iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Tru-117781

UUCD1 version

UUC-TaR-00849

Ensembl Protein ID

ENSTRUP00000039458.1

UniProt Accession

H2UR85; H2UR85_TAKRU

Protein Name

Uncharacterized protein

Gene Name

socs4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTRUG00000015433.1	ENSTRUT00000039599.1	ENSTRUP00000039458.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	3.90e-12	47.1	340	383

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box

   S: 5    wllrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlyed 51
           +l r+ p+SLqhLCR  I++ +++q++   + LPLP+ L+dYL++++
   Q: 340  PLSRTFPFSLQHLCRTLICSRTTYQGV---ESLPLPPQLRDYLRQYH 383
           567899*********************...***************98 PP

Organism

Takifugu rubripes

Protein Sequence
(Fasta)

TNMSEKKPKG SGTRPKCGFR SWSADSYIWR SKKRSRNGST PSGLDSEGTE ELGGRSTSCP 60
RRRRERMCSC TTLGDGPASA DNDVVCRKAL SRRSLRQKFQ DAMGQCLPLR SHHHIHHHHP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACAAACATGT CGGAGAAGAA GCCAAAAGGT TCTGGCACTC GACCCAAATG TGGCTTCCGC 60
AGTTGGAGTG CAGACAGCTA CATCTGGAGA AGCAAGAAAC GCTCTCGGAA CGGGTCGACT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR000980--SH2
IPR022252--SOCS4/SOCS5_dom
IPR001496--SOCS_box

PROSITE

PS50001--SH2
PS50225--SOCS

Pfam

PF00017--SH2
PF12610--SOCS
PF07525--SOCS_box

SMART

SM00252--SH2
SM00253--SOCS
SM00969--SOCS_box

Gene Ontology

GO:0005737--C:cytoplasm
GO:0004860--F:protein kinase inhibitor activity
GO:0019221--P:cytokine-mediated signaling pathway
GO:0035556--P:intracellular signal transduction
GO:0042059--P:negative regulation of epidermal growth factor receptor signaling pathway
GO:0046426--P:negative regulation of JAK-STAT cascade
GO:0006469--P:negative regulation of protein kinase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ame-010911	Astyanax mexicanus	63.73	7.00e-113	400.00
IUUC-Cgl-026389	Colletotrichum gloeosporioides	28.95	1.00e+00	28.50
IUUC-Dre-027393	Danio rerio	68.39	3.00e-119	421.00
IUUC-Dme-031965	Drosophila melanogaster	62.50	6.00e-55	209.00
IUUC-Fal-036829	Ficedula albicollis	69.62	4.00e-67	248.00
IUUC-Gmo-038503	Gadus morhua	69.90	4.00e-133	467.00
IUUC-Gac-041285	Gasterosteus aculeatus	75.39	3.00e-135	474.00
IUUC-Loc-052058	Lepisosteus oculatus	65.46	6.00e-122	430.00
IUUC-Mtr-057670	Medicago truncatula	37.50	1.60e+00	26.90
IUUC-Ont-071619	Oreochromis niloticus	79.23	1.00e-154	538.00
IUUC-Pfo-096756	Poecilia formosa	74.87	5.00e-145	507.00
IUUC-Pop-098820	Populus trichocarpa	28.42	7.60e-02	31.60
IUUC-Tgu-117117	Taeniopygia guttata	69.62	4.00e-67	248.00
IUUC-Tsy-118979	Tarsius syrichta	68.99	1.00e-65	242.00
IUUC-Tni-120065	Tetraodon nigroviridis	79.90	2.00e-152	532.00
IUUC-Vvi-131327	Vitis vinifera	43.24	1.30e-01	30.80

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence