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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045812
UUCD1 version UUC-HoS-00369
Ensembl Protein ID ENSP00000321388.5
UniProt Accession Q9Y574; A4D1H6; O14586; Q14D68; Q8TBT2; ASB4_HUMAN
Genbank Protein ID AAD41896.1; AAB83943.2; EAW76761.1; EAW76762.1; EAL24129.1; EAL24130.1; AAI13480.1; AAI13482.1; AAH25024.1
Protein Name Ankyrin repeat and SOCS box protein 4
Genbank Nucleotide ID AF156779; AC002451; CH471091; CH471091; CH236949; CH236949; BC113479; BC113481; BC025024
Gene Name ASB4
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000005981.12 ENST00000428113.5 ENSP00000397070.1
ENSG00000005981.12 ENST00000325885.5 ENSP00000321388.5
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitemiRTarBasemicroRNA
TRANSFACTargetScanRepTarmiRcode
RAID2LncRNADisease
Protein-protein Interaction
IIDiRefIndexPINAMentha
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
dbPAFPhosphositePlus
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box SOCS 17636018
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box 6.60e-14 53.2 371 421
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box
   S: 1    lsklwllrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlyed 51
           +s +++++++pr+L+hL+R+aIrr+l++++++ai+ L LP sLk+YLl e+
   Q: 371  HSLFTVCCNSPRTLMHLSRCAIRRTLHNRCHRAIPLLSLPLSLKKYLLLEP 421
           57899*******************************************986 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes differentiation and maturation of the vascular lineage by an oxygen-dependent mechanism (By similarity).
 Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes differentiation and maturation of the vascular lineage by an oxygen-dependent mechanism (By similarity).
Protein Sequence
(Fasta)
MDGTTAPVTK SGAAKLVKRN FLEALKSNDF GKLKAILIQR QIDVDTVFEV EDENMVLASY 60
KQGYWLPSYK LKSSWATGLH LSVLFGHVEC LLVLLDHNAT INCRPNGKTP LHVACEMANV 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045812|E3,SOCS|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GTGAAATGAA TAGTCTGTCA AAATTCAGGT GGGCCAGTGC TTGGTTACTG CTTATGTCAA 60
TCCAGCCATT CTGACATCCA CCACCTGTAA AGAGAGTCGC TGAAACGGAA CAATCTAGCA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045812|E3,SOCS|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0040--ANK repeat
KW-0181--Complete proteome
KW-0379--Hydroxylation
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR001496--SOCS_box
PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS50225--SOCS
Pfam

PF12796--Ank_2
PF07525--SOCS_box
SMART

SM00248--ANK
SM00969--SOCS_box
Gene Ontology

GO:0031462--C:Cul2-RING ubiquitin ligase complex
GO:0031466--C:Cul5-RING ubiquitin ligase complex
GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0035556--P:intracellular signal transduction
GO:2001214--P:positive regulation of vasculogenesis
GO:0051865--P:protein autoubiquitination
KEGG hsa:51666
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002121 Ailuropoda melanoleuca 96.01 0.00e+00 827.00
IUUC-Apl-003640 Anas platyrhynchos 73.88 0.00e+00 668.00
IUUC-Aca-004633 Anolis carolinensis 70.94 2.00e-165 575.00
IUUC-Ame-011455 Astyanax mexicanus 56.59 3.00e-143 501.00
IUUC-Bta-012772 Bos taurus 95.07 0.00e+00 817.00
IUUC-Cja-018805 Callithrix jacchus 98.36 0.00e+00 846.00
IUUC-Cfa-021119 Canis familiaris 95.29 0.00e+00 810.00
IUUC-Cpo-022349 Cavia porcellus 96.01 0.00e+00 824.00
IUUC-Csa-023426 Chlorocebus sabaeus 99.30 0.00e+00 850.00
IUUC-Cho-024384 Choloepus hoffmanni 89.44 0.00e+00 737.00
IUUC-Dre-028243 Danio rerio 59.57 1.00e-148 519.00
IUUC-Dno-029462 Dasypus novemcinctus 95.54 0.00e+00 818.00
IUUC-Dor-030208 Dipodomys ordii 94.37 0.00e+00 818.00
IUUC-Eca-033920 Equus caballus 94.84 0.00e+00 798.00
IUUC-Fca-035828 Felis catus 96.48 0.00e+00 830.00
IUUC-Fal-037195 Ficedula albicollis 74.12 0.00e+00 635.00
IUUC-Gmo-039649 Gadus morhua 57.73 1.00e-142 499.00
IUUC-Gga-040225 Gallus gallus 74.12 0.00e+00 670.00
IUUC-Gac-041685 Gasterosteus aculeatus 60.14 7.00e-142 496.00
IUUC-Ggo-044623 Gorilla gorilla 100.00 0.00e+00 855.00
IUUC-Itr-048132 Ictidomys tridecemlineatus 96.45 8.00e-172 595.00
IUUC-Lch-049996 Latimeria chalumnae 68.82 6.00e-169 587.00
IUUC-Loc-052262 Lepisosteus oculatus 64.05 1.00e-155 542.00
IUUC-Laf-054527 Loxodonta africana 94.84 0.00e+00 818.00
IUUC-Mcc-054758 Macaca mulatta 98.83 0.00e+00 848.00
IUUC-Meu-056293 Macropus eugenii 82.91 3.00e-74 272.00
IUUC-Mga-059970 Meleagris gallopavo 73.88 0.00e+00 667.00
IUUC-Mdo-061829 Monodelphis domestica 57.21 3.00e-123 435.00
IUUC-Mmu-063497 Mus musculus 92.49 0.00e+00 797.00
IUUC-Mpu-066315 Mustela putorius furo 96.48 0.00e+00 829.00
IUUC-Mlu-067796 Myotis lucifugus 94.84 0.00e+00 816.00
IUUC-Nle-069623 Nomascus leucogenys 99.53 0.00e+00 853.00
IUUC-Opr-070668 Ochotona princeps 96.30 2.00e-90 326.00
IUUC-Ont-071845 Oreochromis niloticus 58.70 1.00e-144 506.00
IUUC-Ocu-073775 Oryctolagus cuniculus 95.77 0.00e+00 818.00
IUUC-Ola-087538 Oryzias latipes 57.89 6.00e-148 517.00
IUUC-Oga-088686 Otolemur garnettii 94.60 0.00e+00 813.00
IUUC-Oar-089699 Ovis aries 95.54 0.00e+00 823.00
IUUC-Ptr-091174 Pan troglodytes 99.77 0.00e+00 852.00
IUUC-Pan-091808 Papio anubis 93.44 0.00e+00 785.00
IUUC-Psi-093303 Pelodiscus sinensis 75.89 0.00e+00 662.00
IUUC-Pma-094421 Petromyzon marinus 50.74 8.00e-72 263.00
IUUC-Pfo-097113 Poecilia formosa 59.71 4.00e-122 431.00
IUUC-Pab-097980 Pongo abelii 100.00 0.00e+00 855.00
IUUC-Pca-100774 Procavia capensis 93.41 0.00e+00 719.00
IUUC-Ppe-101537 Prunus persica 37.74 1.00e-11 64.70
IUUC-Pva-102657 Pteropus vampyrus 96.97 0.00e+00 706.00
IUUC-Rno-105621 Rattus norvegicus 92.02 0.00e+00 791.00
IUUC-Sha-107576 Sarcophilus harrisii 73.94 0.00e+00 627.00
IUUC-Sar-113553 Sorex araneus 95.33 0.00e+00 732.00
IUUC-Ssc-115943 Sus scrofa 96.48 0.00e+00 829.00
IUUC-Tgu-116687 Taeniopygia guttata 74.12 0.00e+00 638.00
IUUC-Tru-117879 Takifugu rubripes 56.35 1.00e-138 486.00
IUUC-Tsy-119538 Tarsius syrichta 94.44 7.00e-89 320.00
IUUC-Tni-120849 Tetraodon nigroviridis 59.34 1.00e-128 452.00
IUUC-Tbe-127993 Tupaia belangeri 96.71 0.00e+00 824.00
IUUC-Ttr-128419 Tursiops truncatus 95.54 0.00e+00 826.00
IUUC-Vpa-130445 Vicugna pacos 95.54 0.00e+00 822.00
IUUC-Xtr-132386 Xenopus tropicalis 65.39 1.00e-159 556.00
Created Date 25-Jun-2017

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