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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046080
Ensembl Protein ID ENSP00000313983.7
UniProt Accession Q9BZ95; B7ZL11; D3DSX1; Q1RMD3; Q3B796; Q6ZSA5; Q9BYU8; Q9BYU9; Q9H2M8; Q9H9W9; Q9NXA6; NSD3_HUMAN
Genbank Protein ID AAK00354.1; AAK00355.1; CAC28350.1; CAC28351.1; CAC28352.1; AAG44637.1; BAA91110.1; BAB14099.1; EAW63320.1; EAW63321.1; AAH12059.1; AAH62631.1; AAI01718.1; AAI07735.1; AAI13470.1; AAI15007.1; AAI43511.1; ENSP00000313410
Protein Name Histone-lysine N-methyltransferase NSD3; Nuclear SET domain-containing protein 3; Protein whistle; WHSC1-like 1 isoform 9 with methyltransferase activity to lysine; Wolf-Hirschhorn syndrome candidate 1-like protein 1
Genbank Nucleotide ID AF332468; AF332469; AJ295990; AJ295991; AJ295992; AF255649; AK000360; AK022560; AK127594; CH471080; BC012059; BC062631; BC101717; BC107734; BC113469; BC115006; BC143510; AC087362
Gene Name WHSC1L1; NSD3; DC28
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000147548.16 ENST00000317025.12 ENSP00000313983.7
ENSG00000147548.16 ENST00000433384.6 ENSP00000393284.2
ENSG00000147548.16 ENST00000527502.5 ENSP00000434730.1
ENSG00000147548.16 ENST00000316985.7 ENSP00000313410.3
ENSG00000147548.16 ENST00000528627.1 ENSP00000435073.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPMSZDB
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
miRWalkTargetScanRepTarmiRNAMap
SomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Variation
OMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDUniProtPHOSIDABioGRID
mUbiSiDa
DNA Methylation
MethyCancerTCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/PHD 6.30e-10 40.7 702 746
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/PHD
   S: 2    kvClvCgeggedekslveCek.CrewfHpaClklsveeelpnsekwiCpkCr 52
           +vC +C+++g+   sl+ Ce  C++ fH +Cl+l+   +lp+s+ +iC +C+
   Q: 702  TVCQICESSGD---SLIPCEGeCCKHFHLECLGLA---SLPDSK-FICMECK 746
           79********9...5********************...*****7.******7 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Histone methyltransferase. Preferentially methylates 'Lys-4' and 'Lys-27' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, while 'Lys-27' is a mark for transcriptional repression.
 Histone methyltransferase. Preferentially methylates 'Lys-4' and 'Lys-27' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, while 'Lys-27' is a mark for transcriptional repression.
Protein Sequence
(Fasta)
MDFSFSFMQG IMGNTIQQPP QLIDSANIRQ EDAFDNNSDI AEDGGQTPYE ATLQQGFQYP 60
ATTEDLPPLT NGYPSSISVY ETQTKYQSYN QYPNGSANGF GAVRNFSPTD YYHSEIPNTR 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046080|E3,PHD|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGGGGCTTTG TGCGCGGCGG CGGCGGGAGA GGCGGCGGCG GCGGCCAGCA CGGAGGCGGA 60
GGCCGAGGGG GCTGTGCACA GGTCGCCGCG GAGAGGCGTG CGAATTCCGA GCCGAGCGCC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046080|E3,PHD|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0156--Chromatin regulator
KW-0160--Chromosomal rearrangement
KW-0158--Chromosome
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0489--Methyltransferase
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0656--Proto-oncogene
KW-1185--Reference proteome
KW-0677--Repeat
KW-0949--S-adenosyl-L-methionine
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR006560--AWS_dom
IPR003616--Post-SET_dom
IPR000313--PWWP_dom
IPR001214--SET_dom
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS51215--AWS
PS50868--POST_SET
PS50812--PWWP
PS50280--SET
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
Pfam

PF00855--PWWP
PF00856--SET
SMART

SM00570--AWS
SM00249--PHD
SM00508--PostSET
SM00293--PWWP
SM00317--SET
Gene Ontology

GO:0005694--C:chromosome
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0018024--F:histone-lysine N-methyltransferase activity
GO:0008270--F:zinc ion binding
GO:0016571--P:histone methylation
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
KEGG hsa:54904
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000310 Aegilops tauschii 29.41 5.00e-12 66.60
IUUC-Aml-001809 Ailuropoda melanoleuca 95.75 0.00e+00 1769.00
IUUC-Apl-004027 Anas platyrhynchos 78.51 0.00e+00 2107.00
IUUC-Aca-005380 Anolis carolinensis 83.02 0.00e+00 2241.00
IUUC-Ame-011234 Astyanax mexicanus 67.96 0.00e+00 1269.00
IUUC-Bta-013575 Bos taurus 92.57 0.00e+00 2647.00
IUUC-Bdi-014781 Brachypodium distachyon 31.61 6.00e-13 69.70
IUUC-Cja-020013 Callithrix jacchus 98.19 0.00e+00 2851.00
IUUC-Cfa-021060 Canis familiaris 96.32 0.00e+00 2694.00
IUUC-Cpo-021834 Cavia porcellus 94.65 0.00e+00 2610.00
IUUC-Csa-023370 Chlorocebus sabaeus 98.40 0.00e+00 2856.00
IUUC-Cho-025058 Choloepus hoffmanni 87.55 0.00e+00 1123.00
IUUC-Dre-027664 Danio rerio 61.82 0.00e+00 1512.00
IUUC-Dno-029302 Dasypus novemcinctus 94.17 0.00e+00 2634.00
IUUC-Eca-033626 Equus caballus 93.76 0.00e+00 2665.00
IUUC-Fca-035556 Felis catus 95.76 0.00e+00 2722.00
IUUC-Fal-037101 Ficedula albicollis 82.98 0.00e+00 2248.00
IUUC-Gmo-038901 Gadus morhua 57.71 0.00e+00 1568.00
IUUC-Gga-040366 Gallus gallus 83.85 0.00e+00 2225.00
IUUC-Gac-042047 Gasterosteus aculeatus 62.60 0.00e+00 1383.00
IUUC-Ggo-044695 Gorilla gorilla 96.32 0.00e+00 2740.00
IUUC-Itr-048622 Ictidomys tridecemlineatus 95.76 0.00e+00 2732.00
IUUC-Lch-050544 Latimeria chalumnae 70.67 0.00e+00 1670.00
IUUC-Loc-052656 Lepisosteus oculatus 66.07 0.00e+00 1631.00
IUUC-Laf-054112 Loxodonta africana 95.22 0.00e+00 2688.00
IUUC-Mcc-054956 Macaca mulatta 99.03 0.00e+00 2868.00
IUUC-Meu-056051 Macropus eugenii 86.61 0.00e+00 2258.00
IUUC-Mga-060139 Meleagris gallopavo 86.06 0.00e+00 2304.00
IUUC-Mmr-060789 Microcebus murinus 96.11 0.00e+00 2794.00
IUUC-Mdo-062908 Monodelphis domestica 90.50 0.00e+00 2534.00
IUUC-Mmu-063165 Mus musculus 87.35 0.00e+00 2443.00
IUUC-Mpu-066002 Mustela putorius furo 96.31 0.00e+00 2718.00
IUUC-Nle-069417 Nomascus leucogenys 97.87 0.00e+00 2666.00
IUUC-Ont-071900 Oreochromis niloticus 59.51 0.00e+00 1658.00
IUUC-Oan-072857 Ornithorhynchus anatinus 90.49 0.00e+00 2541.00
IUUC-Ocu-073809 Oryctolagus cuniculus 95.35 0.00e+00 2679.00
IUUC-Obr-076122 Oryza brachyantha 30.36 8.00e-09 54.30
IUUC-Ola-087085 Oryzias latipes 59.50 0.00e+00 1625.00
IUUC-Oga-088289 Otolemur garnettii 95.20 0.00e+00 2681.00
IUUC-Oar-089398 Ovis aries 93.26 0.00e+00 2644.00
IUUC-Ptr-090510 Pan troglodytes 99.65 0.00e+00 2863.00
IUUC-Pan-092291 Papio anubis 98.54 0.00e+00 2860.00
IUUC-Psi-093547 Pelodiscus sinensis 87.66 0.00e+00 2386.00
IUUC-Pma-094747 Petromyzon marinus 48.72 0.00e+00 1098.00
IUUC-Pfo-096669 Poecilia formosa 60.07 0.00e+00 1628.00
IUUC-Pab-097727 Pongo abelii 98.75 0.00e+00 2843.00
IUUC-Pca-100474 Procavia capensis 87.04 0.00e+00 2343.00
IUUC-Pva-102539 Pteropus vampyrus 94.40 0.00e+00 2419.00
IUUC-Rno-105685 Rattus norvegicus 90.24 0.00e+00 2490.00
IUUC-Sha-107287 Sarcophilus harrisii 91.60 0.00e+00 2529.00
IUUC-Sar-113547 Sorex araneus 88.76 0.00e+00 2538.00
IUUC-Ssc-116208 Sus scrofa 96.24 0.00e+00 2783.00
IUUC-Tgu-117006 Taeniopygia guttata 85.63 0.00e+00 2343.00
IUUC-Tru-118375 Takifugu rubripes 59.09 0.00e+00 1655.00
IUUC-Tsy-119323 Tarsius syrichta 96.18 0.00e+00 2729.00
IUUC-Tni-120509 Tetraodon nigroviridis 59.61 0.00e+00 1667.00
IUUC-Tae-124687 Triticum aestivum 29.41 5.00e-12 66.60
IUUC-Ttr-128240 Tursiops truncatus 93.60 0.00e+00 2611.00
IUUC-Vpa-130666 Vicugna pacos 94.85 0.00e+00 2654.00
Created Date 25-Jun-2017

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