLPYINLEFLKAHTMYQVGL 3840
           67*****************************99****************************************************** PP
   S: 240  tedspaiqwFwevleefsseerkafLqFvTgssrlPl......gGfaelk....prlfvirk...dasddrlPssnTCfnyLkLPeY 313
           +e++++i++Fw++le+f++ee ++f++F+++++r+P+      gG ++ +    p+++  ++    + d+r+++++TC++++kLP+Y
   Q: 3841 METDQHIEYFWSALEMFTQEELCKFIKFACNQERIPFtcpckdGGPDTAHvppyPMKIAPPDgatGSPDSRYIRVETCMFMIKLPQY 3927
           *******************************************99999999988888888889955566****************** PP
   S: 314  sskeilkekLlyAieet 330
           ss e + ekL+yAi+++
   Q: 3928 SSLEMMLEKLRYAIHYR 3944
           **************986 PP

Organism

Xenopus tropicalis

Protein Sequence
(Fasta)

LQVQNGVCIA SPLHERIILM RKEGESAKSI NEMLLSRLSR YRASPSATLA ALTGSTISNT 60
LKEDQTAANT SCGLPLKMLR KTPMYTCGTY LVLLVPPPGG SGSSATRSLF GGTSGLSSLK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTCCAGGTGC AAAATGGAGT ATGCATTGCA AGCCCTCTTC ATGAGCGCAT TATATTAATG 60
AGGAAAGAGG GAGAATCTGC TAAAAGTATT AATGAAATGC TTTTGAGCAG ATTATCACGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom

PROSITE

PS50237--HECT

Pfam

PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002256	Ailuropoda melanoleuca	89.28	0.00e+00	4820.00
IUUC-Apl-004161	Anas platyrhynchos	88.03	0.00e+00	4971.00
IUUC-Aca-005341	Anolis carolinensis	85.46	0.00e+00	6261.00
IUUC-Ame-011574	Astyanax mexicanus	79.90	0.00e+00	4345.00
IUUC-Bta-012514	Bos taurus	83.22	0.00e+00	1680.00
IUUC-Cja-019148	Callithrix jacchus	86.38	0.00e+00	4797.00
IUUC-Cfa-020499	Canis familiaris	87.71	0.00e+00	4803.00
IUUC-Cpo-021894	Cavia porcellus	90.52	0.00e+00	2605.00
IUUC-Csa-023079	Chlorocebus sabaeus	86.53	0.00e+00	6432.00
IUUC-Cho-024415	Choloepus hoffmanni	84.99	0.00e+00	4515.00
IUUC-Dre-027452	Danio rerio	78.24	0.00e+00	4357.00
IUUC-Dno-029595	Dasypus novemcinctus	85.57	0.00e+00	6421.00
IUUC-Dor-030849	Dipodomys ordii	90.91	0.00e+00	1692.00
IUUC-Ete-032563	Echinops telfairi	80.38	0.00e+00	1047.00
IUUC-Eca-034202	Equus caballus	89.40	0.00e+00	4819.00
IUUC-Eeu-035175	Erinaceus europaeus	89.69	0.00e+00	1004.00
IUUC-Fca-036295	Felis catus	85.63	0.00e+00	6333.00
IUUC-Fal-037003	Ficedula albicollis	86.69	0.00e+00	5801.00
IUUC-Gmo-038579	Gadus morhua	84.09	0.00e+00	2855.00
IUUC-Gga-040961	Gallus gallus	86.98	0.00e+00	6571.00
IUUC-Gac-041899	Gasterosteus aculeatus	83.71	0.00e+00	2893.00
IUUC-Ggo-045099	Gorilla gorilla	87.72	0.00e+00	5795.00
IUUC-Hsa-046331	Homo sapiens	85.93	0.00e+00	6480.00
IUUC-Itr-048190	Ictidomys tridecemlineatus	82.62	0.00e+00	1876.00
IUUC-Lch-049923	Latimeria chalumnae	84.00	0.00e+00	2568.00
IUUC-Loc-052630	Lepisosteus oculatus	83.67	0.00e+00	4027.00
IUUC-Laf-053394	Loxodonta africana	87.39	0.00e+00	4792.00
IUUC-Mcc-055763	Macaca mulatta	86.48	0.00e+00	6426.00
IUUC-Meu-056039	Macropus eugenii	82.68	0.00e+00	4754.00
IUUC-Mga-059500	Meleagris gallopavo	87.63	0.00e+00	6593.00
IUUC-Mmr-060868	Microcebus murinus	82.49	0.00e+00	6175.00
IUUC-Mdo-062772	Monodelphis domestica	86.81	0.00e+00	6485.00
IUUC-Mmu-063606	Mus musculus	86.97	0.00e+00	4783.00
IUUC-Mpu-065860	Mustela putorius furo	86.65	0.00e+00	4689.00
IUUC-Mlu-067376	Myotis lucifugus	89.32	0.00e+00	4809.00
IUUC-Nle-069693	Nomascus leucogenys	85.63	0.00e+00	6375.00
IUUC-Opr-071065	Ochotona princeps	84.04	0.00e+00	1050.00
IUUC-Ont-072470	Oreochromis niloticus	82.57	0.00e+00	4501.00
IUUC-Oan-073693	Ornithorhynchus anatinus	90.31	0.00e+00	3245.00
IUUC-Ocu-074032	Oryctolagus cuniculus	84.99	0.00e+00	6415.00
IUUC-Ola-087433	Oryzias latipes	81.64	0.00e+00	1577.00
IUUC-Oga-088546	Otolemur garnettii	86.57	0.00e+00	6287.00
IUUC-Oar-089643	Ovis aries	82.80	0.00e+00	702.00
IUUC-Ptr-090504	Pan troglodytes	87.00	0.00e+00	6502.00
IUUC-Pan-092543	Papio anubis	86.45	0.00e+00	6419.00
IUUC-Psi-093952	Pelodiscus sinensis	86.04	0.00e+00	6430.00
IUUC-Pfo-096356	Poecilia formosa	78.72	0.00e+00	6017.00
IUUC-Pab-098240	Pongo abelii	85.80	0.00e+00	6425.00
IUUC-Pca-100994	Procavia capensis	89.54	0.00e+00	2771.00
IUUC-Pva-102263	Pteropus vampyrus	88.08	0.00e+00	4734.00
IUUC-Rno-104888	Rattus norvegicus	85.56	0.00e+00	4965.00
IUUC-Sha-106944	Sarcophilus harrisii	87.12	0.00e+00	6533.00
IUUC-Sar-113556	Sorex araneus	80.83	0.00e+00	909.00
IUUC-Ssc-116187	Sus scrofa	86.75	0.00e+00	4690.00
IUUC-Tgu-116655	Taeniopygia guttata	88.35	0.00e+00	4921.00
IUUC-Tru-118093	Takifugu rubripes	82.52	0.00e+00	2978.00
IUUC-Tni-119739	Tetraodon nigroviridis	82.05	0.00e+00	1591.00
IUUC-Tbe-127962	Tupaia belangeri	72.01	0.00e+00	987.00
IUUC-Ttr-128819	Tursiops truncatus	80.47	0.00e+00	2507.00
IUUC-Vpa-130482	Vicugna pacos	87.95	0.00e+00	4029.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence