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Tag Content
UUCD2 ID IUUC-Mcc-055522
UUCD1 version UUC-MaM-01097
Ensembl Protein ID ENSMMUP00000033515.2
UniProt Accession F7FZ01; F7FZ01_MACMU
Genbank Protein ID AFH34908.1; AFI33486.1
Protein Name Ubiquitinyl hydrolase 1
Genbank Nucleotide ID JSUE03038485; JV043415
Gene Name USP3
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMMUG00000012114.3 ENSMMUT00000040455.2 ENSMMUP00000033515.2
ENSMMUG00000012114.3 ENSMMUT00000040454.2 ENSMMUP00000033514.2
ENSMMUG00000012114.3 ENSMMUT00000073211.1 ENSMMUP00000048000.1
ENSMMUG00000012114.3 ENSMMUT00000055726.1 ENSMMUP00000055803.1
ENSMMUG00000012114.3 ENSMMUT00000016959.3 ENSMMUP00000015882.3
ENSMMUG00000012114.3 ENSMMUT00000057686.1 ENSMMUP00000059797.1
ENSMMUG00000012114.3 ENSMMUT00000067677.1 ENSMMUP00000052353.1
ENSMMUG00000012114.3 ENSMMUT00000058241.1 ENSMMUP00000044497.1
Status Unreviewed
Classification
Family E-Value Score Start End
DUB/USP 2.40e-100 337.1 159 510
UBD/ZnF/ZnF_UBP 5.80e-27 94.8 27 104
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   DUB/USP
   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle...........kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalk 78
           tGl+NlgNtC+mN++LQ+Lsni+++ ++++e             +++ + +++ +++ +l+++++k + +lw+++++a+sp++l+ +++
   Q: 159  TGLRNLGNTCFMNAILQSLSNIEQFCCYFKElpavelrngktAGRRTYHTRSQGDNNVSLVEEFRKTLCALWQGSQTAFSPESLFYVVW 247
           7******************************888888777765555555555688889******************************* PP
   S: 79   keaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssree 167
           k+ ++f+gy+qqDa+Ef+++lld+l+ el+   n    ++  +++s+ls  +++   +  +++++ +F+g l++++ cl c+++s +++
   Q: 248  KIMPNFRGYQQQDAHEFMRYLLDHLHLELQGGFNGVSRSAILQENSTLS-ASNKCCINGASTVVTAIFGGILQNEVNCLICGTESRKFD 335
           *****************************77444444444444444444.45688899999**************************** PP
   S: 168  pfldlslpvpgkeetkke.........slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksre 247
           pfldlsl++p++  +k +         sl+dcL+sft  eel++ + y c kckkkq+++kk++++klP+vL+lhLkRf+++   + r+
   Q: 336  PFLDLSLDIPSQFRSKRSknqengpvcSLRDCLRSFTDLEELDETELYMCHKCKKKQKSTKKFWIQKLPKVLCLHLKRFHWTA--YLRN 422
           **********77655555678899999****************************************************7755..799* PP
   S: 248  kinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsG.slssGHYvayvknekgkWllfdDskVtevkeeevleetgstaYvlf 334
           k++++vefpl+ Ld++ ++ +pe++  e++ Y+L avvvH+G +++sGHY+ay+ + +g+W++f+Ds+Vt ++ee+v++   ++aY+lf
   Q: 423  KVDTYVEFPLRgLDMKCYLLEPENSGPESCLYDLAAVVVHHGsGVGSGHYTAYATH-EGRWFHFNDSTVTLTDEETVVK---AKAYILF 507
           ********************************************************.9*********************...******* PP
   S: 335  Ykr 337
           Y +
   Q: 508  YVE 510
           *76 PP
   

   UBD/ZnF/ZnF_UBP
   S: 1    kkcsvcdktenlWlcLtcgsvgCGRyvegHalkHyeetqhpl................vlslstlsvycYacddyvhr 62
           ++csvc++++++W+cLtc+sv+CGRyv+gHa+kHye++q+pl                ++++s++s+ycY+cdd+v++
   Q: 27   WCCSVCRSNKSPWVCLTCSSVHCGRYVNGHAKKHYEDAQVPLtnhkksekqdkaqhtvCMDCSSYSTYCYRCDDFVVN 104
           9***************************************************************************85 PP
   
Organism Macaca mulatta
Protein Sequence
(Fasta)
MECPHLSSSV CIAPDAAKFP NGSPSSWCCS VCRSNKSPWV CLTCSSVHCG RYVNGHAKKH 60
YEDAQVPLTN HKKSEKQDKA QHTVCMDCSS YSTYCYRCDD FVVNDTKLGL VQKVREHLQN 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mcc-055522|DUB,USP;UBD,ZnF_UBP|Macaca mulatta
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GCGGGGAGGG GCCGGCCTGG GAAGGCGGAA GCCTCCAGTC TAGGGGTGGC TGCAGAACCC 60
GGATCTCGGA GTTACACGTT CTACGGAGCG GGGCGCCGGG AGACGGCGGG CGAGAAAACA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mcc-055522|DUB,USP;UBD,ZnF_UBP|Macaca mulatta
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP
PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP
Pfam

PF00443--UCH
PF02148--zf-UBP
SMART

SM00290--ZnF_UBP
Gene Ontology

GO:0070938--C:contractile ring
GO:0000790--C:nuclear chromatin
GO:0005654--C:nucleoplasm
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0008270--F:zinc ion binding
GO:0006281--P:DNA repair
GO:0016578--P:histone deubiquitination
GO:0000278--P:mitotic cell cycle
GO:0031647--P:regulation of protein stability
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG mcc:705973
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001537 Ailuropoda melanoleuca 98.08 0.00e+00 958.00
IUUC-Apl-003358 Anas platyrhynchos 95.92 0.00e+00 902.00
IUUC-Aca-004454 Anolis carolinensis 91.80 0.00e+00 825.00
IUUC-Ame-011544 Astyanax mexicanus 76.98 0.00e+00 741.00
IUUC-Bta-012738 Bos taurus 97.50 0.00e+00 937.00
IUUC-Cel-018186 Caenorhabditis elegans 37.08 2.00e-55 209.00
IUUC-Cja-018893 Callithrix jacchus 99.04 0.00e+00 958.00
IUUC-Cfa-020607 Canis familiaris 98.65 0.00e+00 945.00
IUUC-Cpo-021828 Cavia porcellus 95.96 0.00e+00 921.00
IUUC-Csa-023884 Chlorocebus sabaeus 100.00 0.00e+00 788.00
IUUC-Cho-024863 Choloepus hoffmanni 88.08 0.00e+00 816.00
IUUC-Dre-028452 Danio rerio 73.66 0.00e+00 751.00
IUUC-Dno-029531 Dasypus novemcinctus 97.76 0.00e+00 877.00
IUUC-Dor-030913 Dipodomys ordii 89.82 2.00e-178 618.00
IUUC-Ete-032611 Echinops telfairi 91.92 0.00e+00 882.00
IUUC-Eca-033622 Equus caballus 98.78 0.00e+00 883.00
IUUC-Eeu-035268 Erinaceus europaeus 92.43 0.00e+00 800.00
IUUC-Fca-035801 Felis catus 98.16 0.00e+00 910.00
IUUC-Fal-036749 Ficedula albicollis 94.91 0.00e+00 855.00
IUUC-Gmo-039598 Gadus morhua 76.91 0.00e+00 770.00
IUUC-Gga-040883 Gallus gallus 96.12 0.00e+00 868.00
IUUC-Gac-042235 Gasterosteus aculeatus 75.82 0.00e+00 742.00
IUUC-Ggo-044767 Gorilla gorilla 93.89 0.00e+00 849.00
IUUC-Hsa-046581 Homo sapiens 99.23 0.00e+00 983.00
IUUC-Itr-047898 Ictidomys tridecemlineatus 98.85 0.00e+00 948.00
IUUC-Lch-049732 Latimeria chalumnae 91.35 0.00e+00 919.00
IUUC-Loc-052371 Lepisosteus oculatus 89.42 0.00e+00 907.00
IUUC-Laf-054565 Loxodonta africana 98.27 0.00e+00 943.00
IUUC-Meu-056754 Macropus eugenii 86.03 4.00e-177 614.00
IUUC-Mga-060095 Meleagris gallopavo 94.36 0.00e+00 639.00
IUUC-Mmr-060839 Microcebus murinus 98.65 0.00e+00 945.00
IUUC-Mdo-062339 Monodelphis domestica 97.70 0.00e+00 761.00
IUUC-Mmu-063638 Mus musculus 96.92 0.00e+00 912.00
IUUC-Mpu-066647 Mustela putorius furo 98.62 0.00e+00 765.00
IUUC-Mlu-067921 Myotis lucifugus 97.14 0.00e+00 895.00
IUUC-Nle-069752 Nomascus leucogenys 99.62 0.00e+00 987.00
IUUC-Opr-070636 Ochotona princeps 82.69 0.00e+00 731.00
IUUC-Ont-071638 Oreochromis niloticus 77.05 0.00e+00 702.00
IUUC-Oan-073417 Ornithorhynchus anatinus 90.38 0.00e+00 893.00
IUUC-Ocu-074620 Oryctolagus cuniculus 96.35 0.00e+00 927.00
IUUC-Ola-087281 Oryzias latipes 79.03 0.00e+00 630.00
IUUC-Olu-087697 Ostreococcus lucimarinus 40.33 5.00e-49 187.00
IUUC-Oga-088448 Otolemur garnettii 97.69 0.00e+00 970.00
IUUC-Oar-090132 Ovis aries 97.31 0.00e+00 939.00
IUUC-Ptr-090696 Pan troglodytes 99.59 0.00e+00 924.00
IUUC-Pan-092124 Papio anubis 99.62 0.00e+00 985.00
IUUC-Psi-093801 Pelodiscus sinensis 96.78 0.00e+00 755.00
IUUC-Pma-094472 Petromyzon marinus 71.93 1.00e-94 338.00
IUUC-Pfo-096330 Poecilia formosa 78.31 0.00e+00 782.00
IUUC-Pab-098191 Pongo abelii 99.81 0.00e+00 989.00
IUUC-Pca-100341 Procavia capensis 96.37 0.00e+00 728.00
IUUC-Pva-103177 Pteropus vampyrus 98.27 0.00e+00 933.00
IUUC-Rno-105048 Rattus norvegicus 95.59 0.00e+00 896.00
IUUC-Sha-107429 Sarcophilus harrisii 96.18 0.00e+00 872.00
IUUC-Sar-113024 Sorex araneus 96.38 0.00e+00 820.00
IUUC-Ssc-115749 Sus scrofa 96.44 4.00e-152 530.00
IUUC-Tgu-117277 Taeniopygia guttata 95.10 0.00e+00 891.00
IUUC-Tru-117844 Takifugu rubripes 78.50 0.00e+00 780.00
IUUC-Tsy-119456 Tarsius syrichta 95.91 0.00e+00 873.00
IUUC-Tni-120251 Tetraodon nigroviridis 74.52 0.00e+00 791.00
IUUC-Tbe-127423 Tupaia belangeri 92.31 0.00e+00 860.00
IUUC-Ttr-128401 Tursiops truncatus 91.21 0.00e+00 795.00
IUUC-Vpa-130549 Vicugna pacos 88.02 1.00e-164 572.00
IUUC-Xtr-131892 Xenopus tropicalis 83.36 0.00e+00 803.00
Created Date 25-Jun-2017

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