• HOME
  • BROWSE
  • SEARCH
  • LINK
  • DOWNLOAD
  • USER GUIDE
  • Protein
  • Gene
  • Annotation
  • Details
  • Classification
  • Domain Profile
  • Function
  • Protein Sequence
  • Nucleotide Sequence
  • Keyword
  • GO
  • Orthology
  • TOP

Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-045979
Ensembl Protein ID ENSP00000057513.3
UniProt Accession Q96KP6; A1A574; A8K2Z4; B4DVF5; B4E023; Q96PQ3; Q9H780; TNIP3_HUMAN
Genbank Protein ID AAL02151.1; CAC85929.1; BAB15018.1; BAF83098.1; BAG62667.1; BAG64285.1; EAX05264.1; AAI28409.1
Protein Name TNFAIP3-interacting protein 3; A20-binding inhibitor of NF-kappa-B activation 3; Listeria-induced gene protein
Genbank Nucleotide ID AF277289; AJ320534; AK024815; AK290409; AK301058; AK303192; AC105254; BC128408
Gene Name TNIP3; ABIN3; LIND
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000050730.15 ENST00000057513.7 ENSP00000057513.3
ENSG00000050730.15 ENST00000509841.1 ENSP00000426613.1
ENSG00000050730.15 ENST00000515036.1 ENSP00000424284.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsiteCircNetmiRTarBase
microRNATRANSFACTargetScanRepTar
miRcodeRAID2
Protein-protein Interaction
IIDiRefIndexHINTMentha
InWeb_IM
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusBioGRID
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
UBD/Alpha-Helix/UBAN UBAN 18212736
Classification
Family E-value Score Start End
UBD/Alpha-Helix/UBAN 4.20e-26 92.3 190 250
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/Alpha-Helix/UBAN
   S: 1    keelletvevLkqQveiYkeDFqaERadRErlneekeeLqeqveklqkqvsklndslkask 61
           +ee+++++evLkqQv+iY+eDF++ER+dRErln+ekeeLq+++e++q+q+++ln+++ka++
   Q: 190  HEEMRTEMEVLKQQVQIYEEDFKKERSDRERLNQEKEELQQINETSQSQLNRLNSQIKACQ 250
           89*********************************************************97 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Binds to zinc finger protein TNFAIP3 and inhibits NF-kappa-B activation induced by tumor necrosis factor, Toll-like receptor 4 (TLR4), interleukin-1 and 12-O-tetradecanoylphorbol-13-acetate. Overexpression inhibits NF-kappa-B-dependent gene expression in response to lipopolysaccharide at a level downstream of TRAF6 and upstream of IKBKB. NF-kappa-B inhibition is independent of TNFAIP3 binding.
 Binds to zinc finger protein TNFAIP3 and inhibits NF-kappa-B activation induced by tumor necrosis factor, Toll-like receptor 4 (TLR4), interleukin-1 and 12-O-tetradecanoylphorbol-13-acetate. Overexpression inhibits NF-kappa-B-dependent gene expression in response to lipopolysaccharide at a level downstream of TRAF6 and upstream of IKBKB. NF-kappa-B inhibition is independent of TNFAIP3 binding.
Protein Sequence
(Fasta)
MAHFVQGTSR MIAAESSTEH KECAEPSTRK NLMNSLEQKI RCLEKQRKEL LEVNQQWDQQ 60
FRSMKELYER KVAELKTKLD AAERFLSTRE KDPHQRQRKD DRQREDDRQR DLTRDRLQRE 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045979|UBD,UBAN|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AAGAGTCTTA AAGACAGGTC TCCGTATTAG ACCTTGTAAT ACGCTTACCT AGATCTGAGA 60
AGGACTTTCA GGATAGAACA TGGTGAGTAA CATAATGTCT TGTGCCTTTA CTTTCATTTC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045979|UBD,UBAN|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0395--Inflammatory response
KW-0621--Polymorphism
KW-1185--Reference proteome
Interpro

IPR032419--CC2-LZ_dom
IPR033574--TNIP3
Pfam

PF16516--CC2-LZ
Gene Ontology

GO:0005829--C:cytosol
GO:0031593--F:polyubiquitin binding
GO:0071222--P:cellular response to lipopolysaccharide
GO:0006954--P:inflammatory response
GO:0002756--P:MyD88-independent toll-like receptor signaling pathway
GO:0043124--P:negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0016579--P:protein deubiquitination
GO:0034142--P:toll-like receptor 4 signaling pathway
KEGG hsa:79931
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002067 Ailuropoda melanoleuca 77.36 2.00e-94 338.00
IUUC-Apl-004206 Anas platyrhynchos 53.96 5.00e-47 181.00
IUUC-Aca-005302 Anolis carolinensis 53.72 5.00e-50 191.00
IUUC-Bta-012335 Bos taurus 72.61 4.00e-99 354.00
IUUC-Cja-018962 Callithrix jacchus 90.14 9.00e-72 263.00
IUUC-Cfa-020391 Canis familiaris 76.85 9.00e-108 383.00
IUUC-Cpo-021748 Cavia porcellus 69.51 2.00e-104 371.00
IUUC-Csa-023223 Chlorocebus sabaeus 90.94 2.00e-124 438.00
IUUC-Cho-024692 Choloepus hoffmanni 85.83 1.00e-50 193.00
IUUC-Dno-029745 Dasypus novemcinctus 71.69 4.00e-117 414.00
IUUC-Dor-030845 Dipodomys ordii 51.59 6.00e-63 234.00
IUUC-Ete-032522 Echinops telfairi 65.89 2.00e-87 315.00
IUUC-Eca-033833 Equus caballus 79.02 2.00e-98 352.00
IUUC-Fca-035554 Felis catus 76.69 1.00e-91 330.00
IUUC-Fal-037572 Ficedula albicollis 52.26 5.00e-61 227.00
IUUC-Gga-040967 Gallus gallus 53.38 1.00e-68 253.00
IUUC-Ggo-044668 Gorilla gorilla 98.15 3.00e-146 511.00
IUUC-Itr-048604 Ictidomys tridecemlineatus 60.57 6.00e-60 224.00
IUUC-Lch-049514 Latimeria chalumnae 46.04 2.00e-48 186.00
IUUC-Loc-052227 Lepisosteus oculatus 37.92 2.00e-37 149.00
IUUC-Laf-053655 Loxodonta africana 77.57 3.00e-108 384.00
IUUC-Mcc-055640 Macaca mulatta 82.95 1.00e-93 336.00
IUUC-Mga-059657 Meleagris gallopavo 53.20 2.00e-65 242.00
IUUC-Mmr-061631 Microcebus murinus 85.71 2.00e-71 262.00
IUUC-Mpu-066506 Mustela putorius furo 64.33 3.00e-77 282.00
IUUC-Mlu-067825 Myotis lucifugus 62.73 1.00e-63 236.00
IUUC-Nle-069637 Nomascus leucogenys 94.75 4.00e-134 471.00
IUUC-Opr-071187 Ochotona princeps 70.73 2.00e-94 339.00
IUUC-Oan-072805 Ornithorhynchus anatinus 60.95 2.00e-52 199.00
IUUC-Ocu-074800 Oryctolagus cuniculus 77.54 1.00e-116 412.00
IUUC-Oga-088454 Otolemur garnettii 79.25 4.00e-98 351.00
IUUC-Oar-089705 Ovis aries 71.43 4.00e-116 410.00
IUUC-Ptr-091489 Pan troglodytes 99.66 1.00e-127 449.00
IUUC-Pan-092492 Papio anubis 92.28 3.00e-127 447.00
IUUC-Psi-092990 Pelodiscus sinensis 52.62 4.00e-70 258.00
IUUC-Pab-097583 Pongo abelii 95.06 4.00e-136 477.00
IUUC-Pca-100575 Procavia capensis 50.31 6.00e-53 201.00
IUUC-Pva-103246 Pteropus vampyrus 65.00 1.00e-73 270.00
IUUC-Pyt-104730 Pyrenophora triticirepentis 44.00 1.60e-01 29.60
IUUC-Rno-104934 Rattus norvegicus 55.90 2.00e-39 155.00
IUUC-Sar-113660 Sorex araneus 58.15 3.00e-87 315.00
IUUC-Ssc-116328 Sus scrofa 69.16 6.00e-111 393.00
IUUC-Tgu-117394 Taeniopygia guttata 53.59 4.00e-40 157.00
IUUC-Tsy-119152 Tarsius syrichta 81.36 1.00e-71 263.00
IUUC-Tbe-127856 Tupaia belangeri 71.64 3.00e-75 274.00
IUUC-Ttr-128333 Tursiops truncatus 64.31 6.00e-99 353.00
IUUC-Vpa-130185 Vicugna pacos 77.78 7.00e-58 217.00
Created Date 25-Jun-2017

https://dev.news.makassarkota.go.id/public/pgsoft-demo/ https://jdih.sumbawabaratkab.go.id/lato/pg-soft-demo/ https://dev.news.makassarkota.go.id/public/slot-gacor/ http://pbb.tanahbumbukab.go.id/-/slot-gacor/ slot gacor https://siakad.unipra.ac.id/sass/slot-gacor-x500/ http://kpm.dinus.ac.id/assets/images/berita/slot/
Copyright © 2004-2017.The CUCKOO Workgroup. All Rights Reserved