iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMMUG00000022404.3	ENSMMUT00000045802.2	ENSMMUP00000038848.2
ENSMMUG00000022404.3	ENSMMUT00000031512.3	ENSMMUP00000029484.3
ENSMMUG00000022404.3	ENSMMUT00000031513.3	ENSMMUP00000029485.3
ENSMMUG00000022404.3	ENSMMUT00000020840.3	ENSMMUP00000019500.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	8.60e-61	200.2	741	776
UBD/Beta-Prp	2.20e-110	369.6	611	796

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgv 34
           gHt+sv+ ++f +d +ll+s+s Dgt+k+WD+++ +
   Q: 741  GHTNSVNHCRFsPDdKLLASCSADGTLKLWDVTSAN 776
           8***********777*****************9876 PP

UBD/Beta-Prp

   S: 90   lkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgg 178
           ++ h+d v+   fs++g++++s ++d+t++v++ etg++l e+++ +d+v +c +++ d++ ++++s D++v++W++ tg+l++t  + 
   Q: 611  VRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCC-AFSTDDRFIATCSVDKKVKIWNSVTGELVHTYDE- 697
           55677777777777777777777777777777777777777555544444444.4444467777777777777777777777777776. PP
   S: 179  htdsvyslsfdsng..kelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlhn. 264
           h ++v++  f+ ++    l++gs d  +klwdl ++ec +t+ ght+ v+  rfsp+d++l+s+s+Dg++++Wd++s +  k+++ ++ 
   Q: 698  HSEQVNCCHFTNSShhLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDVTSANERKSFNVKQf 786
           77777777777777333345777777777777777777777777777777777777777777777777777777777777777777665 PP
   S: 265  .........s 265
                    +
   Q: 787  flnsedpqeD 796
           5555555553 PP

Organism

Macaca mulatta

Functional Description
(View)

Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.

Protein Sequence
(Fasta)

MDAKARNCLL QHREALEKDI KTSYIMDHMI SDGFLTISEE EKVKNEPTQQ QRAAMLIKMI 60
LKKDNDSYIS FYNALLHEGY KDLAALLHDG IPVVSSSSGK DSVSGITSYV RTVLCEGGVP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TACGCGCGCG GGCACGAGCC GTGGCGGGAG TGCGCGGCGC CGGCGGCCGC CCCTTGGGGC 60
TTCGGGTGTG TTTATTTGCA TAAGCGGGCG CGCGCAGTCC GGGCTGGGTG GGTCCGGCGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0053--Apoptosis
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR017251--Apaf-1
IPR001315--CARD
IPR003143--Cyt_cd1_C
IPR011029--DEATH-like_dom
IPR020472--G-protein_beta_WD-40_rep
IPR002182--NB-ARC
IPR027417--P-loop_NTPase
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
IPR011991--WHTH_DNA-bd_dom

PROSITE

PS50209--CARD
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00619--CARD
PF00931--NB-ARC
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0043293--C:apoptosome
GO:0070062--C:extracellular exosome
GO:0005634--C:nucleus
GO:0043531--F:ADP binding
GO:0005524--F:ATP binding
GO:0008656--F:cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0008635--P:activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
GO:0030900--P:forebrain development
GO:0070059--P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0001843--P:neural tube closure
GO:0051402--P:neuron apoptotic process
GO:2001235--P:positive regulation of apoptotic signaling pathway
GO:1902510--P:regulation of apoptotic DNA fragmentation

KEGG

mcc:694164

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001432	Ailuropoda melanoleuca	91.85	0.00e+00	2323.00
IUUC-Apl-004201	Anas platyrhynchos	70.82	0.00e+00	1821.00
IUUC-Aca-004638	Anolis carolinensis	69.19	0.00e+00	1811.00
IUUC-Ani-009285	Aspergillus nidulans	25.88	8.00e-68	253.00
IUUC-Ame-011062	Astyanax mexicanus	54.99	0.00e+00	1377.00
IUUC-Bta-012865	Bos taurus	90.87	0.00e+00	2337.00
IUUC-Cel-018376	Caenorhabditis elegans	21.22	3.00e-30	128.00
IUUC-Cja-018815	Callithrix jacchus	84.82	0.00e+00	2127.00
IUUC-Cfa-020222	Canis familiaris	87.40	0.00e+00	2190.00
IUUC-Cpo-021524	Cavia porcellus	88.71	0.00e+00	2278.00
IUUC-Csa-023861	Chlorocebus sabaeus	99.04	0.00e+00	2538.00
IUUC-Cho-024484	Choloepus hoffmanni	80.66	0.00e+00	1224.00
IUUC-Dre-028006	Danio rerio	53.58	0.00e+00	1270.00
IUUC-Dno-029591	Dasypus novemcinctus	91.35	0.00e+00	2349.00
IUUC-Dor-030237	Dipodomys ordii	77.37	0.00e+00	1109.00
IUUC-Ete-032620	Echinops telfairi	85.32	0.00e+00	1090.00
IUUC-Eca-033569	Equus caballus	91.11	0.00e+00	2326.00
IUUC-Eeu-035354	Erinaceus europaeus	65.62	2.00e-180	627.00
IUUC-Fca-036337	Felis catus	91.92	0.00e+00	2356.00
IUUC-Fal-037077	Ficedula albicollis	70.78	0.00e+00	1819.00
IUUC-Gmo-039687	Gadus morhua	50.92	0.00e+00	945.00
IUUC-Ggr-039828	Gaeumannomyces graminis	23.41	1.00e-40	162.00
IUUC-Gga-040299	Gallus gallus	69.62	0.00e+00	1833.00
IUUC-Gac-041762	Gasterosteus aculeatus	52.47	0.00e+00	1286.00
IUUC-Ggo-045563	Gorilla gorilla	98.08	0.00e+00	2511.00
IUUC-Hsa-046771	Homo sapiens	97.68	0.00e+00	2503.00
IUUC-Lch-050200	Latimeria chalumnae	65.42	0.00e+00	1645.00
IUUC-Loc-052090	Lepisosteus oculatus	59.40	0.00e+00	1514.00
IUUC-Laf-053861	Loxodonta africana	91.67	0.00e+00	2346.00
IUUC-Meu-056688	Macropus eugenii	80.67	0.00e+00	2051.00
IUUC-Mga-059243	Meleagris gallopavo	70.15	0.00e+00	1840.00
IUUC-Mmr-061134	Microcebus murinus	86.81	0.00e+00	2023.00
IUUC-Mdo-062913	Monodelphis domestica	79.47	0.00e+00	2064.00
IUUC-Mmu-063811	Mus musculus	87.83	0.00e+00	2278.00
IUUC-Mpu-066780	Mustela putorius furo	91.76	0.00e+00	2319.00
IUUC-Mlu-067276	Myotis lucifugus	91.12	0.00e+00	2338.00
IUUC-Nle-069129	Nomascus leucogenys	97.44	0.00e+00	2496.00
IUUC-Opr-071007	Ochotona princeps	67.84	0.00e+00	1128.00
IUUC-Ont-071348	Oreochromis niloticus	54.93	0.00e+00	1403.00
IUUC-Oan-072717	Ornithorhynchus anatinus	81.93	0.00e+00	2130.00
IUUC-Ocu-074286	Oryctolagus cuniculus	91.83	0.00e+00	2001.00
IUUC-Ola-086895	Oryzias latipes	50.41	0.00e+00	1189.00
IUUC-Oga-088678	Otolemur garnettii	91.99	0.00e+00	2357.00
IUUC-Oar-089359	Ovis aries	90.55	0.00e+00	2334.00
IUUC-Ptr-091062	Pan troglodytes	97.76	0.00e+00	2505.00
IUUC-Pan-092528	Papio anubis	99.45	0.00e+00	1467.00
IUUC-Psi-093430	Pelodiscus sinensis	74.08	0.00e+00	1925.00
IUUC-Pma-094690	Petromyzon marinus	38.69	1.00e-152	533.00
IUUC-Pfo-097204	Poecilia formosa	54.72	0.00e+00	1380.00
IUUC-Pab-097690	Pongo abelii	98.08	0.00e+00	2512.00
IUUC-Pca-100778	Procavia capensis	71.63	0.00e+00	1194.00
IUUC-Pva-102870	Pteropus vampyrus	88.85	0.00e+00	2111.00
IUUC-Rno-104889	Rattus norvegicus	88.07	0.00e+00	2246.00
IUUC-Sha-107465	Sarcophilus harrisii	79.52	0.00e+00	2098.00
IUUC-Sar-113268	Sorex araneus	91.17	0.00e+00	674.00
IUUC-Ssc-115654	Sus scrofa	90.71	0.00e+00	2333.00
IUUC-Tgu-117302	Taeniopygia guttata	70.86	0.00e+00	1832.00
IUUC-Tru-118363	Takifugu rubripes	54.45	0.00e+00	1382.00
IUUC-Tsy-119007	Tarsius syrichta	88.86	0.00e+00	2256.00
IUUC-Tni-120910	Tetraodon nigroviridis	53.28	0.00e+00	1335.00
IUUC-Tbe-127413	Tupaia belangeri	78.00	0.00e+00	1419.00
IUUC-Ttr-129213	Tursiops truncatus	85.34	0.00e+00	2144.00
IUUC-Vpa-130146	Vicugna pacos	85.48	0.00e+00	1625.00
IUUC-Xtr-132559	Xenopus tropicalis	61.18	0.00e+00	1543.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence