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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Rno-105362
Ensembl Protein ID ENSRNOP00000005522.5
UniProt Accession Q99MZ8; Q499R9; LASP1_RAT
Genbank Protein ID AAK28338.1; AAH99791.1
Protein Name LIM and SH3 domain protein 1
Genbank Nucleotide ID AF242187; BC099791
Gene Name Lasp1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSRNOG00000004132.7 ENSRNOT00000005522.7 ENSRNOP00000005522.5
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
DNA & RNA Element
microRNATRANSFACRAID2
Protein-protein Interaction
IIDMentha
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusUniProt
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/SH3 1.70e-14 53.9 208 263
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/SH3
   S: 5    kvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekl 62
           + ++ ydy+a+++de +++ Gd++  +  ++ d gW++g+ e +g  G++P+n+ve +
   Q: 208  RYRAVYDYSAADEDEVSFQDGDTIVNV--QQIDDGWMYGTVERTGDTGMLPANYVEAI 263
           56899*******************999..99************************975 PP
   
Organism Rattus norvegicus
Functional Description
(View)

Functional Description


     Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types.
 Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types.
Protein Sequence
(Fasta)
MNPNCARCGK IVYPTEKVNC LDKFWHKACF HCETCKMTLN MKNYKGYEKK PYCNAHYPKQ 60
SFTMVADTPE NLRLKQQSEL QSQVRYKEEF EKNKGKGFSV VADTPELQRI KKTQDQISNI 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Rno-105362|UBD,SH3|Rattus norvegicus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GCAGCCCCTC CTCCCCACTG TGTTTATTAG GGGAAGGAGG GCGGAGGCGG AGGCCAGTTC 60
CCCAGTTCCA GTCGCCGTCG CCTGCACAGT TGCAGCCGCC GCCTCCTCCT ACCAGCTCGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Rno-105362|UBD,SH3|Rattus norvegicus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0009--Actin-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0903--Direct protein sequencing
KW-0406--Ion transport
KW-0440--LIM domain
KW-0479--Metal-binding
KW-0488--Methylation
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0728--SH3 domain
KW-0813--Transport
KW-0862--Zinc
Interpro

IPR000900--Nebulin_repeat
IPR001452--SH3_domain
IPR001781--Znf_LIM
PROSITE

PS00478--LIM_DOMAIN_1
PS50023--LIM_DOMAIN_2
PS51216--NEBULIN
PS50002--SH3
Pfam

PF00412--LIM
PF00880--Nebulin
PF14604--SH3_9
PRINTS

PR00452--SH3DOMAIN
SMART

SM00132--LIM
SM00227--NEBU
SM00326--SH3
Gene Ontology

GO:0030864--C:cortical actin cytoskeleton
GO:0070062--C:extracellular exosome
GO:0005925--C:focal adhesion
GO:0015075--F:ion transmembrane transporter activity
GO:0008270--F:zinc ion binding
GO:0006811--P:ion transport
KEGG rno:29278
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000663 Aegilops tauschii 29.63 5.00e-04 39.30
IUUC-Aml-001609 Ailuropoda melanoleuca 92.02 1.00e-110 392.00
IUUC-Atr-002465 Amborella trichopoda 26.67 3.90e-02 33.10
IUUC-Apl-003494 Anas platyrhynchos 73.80 2.00e-95 341.00
IUUC-Aca-004462 Anolis carolinensis 84.59 1.00e-118 418.00
IUUC-Ame-011113 Astyanax mexicanus 63.88 4.00e-77 280.00
IUUC-Bta-012469 Bos taurus 93.54 2.00e-132 464.00
IUUC-Bol-015361 Brassica oleracea 26.67 2.00e-01 30.80
IUUC-Cel-018413 Caenorhabditis elegans 52.80 2.00e-36 146.00
IUUC-Cja-019344 Callithrix jacchus 87.11 3.00e-65 240.00
IUUC-Cfa-020384 Canis familiaris 94.68 8.00e-114 402.00
IUUC-Cpo-022244 Cavia porcellus 86.59 3.00e-113 400.00
IUUC-Csa-023039 Chlorocebus sabaeus 95.44 9.00e-120 422.00
IUUC-Cin-025236 Ciona intestinalis 52.08 1.00e-36 146.00
IUUC-Csv-026002 Ciona savignyi 46.39 5.00e-52 197.00
IUUC-Dre-028335 Danio rerio 66.16 3.00e-86 310.00
IUUC-Dno-029377 Dasypus novemcinctus 91.63 1.00e-100 358.00
IUUC-Dor-031101 Dipodomys ordii 98.96 6.00e-46 177.00
IUUC-Dme-031598 Drosophila melanogaster 57.03 3.00e-41 163.00
IUUC-Eca-033966 Equus caballus 92.95 6.00e-114 402.00
IUUC-Fca-035699 Felis catus 93.54 2.00e-120 424.00
IUUC-Gmo-038981 Gadus morhua 44.87 9.00e-57 213.00
IUUC-Gga-040316 Gallus gallus 82.89 5.00e-116 410.00
IUUC-Gac-042632 Gasterosteus aculeatus 61.22 5.00e-79 287.00
IUUC-Gma-042981 Glycine max 28.33 1.00e-03 38.10
IUUC-Ggo-044835 Gorilla gorilla 96.58 1.00e-116 412.00
IUUC-Hsa-046825 Homo sapiens 96.20 7.00e-122 429.00
IUUC-Hvu-047787 Hordeum vulgare 27.94 6.00e-04 39.30
IUUC-Itr-048498 Ictidomys tridecemlineatus 95.02 5.00e-118 416.00
IUUC-Lpe-050758 Leersia perrieri 35.48 1.10e-01 31.60
IUUC-Loc-052082 Lepisosteus oculatus 68.42 5.00e-90 323.00
IUUC-Laf-053578 Loxodonta africana 93.92 1.00e-117 415.00
IUUC-Mcc-055650 Macaca mulatta 95.82 2.00e-121 428.00
IUUC-Meu-056479 Macropus eugenii 90.12 1.00e-113 401.00
IUUC-Mtr-058103 Medicago truncatula 26.67 5.00e-03 36.20
IUUC-Mga-059763 Meleagris gallopavo 82.38 1.00e-103 369.00
IUUC-Mmr-061164 Microcebus murinus 93.92 1.00e-117 415.00
IUUC-Mdo-061979 Monodelphis domestica 90.26 1.00e-129 455.00
IUUC-Mmu-063302 Mus musculus 98.48 7.00e-144 502.00
IUUC-Mac-065516 Musa acuminata 35.48 2.00e-03 34.70
IUUC-Mpu-066114 Mustela putorius furo 91.25 3.00e-121 427.00
IUUC-Mlu-068217 Myotis lucifugus 94.68 2.00e-125 441.00
IUUC-Nle-069636 Nomascus leucogenys 85.61 4.00e-94 337.00
IUUC-Opr-070892 Ochotona princeps 93.54 1.00e-129 455.00
IUUC-Ont-072280 Oreochromis niloticus 62.91 5.00e-86 310.00
IUUC-Oan-073220 Ornithorhynchus anatinus 90.67 2.00e-32 130.00
IUUC-Ocu-073804 Oryctolagus cuniculus 88.97 5.00e-133 466.00
IUUC-Oba-075638 Oryza barthii 27.54 2.00e-03 37.00
IUUC-Obr-076045 Oryza brachyantha 27.94 1.00e-03 38.10
IUUC-Ogl-077659 Oryza glaberrima 27.94 2.00e-03 37.40
IUUC-Oin-079541 Oryza indica 27.94 3.00e-03 37.00
IUUC-Opu-083412 Oryza punctata 27.54 1.00e-03 38.10
IUUC-Osa-085312 Oryza sativa 27.94 2.00e-03 37.40
IUUC-Ola-086514 Oryzias latipes 62.64 8.00e-93 333.00
IUUC-Oga-088707 Otolemur garnettii 94.30 2.00e-123 434.00
IUUC-Oar-089771 Ovis aries 93.92 5.00e-134 469.00
IUUC-Ptr-091237 Pan troglodytes 96.20 7.00e-122 429.00
IUUC-Pan-092656 Papio anubis 95.82 2.00e-121 428.00
IUUC-Pma-094377 Petromyzon marinus 54.34 2.00e-65 241.00
IUUC-Pfo-097079 Poecilia formosa 56.65 3.00e-82 297.00
IUUC-Pab-097833 Pongo abelii 96.58 1.00e-116 412.00
IUUC-Pop-099698 Populus trichocarpa 31.25 2.00e-04 40.40
IUUC-Pca-100691 Procavia capensis 91.29 5.00e-116 410.00
IUUC-Pva-102270 Pteropus vampyrus 96.20 3.00e-120 424.00
IUUC-Sha-107134 Sarcophilus harrisii 86.51 2.00e-114 404.00
IUUC-Smo-108841 Selaginella moellendorffii 28.33 5.00e-03 35.40
IUUC-Sit-110147 Setaria italica 26.67 8.00e-02 32.00
IUUC-Sly-111106 Solanum lycopersicum 28.33 6.00e-03 35.80
IUUC-Stu-112570 Solanum tuberosum 28.33 6.00e-03 35.40
IUUC-Sre-115023 Sporisorium reilianum 55.77 4.00e-11 63.20
IUUC-Tru-118693 Takifugu rubripes 54.72 4.00e-75 274.00
IUUC-Tni-120393 Tetraodon nigroviridis 59.70 4.00e-76 277.00
IUUC-Tca-121863 Theobroma cacao 26.67 1.60e-02 34.30
IUUC-Tae-125727 Triticum aestivum 28.99 5.00e-04 39.30
IUUC-Tur-126326 Triticum urartu 28.99 5.00e-04 39.30
IUUC-Ttr-128639 Tursiops truncatus 92.40 6.00e-128 449.00
IUUC-Uma-129649 Ustilago maydis 53.85 5.00e-11 62.80
IUUC-Vpa-130114 Vicugna pacos 91.11 1.00e-67 248.00
IUUC-Vvi-131569 Vitis vinifera 24.56 3.30e-02 33.10
IUUC-Xtr-131827 Xenopus tropicalis 76.81 2.00e-110 391.00
IUUC-Xma-134054 Xiphophorus maculatus 63.22 2.00e-85 308.00
Created Date 25-Jun-2017

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