iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mdo-062866

UUCD1 version

UUC-MoD-00245

Ensembl Protein ID

ENSMODP00000026529.4

UniProt Accession

F6U191; F6U191_MONDO

Protein Name

Uncharacterized protein

Gene Name

TRIP12

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMODG00000021224.4	ENSMODT00000027004.4	ENSMODP00000026529.4

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.70e-69	234.3	1663	1978

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/HECT

   S: 6    kkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknp.......................ehlk 69
           ++ le+++++E g++l G+t+ef+al+s+elq++dlgl++ +e   ++ + +++  +  +                       ++  
   Q: 1663 RAMLEIQYENEVGTGL-GPTLEFYALVSQELQRADLGLWRGEEVTLTNPKGSQEG-T--KyiqnlqglfalpfgrtakpahiaKVKM 1745
           56899***********.**********************6666533333322221.1..1234558888999**********9999* PP
   S: 70   lFeflGrllgkalqdgrlldlplsksfyklllgkklsl..edleevdpelykslkeikena......es.................. 130
            F+flG+l++ka++d rl+dlpl  +fyk +l+++ sl  +dl ++dp +++s+  +++ +      e+                  
   Q: 1746 KFRFLGKLMAKAIMDFRLVDLPLGLPFYKWMLRQETSLtsHDLFDIDPVVARSVYHLEDIVrqkkrlEQdksqtkeslqyaletlnm 1832
           **********************************654444**************999999855555511555666666444444444 PP
   S: 131  ...dieelgldltfsvseei.....lgetkeeeLkpgGenipVtneNkeeYvklvveyrlkegikeqveafreGfneviplellslF 209
              ++e+            +     l+   + eLk gG++ipVt+ N+eeY +lv+ + l+eg+++q+++fr+Gf++v+pl++l++F
   Q: 1833 ngcSVED------------LgldftLPGFPNIELKKGGKDIPVTIHNLEEYLRLVIFWALNEGVARQFDSFRDGFESVFPLSHLQYF 1907
           4333333............35555588999********************************************************* PP
   S: 210  teeelellicGe..eeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTgssrlPlgG 278
            +eel++l+cG+  +++d+++l + ++ ++gyt+ds+a+++++e+l++f++e+++ fLqFvTgs+rlP+gG
   Q: 1908 YPEELDQLLCGSkaDTWDAKTLMECCRPDHGYTHDSRAVKYLFEILSGFDNEQQRLFLQFVTGSPRLPVGG 1978
           ************7778999999999999*****************************************98 PP

Organism

Monodelphis domestica

Protein Sequence
(Fasta)

MSNRPNNNPG GSLRRSQRNT AGAQPQDDSI GGRSHLGQAK HKAYSPPESR KSISKAPKVQ 60
SNTTSEQSRG HISKRSCSSS SAVIVPQPED PDRANTSEKQ KTGQVPKKDS SRGVKRSASP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGAATGGTAG TGTCTAGAAA GGGTATGTCC CTTCAGGAGA GAGGTGCCAA TGTCCAACCG 60
GCCTAATAAC AATCCAGGGG GGTCACTGCG ACGTTCACAG AGGAACACTG CCGGGGCCCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR000569--HECT_dom
IPR004170--WWE-dom
IPR018123--WWE-dom_subgr

PROSITE

PS50237--HECT
PS50918--WWE

Pfam

PF00632--HECT
PF02825--WWE

SMART

SM00119--HECTc
SM00678--WWE

Gene Ontology

GO:0016607--C:nuclear speck
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006974--P:cellular response to DNA damage stimulus
GO:0009790--P:embryo development
GO:2000780--P:negative regulation of double-strand break repair
GO:1901315--P:negative regulation of histone H2A K63-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000750	Aegilops tauschii	36.33	2.00e-105	377.00
IUUC-Aml-001502	Ailuropoda melanoleuca	94.56	0.00e+00	3422.00
IUUC-Atr-002821	Amborella trichopoda	35.23	7.00e-96	346.00
IUUC-Apl-003531	Anas platyrhynchos	91.03	0.00e+00	3225.00
IUUC-Aly-005962	Arabidopsis lyrata	36.83	5.00e-94	340.00
IUUC-Ath-006636	Arabidopsis thaliana	36.51	2.00e-93	338.00
IUUC-Ago-007875	Ashbya gossypii	33.56	1.00e-60	229.00
IUUC-Acl-008242	Aspergillus clavatus	33.17	2.00e-88	321.00
IUUC-Afl-008736	Aspergillus flavus	35.89	7.00e-85	309.00
IUUC-Afu-008812	Aspergillus fumigatus	31.99	2.00e-87	318.00
IUUC-Ani-009407	Aspergillus nidulans	34.06	1.00e-84	308.00
IUUC-Ang-009763	Aspergillus niger	37.01	1.00e-79	292.00
IUUC-Aor-009941	Aspergillus oryzae	28.55	2.00e-87	318.00
IUUC-Ate-010459	Aspergillus terreus	37.31	1.00e-84	308.00
IUUC-Ame-011761	Astyanax mexicanus	87.81	0.00e+00	2843.00
IUUC-Bgr-012265	Blumeria graminis	32.04	4.00e-77	284.00
IUUC-Bta-013070	Bos taurus	93.38	0.00e+00	3293.00
IUUC-Bci-013890	Botrytis cinerea	36.84	9.00e-78	286.00
IUUC-Bdi-014046	Brachypodium distachyon	35.81	2.00e-99	358.00
IUUC-Bol-015942	Brassica oleracea	42.54	1.00e-92	335.00
IUUC-Bra-016849	Brassica rapa	42.54	2.00e-92	335.00
IUUC-Cja-019046	Callithrix jacchus	93.36	0.00e+00	3065.00
IUUC-Cfa-020521	Canis familiaris	94.74	0.00e+00	3377.00
IUUC-Cpo-021639	Cavia porcellus	90.38	0.00e+00	3299.00
IUUC-Cre-022767	Chlamydomonas reinhardtii	39.55	5.00e-73	268.00
IUUC-Csa-023231	Chlorocebus sabaeus	96.05	0.00e+00	3140.00
IUUC-Cho-024380	Choloepus hoffmanni	91.35	0.00e+00	1995.00
IUUC-Cin-025482	Ciona intestinalis	48.63	6.00e-133	467.00
IUUC-Csv-026121	Ciona savignyi	47.36	0.00e+00	1449.00
IUUC-Cgl-026716	Colletotrichum gloeosporioides	32.00	6.00e-85	310.00
IUUC-Cne-026857	Cryptococcus neoformans	37.61	4.00e-72	267.00
IUUC-Cme-027226	Cyanidioschyzon merolae	32.03	1.00e-50	196.00
IUUC-Dre-028174	Danio rerio	87.24	0.00e+00	2871.00
IUUC-Dor-030939	Dipodomys ordii	85.24	0.00e+00	2622.00
IUUC-Dse-031444	Dothistroma septosporum	36.34	7.00e-80	293.00
IUUC-Dme-032162	Drosophila melanogaster	60.71	0.00e+00	739.00
IUUC-Ete-032345	Echinops telfairi	91.51	0.00e+00	2224.00
IUUC-Eca-033229	Equus caballus	94.01	0.00e+00	3336.00
IUUC-Eeu-035205	Erinaceus europaeus	82.04	0.00e+00	2840.00
IUUC-Fca-036444	Felis catus	93.82	0.00e+00	3384.00
IUUC-Fal-037131	Ficedula albicollis	94.11	0.00e+00	3380.00
IUUC-Fox-038035	Fusarium oxysporum	32.94	2.00e-83	303.00
IUUC-Fso-038320	Fusarium solani	33.50	3.00e-84	307.00
IUUC-Gmo-039497	Gadus morhua	78.72	0.00e+00	2880.00
IUUC-Ggr-040057	Gaeumannomyces graminis	32.44	2.00e-83	304.00
IUUC-Gga-041021	Gallus gallus	94.46	0.00e+00	3383.00
IUUC-Gac-042474	Gasterosteus aculeatus	80.32	0.00e+00	2861.00
IUUC-Gma-043060	Glycine max	36.57	2.00e-100	362.00
IUUC-Ggo-044855	Gorilla gorilla	93.19	0.00e+00	3061.00
IUUC-Hsa-046147	Homo sapiens	93.81	0.00e+00	3061.00
IUUC-Hvu-047775	Hordeum vulgare	36.33	8.00e-105	375.00
IUUC-Itr-048131	Ictidomys tridecemlineatus	92.77	0.00e+00	3268.00
IUUC-Kpa-049098	Komagataella pastoris	35.23	2.00e-62	234.00
IUUC-Lch-049818	Latimeria chalumnae	84.47	0.00e+00	2943.00
IUUC-Lpe-051017	Leersia perrieri	36.73	6.00e-99	356.00
IUUC-Loc-051777	Lepisosteus oculatus	87.24	0.00e+00	3224.00
IUUC-Lma-052990	Leptosphaeria maculans	33.00	6.00e-86	313.00
IUUC-Laf-053727	Loxodonta africana	94.31	0.00e+00	3383.00
IUUC-Mcc-055799	Macaca mulatta	93.43	0.00e+00	3444.00
IUUC-Meu-056065	Macropus eugenii	96.68	0.00e+00	2150.00
IUUC-Mor-057054	Magnaporthe oryzae	32.05	1.00e-82	302.00
IUUC-Mpo-057417	Magnaporthe poae	36.19	3.00e-82	301.00
IUUC-Mtr-057849	Medicago truncatula	35.32	4.00e-92	333.00
IUUC-Mla-058870	Melampsora laricipopulina	38.94	5.00e-79	290.00
IUUC-Mga-059580	Meleagris gallopavo	92.79	0.00e+00	2980.00
IUUC-Mvi-060507	Microbotryum violaceum	38.05	3.00e-92	334.00
IUUC-Mmr-060816	Microcebus murinus	94.96	0.00e+00	3462.00
IUUC-Mmu-063906	Mus musculus	92.91	0.00e+00	3367.00
IUUC-Mac-064675	Musa acuminata	37.39	3.00e-93	336.00
IUUC-Mpu-066199	Mustela putorius furo	96.36	0.00e+00	3431.00
IUUC-Mlu-067110	Myotis lucifugus	93.31	0.00e+00	3360.00
IUUC-Nfi-068482	Neosartorya fischeri	32.16	3.00e-87	317.00
IUUC-Ncr-068906	Neurospora crassa	36.13	3.00e-83	304.00
IUUC-Nle-069410	Nomascus leucogenys	94.04	0.00e+00	3050.00
IUUC-Opr-070401	Ochotona princeps	83.74	0.00e+00	1789.00
IUUC-Ont-072100	Oreochromis niloticus	82.37	0.00e+00	2974.00
IUUC-Oan-073121	Ornithorhynchus anatinus	95.11	0.00e+00	3519.00
IUUC-Ocu-074623	Oryctolagus cuniculus	96.06	0.00e+00	3463.00
IUUC-Oba-075380	Oryza barthii	29.21	1.00e-93	338.00
IUUC-Obr-076915	Oryza brachyantha	35.52	2.00e-97	351.00
IUUC-Ogl-077055	Oryza glaberrima	36.44	2.00e-96	348.00
IUUC-Ogu-078892	Oryza glumaepatula	33.61	4.00e-90	327.00
IUUC-Oin-079256	Oryza indica	36.44	1.00e-96	348.00
IUUC-Olo-080343	Oryza longistaminata	36.44	6.00e-97	349.00
IUUC-Ome-081422	Oryza meridionalis	36.12	4.00e-96	347.00
IUUC-Oni-083047	Oryza nivara	33.94	5.00e-92	333.00
IUUC-Opu-083641	Oryza punctata	33.44	3.00e-88	320.00
IUUC-Oru-084439	Oryza rufipogon	33.77	9.00e-91	328.00
IUUC-Osa-085972	Oryza sativa	35.97	7.00e-95	341.00
IUUC-Ola-087173	Oryzias latipes	80.42	0.00e+00	2909.00
IUUC-Olu-087871	Ostreococcus lucimarinus	35.09	1.00e-72	266.00
IUUC-Oga-087908	Otolemur garnettii	92.18	0.00e+00	3369.00
IUUC-Oar-090277	Ovis aries	94.64	0.00e+00	3359.00
IUUC-Ptr-091543	Pan troglodytes	93.93	0.00e+00	3066.00
IUUC-Pan-092243	Papio anubis	93.48	0.00e+00	3443.00
IUUC-Psi-093150	Pelodiscus sinensis	93.67	0.00e+00	3413.00
IUUC-Pno-094891	Phaeosphaeria nodorum	38.17	2.00e-86	315.00
IUUC-Ppa-095181	Physcomitrella patens	41.11	4.00e-89	322.00
IUUC-Pfo-096267	Poecilia formosa	87.17	0.00e+00	2881.00
IUUC-Pab-098072	Pongo abelii	94.38	0.00e+00	3061.00
IUUC-Pop-099190	Populus trichocarpa	35.03	4.00e-95	343.00
IUUC-Pca-100311	Procavia capensis	87.42	0.00e+00	3022.00
IUUC-Ppe-101284	Prunus persica	35.81	6.00e-96	346.00
IUUC-Pva-102215	Pteropus vampyrus	90.38	0.00e+00	1258.00
IUUC-Pgr-103694	Puccinia graminis	36.95	4.00e-77	284.00
IUUC-Ptt-103916	Puccinia triticina	35.57	9.00e-71	263.00
IUUC-Pte-104346	Pyrenophora teres	36.29	1.00e-83	305.00
IUUC-Pyt-104508	Pyrenophora triticirepentis	36.36	1.00e-83	305.00
IUUC-Rno-105315	Rattus norvegicus	95.35	0.00e+00	3372.00
IUUC-Sce-106273	Saccharomyces cerevisiae	32.14	8.00e-50	193.00
IUUC-Sha-106835	Sarcophilus harrisii	97.86	0.00e+00	3591.00
IUUC-Sja-107943	Schizosaccharomyces japonicus	33.49	4.00e-69	257.00
IUUC-Spo-108081	Schizosaccharomyces pombe	34.81	1.00e-70	262.00
IUUC-Ssl-108560	Sclerotinia sclerotiorum	37.07	2.00e-81	298.00
IUUC-Smo-108776	Selaginella moellendorffii	42.26	9.00e-93	336.00
IUUC-Sit-110717	Setaria italica	36.24	9.00e-100	359.00
IUUC-Sly-111469	Solanum lycopersicum	37.54	6.00e-101	363.00
IUUC-Stu-112896	Solanum tuberosum	35.33	2.00e-89	323.00
IUUC-Sar-113224	Sorex araneus	82.38	0.00e+00	1805.00
IUUC-Sbi-114313	Sorghum bicolor	36.12	6.00e-103	369.00
IUUC-Sre-114993	Sporisorium reilianum	31.24	4.00e-75	277.00
IUUC-Ssc-115535	Sus scrofa	89.46	0.00e+00	3233.00
IUUC-Tgu-117493	Taeniopygia guttata	92.48	0.00e+00	2714.00
IUUC-Tru-118669	Takifugu rubripes	80.37	0.00e+00	2894.00
IUUC-Tsy-119373	Tarsius syrichta	92.46	0.00e+00	1833.00
IUUC-Tni-120049	Tetraodon nigroviridis	75.47	0.00e+00	740.00
IUUC-Tca-121779	Theobroma cacao	36.69	5.00e-94	340.00
IUUC-Tre-122195	Trichoderma reesei	33.95	1.00e-84	309.00
IUUC-Tvi-122650	Trichoderma virens	33.83	1.00e-87	319.00
IUUC-Tae-123580	Triticum aestivum	36.25	8.00e-104	371.00
IUUC-Tur-126295	Triticum urartu	36.17	3.00e-104	374.00
IUUC-Tme-126964	Tuber melanosporum	37.05	6.00e-80	293.00
IUUC-Tbe-128149	Tupaia belangeri	83.45	0.00e+00	1228.00
IUUC-Ttr-128165	Tursiops truncatus	92.95	0.00e+00	2883.00
IUUC-Uma-129365	Ustilago maydis	32.26	1.00e-62	236.00
IUUC-Vda-129725	Verticillium dahliae	37.70	3.00e-82	301.00
IUUC-Vpa-130678	Vicugna pacos	95.15	0.00e+00	2513.00
IUUC-Vvi-131147	Vitis vinifera	36.78	6.00e-99	356.00
IUUC-Xtr-132636	Xenopus tropicalis	85.69	0.00e+00	3101.00
IUUC-Xma-133458	Xiphophorus maculatus	82.16	0.00e+00	2969.00
IUUC-Yli-134481	Yarrowia lipolytica	36.61	4.00e-73	270.00
IUUC-Zma-135782	Zea mays	34.78	3.00e-96	347.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence