iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAMEG00000014752.1	ENSAMET00000016175.1	ENSAMEP00000015529.1
ENSAMEG00000014752.1	ENSAMET00000016179.1	ENSAMEP00000015532.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	1.40e-13	50.6	137	184

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box

   S: 3    klwllrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlyedyq 53
            ++l+++++r+Lq+LCR +I+ ++g+++l    ++PL+++L+dYL+++++q
   Q: 137  GAPLRQRRVRPLQELCRQRIVATVGRENL---ARIPLNPVLRDYLSSFPFQ 184
           6789*************************...***************9986 PP

Organism

Ailuropoda melanoleuca

Protein Sequence
(Fasta)

SASASRTPAA PASCSRPAPW QPXXXXXDTH FRTFRSHAEY RRITRASALL DACXXXXXXX 60
XXXHERLRAE PVGTFLVRDS RQRNCFFALS VKMASGPTSI RVHFQAGRFH LDGSRESFDC 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCCGCCTCTG CATCCAGGAC GCCTGCGGCC CCCGCGAGCT GCTCCCGGCC TGCACCCTGG 60
CAGCCACCTA CATCCACCTG TGTGCACGGG CCTTCGTGCC CCTGGACCCT CCTCCACAGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR000980--SH2
IPR028411--SOCS1
IPR001496--SOCS_box

PROSITE

PS50001--SH2
PS50225--SOCS

Pfam

PF00017--SH2
PF07525--SOCS_box

SMART

SM00252--SH2
SM00253--SOCS
SM00969--SOCS_box

Gene Ontology

GO:0005654--C:nucleoplasm
GO:0000932--C:P-body
GO:0019210--F:kinase inhibitor activity
GO:0071230--P:cellular response to amino acid stimulus
GO:0019221--P:cytokine-mediated signaling pathway
GO:0045444--P:fat cell differentiation
GO:0007259--P:JAK-STAT cascade
GO:0046627--P:negative regulation of insulin receptor signaling pathway
GO:0042512--P:negative regulation of tyrosine phosphorylation of Stat1 protein
GO:0042518--P:negative regulation of tyrosine phosphorylation of Stat3 protein
GO:0010534--P:regulation of activation of JAK2 kinase activity
GO:0050707--P:regulation of cytokine secretion
GO:0060334--P:regulation of interferon-gamma-mediated signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Apl-003313	Anas platyrhynchos	63.37	3.00e-62	231.00
IUUC-Aca-005109	Anolis carolinensis	62.03	2.00e-53	201.00
IUUC-Ame-011550	Astyanax mexicanus	44.38	8.00e-39	152.00
IUUC-Bta-013411	Bos taurus	92.50	1.00e-80	292.00
IUUC-Cja-019595	Callithrix jacchus	91.88	3.00e-80	290.00
IUUC-Cfa-020563	Canis familiaris	91.25	5.00e-79	286.00
IUUC-Cpo-021374	Cavia porcellus	91.25	7.00e-80	289.00
IUUC-Csa-023333	Chlorocebus sabaeus	91.25	8.00e-80	289.00
IUUC-Dre-028507	Danio rerio	41.03	1.00e-34	139.00
IUUC-Dno-029406	Dasypus novemcinctus	90.62	9.00e-79	285.00
IUUC-Ete-032399	Echinops telfairi	91.88	1.00e-79	288.00
IUUC-Eca-033519	Equus caballus	91.19	5.00e-80	290.00
IUUC-Fal-036726	Ficedula albicollis	65.62	2.00e-62	231.00
IUUC-Gmo-039667	Gadus morhua	50.44	9.00e-27	113.00
IUUC-Gga-040970	Gallus gallus	66.67	7.00e-62	229.00
IUUC-Gac-041838	Gasterosteus aculeatus	40.00	3.00e-27	114.00
IUUC-Ggo-045569	Gorilla gorilla	91.88	2.00e-80	291.00
IUUC-Hsa-046010	Homo sapiens	91.88	4.00e-80	290.00
IUUC-Itr-047995	Ictidomys tridecemlineatus	91.88	7.00e-80	289.00
IUUC-Lch-050219	Latimeria chalumnae	56.96	6.00e-53	199.00
IUUC-Loc-052494	Lepisosteus oculatus	52.20	4.00e-45	173.00
IUUC-Laf-054219	Loxodonta africana	96.72	1.00e-62	231.00
IUUC-Mcc-054830	Macaca mulatta	91.25	8.00e-80	289.00
IUUC-Meu-056565	Macropus eugenii	68.48	1.00e-68	252.00
IUUC-Mga-060153	Meleagris gallopavo	66.04	5.00e-61	226.00
IUUC-Mmr-061365	Microcebus murinus	91.88	5.00e-80	290.00
IUUC-Mdo-062824	Monodelphis domestica	72.89	6.00e-68	249.00
IUUC-Mmu-064120	Mus musculus	89.38	2.00e-78	285.00
IUUC-Mpu-066839	Mustela putorius furo	91.88	3.00e-80	290.00
IUUC-Mlu-067829	Myotis lucifugus	89.38	2.00e-78	284.00
IUUC-Nle-069592	Nomascus leucogenys	88.12	2.00e-76	278.00
IUUC-Ont-072173	Oreochromis niloticus	38.75	1.00e-27	115.00
IUUC-Oan-073586	Ornithorhynchus anatinus	46.15	3.00e-19	87.40
IUUC-Ocu-073996	Oryctolagus cuniculus	90.62	4.00e-79	286.00
IUUC-Oba-075150	Oryza barthii	31.82	5.50e-02	30.40
IUUC-Ola-087158	Oryzias latipes	40.00	8.00e-30	123.00
IUUC-Oga-088076	Otolemur garnettii	86.14	1.00e-77	281.00
IUUC-Ptr-091241	Pan troglodytes	91.88	3.00e-80	291.00
IUUC-Pan-091836	Papio anubis	91.25	6.00e-80	289.00
IUUC-Psi-093628	Pelodiscus sinensis	62.30	2.00e-63	234.00
IUUC-Pfo-097501	Poecilia formosa	38.99	4.00e-27	114.00
IUUC-Pab-098170	Pongo abelii	91.88	4.00e-80	290.00
IUUC-Pop-100072	Populus trichocarpa	32.69	1.60e-02	33.50
IUUC-Pva-102796	Pteropus vampyrus	92.50	1.00e-80	291.00
IUUC-Rno-105319	Rattus norvegicus	89.38	2.00e-78	285.00
IUUC-Sha-107201	Sarcophilus harrisii	74.03	3.00e-64	236.00
IUUC-Ssc-116004	Sus scrofa	91.88	6.00e-80	289.00
IUUC-Tgu-116836	Taeniopygia guttata	66.88	2.00e-62	231.00
IUUC-Tru-118090	Takifugu rubripes	36.88	4.00e-26	110.00
IUUC-Tni-120719	Tetraodon nigroviridis	37.50	8.00e-22	96.70
IUUC-Vpa-130235	Vicugna pacos	91.88	4.00e-80	290.00
IUUC-Xtr-132610	Xenopus tropicalis	54.84	5.00e-58	217.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence