iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSONIG00000018934.1	ENSONIT00000023864.1	ENSONIP00000023843.1
ENSONIG00000018934.1	ENSONIT00000023865.1	ENSONIP00000023844.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	2.40e-97	326.6	263	666

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle....kkkeklneenp........................................... 42
           tGl+NlgNtCYmNS+LQ+Ls+++++re++l+    +++e l+++n+                                           
   Q: 263  TGLRNLGNTCYMNSILQVLSHLQKFRECFLTldlcETEELLAKTNHsqgmkgvtggvvssgntalaeyplgrmgkagcwnlpvgkkesv 351
           7******************************9997444444444447788999999999999999999999999999999999999999 PP
   S: 43   .......kepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedks 124
                  + ++ +l+++l++lf+ +w+++++ vsp ++l++++++ + f+gy+qqDaqEfl+ lld++++el         ++e+++++
   Q: 352  sppprcsTRQQMSLCHELHTLFRVMWSGRWSLVSPFAMLHSVWNLIPAFRGYDQQDAQEFLCELLDKVQQEL---------DTEGSKRR 431
           999999888888************************************************************.........78889999 PP
   S: 125  elsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke...........slqdcLesftkeeeleg 202
               + ++k  k+  ++++++F+gql sq++cl+c+++s++ epf+dlsl++p++ ++  +           +l+++L++ft+ e leg
   Q: 432  IVIPITKRKLSKQVLKVLNTIFHGQLLSQVTCLSCKHKSNTVEPFWDLSLEFPERYHSIDKgssstayqrscTLTEMLSKFTEMEALEG 520
           99999************************************************999876669999***********************9 PP
   S: 203  enkyycekckkkqe...........aekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspeekqke..kkkY 278
           +  y c++c+k+++           a k+l + +lP+vL lhLkRf++s + ++reki  +v f + L+++p+c++ +  + +   ++Y
   Q: 521  SI-YACNHCNKRRRksshkplvlseACKQLLIYRLPQVLRLHLKRFRWSGR-NHREKIGVHVAFDQVLNIKPYCCTGSGHSVHrgGYTY 607
           66.*******999999999999999***********************997.8889*****************9995554433679*** PP
   S: 279  eLiavvvHsG.slssGHYvayvknekgk.WllfdDskVtevkeeevleetgstaYvlfYkrr 338
           +L+avv+H+G +++sGHY+ay++n++g+ W++++Ds+ ++++ eev++   ++aY+lfY++r
   Q: 608  DLSAVVMHHGkGFGSGHYTAYCYNTEGGfWVHCNDSEMKVCSVEEVCN---TQAYILFYTQR 666
           ************************9999********************...********985 PP

Organism

Oreochromis niloticus

Protein Sequence
(Fasta)

MDRCKHVVRL RLGQDHSILN PQKWHCVDCS TTDSVWACLK CSHVACGRFM EEHSLKHFQE 60
SHHPLAMEVR ELDVFCFACG DYVLNDNAEG DLKLLRGALS TVRSPGRRSL RSSTGGECTP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACTCTCTCTG GAGCCACTGG TGCTGACGGT GGGCATGGGT GATCGGGCTG AACTGTCCTG 60
TTGTGTTCTT TGCAGATGTT GTGATGTGTT GTCCAGAATT TGATCACAAA AACTCCTTTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0008270--F:zinc ion binding
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aca-005278	Anolis carolinensis	63.90	0.00e+00	827.00
IUUC-Ame-011403	Astyanax mexicanus	72.81	0.00e+00	859.00
IUUC-Cpo-022233	Cavia porcellus	71.36	2.00e-169	589.00
IUUC-Cho-025051	Choloepus hoffmanni	75.27	6.00e-125	441.00
IUUC-Dre-027577	Danio rerio	73.12	0.00e+00	890.00
IUUC-Gmo-039249	Gadus morhua	90.60	3.00e-171	595.00
IUUC-Gac-042595	Gasterosteus aculeatus	89.66	0.00e+00	1161.00
IUUC-Lch-050294	Latimeria chalumnae	63.69	0.00e+00	793.00
IUUC-Loc-051961	Lepisosteus oculatus	76.47	0.00e+00	704.00
IUUC-Meu-055971	Macropus eugenii	50.31	2.00e-104	373.00
IUUC-Mlu-067090	Myotis lucifugus	69.30	2.00e-169	588.00
IUUC-Ocu-074851	Oryctolagus cuniculus	67.84	7.00e-129	454.00
IUUC-Ola-086413	Oryzias latipes	79.82	0.00e+00	1066.00
IUUC-Psi-093353	Pelodiscus sinensis	64.17	0.00e+00	839.00
IUUC-Pfo-096413	Poecilia formosa	90.59	0.00e+00	1197.00
IUUC-Pva-102868	Pteropus vampyrus	70.63	1.00e-170	593.00
IUUC-Sar-113561	Sorex araneus	79.71	3.00e-65	242.00
IUUC-Ssc-115727	Sus scrofa	59.71	0.00e+00	729.00
IUUC-Tru-117585	Takifugu rubripes	87.15	0.00e+00	1111.00
IUUC-Tni-120600	Tetraodon nigroviridis	83.82	0.00e+00	1014.00
IUUC-Xtr-132090	Xenopus tropicalis	64.43	0.00e+00	817.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence