iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSHAG00000012542.1	ENSSHAT00000014818.1	ENSSHAP00000014694.1
ENSSHAG00000012542.1	ENSSHAT00000014819.1	ENSSHAP00000014695.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.50e-82	277.7	207	837

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.....kkkeklneenp..............kepkgellkslqklfeelwkskkkavsp 70
           +G++NlgNtC++N+v+Q L++++ l el+ e           + +                 ++ g+l++++  +++++ +  k+  sp
   Q: 207  KGINNLGNTCFFNAVMQNLAQTHMLNELMYEvkekgT-----KLK-IfhtsdpqldplvvnLSSPGTLTSAMFLFLHSMKEPGKGPLSP 289
           59*****************************554331.....222.23444556666666688888*********************** PP
   S: 71   rellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknk......slisdlFqgqlksq 153
           + l+++l+++a++f+g++qqD+qE+l++lld+++ e +k+ ++ + +++++ ++++ de+ +kk k +       ++i+++F g+l+s+
   Q: 290  KVLFNQLCQKAPRFKGFQQQDSQELLHYLLDAMRIEETKRIQTGILKAFNNPTTKTADEETRKKIKAYGregvkmNFIDRIFVGELTST 378
           ***********************************9999788888888777777777776666655555556666************** PP
   S: 154  ikclecdnvssreepfldlslpvpgkeetkke......................................................... 185
           ++c+ec+n+s  +epf+dlslp+ +++ +k+                                                          
   Q: 379  VMCEECENISAMKEPFIDLSLPIIEERVSKPVplgrtnkckslqeadldqyncttattmnnhlkstrkhsltkdkkckcikkegervre 467
           ***************************98777********************************************************* PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 468  ekkirnkcknskgipfkctffklengvrirdreinieayikhlsqqnlkhtdfslnsnqlnyerrlvrksssgeeekipvimhqkngnl 556
           ***************************************************************************************** PP
   S: 186  ........................................................................................s 186
                                                                                                   s
   Q: 557  eingnssilsigdtsrvsettanasqtdgsekeegipthssivpelpfavanesgnslcsvekytlshgpqnafqtlsqsytpsskecS 645
           ***************************************************************************************** PP
   S: 187  lqdcLesftkeeelegenkyycekckkkqe...................aekklklkklPevLilhLkRfsfseeqksrekinkkvefp 256
           +q+cL +ft+ e l g+nk+ ce+c++k++                   a+k+l ++ +P +LilhLkRf  ++++ s +k+n++v+fp
   Q: 646  IQSCLYQFTSVELLMGNNKLLCENCTEKKQmyqkkinstekkpegvytnARKQLLISAVPAILILHLKRF--HQAGLSLRKVNRHVDFP 732
           **************************99999999999999999999999*********************..9999************* PP
   S: 257  leLdlspfctspeekqke..kkkYeLiavvvHsGslssGHYvayvkn.........................ekgkWllfdDskVtevk 318
           l Ldl+pfc+ +++++++  ++ Y L+++v HsGs+++GHY+a+vk                          ++g+W++++D++V+ v+
   Q: 733  LVLDLAPFCSVTCKNVTSgeRVLYGLYGIVEHSGSMRGGHYTAFVKVrtskksldhvvgnknihglkettgaSTGQWVHVSDTHVQMVP 821
           ***********98887766699*************************99999999999999999999888888999************* PP
   S: 319  eeevleetgstaYvlfYkr 337
           e++ l+   ++aY+lfY+r
   Q: 822  ESRALN---AQAYLLFYER 837
           ******...********98 PP

Organism

Sarcophilus harrisii

Protein Sequence
(Fasta)

MRVKDPSRAV SEKTKRNRRP NTPPDEDSSD DIAAGLTCQH VSQAVSVHHV KRAVAQNLWS 60
VCSECLKERR LCDGESIKPD IWLCLKCGFQ GCSQNSEDQH SLKHFQTSRT EPHCIIINLS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAAATAACAG ATGCGGGTGA AAGATCCATC CAGGGCTGTT TCTGAAAAAA CCAAAAGAAA 60
CAGAAGGCCT AATACTCCTC CAGATGAAGA CTCTTCAGAT GACATTGCTG GTAATTTATG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0006281--P:DNA repair
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002331	Ailuropoda melanoleuca	65.56	2.00e-151	529.00
IUUC-Apl-003512	Anas platyrhynchos	78.05	0.00e+00	731.00
IUUC-Aca-004284	Anolis carolinensis	71.62	0.00e+00	649.00
IUUC-Aly-006422	Arabidopsis lyrata	28.01	2.00e-29	124.00
IUUC-Ath-006732	Arabidopsis thaliana	29.91	6.00e-32	133.00
IUUC-Ame-010735	Astyanax mexicanus	66.67	1.00e-87	317.00
IUUC-Bta-012880	Bos taurus	71.40	0.00e+00	653.00
IUUC-Cja-019144	Callithrix jacchus	60.42	0.00e+00	989.00
IUUC-Cfa-020971	Canis familiaris	68.37	0.00e+00	630.00
IUUC-Cpo-022497	Cavia porcellus	70.00	5.00e-177	614.00
IUUC-Csa-023910	Chlorocebus sabaeus	72.85	0.00e+00	643.00
IUUC-Cho-024358	Choloepus hoffmanni	48.88	3.00e-85	308.00
IUUC-Dre-028106	Danio rerio	61.27	2.00e-148	519.00
IUUC-Dno-029456	Dasypus novemcinctus	53.57	9.00e-101	360.00
IUUC-Dor-030438	Dipodomys ordii	53.79	4.00e-125	442.00
IUUC-Dme-031870	Drosophila melanogaster	49.35	5.00e-37	149.00
IUUC-Ete-032736	Echinops telfairi	57.73	4.00e-131	462.00
IUUC-Eca-034211	Equus caballus	61.36	0.00e+00	999.00
IUUC-Eeu-034797	Erinaceus europaeus	75.42	4.00e-78	285.00
IUUC-Fca-035947	Felis catus	67.22	5.00e-158	551.00
IUUC-Fal-037199	Ficedula albicollis	72.98	0.00e+00	725.00
IUUC-Gmo-039228	Gadus morhua	61.12	7.00e-138	484.00
IUUC-Gga-040823	Gallus gallus	80.52	4.00e-110	391.00
IUUC-Gac-042406	Gasterosteus aculeatus	60.00	2.00e-136	479.00
IUUC-Ggo-045402	Gorilla gorilla	61.48	0.00e+00	976.00
IUUC-Hsa-046430	Homo sapiens	61.44	0.00e+00	978.00
IUUC-Itr-048855	Ictidomys tridecemlineatus	79.65	1.00e-98	353.00
IUUC-Lch-049547	Latimeria chalumnae	66.96	3.00e-168	585.00
IUUC-Loc-052842	Lepisosteus oculatus	63.52	4.00e-163	568.00
IUUC-Laf-053988	Loxodonta africana	70.82	0.00e+00	645.00
IUUC-Mcc-055491	Macaca mulatta	73.46	3.00e-176	611.00
IUUC-Meu-056256	Macropus eugenii	76.20	6.00e-167	580.00
IUUC-Mtr-057945	Medicago truncatula	29.64	1.00e-31	132.00
IUUC-Mla-059026	Melampsora laricipopulina	31.37	6.00e-19	89.00
IUUC-Mga-059833	Meleagris gallopavo	57.78	3.00e-114	405.00
IUUC-Mmr-060952	Microcebus murinus	69.93	0.00e+00	631.00
IUUC-Mdo-062642	Monodelphis domestica	87.53	0.00e+00	784.00
IUUC-Mmu-063945	Mus musculus	69.78	0.00e+00	637.00
IUUC-Mpu-065944	Mustela putorius furo	67.26	6.00e-178	617.00
IUUC-Nle-069828	Nomascus leucogenys	73.44	0.00e+00	647.00
IUUC-Ont-072121	Oreochromis niloticus	60.92	1.00e-135	477.00
IUUC-Oan-073656	Ornithorhynchus anatinus	65.05	0.00e+00	1040.00
IUUC-Ocu-074323	Oryctolagus cuniculus	69.93	6.00e-175	607.00
IUUC-Ola-087238	Oryzias latipes	57.43	5.00e-144	504.00
IUUC-Oga-088379	Otolemur garnettii	58.22	0.00e+00	939.00
IUUC-Oar-089718	Ovis aries	71.18	0.00e+00	646.00
IUUC-Ptr-091358	Pan troglodytes	61.32	0.00e+00	978.00
IUUC-Pan-092023	Papio anubis	72.92	0.00e+00	644.00
IUUC-Psi-093256	Pelodiscus sinensis	80.72	3.00e-99	356.00
IUUC-Pfo-097285	Poecilia formosa	55.03	7.00e-121	427.00
IUUC-Pab-098539	Pongo abelii	61.38	0.00e+00	986.00
IUUC-Pca-100610	Procavia capensis	62.12	9.00e-123	434.00
IUUC-Pva-102985	Pteropus vampyrus	71.83	7.00e-166	577.00
IUUC-Rno-105538	Rattus norvegicus	69.78	0.00e+00	640.00
IUUC-Sja-107712	Schizosaccharomyces japonicus	27.70	4.00e-19	89.70
IUUC-Spo-108149	Schizosaccharomyces pombe	31.53	1.00e-21	99.00
IUUC-Sly-111491	Solanum lycopersicum	28.77	8.00e-33	135.00
IUUC-Sar-113637	Sorex araneus	61.38	0.00e+00	629.00
IUUC-Ssc-115870	Sus scrofa	69.93	0.00e+00	642.00
IUUC-Tgu-116907	Taeniopygia guttata	77.16	0.00e+00	720.00
IUUC-Tru-117835	Takifugu rubripes	55.89	3.00e-111	395.00
IUUC-Tsy-118869	Tarsius syrichta	59.92	0.00e+00	831.00
IUUC-Tni-119716	Tetraodon nigroviridis	74.06	2.00e-94	339.00
IUUC-Tca-121701	Theobroma cacao	28.61	1.00e-34	142.00
IUUC-Tbe-128041	Tupaia belangeri	82.09	2.00e-98	353.00
IUUC-Ttr-128901	Tursiops truncatus	64.14	2.00e-165	576.00
IUUC-Vpa-130331	Vicugna pacos	59.72	0.00e+00	872.00
IUUC-Xtr-131794	Xenopus tropicalis	69.00	3.00e-149	521.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence