iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Cpo-022544

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAKN02049212

Gene Name

Vhl

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCPOG00000023134.1	ENSCPOT00000023411.1	ENSCPOP00000019024.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	26.72	3.00e-04	41.60	IUUC-Dme-031988
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	86.03	4.00e-83	304.00	IUUC-Hsa-046547

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Cavia porcellus

Protein Sequence
(Fasta)

EAGANLEAGS RRAGPPPEME AGRPRPVLRS VNSREPSQVI FCNRSPRVVL PVWLNFDGEP 60
QPYPTLAPGT GRRIHSYRGH LWLFRDAGTY DGLLVNQTEL FVPSLNVDGQ PIFANITLPV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAGGCCGGGG CGAACCTGGA GGCGGGCTCT CGGCGAGCCG GACCGCCGCC GGAGATGGAG 60
GCCGGGCGCC CGCGGCCGGT GCTGCGCTCC GTGAATTCGC GCGAGCCGTC CCAAGTCATC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR002714--VHL
IPR024048--VHL_alpha_dom
IPR024053--VHL_beta_dom
IPR022772--VHL_tumour_suppress_b/a_dom

Pfam

PF01847--VHL
PF17211--VHL_C

Gene Ontology

GO:0005929--C:cilium
GO:0031462--C:Cul2-RING ubiquitin ligase complex
GO:0005737--C:cytoplasm
GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0001525--P:angiogenesis
GO:0043534--P:blood vessel endothelial cell migration
GO:0061073--P:ciliary body morphogenesis
GO:0030198--P:extracellular matrix organization
GO:0048069--P:eye pigmentation
GO:0048877--P:homeostasis of number of retina cells
GO:0061072--P:iris morphogenesis
GO:0006582--P:melanin metabolic process
GO:0045602--P:negative regulation of endothelial cell differentiation
GO:0010629--P:negative regulation of gene expression
GO:1902072--P:negative regulation of hypoxia-inducible factor-1alpha signaling pathway
GO:0070244--P:negative regulation of thymocyte apoptotic process
GO:0006607--P:NLS-bearing protein import into nucleus
GO:0003310--P:pancreatic A cell differentiation
GO:0050679--P:positive regulation of epithelial cell proliferation
GO:0010498--P:proteasomal protein catabolic process
GO:2001233--P:regulation of apoptotic signaling pathway
GO:1903827--P:regulation of cellular protein localization
GO:0003309--P:type B pancreatic cell differentiation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002327	Ailuropoda melanoleuca	82.50	6.00e-69	253.00
IUUC-Apl-003580	Anas platyrhynchos	69.74	6.00e-25	104.00
IUUC-Aca-004492	Anolis carolinensis	77.95	1.00e-56	211.00
IUUC-Ang-009806	Aspergillus niger	40.62	1.20e-01	27.30
IUUC-Ame-011818	Astyanax mexicanus	54.55	9.00e-45	172.00
IUUC-Bta-013459	Bos taurus	94.90	4.00e-85	306.00
IUUC-Cel-018173	Caenorhabditis elegans	32.97	2.00e-05	41.60
IUUC-Cja-019826	Callithrix jacchus	94.27	1.00e-83	301.00
IUUC-Cfa-021280	Canis familiaris	92.99	1.00e-81	295.00
IUUC-Cre-022809	Chlamydomonas reinhardtii	40.91	3.00e-07	49.70
IUUC-Csa-023644	Chlorocebus sabaeus	95.45	1.00e-83	301.00
IUUC-Cho-024479	Choloepus hoffmanni	62.50	7.00e-38	148.00
IUUC-Cin-025505	Ciona intestinalis	27.05	9.00e-06	42.70
IUUC-Cme-027232	Cyanidioschyzon merolae	33.78	9.00e-06	43.50
IUUC-Dre-028350	Danio rerio	52.60	1.00e-33	135.00
IUUC-Dno-029207	Dasypus novemcinctus	85.09	4.00e-52	197.00
IUUC-Dor-030912	Dipodomys ordii	68.24	2.00e-49	188.00
IUUC-Dme-031988	Drosophila melanogaster	26.72	2.00e-05	41.60
IUUC-Eca-034007	Equus caballus	100.00	2.00e-19	86.30
IUUC-Fca-036350	Felis catus	94.16	2.00e-80	291.00
IUUC-Fal-037192	Ficedula albicollis	68.46	1.00e-54	205.00
IUUC-Gmo-038921	Gadus morhua	57.33	1.00e-44	171.00
IUUC-Gga-041016	Gallus gallus	68.31	1.00e-53	202.00
IUUC-Gac-042560	Gasterosteus aculeatus	48.47	5.00e-36	143.00
IUUC-Ggo-045419	Gorilla gorilla	95.39	6.00e-82	296.00
IUUC-Hsa-046547	Homo sapiens	95.39	8.00e-82	296.00
IUUC-Itr-048225	Ictidomys tridecemlineatus	96.18	6.00e-86	309.00
IUUC-Lch-050463	Latimeria chalumnae	62.99	6.00e-53	199.00
IUUC-Loc-052053	Lepisosteus oculatus	58.04	8.00e-48	182.00
IUUC-Laf-053893	Loxodonta africana	92.55	4.00e-84	303.00
IUUC-Mcc-055347	Macaca mulatta	65.92	4.00e-55	206.00
IUUC-Mtr-058490	Medicago truncatula	46.88	3.40e-02	31.60
IUUC-Mdo-062169	Monodelphis domestica	75.53	3.00e-38	149.00
IUUC-Mmu-064366	Mus musculus	92.81	3.00e-73	267.00
IUUC-Mpu-066593	Mustela putorius furo	92.59	5.00e-84	303.00
IUUC-Mlu-066926	Myotis lucifugus	94.27	9.00e-84	302.00
IUUC-Nle-069724	Nomascus leucogenys	96.05	1.00e-82	298.00
IUUC-Opr-070679	Ochotona princeps	82.14	2.00e-78	283.00
IUUC-Ont-071332	Oreochromis niloticus	52.94	7.00e-42	162.00
IUUC-Ola-086869	Oryzias latipes	51.61	2.00e-40	158.00
IUUC-Oga-089124	Otolemur garnettii	90.96	2.00e-84	304.00
IUUC-Oar-089799	Ovis aries	95.83	1.00e-50	190.00
IUUC-Ptr-091186	Pan troglodytes	92.78	2.00e-48	184.00
IUUC-Pan-092150	Papio anubis	94.74	2.00e-81	295.00
IUUC-Psi-094039	Pelodiscus sinensis	64.00	2.00e-51	194.00
IUUC-Pma-094129	Petromyzon marinus	43.97	3.00e-27	114.00
IUUC-Pfo-096892	Poecilia formosa	51.05	7.00e-37	146.00
IUUC-Pab-097822	Pongo abelii	96.05	7.00e-83	299.00
IUUC-Pca-101058	Procavia capensis	89.87	7.00e-77	279.00
IUUC-Pva-102932	Pteropus vampyrus	96.79	8.00e-86	309.00
IUUC-Rno-105050	Rattus norvegicus	90.91	2.00e-85	307.00
IUUC-Sha-106738	Sarcophilus harrisii	79.17	8.00e-42	160.00
IUUC-Ssc-115973	Sus scrofa	94.27	2.00e-84	304.00
IUUC-Tgu-116663	Taeniopygia guttata	71.43	2.00e-32	129.00
IUUC-Tru-118654	Takifugu rubripes	57.34	5.00e-43	166.00
IUUC-Tca-121306	Theobroma cacao	41.67	1.10e-02	31.60
IUUC-Ttr-128418	Tursiops truncatus	94.90	6.00e-85	306.00
IUUC-Vpa-130268	Vicugna pacos	90.10	2.00e-48	184.00
IUUC-Xtr-132506	Xenopus tropicalis	64.79	7.00e-53	199.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence