iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Sha-107114

Ensembl Protein ID

ENSSHAP00000019917.1

UniProt Accession

G3WWW2; G3WWW2_SARHA

Genbank Protein ID

ENSSHAP00000019917

Protein Name

Tyrosine-protein kinase

Genbank Nucleotide ID

AEFK01156257

Gene Name

ABL2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSHAG00000016902.1	ENSSHAT00000020074.1	ENSSHAP00000019917.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	2.10e-12	47.0	73	130

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 3    kekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
            +++ +lyd+ a+ d++L+++kG++++v+  ++q+++W +     ++ +G +P+n+++ ++
   Q: 73   PNLFVALYDFVASGDNTLSITKGEKLRVL-GYNQNGEWSEV--RSKNGQGWVPSNYITPVN 130
           67899************************.*********98..788899*********997 PP

Organism

Sarcophilus harrisii

Protein Sequence
(Fasta)

MILGTVLLPS SSYAREQDKL FCCLYNEASE TDLPNLREAL HRPYGCEAES QALNEAIRWS 60
SKENLLGATE SDPNLFVALY DFVASGDNTL SITKGEKLRV LGYNQNGEWS EVRSKNGQGW 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGCAAGGAAT GTGGCCTTGC TAGTCAGGAA GTTGGATTTT AACGTTTCCT CTTGTGCTCA 60
GAAGCTTGGC TTTTGTGCTT TTGAACAGAG TATGATCCTT GGGACGGTCC TGTTACCTTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR015015--F-actin_binding
IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF08919--F_actin_bind
PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00109--TYRKINASE

SMART

SM00808--FABD
SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0005623--C:cell
GO:0005524--F:ATP binding
GO:0000287--F:magnesium ion binding
GO:0030145--F:manganese ion binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0071300--P:cellular response to retinoic acid
GO:0007204--P:positive regulation of cytosolic calcium ion concentration
GO:0010976--P:positive regulation of neuron projection development
GO:0051353--P:positive regulation of oxidoreductase activity
GO:0010863--P:positive regulation of phospholipase C activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002263	Ailuropoda melanoleuca	87.96	0.00e+00	1425.00
IUUC-Apl-003389	Anas platyrhynchos	83.06	0.00e+00	1324.00
IUUC-Bta-013370	Bos taurus	88.31	0.00e+00	1403.00
IUUC-Cja-018894	Callithrix jacchus	87.22	0.00e+00	1421.00
IUUC-Cfa-020398	Canis familiaris	95.45	0.00e+00	1176.00
IUUC-Cpo-022367	Cavia porcellus	84.37	0.00e+00	1613.00
IUUC-Csa-023386	Chlorocebus sabaeus	87.87	0.00e+00	1425.00
IUUC-Cho-024714	Choloepus hoffmanni	90.34	0.00e+00	1356.00
IUUC-Dre-027741	Danio rerio	76.43	0.00e+00	1139.00
IUUC-Dno-029246	Dasypus novemcinctus	87.60	0.00e+00	1399.00
IUUC-Dor-030416	Dipodomys ordii	79.46	0.00e+00	1249.00
IUUC-Ete-032899	Echinops telfairi	98.37	2.00e-136	480.00
IUUC-Eca-033387	Equus caballus	85.19	0.00e+00	1460.00
IUUC-Eeu-035058	Erinaceus europaeus	81.21	0.00e+00	1283.00
IUUC-Fca-036578	Felis catus	81.46	0.00e+00	1585.00
IUUC-Fal-037491	Ficedula albicollis	87.34	0.00e+00	1395.00
IUUC-Gmo-038509	Gadus morhua	75.84	0.00e+00	1089.00
IUUC-Gga-040638	Gallus gallus	86.97	0.00e+00	1389.00
IUUC-Gac-042550	Gasterosteus aculeatus	76.46	0.00e+00	1135.00
IUUC-Ggo-044487	Gorilla gorilla	87.96	0.00e+00	1426.00
IUUC-Hsa-046636	Homo sapiens	88.08	0.00e+00	1425.00
IUUC-Itr-048685	Ictidomys tridecemlineatus	88.71	0.00e+00	1430.00
IUUC-Lch-049530	Latimeria chalumnae	81.89	0.00e+00	1334.00
IUUC-Lpe-051291	Leersia perrieri	30.59	1.00e-21	98.60
IUUC-Loc-051933	Lepisosteus oculatus	76.90	0.00e+00	1246.00
IUUC-Laf-053802	Loxodonta africana	87.63	0.00e+00	1465.00
IUUC-Mcc-054836	Macaca mulatta	87.84	0.00e+00	1432.00
IUUC-Mga-059277	Meleagris gallopavo	87.44	0.00e+00	1399.00
IUUC-Mmr-061206	Microcebus murinus	87.41	0.00e+00	1352.00
IUUC-Mdo-062281	Monodelphis domestica	97.56	0.00e+00	1192.00
IUUC-Mmu-063847	Mus musculus	86.64	0.00e+00	1348.00
IUUC-Mpu-066309	Mustela putorius furo	94.96	0.00e+00	1174.00
IUUC-Mlu-068070	Myotis lucifugus	88.08	0.00e+00	1427.00
IUUC-Nle-070062	Nomascus leucogenys	94.96	0.00e+00	1174.00
IUUC-Opr-070534	Ochotona princeps	79.90	0.00e+00	900.00
IUUC-Ont-072440	Oreochromis niloticus	74.81	0.00e+00	1109.00
IUUC-Oan-073526	Ornithorhynchus anatinus	87.93	0.00e+00	1401.00
IUUC-Ocu-074051	Oryctolagus cuniculus	85.97	0.00e+00	1375.00
IUUC-Oga-088767	Otolemur garnettii	81.06	0.00e+00	1258.00
IUUC-Oar-089800	Ovis aries	88.31	0.00e+00	1402.00
IUUC-Ptr-090857	Pan troglodytes	94.96	0.00e+00	1173.00
IUUC-Pan-092279	Papio anubis	87.84	0.00e+00	1421.00
IUUC-Psi-093573	Pelodiscus sinensis	87.35	0.00e+00	1374.00
IUUC-Pfo-096543	Poecilia formosa	75.46	0.00e+00	1107.00
IUUC-Pab-097949	Pongo abelii	88.19	0.00e+00	1396.00
IUUC-Pca-100370	Procavia capensis	85.50	0.00e+00	950.00
IUUC-Pva-103220	Pteropus vampyrus	79.74	0.00e+00	1209.00
IUUC-Rno-105924	Rattus norvegicus	86.04	0.00e+00	1360.00
IUUC-Smo-109661	Selaginella moellendorffii	30.22	1.00e-22	100.00
IUUC-Sit-110219	Setaria italica	29.91	3.00e-20	94.00
IUUC-Ssc-115968	Sus scrofa	87.96	0.00e+00	1435.00
IUUC-Tgu-117301	Taeniopygia guttata	87.32	0.00e+00	1399.00
IUUC-Tru-118410	Takifugu rubripes	74.21	0.00e+00	1113.00
IUUC-Tni-119991	Tetraodon nigroviridis	75.62	0.00e+00	1132.00
IUUC-Tca-121389	Theobroma cacao	34.36	8.00e-24	105.00
IUUC-Tbe-127362	Tupaia belangeri	91.00	0.00e+00	1353.00
IUUC-Ttr-129291	Tursiops truncatus	87.64	0.00e+00	1473.00
IUUC-Vpa-130800	Vicugna pacos	89.73	0.00e+00	1442.00
IUUC-Xtr-132965	Xenopus tropicalis	79.60	0.00e+00	1173.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence