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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046283
UUCD1 version UUC-HoS-00414
Ensembl Protein ID ENSP00000370671.2
UniProt Accession Q9P2K6; Q2VPK1; Q8N334; KLH42_HUMAN
Genbank Protein ID AAI08670.1; AAH28742.2; BAA92578.1
Protein Name Kelch-like protein 42; Cullin-3-binding protein 9; Kelch domain-containing protein 5
Genbank Nucleotide ID AC009511; BC028742; AB037761
Gene Name KLHL42; KIAA1340; KLHDC5
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000087448.9 ENST00000381271.6 ENSP00000370671.2
ENSG00000087448.9 ENST00000539176.1 ENSP00000444748.1
ENSG00000087448.9 ENST00000543254.1 ENSP00000443934.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsiteCircNetmiRTarBase
microRNATRANSFACTargetScanmiRecords
RepTarSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDPINAHINTMentha
InWeb_IM
Disease-associated Information
GWASdb
Post-translational Modifications (PTMs)
CPLMdbPAFPhosSNPPhosphositePlus
dbPTMHPRDPhospho.ELMUniProt
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/BCR/BTB_3-box BTB_3-box 19261606
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB 0.00036 22.5 7 76
E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box 4.00e-10 38.8 127 158
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB
   S: 3    vilvvggeeffahkivLaasSsvFyalflmelees.....ksklmveikdvqpevfrallkFlYtgklde 67
           v++ ++++ +++ k  L  +S++F+al  ++++e         +  +++++++  +r +l+F+  g ++e
   Q: 7    VQIRLEDRCYPVSKRKLIEQSDYFRALYRSGMREAlsqeaGGPEVQQLRGLSAPGLRLVLDFINAGGARE 76
           889999***************************99777764356667778*************9987766 PP
   

   E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box
   S: 1    leNclgilrfAdlydcpdLkdaaldfilkhFk 32
           l+Ncl+++r+A+ y++pdL +a+l+f+  hF+
   Q: 127  LNNCLEMYRLAQVYGLPDLQEACLRFMVVHFH 158
           68*****************************8 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL42) E3 ubiquitin ligase complex mediates the ubiquitination and subsequent degradation of KATNA1. Involved in microtubule dynamics throughout mitosis.
 Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL42) E3 ubiquitin ligase complex mediates the ubiquitination and subsequent degradation of KATNA1. Involved in microtubule dynamics throughout mitosis.
Protein Sequence
(Fasta)
MSAEEMVQIR LEDRCYPVSK RKLIEQSDYF RALYRSGMRE ALSQEAGGPE VQQLRGLSAP 60
GLRLVLDFIN AGGAREGWLL GPRGEKGGGV DEDEEMDEVS LLSELVEAAS FLQVTSLLQL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046283|E3,BTB_3-box|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CTGGCTGGGA GCTGGAATTC CCTTCCCGCC TGGCGCCGCC CGGGAGAGCC CGCGCGAGGA 60
CGCCCGCCGC GCTCCGCCGG CCCTTTTTTG GCGCTGAGGG AAAGGAGAAG GGCAGGGCCG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046283|E3,BTB_3-box|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0880--Kelch repeat
KW-0498--Mitosis
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
Interpro

IPR011705--BACK
IPR000210--BTB/POZ_dom
IPR015916--Gal_Oxidase_b-propeller
IPR006652--Kelch_1
IPR011333--SKP1/BTB/POZ
PROSITE

PS50097--BTB
Pfam

PF07707--BACK
PF01344--Kelch_1
SMART

SM00612--Kelch
Gene Ontology

GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0005737--C:cytoplasm
GO:0005819--C:spindle
GO:0051301--P:cell division
GO:0007067--P:mitotic nuclear division
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0000209--P:protein polyubiquitination
GO:0032886--P:regulation of microtubule-based process
KEGG hsa:57542
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002285 Ailuropoda melanoleuca 96.24 0.00e+00 939.00
IUUC-Apl-004005 Anas platyrhynchos 70.02 0.00e+00 638.00
IUUC-Aca-004932 Anolis carolinensis 65.22 3.00e-137 482.00
IUUC-Ame-011389 Astyanax mexicanus 61.51 3.00e-174 604.00
IUUC-Bta-013120 Bos taurus 93.87 0.00e+00 892.00
IUUC-Cfa-020969 Canis familiaris 96.83 0.00e+00 931.00
IUUC-Cpo-022181 Cavia porcellus 85.35 0.00e+00 837.00
IUUC-Csa-023917 Chlorocebus sabaeus 99.60 0.00e+00 956.00
IUUC-Cho-024950 Choloepus hoffmanni 97.75 4.00e-178 617.00
IUUC-Dre-028648 Danio rerio 60.12 2.00e-171 595.00
IUUC-Dno-028937 Dasypus novemcinctus 74.85 0.00e+00 689.00
IUUC-Dor-031019 Dipodomys ordii 81.72 6.00e-112 397.00
IUUC-Ete-032490 Echinops telfairi 86.26 0.00e+00 822.00
IUUC-Eca-033326 Equus caballus 94.83 0.00e+00 943.00
IUUC-Eeu-034985 Erinaceus europaeus 89.66 3.00e-76 279.00
IUUC-Fca-035493 Felis catus 98.39 0.00e+00 779.00
IUUC-Fal-036818 Ficedula albicollis 65.26 5.00e-152 530.00
IUUC-Gmo-039278 Gadus morhua 49.00 4.00e-56 211.00
IUUC-Gga-040470 Gallus gallus 70.18 0.00e+00 634.00
IUUC-Gac-041998 Gasterosteus aculeatus 59.92 2.00e-168 585.00
IUUC-Ggo-045547 Gorilla gorilla 100.00 0.00e+00 951.00
IUUC-Itr-048418 Ictidomys tridecemlineatus 96.83 0.00e+00 972.00
IUUC-Lch-049748 Latimeria chalumnae 61.85 7.00e-173 600.00
IUUC-Loc-052270 Lepisosteus oculatus 60.48 1.00e-170 592.00
IUUC-Laf-054165 Loxodonta africana 93.16 0.00e+00 739.00
IUUC-Mcc-054993 Macaca mulatta 99.72 0.00e+00 640.00
IUUC-Meu-056500 Macropus eugenii 84.73 2.00e-176 611.00
IUUC-Mga-059376 Meleagris gallopavo 70.63 0.00e+00 657.00
IUUC-Mmr-060782 Microcebus murinus 96.63 0.00e+00 954.00
IUUC-Mdo-062068 Monodelphis domestica 80.36 0.00e+00 752.00
IUUC-Mmu-064288 Mus musculus 91.29 0.00e+00 890.00
IUUC-Mpu-065815 Mustela putorius furo 97.82 0.00e+00 963.00
IUUC-Mlu-067560 Myotis lucifugus 93.19 0.00e+00 918.00
IUUC-Nle-069737 Nomascus leucogenys 99.80 0.00e+00 956.00
IUUC-Opr-070332 Ochotona princeps 87.57 0.00e+00 851.00
IUUC-Ont-072368 Oreochromis niloticus 61.11 2.00e-163 568.00
IUUC-Ocu-074509 Oryctolagus cuniculus 94.65 0.00e+00 908.00
IUUC-Ola-087330 Oryzias latipes 58.53 7.00e-163 566.00
IUUC-Oga-089095 Otolemur garnettii 98.22 0.00e+00 948.00
IUUC-Oar-090108 Ovis aries 97.15 0.00e+00 650.00
IUUC-Ptr-091031 Pan troglodytes 100.00 0.00e+00 957.00
IUUC-Pan-091834 Papio anubis 99.41 0.00e+00 947.00
IUUC-Psi-093483 Pelodiscus sinensis 68.53 2.00e-166 578.00
IUUC-Pfo-097126 Poecilia formosa 60.52 2.00e-169 588.00
IUUC-Pab-098446 Pongo abelii 99.60 0.00e+00 956.00
IUUC-Pca-100423 Procavia capensis 96.83 0.00e+00 920.00
IUUC-Ppe-101313 Prunus persica 35.24 1.00e-11 63.50
IUUC-Pva-102436 Pteropus vampyrus 82.98 4.00e-171 594.00
IUUC-Rno-105244 Rattus norvegicus 90.69 0.00e+00 886.00
IUUC-Sha-107215 Sarcophilus harrisii 79.92 0.00e+00 775.00
IUUC-Ssc-115433 Sus scrofa 95.64 0.00e+00 923.00
IUUC-Tgu-116589 Taeniopygia guttata 65.17 9.00e-171 593.00
IUUC-Tru-118575 Takifugu rubripes 60.12 2.00e-168 585.00
IUUC-Tsy-118895 Tarsius syrichta 89.36 0.00e+00 694.00
IUUC-Tni-119944 Tetraodon nigroviridis 59.88 7.00e-167 580.00
IUUC-Ttr-128828 Tursiops truncatus 96.75 0.00e+00 686.00
IUUC-Vpa-130506 Vicugna pacos 92.33 0.00e+00 675.00
IUUC-Xtr-131850 Xenopus tropicalis 46.41 4.00e-109 388.00
Created Date 25-Jun-2017

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