iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Tgu-116491

Ensembl Protein ID

ENSTGUP00000012321.1

UniProt Accession

H0ZNZ2; H0ZNZ2_TAEGU

Genbank Protein ID

ENSTGUP00000012321

Protein Name

Tyrosine-protein kinase

Genbank Nucleotide ID

ABQF01000315

Gene Name

FRK

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTGUG00000011957.1	ENSTGUT00000012457.1	ENSTGUP00000012321.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	7.00e-11	41.8	33	93

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 6    vqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvk........elegkrGlfPenFve 60
           + +l+dy+a ++d+L++++Gd+++v+      egW++++           ++  G +P+n+++
   Q: 33   FVALFDYDARTEDDLSFRAGDKLEVL--SASHEGWWYAKLllpegsacPGRKLTGYIPANYIA 93
           679***********************..78889*****8899999988778889*******96 PP

Organism

Taeniopygia guttata

Protein Sequence
(Fasta)

PDLQAGQKDL ESKIKEKPLP PLPGQDLANI CNFVALFDYD ARTEDDLSFR AGDKLEVLSA 60
SHEGWWYAKL LLPEGSACPG RKLTGYIPAN YIAADQSIEA EPWFFGSTKR ADAERQLLYP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCTGACCTCC AAGCAGGACA GAAGGACTTA GAGAGTAAGA TAAAAGAGAA ACCTTTACCT 60
CCACTGCCTG GCCAGGATCT AGCAAACATT TGCAACTTTG TGGCACTGTT TGACTATGAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0005654--C:nucleoplasm
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000727	Aegilops tauschii	31.05	2.00e-20	94.40
IUUC-Apl-003394	Anas platyrhynchos	77.83	0.00e+00	743.00
IUUC-Aca-004553	Anolis carolinensis	73.48	0.00e+00	704.00
IUUC-Bol-015477	Brassica oleracea	31.31	6.00e-21	95.90
IUUC-Bra-017825	Brassica rapa	31.53	2.00e-21	97.40
IUUC-Cja-019885	Callithrix jacchus	74.50	0.00e+00	712.00
IUUC-Cre-022669	Chlamydomonas reinhardtii	30.21	6.00e-23	101.00
IUUC-Dre-028274	Danio rerio	59.10	1.00e-165	575.00
IUUC-Dno-029689	Dasypus novemcinctus	73.11	0.00e+00	701.00
IUUC-Dme-031976	Drosophila melanogaster	60.34	3.00e-168	584.00
IUUC-Eeu-034770	Erinaceus europaeus	59.80	3.00e-139	487.00
IUUC-Fal-036892	Ficedula albicollis	89.07	0.00e+00	905.00
IUUC-Gga-041072	Gallus gallus	83.20	0.00e+00	811.00
IUUC-Loc-052913	Lepisosteus oculatus	63.73	4.00e-174	603.00
IUUC-Mga-059456	Meleagris gallopavo	80.83	0.00e+00	783.00
IUUC-Mmr-061480	Microcebus murinus	71.94	0.00e+00	684.00
IUUC-Mlu-067167	Myotis lucifugus	74.66	0.00e+00	692.00
IUUC-Nle-069786	Nomascus leucogenys	71.46	0.00e+00	710.00
IUUC-Ont-072417	Oreochromis niloticus	61.12	5.00e-173	600.00
IUUC-Obr-076765	Oryza brachyantha	30.28	1.00e-19	91.70
IUUC-Ola-086419	Oryzias latipes	62.61	6.00e-171	593.00
IUUC-Pan-092732	Papio anubis	71.13	0.00e+00	707.00
IUUC-Psi-093899	Pelodiscus sinensis	76.03	0.00e+00	729.00
IUUC-Pma-094230	Petromyzon marinus	59.20	1.00e-160	558.00
IUUC-Pfo-096035	Poecilia formosa	60.89	2.00e-169	588.00
IUUC-Rno-105269	Rattus norvegicus	73.99	0.00e+00	694.00
IUUC-Stu-112831	Solanum tuberosum	32.52	3.00e-22	100.00
IUUC-Tru-117795	Takifugu rubripes	57.08	6.00e-152	530.00
IUUC-Tni-120512	Tetraodon nigroviridis	62.75	2.00e-172	598.00
IUUC-Tae-124547	Triticum aestivum	31.00	6.00e-21	95.90
IUUC-Ttr-128817	Tursiops truncatus	72.38	0.00e+00	694.00
IUUC-Vpa-130389	Vicugna pacos	67.53	0.00e+00	635.00
IUUC-Xtr-132360	Xenopus tropicalis	62.45	6.00e-176	610.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence