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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-064370
UUCD1 version UUC-MuM-00930
Ensembl Protein ID ENSMUSP00000048969.2
UniProt Accession Q9D5L7; Q5FWI0; Q8BJA4; SPSB1_MOUSE
Genbank Protein ID AAL57355.1; BAB29738.1; BAC25049.1; BAC26954.1; BAC30739.1; BAC40957.1; BAE35613.1; BAE42952.1; AAH46787.1; AAH57563.1; AAH89357.1
Protein Name SPRY domain-containing SOCS box protein 1
Genbank Nucleotide ID AF403036; AK015181; AK003707; AK030417; AK040909; AK089767; AK160081; AK172334; BC046787; BC057563; BC089357
Gene Name Spsb1; Ssb1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000039911.13 ENSMUST00000038562.8 ENSMUSP00000048969.2
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemicroRNATRANSFACRepTar
RAID2
Protein-protein Interaction
IIDiRefIndexMentha
Post-translational Modifications (PTMs)
dbPAFPhosphositePlus
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box 1.10e-15 58.4 230 273
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box
   S: 7    lrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlye 50
           l  ep +L++LCR+++r +lg++rl ai++LPLP sLk YLly+
   Q: 230  LDPEPLPLMDLCRRSVRLALGKERLGAIPALPLPASLKAYLLYQ 273
           5679***************************************8 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
 Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Protein Sequence
(Fasta)
MGQKVTGGIK TVDMRDPTYR PLKQELQGLD YCKPTRLDLL LDMPPVSYDV QLLHSWNNND 60
RSLNVFVKED DKLIFHRHPV AQSTDAIRGK VGYTRGLHVW QITWAMRQRG THAVVGVATA 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-064370|E3,SOCS|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGAGCTGTCG GTGGCTTTTT CTTCTCAGCG CAGGAGTCGC GCTCGAGCGG CCCGCGCGCT 60
TGCTGCAGGA ACCAGCTCCA GGCGCTGGCG CCGGGGCCAC GGGGAGGAAG CGACTTCGCT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-064370|E3,SOCS|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
Interpro

IPR001870--B30.2/SPRY
IPR013320--ConA-like_dom
IPR001496--SOCS_box
IPR003877--SPRY_dom
PROSITE

PS50188--B302_SPRY
PS50225--SOCS
Pfam

PF07525--SOCS_box
PF00622--SPRY
SMART

SM00969--SOCS_box
SM00449--SPRY
Gene Ontology

GO:0005737--C:cytoplasm
GO:0004842--F:ubiquitin-protein transferase activity
GO:0035556--P:intracellular signal transduction
KEGG mmu:74646
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002040 Ailuropoda melanoleuca 97.44 5.00e-158 549.00
IUUC-Apl-004008 Anas platyrhynchos 96.70 1.00e-157 548.00
IUUC-Aca-004631 Anolis carolinensis 91.58 6.00e-151 526.00
IUUC-Aly-006295 Arabidopsis lyrata 24.27 1.50e-01 31.20
IUUC-Ame-010841 Astyanax mexicanus 85.35 1.00e-142 498.00
IUUC-Bta-012816 Bos taurus 98.53 8.00e-160 555.00
IUUC-Cja-019531 Callithrix jacchus 98.90 2.00e-160 557.00
IUUC-Cfa-020107 Canis familiaris 98.53 5.00e-160 556.00
IUUC-Cpo-021983 Cavia porcellus 100.00 2.00e-162 564.00
IUUC-Csa-023603 Chlorocebus sabaeus 98.53 3.00e-160 557.00
IUUC-Cin-025737 Ciona intestinalis 60.48 2.00e-93 335.00
IUUC-Csv-026238 Ciona savignyi 59.20 3.00e-90 325.00
IUUC-Dre-028699 Danio rerio 86.08 2.00e-143 501.00
IUUC-Dno-028959 Dasypus novemcinctus 98.83 8.00e-152 529.00
IUUC-Dor-030400 Dipodomys ordii 98.90 3.00e-161 560.00
IUUC-Dme-031730 Drosophila melanogaster 69.68 8.00e-115 406.00
IUUC-Eca-034017 Equus caballus 99.27 7.00e-161 559.00
IUUC-Eeu-035331 Erinaceus europaeus 97.07 9.00e-157 545.00
IUUC-Fca-035981 Felis catus 98.53 5.00e-160 556.00
IUUC-Fal-037253 Ficedula albicollis 92.31 1.00e-151 528.00
IUUC-Fox-037964 Fusarium oxysporum 34.48 1.00e-02 35.40
IUUC-Gmo-038813 Gadus morhua 78.75 6.00e-132 463.00
IUUC-Gga-040286 Gallus gallus 95.60 1.00e-155 541.00
IUUC-Gac-041392 Gasterosteus aculeatus 80.59 4.00e-135 473.00
IUUC-Ggo-044990 Gorilla gorilla 98.90 2.00e-160 557.00
IUUC-Hsa-045783 Homo sapiens 98.53 6.00e-160 556.00
IUUC-Itr-048565 Ictidomys tridecemlineatus 100.00 6.00e-151 526.00
IUUC-Lch-049583 Latimeria chalumnae 87.91 5.00e-139 486.00
IUUC-Loc-052220 Lepisosteus oculatus 86.08 6.00e-142 496.00
IUUC-Laf-053976 Loxodonta africana 98.44 8.00e-150 522.00
IUUC-Mcc-055223 Macaca mulatta 98.90 2.00e-160 557.00
IUUC-Meu-056426 Macropus eugenii 97.80 1.00e-158 551.00
IUUC-Mga-059620 Meleagris gallopavo 95.60 1.00e-155 541.00
IUUC-Mmr-061373 Microcebus murinus 98.17 7.00e-159 552.00
IUUC-Mdo-063064 Monodelphis domestica 98.17 4.00e-159 553.00
IUUC-Mpu-066516 Mustela putorius furo 98.17 3.00e-159 553.00
IUUC-Opr-070732 Ochotona princeps 97.07 5.00e-157 546.00
IUUC-Ont-071692 Oreochromis niloticus 80.59 1.00e-134 472.00
IUUC-Oan-072793 Ornithorhynchus anatinus 91.70 4.00e-137 480.00
IUUC-Ocu-074726 Oryctolagus cuniculus 98.17 4.00e-159 553.00
IUUC-Ogl-077661 Oryza glaberrima 50.00 7.00e-03 31.60
IUUC-Ola-086593 Oryzias latipes 80.22 4.00e-133 466.00
IUUC-Oga-089174 Otolemur garnettii 98.17 4.00e-159 553.00
IUUC-Oar-089518 Ovis aries 98.90 6.00e-160 556.00
IUUC-Ptr-090932 Pan troglodytes 98.90 2.00e-160 557.00
IUUC-Pan-091876 Papio anubis 98.90 2.00e-160 557.00
IUUC-Psi-093032 Pelodiscus sinensis 96.34 8.00e-158 548.00
IUUC-Pfo-096274 Poecilia formosa 79.85 3.00e-133 467.00
IUUC-Pab-097701 Pongo abelii 100.00 1.00e-137 481.00
IUUC-Pca-100140 Procavia capensis 96.10 2.00e-133 468.00
IUUC-Pva-102977 Pteropus vampyrus 98.90 2.00e-160 557.00
IUUC-Rno-105030 Rattus norvegicus 99.63 4.00e-162 563.00
IUUC-Sha-107161 Sarcophilus harrisii 93.04 8.00e-150 522.00
IUUC-Tgu-116619 Taeniopygia guttata 94.87 3.00e-153 534.00
IUUC-Tru-118256 Takifugu rubripes 79.85 1.00e-133 468.00
IUUC-Tni-120305 Tetraodon nigroviridis 80.95 1.00e-133 468.00
IUUC-Tbe-127668 Tupaia belangeri 100.00 1.00e-137 481.00
IUUC-Xtr-132803 Xenopus tropicalis 90.11 6.00e-150 523.00
Created Date 25-Jun-2017

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