iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Dre-027864

UUCD1 version

UUC-DaR-00010

Ensembl Protein ID

ENSDARP00000130268.1

UniProt Accession

A0A0R4IBK5; R213A_DANRE

Genbank Protein ID

ENSDARP00000130268

Protein Name

E3 ubiquitin-protein ligase rnf213-alpha; Mysterin-A; Mysterin-alpha; RING finger protein 213-A; RING finger protein 213-alpha; RING-type E3 ubiquitin transferase rnf213-alpha

Genbank Nucleotide ID

CABZ01009724

Gene Name

rnf213a

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000099465.1	ENSDART00000168133.1	ENSDARP00000130268.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/U-box	8.90e-06	26.6	4004	4065
E3 activity/RING/RING	4.50e-06	28.0	4005	4043

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 7    lCpIslelMrdPvvlpsGitydrssIekwlasggktcPvtrqpl.teedlvPnltlrrliqa 67
           lCp+ +  +rdP  lp+ + y  ++I++wl  g+  cP++ q++ ++ +l+P+ +lrrli++
   Q: 4004 LCPVCMGDPRDPLSLPCDHIYCLTCIRQWLVPGQMHCPLCVQEVpDNFELKPSDELRRLISQ 4065
           69999999**************************9*********8999************86 PP

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlC 45
           C++C+ d++d pl+lpC H+++++C+ +w     +  ++ +CPlC
   Q: 4005 CPVCMGDPRD-PLSLPCDHIYCLTCIRQW-----LVPGQMHCPLC 4043
           **********.******************.....899******** PP

Organism

Danio rerio

Functional Description
(View)

E3 ubiquitin-protein ligase involved in angiogenesis (PubMed:21799892). Involved in the non-canonical Wnt signaling pathway in vascular development: acts by mediating ubiquitination and degradation of proteins downstream of rspo3, leading to inhibit the non-canonical Wnt signaling pathway and promoting vessel regression. Also has ATPase activity (By similarity). Also involved in neuromuscular regulation (PubMed:26530008).

Protein Sequence
(Fasta)

MKCPKCSHEA LEKAPKFCSE CGHKLQSQSY ETTQGTPHDK SQTPSIVPQI TNAEMDETGS 60
ESKSLEIQNA NVSPKRPNEN TSPNPKKKKR KKRKKEKKKK SGVSEGPSSL TSDLSDISLT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTCACGAATC GAAAGTTCTG AGATGCAAGT GCCCGGGCTC TTCTTCAGCA AGGTTAGCTT 60
TCTTGCATGA GAAGCAGAGA CGCGGTCAGA TCTGCTCAGA GTAGCTGTGT CAAATACACG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0037--Angiogenesis
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR003593--AAA+_ATPase
IPR027417--P-loop_NTPase
IPR031248--RNF213
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2

SMART

SM00382--AAA
SM00184--RING

Gene Ontology

GO:0005829--C:cytosol
GO:0016887--F:ATPase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0002040--P:sprouting angiogenesis

KEGG

dre:503775

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Apl-004090	Anas platyrhynchos	50.90	0.00e+00	4181.00
IUUC-Ame-010883	Astyanax mexicanus	56.89	0.00e+00	4900.00
IUUC-Cja-019209	Callithrix jacchus	53.14	0.00e+00	3415.00
IUUC-Cfa-020058	Canis familiaris	48.07	0.00e+00	4083.00
IUUC-Cpo-022285	Cavia porcellus	52.84	0.00e+00	2794.00
IUUC-Csa-023613	Chlorocebus sabaeus	47.73	0.00e+00	4343.00
IUUC-Cho-024453	Choloepus hoffmanni	58.81	0.00e+00	2067.00
IUUC-Cin-025584	Ciona intestinalis	32.50	0.00e+00	1503.00
IUUC-Dno-029563	Dasypus novemcinctus	46.02	0.00e+00	2448.00
IUUC-Dor-030748	Dipodomys ordii	59.33	0.00e+00	1855.00
IUUC-Eca-034252	Equus caballus	47.75	0.00e+00	4276.00
IUUC-Eeu-035087	Erinaceus europaeus	62.65	0.00e+00	1709.00
IUUC-Fca-036042	Felis catus	57.89	0.00e+00	1295.00
IUUC-Fal-037402	Ficedula albicollis	48.32	0.00e+00	4366.00
IUUC-Gmo-039713	Gadus morhua	61.59	0.00e+00	5135.00
IUUC-Gga-040437	Gallus gallus	51.52	0.00e+00	3256.00
IUUC-Gac-042182	Gasterosteus aculeatus	40.63	0.00e+00	2635.00
IUUC-Ggo-045212	Gorilla gorilla	53.02	0.00e+00	3370.00
IUUC-Hsa-046140	Homo sapiens	46.11	0.00e+00	4283.00
IUUC-Itr-047894	Ictidomys tridecemlineatus	53.27	0.00e+00	3385.00
IUUC-Lch-050262	Latimeria chalumnae	50.38	0.00e+00	4628.00
IUUC-Loc-052115	Lepisosteus oculatus	58.32	0.00e+00	5847.00
IUUC-Mcc-055793	Macaca mulatta	47.09	0.00e+00	4234.00
IUUC-Meu-055905	Macropus eugenii	66.92	0.00e+00	924.00
IUUC-Mdo-062190	Monodelphis domestica	48.78	0.00e+00	4489.00
IUUC-Mmu-063486	Mus musculus	45.38	0.00e+00	4346.00
IUUC-Mpu-065783	Mustela putorius furo	45.41	0.00e+00	4285.00
IUUC-Mlu-067959	Myotis lucifugus	51.87	0.00e+00	3243.00
IUUC-Nle-069617	Nomascus leucogenys	51.56	0.00e+00	3565.00
IUUC-Opr-071117	Ochotona princeps	59.32	0.00e+00	1881.00
IUUC-Ont-072667	Oreochromis niloticus	60.71	0.00e+00	6400.00
IUUC-Ocu-074421	Oryctolagus cuniculus	46.56	0.00e+00	1038.00
IUUC-Ola-086411	Oryzias latipes	62.12	0.00e+00	5425.00
IUUC-Oga-088090	Otolemur garnettii	52.07	0.00e+00	3327.00
IUUC-Oar-089763	Ovis aries	46.78	0.00e+00	4341.00
IUUC-Pan-091737	Papio anubis	45.61	0.00e+00	4257.00
IUUC-Psi-093008	Pelodiscus sinensis	52.34	0.00e+00	4421.00
IUUC-Pma-094477	Petromyzon marinus	39.03	0.00e+00	2094.00
IUUC-Pfo-096327	Poecilia formosa	61.59	0.00e+00	6263.00
IUUC-Pab-098316	Pongo abelii	49.16	0.00e+00	4001.00
IUUC-Pca-101059	Procavia capensis	61.95	0.00e+00	1751.00
IUUC-Pva-102703	Pteropus vampyrus	49.96	0.00e+00	2498.00
IUUC-Rno-105537	Rattus norvegicus	45.11	0.00e+00	4254.00
IUUC-Sha-106990	Sarcophilus harrisii	54.54	0.00e+00	3484.00
IUUC-Tgu-116501	Taeniopygia guttata	49.15	0.00e+00	687.00
IUUC-Tsy-118810	Tarsius syrichta	65.98	0.00e+00	1566.00
IUUC-Tni-119963	Tetraodon nigroviridis	59.17	0.00e+00	5176.00
IUUC-Tbe-127986	Tupaia belangeri	57.13	0.00e+00	889.00
IUUC-Vda-129783	Verticillium dahliae	32.89	1.00e-08	54.70

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence