iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Laf-053364

UUCD1 version

UUC-LoA-00195

Ensembl Protein ID

ENSLAFP00000004656.3

UniProt Accession

G3SWG1; G3SWG1_LOXAF

Protein Name

Uncharacterized protein

Gene Name

HERC3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLAFG00000005544.3	ENSLAFT00000005547.3	ENSLAFP00000004656.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.60e-95	320.0	726	1049

Active Site

Position(s)	Description	Evidence
1018	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 4    dlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           dlkk l+v f gEe++d+gGvt+ef+ ll+kel np +g+f+y ++++  ++ +         + ++F+++G+++g+a++++ ++dl
   Q: 726  DLKKPLKVIFDGEEAVDAGGVTKEFFLLLLKELLNPIYGMFTYYQDSNLLWFSDTCFV-----EHNWFHLIGIICGLAIYNSTVVDL 807
           899******************************************9999999776554.....579********************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklv 177
           +++ ++yk+ll++k  ledl+e+ p+  +sl+e++++  +d+ee+ ++l+f++  e++g +++++L+pgGe++ V ++N++e+v+++
   Q: 808  HFPLALYKKLLNVKPGLEDLKELSPTEGRSLQELLDYPGEDVEEI-FCLNFTICRESYGVIEQKKLIPGGEKVTVCKDNRQEFVDAY 893
           ***************************************9***99.******99********************************* PP
   S: 178  veyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkaf 264
           v+y ++ +++e ++af++Gf +v+  ++l+lF+++el+ ++ G++++++e+l++++ ykg+y++++p+++ Fwe+++ef  e++k+f
   Q: 894  VNYVFQISVHEWYTAFSSGFLKVCGGKVLELFQPSELRAMMVGNSNYNWEELEETAIYKGDYSATHPTVRLFWETFHEFPLEKKKKF 980
           *************************************************************************************** PP
   S: 265  LqFvTgssrlPlgGfaelkprlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           L F+Tgs+r+P+ G+a+l+   +vi+  ++ ++ lP ++TC+n+L+LP+Ysskeil+ +L+ A ++ +gF+l
   Q: 981  LLFLTGSDRIPIYGMASLQ---IVIQStASGEEYLPVAHTCYNLLDLPKYSSKEILNARLTQALDNYEGFSL 1049
           *******************...8888867788**************************************97 PP

Organism

Loxodonta africana

Protein Sequence
(Fasta)

MLCWGYWSLG QPGISTNLQG IVAEPQVCGF ISDRSVKEVA CGGNHSVFLL EDGEVYTCGL 60
NTKGQLGHER EGNKPEQIGA LADQHIVHVA CGESHSLALS DRGQLFSWGA GSDGQLGLMT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTTATGTT GGGGATATTG GTCTCTGGGC CAACCTGGTA TCAGTACCAA CCTGCAAGGG 60
ATTGTGGCTG AGCCGCAGGT GTGTGGATTC ATATCTGACA GAAGCGTCAA GGAAGTCGCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens

PROSITE

PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3

Pfam

PF00632--HECT
PF00415--RCC1

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc

Gene Ontology

GO:0005829--C:cytosol
GO:0004842--F:ubiquitin-protein transferase activity

KEGG

lav:100668834

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001673	Ailuropoda melanoleuca	98.29	0.00e+00	2085.00
IUUC-Apl-003535	Anas platyrhynchos	88.10	0.00e+00	1878.00
IUUC-Aca-005223	Anolis carolinensis	85.43	0.00e+00	1832.00
IUUC-Ame-010816	Astyanax mexicanus	66.03	0.00e+00	1164.00
IUUC-Bta-013373	Bos taurus	97.62	0.00e+00	2080.00
IUUC-Cel-018150	Caenorhabditis elegans	33.09	4.00e-155	542.00
IUUC-Cja-019609	Callithrix jacchus	98.29	0.00e+00	2086.00
IUUC-Cfa-021071	Canis familiaris	98.10	0.00e+00	2081.00
IUUC-Cpo-021548	Cavia porcellus	96.76	0.00e+00	2062.00
IUUC-Csa-023987	Chlorocebus sabaeus	98.57	0.00e+00	2088.00
IUUC-Cho-024325	Choloepus hoffmanni	98.09	0.00e+00	1202.00
IUUC-Dre-027472	Danio rerio	66.54	0.00e+00	1400.00
IUUC-Dno-029241	Dasypus novemcinctus	97.24	0.00e+00	2065.00
IUUC-Dor-030672	Dipodomys ordii	91.53	0.00e+00	1127.00
IUUC-Ete-032642	Echinops telfairi	92.86	0.00e+00	1910.00
IUUC-Eca-033646	Equus caballus	98.10	0.00e+00	2080.00
IUUC-Eeu-035098	Erinaceus europaeus	84.04	0.00e+00	1368.00
IUUC-Fal-036952	Ficedula albicollis	88.00	0.00e+00	1875.00
IUUC-Gmo-039297	Gadus morhua	64.48	0.00e+00	1324.00
IUUC-Gga-040591	Gallus gallus	87.25	0.00e+00	1858.00
IUUC-Gac-041741	Gasterosteus aculeatus	65.75	0.00e+00	1389.00
IUUC-Ggo-044769	Gorilla gorilla	98.67	0.00e+00	2091.00
IUUC-Hsa-046066	Homo sapiens	98.76	0.00e+00	2095.00
IUUC-Itr-048311	Ictidomys tridecemlineatus	98.00	0.00e+00	2074.00
IUUC-Lch-050301	Latimeria chalumnae	73.43	0.00e+00	1617.00
IUUC-Loc-052803	Lepisosteus oculatus	67.16	0.00e+00	1449.00
IUUC-Mcc-054930	Macaca mulatta	98.48	0.00e+00	2088.00
IUUC-Meu-056274	Macropus eugenii	79.27	0.00e+00	869.00
IUUC-Mga-059563	Meleagris gallopavo	87.71	0.00e+00	1872.00
IUUC-Mmr-060792	Microcebus murinus	96.38	0.00e+00	2033.00
IUUC-Mdo-062195	Monodelphis domestica	91.72	0.00e+00	1961.00
IUUC-Mmu-063855	Mus musculus	94.48	0.00e+00	2031.00
IUUC-Mpu-066308	Mustela putorius furo	98.38	0.00e+00	2087.00
IUUC-Mlu-066927	Myotis lucifugus	97.52	0.00e+00	2069.00
IUUC-Nle-070090	Nomascus leucogenys	98.57	0.00e+00	2088.00
IUUC-Opr-070891	Ochotona princeps	85.33	0.00e+00	1760.00
IUUC-Ont-072201	Oreochromis niloticus	64.46	0.00e+00	1345.00
IUUC-Ocu-074770	Oryctolagus cuniculus	97.24	0.00e+00	2068.00
IUUC-Ola-086550	Oryzias latipes	65.34	0.00e+00	1391.00
IUUC-Olu-087836	Ostreococcus lucimarinus	34.44	8.00e-42	164.00
IUUC-Oga-088831	Otolemur garnettii	98.10	0.00e+00	2080.00
IUUC-Oar-090449	Ovis aries	97.52	0.00e+00	2072.00
IUUC-Pan-092135	Papio anubis	98.48	0.00e+00	2085.00
IUUC-Psi-093832	Pelodiscus sinensis	85.54	0.00e+00	1873.00
IUUC-Pfo-097268	Poecilia formosa	65.91	0.00e+00	1390.00
IUUC-Pab-098249	Pongo abelii	98.48	0.00e+00	2087.00
IUUC-Pca-100855	Procavia capensis	94.54	0.00e+00	1438.00
IUUC-Pva-102506	Pteropus vampyrus	89.25	0.00e+00	1831.00
IUUC-Rno-105242	Rattus norvegicus	94.76	0.00e+00	2074.00
IUUC-Sha-107186	Sarcophilus harrisii	89.39	0.00e+00	1197.00
IUUC-Sar-113612	Sorex araneus	95.65	0.00e+00	747.00
IUUC-Ssc-115473	Sus scrofa	97.14	0.00e+00	2065.00
IUUC-Tgu-116974	Taeniopygia guttata	88.20	0.00e+00	1855.00
IUUC-Tru-118077	Takifugu rubripes	63.83	0.00e+00	1321.00
IUUC-Tsy-119619	Tarsius syrichta	86.48	0.00e+00	1847.00
IUUC-Tni-120807	Tetraodon nigroviridis	64.27	0.00e+00	1345.00
IUUC-Tbe-127640	Tupaia belangeri	93.81	0.00e+00	1940.00
IUUC-Ttr-129172	Tursiops truncatus	97.14	0.00e+00	2061.00
IUUC-Vpa-130442	Vicugna pacos	82.58	0.00e+00	1690.00
IUUC-Xtr-132194	Xenopus tropicalis	71.60	0.00e+00	1439.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence