iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ocu-074207

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAGW02036914

Gene Name

HERC4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOCUG00000009927.3	ENSOCUT00000027421.2	ENSOCUP00000025329.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	7.90e-101	337.8	693	1016

Active Site

Position(s)	Description	Evidence
985	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 4    dlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           d kk l+v fvgE+++d+gGv +ef+ l+++el +p++g+f+y e+++  ++ +++      e  +lF+++G+++g+a+++  ++dl
   Q: 693  DYKKPLKVIFVGEDAVDAGGVRKEFFLLIMRELLDPKYGMFRYYEDSRLIWFSDKTF-----EDSDLFHLIGVICGLAIYNFTIVDL 774
           78999***********************************************88877.....689********************** PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklv 177
           +++ ++yk+ll+kk sl+dl+e++p++ +s+++++++ e+diee+ ++l+f+++ e++g t+++eL+ +G+++ V+++N++e+v+++
   Q: 775  HFPLALYKKLLKKKPSLDDLKELMPDVGRSMQQLLDYPEDDIEET-FCLNFTITVENFGATEVKELVLNGADTAVNKQNRQEFVDAY 860
           ***************************************9**998.***************************************** PP
   S: 178  veyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkaf 264
           v+y++++++++ ++af++Gf++v+  ++l lF+++el+ ++ G++++d+++l+k+t+ykg+y +++p+i+ Fwev++e+  e++k+f
   Q: 861  VDYIFNKSVASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVIGNTNYDWKELEKNTEYKGEYWAEHPTIKIFWEVFHELPLEKKKQF 947
           *************************************************************************************** PP
   S: 265  LqFvTgssrlPlgGfaelkprlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           L F+Tgs+r+P+ G+++lk    vi+   + ++ lP s+TCfn+L+LP+Y++ke+l++kL+ Ai++++gF+l
   Q: 948  LLFLTGSDRIPILGMKSLK---LVIQStGGGEEYLPVSHTCFNLLDLPKYTEKETLRSKLIQAIDHNEGFSL 1016
           *******************...7777758889**************************************86 PP

Organism

Oryctolagus cuniculus

Protein Sequence
(Fasta)

MAAQVEQVVA LDAQNIVAVS CGEAHTLALN DKGQVYAWGL DSDGQLGLLG SEECIRVPSC 60
LLKIMGIDTL VRTCFGLSYG RIRSGGSIRN IKSLSDIQIV QVACGYYHSL ALSKASEVFC 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTAAGAACTT CAGTTTTCTG TTGATGTGGA GGTAGGTATT AGAGGGTTTA ATTACACTAT 60
GACTTTTAGG GGATTGCAGG ATGATGTGTC TGCTGTTAGC TCAATTTTTC ATCGTTTCCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens

PROSITE

PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3

Pfam

PF00632--HECT
PF00415--RCC1

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc

Gene Ontology

GO:0005829--C:cytosol
GO:0001650--C:fibrillar center
GO:0004842--F:ubiquitin-protein transferase activity
GO:0007283--P:spermatogenesis

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001666	Ailuropoda melanoleuca	95.65	0.00e+00	1848.00
IUUC-Apl-003295	Anas platyrhynchos	85.59	0.00e+00	1710.00
IUUC-Aca-004336	Anolis carolinensis	83.74	0.00e+00	1666.00
IUUC-Ame-010768	Astyanax mexicanus	70.19	0.00e+00	1426.00
IUUC-Bta-013279	Bos taurus	95.16	0.00e+00	1840.00
IUUC-Cja-019023	Callithrix jacchus	95.55	0.00e+00	1842.00
IUUC-Cfa-021074	Canis familiaris	95.85	0.00e+00	1853.00
IUUC-Cpo-021461	Cavia porcellus	93.39	0.00e+00	1793.00
IUUC-Csa-024261	Chlorocebus sabaeus	95.95	0.00e+00	1852.00
IUUC-Cho-024513	Choloepus hoffmanni	74.78	0.00e+00	1322.00
IUUC-Cin-025232	Ciona intestinalis	42.58	0.00e+00	779.00
IUUC-Dre-028829	Danio rerio	71.92	0.00e+00	1405.00
IUUC-Dno-029445	Dasypus novemcinctus	95.27	0.00e+00	1632.00
IUUC-Dor-030158	Dipodomys ordii	97.36	0.00e+00	883.00
IUUC-Ete-033072	Echinops telfairi	83.60	0.00e+00	1560.00
IUUC-Eca-033317	Equus caballus	93.48	0.00e+00	1802.00
IUUC-Fca-035682	Felis catus	95.26	0.00e+00	1833.00
IUUC-Fal-036969	Ficedula albicollis	84.49	0.00e+00	1687.00
IUUC-Gmo-038671	Gadus morhua	71.32	0.00e+00	1425.00
IUUC-Gga-041174	Gallus gallus	85.57	0.00e+00	1713.00
IUUC-Gac-042600	Gasterosteus aculeatus	71.53	0.00e+00	1373.00
IUUC-Ggo-044589	Gorilla gorilla	95.95	0.00e+00	1882.00
IUUC-Hsa-046772	Homo sapiens	95.85	0.00e+00	1879.00
IUUC-Lch-050147	Latimeria chalumnae	77.84	0.00e+00	1283.00
IUUC-Loc-052684	Lepisosteus oculatus	78.26	0.00e+00	1559.00
IUUC-Laf-053844	Loxodonta africana	94.86	0.00e+00	1831.00
IUUC-Mcc-055531	Macaca mulatta	97.53	0.00e+00	1894.00
IUUC-Mga-060151	Meleagris gallopavo	84.42	0.00e+00	1396.00
IUUC-Mmr-060954	Microcebus murinus	95.75	0.00e+00	1845.00
IUUC-Mdo-062246	Monodelphis domestica	89.68	0.00e+00	1772.00
IUUC-Mmu-063369	Mus musculus	94.07	0.00e+00	1826.00
IUUC-Mpu-065936	Mustela putorius furo	95.08	0.00e+00	1853.00
IUUC-Mlu-067326	Myotis lucifugus	94.57	0.00e+00	1796.00
IUUC-Nle-069453	Nomascus leucogenys	95.36	0.00e+00	1830.00
IUUC-Ont-071720	Oreochromis niloticus	72.30	0.00e+00	1427.00
IUUC-Oan-073464	Ornithorhynchus anatinus	90.52	0.00e+00	1794.00
IUUC-Ola-086762	Oryzias latipes	71.02	0.00e+00	1376.00
IUUC-Oga-088435	Otolemur garnettii	95.65	0.00e+00	1846.00
IUUC-Oar-089233	Ovis aries	95.26	0.00e+00	1841.00
IUUC-Ptr-091368	Pan troglodytes	96.05	0.00e+00	1882.00
IUUC-Pan-092300	Papio anubis	95.95	0.00e+00	1852.00
IUUC-Psi-093406	Pelodiscus sinensis	86.96	0.00e+00	1731.00
IUUC-Pma-094113	Petromyzon marinus	71.77	0.00e+00	1146.00
IUUC-Pfo-097021	Poecilia formosa	70.85	0.00e+00	1438.00
IUUC-Pab-098327	Pongo abelii	96.15	0.00e+00	1884.00
IUUC-Pca-101075	Procavia capensis	96.27	0.00e+00	822.00
IUUC-Pva-102909	Pteropus vampyrus	83.60	0.00e+00	1533.00
IUUC-Rno-105457	Rattus norvegicus	94.76	0.00e+00	1845.00
IUUC-Sha-106632	Sarcophilus harrisii	90.81	0.00e+00	1782.00
IUUC-Sar-113679	Sorex araneus	85.02	0.00e+00	1135.00
IUUC-Tgu-116849	Taeniopygia guttata	80.34	0.00e+00	1579.00
IUUC-Tru-118206	Takifugu rubripes	70.00	0.00e+00	1321.00
IUUC-Tsy-119521	Tarsius syrichta	80.34	0.00e+00	1443.00
IUUC-Tni-120233	Tetraodon nigroviridis	69.20	0.00e+00	1312.00
IUUC-Tbe-127941	Tupaia belangeri	81.36	0.00e+00	1379.00
IUUC-Ttr-128926	Tursiops truncatus	93.89	0.00e+00	1134.00
IUUC-Vpa-130448	Vicugna pacos	94.57	0.00e+00	1825.00
IUUC-Xtr-132719	Xenopus tropicalis	70.26	0.00e+00	1303.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence