iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Cpo-022497

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

AAKN02041248

Gene Name

USP45

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCPOG00000010267.3	ENSCPOT00000010361.2	ENSCPOP00000009218.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	2.70e-87	293.1	191	814

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle..kkkeklneenp...........kepkgellkslqklfeelwkskkkavsprellka 76
           +G++NlgNtC++N+v+Q L+++  l el++e  ++  kl+ + +            ++ g+l+++l  +++++++++++  sp+ l+++
   Q: 191  KGITNLGNTCFFNAVIQNLAQTYILIELMNEiqEDGTKLKISPStdsqldplsveLSSPGPLTSALLLFLHSMTETERGPLSPKVLFNQ 279
           59*****************************66333333333224445555555567777***************************** PP
   S: 77   lkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde......aeekkkkknkslisdlFqgqlksqikclec 159
           l+++a++f+ ++qqD+qE+l++lld++++e kk+ + ++ +++++ ++++ d+      + + k+  + ++i+++F g+l+s+++c+ec
   Q: 280  LCQKAPRFKDFQQQDSQELLHYLLDAVRTEEKKRIQASILKAFNNPTTKTADDetrkkvKAYGKEGVKMNFIDRIFIGELTSTVMCEEC 368
           *********************************888888888888887777773443335555555555******************** PP
   S: 160  dnvssreepfldlslpvpgkeetkke............................................................... 185
           +n+s+ ++pf+d+slp+ +++ +k+                                                                
   Q: 369  ANISTVKDPFIDISLPIIEERVSKPVflgkvnkhrslqeadhgqcsgadavenaqskaankqpssedktsrciserycvykmfdgfeft 457
           *********************98777*************************************************************** PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 458  pqkfkntqergkilcfcylssiesrdehgvcscrsqqqgsrhgnvkdsafpsgdavghknlglnhstcecpvqplcigksppgkhgsir 546
           ***************************************************************************************** PP
   S: 186  .........................................................................slqdcLesftkeeele 201
                                                                                    s+q+cL++ft+ e l 
   Q: 547  vaqeaessdeggagllglclssaprwsprgsdaespgprapgafpgepgrrarspqaafqtlsqgyaaasrecSVQSCLHQFTAVELLM 635
           ***************************************************************************************** PP
   S: 202  genkyycekckkkqe..................aekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspeekq 272
           g+n++ ce+c+++ +                  a+k+l ++ +P +LilhLkRf  +++++s +k+n++v+fpl+Ldl+pfc+ +++k+
   Q: 636  GNNRLLCENCTGRERrqrpqagsaekkegvyttARKQLLISAVPAILILHLKRF--HQAGMSLRKVNRHVDFPLMLDLAPFCSATCKKN 722
           ***********7777778888888888888888*********************..999*************************88877 PP
   S: 273  ke...kkkYeLiavvvHsGslssGHYvayvkn...........................ekgkWllfdDskVtevkeeevleetgstaY 331
            +   k+ Y+L+++v HsGs+++GHY+ayvk                            + g+W++++D++V++v+e++ l    ++aY
   Q: 723  VNmgdKVLYDLYGIVEHSGSMRGGHYTAYVKVrlpsrkllehitgkksitvglkeldseSGGQWVHVSDTYVQVVPESRALC---AQAY 808
           66888***************************99*9999999999999999999998866777*******************...**** PP
   S: 332  vlfYkr 337
           +lfY+r
   Q: 809  LLFYER 814
           ****98 PP

Organism

Cavia porcellus

Protein Sequence
(Fasta)

MRVKDPSKAP PEKEKRNRKP SILYDEDSSD DITVDLTCQH VSHAVSVNHV KKAIAENLWS 60
VCSECLKERR FYDGQPVFPS DIWLCLKCGF QGCGRNSENQ HSLKHFKSSR PESHCIIINL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAGGGTGA AAGATCCATC CAAAGCTCCA CCTGAGAAAG AAAAAAGAAA TAGAAAGCCT 60
TCAATACTTT ATGATGAAGA TTCTTCAGAT GACATTACTG GTAAATTGTG GAATCTCAGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0006281--P:DNA repair
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002331	Ailuropoda melanoleuca	63.08	0.00e+00	924.00
IUUC-Apl-003512	Anas platyrhynchos	72.89	0.00e+00	658.00
IUUC-Aca-004284	Anolis carolinensis	64.94	5.00e-170	591.00
IUUC-Ame-010735	Astyanax mexicanus	67.89	5.00e-83	301.00
IUUC-Bta-012880	Bos taurus	79.25	0.00e+00	738.00
IUUC-Cja-019144	Callithrix jacchus	68.57	0.00e+00	1094.00
IUUC-Cfa-020971	Canis familiaris	79.13	0.00e+00	697.00
IUUC-Csa-023910	Chlorocebus sabaeus	68.17	0.00e+00	1017.00
IUUC-Cho-024358	Choloepus hoffmanni	59.94	8.00e-106	377.00
IUUC-Dre-028106	Danio rerio	58.20	4.00e-146	511.00
IUUC-Dor-030438	Dipodomys ordii	61.43	5.00e-146	511.00
IUUC-Dme-031870	Drosophila melanogaster	50.98	1.00e-35	145.00
IUUC-Ete-032736	Echinops telfairi	54.31	0.00e+00	783.00
IUUC-Eca-034211	Equus caballus	78.81	0.00e+00	746.00
IUUC-Eeu-034797	Erinaceus europaeus	78.68	5.00e-87	315.00
IUUC-Fca-035947	Felis catus	77.49	0.00e+00	632.00
IUUC-Fal-037199	Ficedula albicollis	72.11	0.00e+00	648.00
IUUC-Gmo-039228	Gadus morhua	59.85	4.00e-139	488.00
IUUC-Gga-040823	Gallus gallus	53.35	6.00e-143	500.00
IUUC-Gac-042406	Gasterosteus aculeatus	58.53	3.00e-136	478.00
IUUC-Ggo-045402	Gorilla gorilla	69.15	0.00e+00	1100.00
IUUC-Hsa-046430	Homo sapiens	69.47	0.00e+00	1110.00
IUUC-Itr-048855	Ictidomys tridecemlineatus	61.67	2.00e-155	542.00
IUUC-Lch-049547	Latimeria chalumnae	63.50	3.00e-161	562.00
IUUC-Loc-052842	Lepisosteus oculatus	64.27	2.00e-157	550.00
IUUC-Laf-053988	Loxodonta africana	79.21	0.00e+00	749.00
IUUC-Mcc-055491	Macaca mulatta	65.57	0.00e+00	1018.00
IUUC-Meu-056256	Macropus eugenii	75.00	3.00e-94	339.00
IUUC-Mga-059833	Meleagris gallopavo	69.92	7.00e-96	344.00
IUUC-Mmr-060952	Microcebus murinus	77.73	0.00e+00	718.00
IUUC-Mdo-062642	Monodelphis domestica	69.72	2.00e-176	612.00
IUUC-Mmu-063945	Mus musculus	81.24	0.00e+00	733.00
IUUC-Mpu-065944	Mustela putorius furo	77.75	0.00e+00	697.00
IUUC-Mlu-067049	Myotis lucifugus	67.19	0.00e+00	1011.00
IUUC-Nle-069828	Nomascus leucogenys	69.55	0.00e+00	1100.00
IUUC-Opr-070672	Ochotona princeps	67.30	7.00e-134	471.00
IUUC-Ont-072121	Oreochromis niloticus	59.75	2.00e-132	466.00
IUUC-Oan-073656	Ornithorhynchus anatinus	71.36	0.00e+00	642.00
IUUC-Ocu-074323	Oryctolagus cuniculus	69.33	0.00e+00	1061.00
IUUC-Ola-087238	Oryzias latipes	56.39	2.00e-145	509.00
IUUC-Oga-088379	Otolemur garnettii	74.27	0.00e+00	670.00
IUUC-Oar-089718	Ovis aries	79.60	0.00e+00	736.00
IUUC-Ptr-091358	Pan troglodytes	69.47	0.00e+00	1110.00
IUUC-Pan-092023	Papio anubis	69.60	0.00e+00	1102.00
IUUC-Psi-093256	Pelodiscus sinensis	70.45	2.00e-179	622.00
IUUC-Pfo-097285	Poecilia formosa	51.81	3.00e-118	419.00
IUUC-Pab-098539	Pongo abelii	69.27	0.00e+00	1097.00
IUUC-Pca-100610	Procavia capensis	65.56	2.00e-144	506.00
IUUC-Pva-102985	Pteropus vampyrus	86.49	0.00e+00	664.00
IUUC-Rno-105538	Rattus norvegicus	81.05	0.00e+00	732.00
IUUC-Sha-107022	Sarcophilus harrisii	70.00	2.00e-171	595.00
IUUC-Sja-107712	Schizosaccharomyces japonicus	27.78	7.00e-20	92.40
IUUC-Spo-108149	Schizosaccharomyces pombe	30.99	4.00e-20	93.60
IUUC-Sar-113637	Sorex araneus	73.35	0.00e+00	686.00
IUUC-Ssc-115870	Sus scrofa	75.41	0.00e+00	744.00
IUUC-Tgu-116907	Taeniopygia guttata	67.80	0.00e+00	642.00
IUUC-Tru-117835	Takifugu rubripes	51.06	1.00e-107	384.00
IUUC-Tsy-118869	Tarsius syrichta	62.86	6.00e-165	574.00
IUUC-Tni-119716	Tetraodon nigroviridis	61.54	1.00e-92	334.00
IUUC-Tbe-128041	Tupaia belangeri	64.27	3.00e-129	455.00
IUUC-Ttr-128901	Tursiops truncatus	74.67	0.00e+00	688.00
IUUC-Vpa-130331	Vicugna pacos	79.90	0.00e+00	694.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence