iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Dre-027393

UUCD1 version

UUC-DaR-00693

Ensembl Protein ID

ENSDARP00000105871.2

UniProt Accession

A9LDR6; F1QN73; A9LDR6_DANRE

Genbank Protein ID

ABQ28698.1

Protein Name

Suppressor of cytokine signaling 4; Suppressor of cytokine-signaling 4

Genbank Nucleotide ID

CU464134

Gene Name

socs4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000078509.4	ENSDART00000124426.2	ENSDARP00000105871.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	1.30e-13	51.5	331	372

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box

   S: 8    rseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlyedy 52
           r+ p+SLqhLCR +I++c+++q++   ++LPLP  L+ +L++++y
   Q: 331  RNFPFSLQHLCRAVICSCTTYQGI---EALPLPYTLRHFLRQYHY 372
           456*********************...****************98 PP

Organism

Danio rerio

Protein Sequence
(Fasta)

MSERKTKNSD TRPKNLRSWS ADSYIRSIKK RSRGSRHETA PRGEEGDGAD EQTARSASCP 60
RRRRERMCSC TIPGETDSDS PCRKALSRRS LRQKFQDAVG QCLPLRNHHH HHHHPSGSSR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCCAGGACAG TGTATTCATC TTAGGATATG ATAGGTTAAC TGTCCATTGA CTGAAGTAGC 60
CCTTCCGTCC AGTGAAGGGC AAGTATTCCT CAGAGGACTG ATACTTGAGA GGTTTTAAAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR000980--SH2
IPR022252--SOCS4/SOCS5_dom
IPR001496--SOCS_box

PROSITE

PS50001--SH2
PS50225--SOCS

Pfam

PF00017--SH2
PF12610--SOCS
PF07525--SOCS_box

SMART

SM00252--SH2
SM00253--SOCS
SM00969--SOCS_box

Gene Ontology

GO:0005737--C:cytoplasm
GO:0004860--F:protein kinase inhibitor activity
GO:0019221--P:cytokine-mediated signaling pathway
GO:0035556--P:intracellular signal transduction
GO:0042059--P:negative regulation of epidermal growth factor receptor signaling pathway
GO:0046426--P:negative regulation of JAK-STAT cascade
GO:0006469--P:negative regulation of protein kinase activity
GO:0016567--P:protein ubiquitination

KEGG

dre:797891

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ame-010911	Astyanax mexicanus	78.34	3.00e-148	518.00
IUUC-Gmo-038503	Gadus morhua	67.02	6.00e-126	444.00
IUUC-Gac-041285	Gasterosteus aculeatus	67.79	7.00e-108	384.00
IUUC-Loc-052058	Lepisosteus oculatus	69.15	8.00e-141	493.00
IUUC-Ont-071619	Oreochromis niloticus	70.96	3.00e-133	468.00
IUUC-Pfo-096756	Poecilia formosa	71.13	1.00e-133	469.00
IUUC-Pop-098820	Populus trichocarpa	27.71	1.00e-01	31.60
IUUC-Tru-117781	Takifugu rubripes	68.65	4.00e-115	407.00
IUUC-Tni-120065	Tetraodon nigroviridis	62.09	4.00e-116	411.00
IUUC-Vvi-131327	Vitis vinifera	43.75	1.80e-01	30.80

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence