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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063112
UUCD1 version UUC-MuM-00323
Ensembl Protein ID ENSMUSP00000031254.2
UniProt Accession P59280; Q8CD84; KLHL8_MOUSE
Genbank Protein ID BAC27220.1; BAC34008.1; CAM21394.1; AAH86802.1
Protein Name Kelch-like protein 8
Genbank Nucleotide ID AK031028; AK049960; AL731554; BC086802
Gene Name Klhl8
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000029312.12 ENSMUST00000112811.7 ENSMUSP00000108430.1
ENSMUSG00000029312.12 ENSMUST00000112815.7 ENSMUSP00000108434.1
ENSMUSG00000029312.12 ENSMUST00000031254.8 ENSMUSP00000031254.2
ENSMUSG00000029312.12 ENSMUST00000131843.1 ENSMUSP00000117671.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitecircBasemicroRNATRANSFAC
RepTarmiRNAMapRAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAFPhosphositePlus
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB 1.40e-17 64.9 76 141
E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box 1.80e-09 36.7 175 206
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB
   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgklde 67
           +Dv+l+vg + +++hk+vLa   ++F+a+fl+e++e k +  +ei+d + +++++l+kF+Y+++l++
   Q: 76   CDVTLKVGSKLISCHKLVLACVIPYFRAMFLSEMSEAK-QALIEIRDFDGDAVEDLVKFVYSSRLTL 141
           9************************************9.*************************986 PP
   

   E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box
   S: 1    leNclgilrfAdlydcpdLkdaaldfilkhFk 32
           ++Ncl++++fA+ ++  dL+d a+ +++ hF+
   Q: 175  PSNCLAVRAFAESHNRIDLMDMADQYACEHFT 206
           89*****************************7 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for The BCR(KLHL8) ubiquitin ligase complex mediates ubiquitination and degradation of RAPSN.
 Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for The BCR(KLHL8) ubiquitin ligase complex mediates ubiquitination and degradation of RAPSN.
Protein Sequence
(Fasta)
MASESTNGKQ ARSHVTKGRR QYQHQHQQQQ QQQQQVRSRS SVSECDGDDS FIFEANEAWK 60
DFHGSLLGFY ENGELCDVTL KVGSKLISCH KLVLACVIPY FRAMFLSEMS EAKQALIEIR 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063112|E3,BTB_3-box|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGCTCTCAAG AGCGCTCGGC CGAGCCGGGC ACGAGCGAGC GGTCGGGCCG GTGAGCGCGT 60
CCCCGGGGTG TCCAAGCGGG GCTGGCGCGG CGCCGGCGCG GAGCGGGTGT GGCGGCTCGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063112|E3,BTB_3-box|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0880--Kelch repeat
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
Interpro

IPR011705--BACK
IPR000210--BTB/POZ_dom
IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR030605--KLHL8
IPR011333--SKP1/BTB/POZ
PROSITE

PS50097--BTB
Pfam

PF07707--BACK
PF00651--BTB
PF01344--Kelch_1
SMART

SM00875--BACK
SM00225--BTB
SM00612--Kelch
Gene Ontology

GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0005654--C:nucleoplasm
GO:0016567--P:protein ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
KEGG mmu:246293
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001443 Ailuropoda melanoleuca 92.69 0.00e+00 1192.00
IUUC-Atr-002726 Amborella trichopoda 35.90 6.00e-42 166.00
IUUC-Apl-003978 Anas platyrhynchos 86.80 0.00e+00 1137.00
IUUC-Aca-004958 Anolis carolinensis 83.17 0.00e+00 1063.00
IUUC-Ame-011139 Astyanax mexicanus 84.94 0.00e+00 1065.00
IUUC-Bta-013142 Bos taurus 91.89 0.00e+00 1187.00
IUUC-Bdi-014143 Brachypodium distachyon 38.89 3.00e-42 167.00
IUUC-Cel-018551 Caenorhabditis elegans 39.93 2.00e-128 453.00
IUUC-Cja-019650 Callithrix jacchus 92.05 0.00e+00 1208.00
IUUC-Cfa-021046 Canis familiaris 93.16 0.00e+00 1197.00
IUUC-Cpo-022445 Cavia porcellus 90.14 0.00e+00 1142.00
IUUC-Csa-023642 Chlorocebus sabaeus 92.69 0.00e+00 1215.00
IUUC-Cho-025012 Choloepus hoffmanni 77.64 0.00e+00 875.00
IUUC-Dre-027723 Danio rerio 82.57 0.00e+00 1049.00
IUUC-Dno-028964 Dasypus novemcinctus 90.80 0.00e+00 988.00
IUUC-Dor-030899 Dipodomys ordii 83.11 9.00e-136 477.00
IUUC-Ete-032815 Echinops telfairi 89.51 0.00e+00 1176.00
IUUC-Eca-034162 Equus caballus 92.85 0.00e+00 1175.00
IUUC-Eeu-034660 Erinaceus europaeus 90.62 0.00e+00 1166.00
IUUC-Fca-035659 Felis catus 93.00 0.00e+00 1196.00
IUUC-Fal-037619 Ficedula albicollis 86.19 0.00e+00 1139.00
IUUC-Gmo-038546 Gadus morhua 83.45 0.00e+00 1048.00
IUUC-Ggr-040041 Gaeumannomyces graminis 31.97 6.00e-08 52.00
IUUC-Gga-040770 Gallus gallus 86.35 0.00e+00 1111.00
IUUC-Gac-042557 Gasterosteus aculeatus 81.76 0.00e+00 1038.00
IUUC-Ggo-044741 Gorilla gorilla 92.53 0.00e+00 1213.00
IUUC-Hsa-046025 Homo sapiens 92.37 0.00e+00 1212.00
IUUC-Hvu-047224 Hordeum vulgare 33.33 3.00e-38 154.00
IUUC-Itr-048541 Ictidomys tridecemlineatus 96.17 0.00e+00 1088.00
IUUC-Loc-052834 Lepisosteus oculatus 85.64 0.00e+00 994.00
IUUC-Lma-052959 Leptosphaeria maculans 28.00 8.00e-06 44.30
IUUC-Laf-054513 Loxodonta africana 92.37 0.00e+00 1187.00
IUUC-Mcc-054707 Macaca mulatta 92.53 0.00e+00 1212.00
IUUC-Meu-056779 Macropus eugenii 87.28 0.00e+00 1137.00
IUUC-Mga-059676 Meleagris gallopavo 86.19 0.00e+00 1110.00
IUUC-Mmr-061359 Microcebus murinus 91.73 0.00e+00 1166.00
IUUC-Mdo-062527 Monodelphis domestica 86.01 0.00e+00 1125.00
IUUC-Mac-064682 Musa acuminata 36.36 2.00e-42 167.00
IUUC-Mpu-065800 Mustela putorius furo 92.21 0.00e+00 1187.00
IUUC-Mlu-067536 Myotis lucifugus 91.35 0.00e+00 1132.00
IUUC-Nle-069397 Nomascus leucogenys 92.69 0.00e+00 1216.00
IUUC-Opr-070599 Ochotona princeps 90.21 0.00e+00 981.00
IUUC-Ont-072580 Oreochromis niloticus 83.28 0.00e+00 1051.00
IUUC-Oan-073180 Ornithorhynchus anatinus 87.62 0.00e+00 1137.00
IUUC-Ocu-074026 Oryctolagus cuniculus 92.53 0.00e+00 1176.00
IUUC-Ola-086776 Oryzias latipes 81.99 0.00e+00 1005.00
IUUC-Oga-088651 Otolemur garnettii 93.00 0.00e+00 1190.00
IUUC-Oar-089567 Ovis aries 91.10 0.00e+00 1164.00
IUUC-Ptr-091564 Pan troglodytes 92.53 0.00e+00 1213.00
IUUC-Pan-092578 Papio anubis 92.69 0.00e+00 1215.00
IUUC-Psi-093635 Pelodiscus sinensis 85.81 0.00e+00 1070.00
IUUC-Pma-094660 Petromyzon marinus 61.38 0.00e+00 757.00
IUUC-Pfo-097507 Poecilia formosa 83.00 0.00e+00 981.00
IUUC-Pab-098025 Pongo abelii 92.53 0.00e+00 1213.00
IUUC-Pca-101046 Procavia capensis 85.21 1.00e-179 623.00
IUUC-Ppe-101154 Prunus persica 32.28 2.00e-38 154.00
IUUC-Pva-102359 Pteropus vampyrus 96.14 0.00e+00 893.00
IUUC-Rno-105750 Rattus norvegicus 96.98 0.00e+00 1233.00
IUUC-Sha-107513 Sarcophilus harrisii 88.10 0.00e+00 1149.00
IUUC-Sly-111482 Solanum lycopersicum 31.91 4.00e-41 162.00
IUUC-Stu-112032 Solanum tuberosum 33.07 2.00e-42 167.00
IUUC-Sar-113616 Sorex araneus 70.65 5.00e-117 414.00
IUUC-Ssc-116205 Sus scrofa 91.57 0.00e+00 994.00
IUUC-Tgu-117435 Taeniopygia guttata 86.35 0.00e+00 1137.00
IUUC-Tru-118709 Takifugu rubripes 81.82 0.00e+00 1041.00
IUUC-Tsy-119466 Tarsius syrichta 96.53 0.00e+00 1089.00
IUUC-Tni-119988 Tetraodon nigroviridis 81.96 0.00e+00 1037.00
IUUC-Tae-124761 Triticum aestivum 33.91 7.00e-39 155.00
IUUC-Tbe-127704 Tupaia belangeri 94.71 0.00e+00 1046.00
IUUC-Ttr-128892 Tursiops truncatus 95.68 0.00e+00 910.00
IUUC-Vpa-130545 Vicugna pacos 92.13 0.00e+00 1001.00
IUUC-Xtr-132289 Xenopus tropicalis 81.73 0.00e+00 1015.00
Created Date 25-Jun-2017

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