iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSRNOG00000016046.7	ENSRNOT00000082040.1	ENSRNOP00000073947.1
ENSRNOG00000016046.7	ENSRNOT00000021703.5	ENSRNOP00000021703.5

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
TRANSFAC	RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	3.30e-121	405.2	1262	1594

Active Site

Position(s)	Description	Evidence
1562	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlld 89
           + ++++l+++fvgEegld++G++ref++lls+el+np++glf+ys+nd++t+q++p s +  +++l++F+f Gr+lg+al ++ lld
   Q: 1262 ELQRNKLYITFVGEEGLDYSGPSREFFFLLSQELFNPYYGLFEYSANDTYTVQISPMSAFV-ENYLEWFRFSGRILGLALIHQYLLD 1347
           567899****************************************************985.5************************ PP
   S: 90   lplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvkl 176
           ++++++fyk ll+ +++l+dle +d+e+++sl+++k+n   +i+++ ldltf+v+ee++g+++e+eLk+gG+n++Vt++Nk+eY+++
   Q: 1348 AFFTRPFYKGLLKLPCDLSDLEYLDEEFHQSLQWMKDN---NITDI-LDLTFTVNEEVFGQVTERELKSGGANTQVTEKNKKEYIER 1430
           ************************************99...9***9.**************************************** PP
   S: 177  vveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerka 263
           +v++r+++g+ +q+ea+ +Gf+ev++ +l+s+F+++elel+i G++eid++d++++t+y+ggy++ + +i+wFw ++e+f++e+r +
   Q: 1431 MVKWRVERGVVQQTEALVRGFYEVVDSRLVSVFDARELELVIAGTAEIDLNDWRNNTEYRGGYHDGHLVIRWFWAAVERFNNEQRLR 1517
           *************************************************************************************** PP
   S: 264  fLqFvTgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFels 336
           +LqFvTg+s++P +Gfa+l+     r+f+i+k+++ ++lP+++TCfn+L+LP+Y+s+++l+ekLl+A+eet+ F+l+
   Q: 1518 LLQFVTGTSSVPYEGFAALRgsngLRRFCIEKWGKITSLPRAHTCFNRLDLPPYPSYSTLYEKLLTAVEETSTFGLE 1594
           ************************999***********************************************985 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MNLYQNRFLG LAAMASPSRN SQSRRRCKEP LRYSYNPDQF HNIDIRNGAH DGITIPRSTS 60
DTDLVTSDSR STLMVSSSYY SIGYSQDLVI HWDIKEEVDA GDWIGMYLIG EVSSENFLDY 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGGAGGATAA AGCAATAAAG TGTTCTGCGT TGCCACGCAC CAGGAGTCCT TGCTTGAGCC 60
GCAACGCCAC GCGCCTCTGA CCCAGGAGGC CCCCTCCTGG CTCGCACAGG TTCACTAGCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0436--Ligase
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR032348--HECW_N
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF16562--HECW_N
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0005829--C:cytosol
GO:0016874--F:ligase activity
GO:0004842--F:ubiquitin-protein transferase activity

KEGG

rno:291209

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001636	Ailuropoda melanoleuca	81.52	0.00e+00	2121.00
IUUC-Apl-003299	Anas platyrhynchos	79.28	0.00e+00	2375.00
IUUC-Aca-005024	Anolis carolinensis	77.67	0.00e+00	2315.00
IUUC-Bta-012604	Bos taurus	86.12	0.00e+00	2489.00
IUUC-Cja-019880	Callithrix jacchus	81.70	0.00e+00	2171.00
IUUC-Cfa-021216	Canis familiaris	87.31	0.00e+00	1777.00
IUUC-Cpo-021466	Cavia porcellus	95.20	0.00e+00	1706.00
IUUC-Csa-023080	Chlorocebus sabaeus	87.96	0.00e+00	2576.00
IUUC-Cho-024740	Choloepus hoffmanni	91.34	0.00e+00	1126.00
IUUC-Dre-028750	Danio rerio	72.11	0.00e+00	1527.00
IUUC-Dno-030019	Dasypus novemcinctus	86.17	0.00e+00	2534.00
IUUC-Dor-031030	Dipodomys ordii	72.21	0.00e+00	1122.00
IUUC-Ete-032352	Echinops telfairi	93.12	0.00e+00	1250.00
IUUC-Eca-033948	Equus caballus	83.26	0.00e+00	2428.00
IUUC-Eeu-034474	Erinaceus europaeus	69.76	0.00e+00	827.00
IUUC-Fca-036148	Felis catus	86.24	0.00e+00	2498.00
IUUC-Fal-036957	Ficedula albicollis	84.87	0.00e+00	1748.00
IUUC-Gmo-038714	Gadus morhua	68.38	0.00e+00	1017.00
IUUC-Gga-041194	Gallus gallus	79.05	0.00e+00	2361.00
IUUC-Gac-041366	Gasterosteus aculeatus	76.91	0.00e+00	1362.00
IUUC-Ggo-045442	Gorilla gorilla	74.13	0.00e+00	1964.00
IUUC-Hsa-045730	Homo sapiens	87.77	0.00e+00	2573.00
IUUC-Itr-048439	Ictidomys tridecemlineatus	88.92	0.00e+00	2640.00
IUUC-Lch-050185	Latimeria chalumnae	69.87	0.00e+00	1925.00
IUUC-Loc-052744	Lepisosteus oculatus	73.84	0.00e+00	2174.00
IUUC-Laf-054368	Loxodonta africana	96.52	0.00e+00	1483.00
IUUC-Mcc-055487	Macaca mulatta	87.75	0.00e+00	2584.00
IUUC-Meu-056751	Macropus eugenii	90.81	0.00e+00	724.00
IUUC-Mga-059545	Meleagris gallopavo	79.50	0.00e+00	2362.00
IUUC-Mmr-061078	Microcebus murinus	85.39	0.00e+00	2445.00
IUUC-Mdo-062176	Monodelphis domestica	83.45	0.00e+00	1702.00
IUUC-Mmu-063513	Mus musculus	94.80	0.00e+00	2786.00
IUUC-Mpu-065786	Mustela putorius furo	85.95	0.00e+00	2488.00
IUUC-Mlu-067780	Myotis lucifugus	79.84	0.00e+00	2236.00
IUUC-Nle-069213	Nomascus leucogenys	87.27	0.00e+00	2533.00
IUUC-Opr-070208	Ochotona princeps	95.26	0.00e+00	1472.00
IUUC-Ont-072132	Oreochromis niloticus	77.12	0.00e+00	1362.00
IUUC-Oan-072807	Ornithorhynchus anatinus	86.26	0.00e+00	1782.00
IUUC-Ocu-074745	Oryctolagus cuniculus	84.77	0.00e+00	2444.00
IUUC-Ola-086981	Oryzias latipes	79.02	0.00e+00	1426.00
IUUC-Oga-087965	Otolemur garnettii	85.62	0.00e+00	2429.00
IUUC-Oar-089749	Ovis aries	87.65	0.00e+00	1808.00
IUUC-Ptr-091243	Pan troglodytes	87.84	0.00e+00	2576.00
IUUC-Pan-092201	Papio anubis	87.16	0.00e+00	2574.00
IUUC-Psi-093511	Pelodiscus sinensis	84.05	0.00e+00	1706.00
IUUC-Pfo-097001	Poecilia formosa	64.96	0.00e+00	1573.00
IUUC-Pab-098728	Pongo abelii	85.48	0.00e+00	2452.00
IUUC-Pca-100129	Procavia capensis	80.12	0.00e+00	1234.00
IUUC-Pva-102250	Pteropus vampyrus	74.41	0.00e+00	2048.00
IUUC-Tgu-117515	Taeniopygia guttata	84.45	0.00e+00	1741.00
IUUC-Tru-117914	Takifugu rubripes	75.93	0.00e+00	1368.00
IUUC-Tsy-119379	Tarsius syrichta	78.26	0.00e+00	1328.00
IUUC-Tni-120178	Tetraodon nigroviridis	76.67	0.00e+00	1387.00
IUUC-Tbe-127762	Tupaia belangeri	79.66	0.00e+00	1875.00
IUUC-Ttr-128806	Tursiops truncatus	90.77	0.00e+00	1700.00
IUUC-Xtr-132903	Xenopus tropicalis	73.50	0.00e+00	1847.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence