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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045699
Ensembl Protein ID ENSP00000370719.3
UniProt Accession Q15811; A7Y322; A8CTX8; A8CTY3; A8CTY7; A8D7D0; A8DCP3; B4DTM2; E7ERJ1; E9PE44; E9PG01; E9PHV2; O95216; Q0PW94; Q0PW95; Q0PW97; Q14BD3; Q1ED40; Q20BK3; Q9UET5; Q9UK60; Q9UNK1; Q9UNK2; Q9UQ92; ITSN1_HUMAN
Genbank Protein ID AAC78611.1; AAC80437.1; AAC80437.1; AAC80437.1; AAC78610.1; AAD29953.1; AAD29952.1; ABG74695.1; ABG74697.1; ABG74698.1; ABV21755.1; ABV58335.1; ABV58336.1; ABV24866.1; ABV24867.1; ABV24868.1; ABV69555.1; ABD72328.1; BAG62034.1; AAI17561.1; AAI16187.1; AAC50592.1; AAD53183.1
Protein Name Intersectin-1; SH3 domain-containing protein 1A; SH3P17
Genbank Nucleotide ID AF064244; AF064247; AF064245; AF064246; AF064243; AF114488; AF114487; DQ679754; DQ679756; DQ679757; EU117382; EU140799; EU140800; EU120733; EU120734; EU120735; EU152331; DQ386455; AK300274; AP000308; BC116186; U61166; AF180522
Gene Name ITSN1; ITSN; SH3D1A
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000205726.14 ENST00000399353.5 ENSP00000382290.1
ENSG00000205726.14 ENST00000381318.7 ENSP00000370719.3
ENSG00000205726.14 ENST00000399367.7 ENSP00000382301.3
ENSG00000205726.14 ENST00000399355.6 ENSP00000382292.2
ENSG00000205726.14 ENST00000399349.5 ENSP00000382286.1
ENSG00000205726.14 ENST00000381283.7 ENSP00000370683.3
ENSG00000205726.14 ENST00000456489.1 ENSP00000411464.1
ENSG00000205726.14 ENST00000419241.1 ENSP00000415302.1
ENSG00000205726.14 ENST00000440794.2 ENSP00000396054.1
ENSG00000205726.14 ENST00000437126.5 ENSP00000413290.1
ENSG00000205726.14 ENST00000381284.7 ENSP00000370684.3
ENSG00000205726.14 ENST00000420666.1 ENSP00000408319.1
ENSG00000205726.14 ENST00000415023.1 ENSP00000409800.1
ENSG00000205726.14 ENST00000379960.9 ENSP00000369294.6
ENSG00000205726.14 ENST00000381285.8 ENSP00000370685.5
ENSG00000205726.14 ENST00000399338.8 ENSP00000382275.4
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
AREsitecircBasecircRNADbCircNet
miRTarBasemicroRNATRANSFACTargetScan
RepTarSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Variation
ClinVarGWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/SH3 1.80e-66 221.6 1159 1210
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/SH3
   S: 5    kvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFve 60
           +v+ +ydy+aqnddeL ++kG ++ v+  +++d +W+kg  e +g+ GlfP+n+v+
   Q: 1159 QVIGMYDYTAQNDDELAFNKGQIINVL--NKEDPDWWKG--EVNGQVGLFPSNYVK 1210
           46779**********************..8889******..9*************8 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Acts as guanine nucleotide exchange factor (GEF) specific for the CDC42 GTPase (By similarity). Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR may involve association with DAB2. Isoform 1 could be involved in brain-specific synaptic vesicle recycling. Inhibits ARHGAP31 activity toward RAC1.
 Acts as guanine nucleotide exchange factor (GEF) specific for the CDC42 GTPase (By similarity). Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR may involve association with DAB2. Isoform 1 could be involved in brain-specific synaptic vesicle recycling. Inhibits ARHGAP31 activity toward RAC1.
Protein Sequence
(Fasta)
MAQFPTPFGG SLDIWAITVE ERAKHDQQFH SLKPISGFIT GDQARNFFFQ SGLPQPVLAQ 60
IWALADMNND GRMDQVEFSI AMKLIKLKLQ GYQLPSALPP VMKQQPVAIS SAPAFGMGGI 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045699|UBD,SH3|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ACTTATGGGC GGAGATGGAT GGTGGATGGG GGGCGGGGGA GGCAGCGGAG GGAGATGAGG 60
AGATAGGCGG GAGCGAGGGA GCGAGGGAGG GAGCGAAGGA GGTAGAGAAG AGTGGAGGCG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045699|UBD,SH3|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0106--Calcium
KW-0965--Cell junction
KW-0966--Cell projection
KW-0168--Coated pit
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0254--Endocytosis
KW-0945--Host-virus interaction
KW-0472--Membrane
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0728--SH3 domain
KW-0770--Synapse
KW-0771--Synaptosome
Interpro

IPR000008--C2_dom
IPR000219--DH-domain
IPR011992--EF-hand-dom_pair
IPR018247--EF_Hand_1_Ca_BS
IPR002048--EF_hand_dom
IPR000261--EH_dom
IPR001331--GDS_CDC24_CS
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR001452--SH3_domain
PROSITE

PS50004--C2
PS00741--DH_1
PS50010--DH_2
PS00018--EF_HAND_1
PS50222--EF_HAND_2
PS50031--EH
PS50003--PH_DOMAIN
PS50002--SH3
Pfam

PF00168--C2
PF12763--EF-hand_4
PF16652--PH_13
PF00621--RhoGEF
PF00018--SH3_1
PF14604--SH3_9
PRINTS

PR00452--SH3DOMAIN
SMART

SM00239--C2
SM00054--EFh
SM00027--EH
SM00233--PH
SM00325--RhoGEF
SM00326--SH3
Gene Ontology

GO:0030054--C:cell junction
GO:0005905--C:clathrin-coated pit
GO:0005829--C:cytosol
GO:0030139--C:endocytic vesicle
GO:0030027--C:lamellipodium
GO:0043005--C:neuron projection
GO:0005886--C:plasma membrane
GO:0045202--C:synapse
GO:0005509--F:calcium ion binding
GO:0005085--F:guanyl-nucleotide exchange factor activity
GO:0019209--F:kinase activator activity
GO:0070064--F:proline-rich region binding
GO:0032947--F:protein complex scaffold
GO:0005089--F:Rho guanyl-nucleotide exchange factor activity
GO:0048013--P:ephrin receptor signaling pathway
GO:0061024--P:membrane organization
GO:0043524--P:negative regulation of neuron apoptotic process
GO:0043065--P:positive regulation of apoptotic process
GO:0051897--P:positive regulation of protein kinase B signaling
GO:0035023--P:regulation of Rho protein signal transduction
GO:0051056--P:regulation of small GTPase mediated signal transduction
GO:0007264--P:small GTPase mediated signal transduction
GO:0048488--P:synaptic vesicle endocytosis
KEGG hsa:6453
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000722 Aegilops tauschii 41.67 4.00e-14 74.70
IUUC-Aml-001218 Ailuropoda melanoleuca 96.03 0.00e+00 2425.00
IUUC-Apl-003335 Anas platyrhynchos 91.91 0.00e+00 2283.00
IUUC-Aca-005130 Anolis carolinensis 89.37 0.00e+00 2249.00
IUUC-Ago-007935 Ashbya gossypii 35.82 2.00e-14 74.30
IUUC-Ani-009403 Aspergillus nidulans 41.38 2.00e-15 73.90
IUUC-Ame-011878 Astyanax mexicanus 75.84 0.00e+00 1941.00
IUUC-Bta-012863 Bos taurus 95.87 0.00e+00 2369.00
IUUC-Bdi-014016 Brachypodium distachyon 40.00 5.00e-14 73.60
IUUC-Cja-019012 Callithrix jacchus 98.97 0.00e+00 2454.00
IUUC-Cfa-020272 Canis familiaris 96.43 0.00e+00 2446.00
IUUC-Cpo-021352 Cavia porcellus 89.10 0.00e+00 2892.00
IUUC-Cho-024969 Choloepus hoffmanni 85.59 0.00e+00 1934.00
IUUC-Cin-025435 Ciona intestinalis 45.58 0.00e+00 977.00
IUUC-Csv-026290 Ciona savignyi 57.80 0.00e+00 778.00
IUUC-Cme-027247 Cyanidioschyzon merolae 25.43 4.00e-11 63.50
IUUC-Dre-028623 Danio rerio 76.36 0.00e+00 1946.00
IUUC-Dno-030044 Dasypus novemcinctus 96.13 0.00e+00 2405.00
IUUC-Dor-030272 Dipodomys ordii 89.53 0.00e+00 2115.00
IUUC-Ete-032927 Echinops telfairi 98.00 0.00e+00 1033.00
IUUC-Eca-033469 Equus caballus 97.06 0.00e+00 2404.00
IUUC-Eeu-034977 Erinaceus europaeus 92.85 0.00e+00 1152.00
IUUC-Fca-036419 Felis catus 96.03 0.00e+00 2390.00
IUUC-Fal-037236 Ficedula albicollis 89.38 0.00e+00 2258.00
IUUC-Gmo-039632 Gadus morhua 70.53 0.00e+00 1684.00
IUUC-Gga-040835 Gallus gallus 90.06 0.00e+00 2251.00
IUUC-Gac-041948 Gasterosteus aculeatus 71.80 0.00e+00 1808.00
IUUC-Ggo-045100 Gorilla gorilla 98.95 0.00e+00 1456.00
IUUC-Hvu-047530 Hordeum vulgare 33.14 1.00e-14 75.50
IUUC-Itr-048773 Ictidomys tridecemlineatus 94.38 0.00e+00 2394.00
IUUC-Kpa-049215 Komagataella pastoris 40.00 6.00e-15 75.90
IUUC-Lch-050502 Latimeria chalumnae 78.71 0.00e+00 1644.00
IUUC-Lpe-051250 Leersia perrieri 41.67 3.00e-14 74.70
IUUC-Loc-052613 Lepisosteus oculatus 80.81 0.00e+00 1970.00
IUUC-Laf-053608 Loxodonta africana 94.98 0.00e+00 2413.00
IUUC-Mcc-055720 Macaca mulatta 99.05 0.00e+00 2471.00
IUUC-Meu-056445 Macropus eugenii 85.30 0.00e+00 1712.00
IUUC-Mla-059128 Melampsora laricipopulina 33.09 4.00e-40 161.00
IUUC-Mmr-061258 Microcebus murinus 97.78 0.00e+00 2423.00
IUUC-Mdo-062019 Monodelphis domestica 92.54 0.00e+00 2254.00
IUUC-Mmu-063885 Mus musculus 94.52 0.00e+00 2431.00
IUUC-Mac-065649 Musa acuminata 32.77 6.00e-12 67.00
IUUC-Mlu-067025 Myotis lucifugus 67.22 0.00e+00 1483.00
IUUC-Nle-069448 Nomascus leucogenys 89.41 0.00e+00 1268.00
IUUC-Opr-070441 Ochotona princeps 91.21 0.00e+00 2118.00
IUUC-Ont-071752 Oreochromis niloticus 72.61 0.00e+00 1804.00
IUUC-Oan-073390 Ornithorhynchus anatinus 87.94 0.00e+00 2173.00
IUUC-Ocu-073753 Oryctolagus cuniculus 94.28 0.00e+00 3048.00
IUUC-Obr-076390 Oryza brachyantha 37.97 6.00e-09 55.10
IUUC-Ogu-078849 Oryza glumaepatula 41.67 3.00e-14 74.70
IUUC-Olo-080259 Oryza longistaminata 41.67 2.00e-14 75.10
IUUC-Ome-081199 Oryza meridionalis 41.67 2.00e-14 75.10
IUUC-Oni-082167 Oryza nivara 41.67 5.00e-14 73.90
IUUC-Oru-084541 Oryza rufipogon 41.67 5.00e-14 73.90
IUUC-Olu-087698 Ostreococcus lucimarinus 28.75 3.00e-16 80.90
IUUC-Oga-088602 Otolemur garnettii 97.54 0.00e+00 2428.00
IUUC-Oar-090195 Ovis aries 95.88 0.00e+00 2375.00
IUUC-Ptr-091363 Pan troglodytes 99.92 0.00e+00 2526.00
IUUC-Pan-092385 Papio anubis 98.89 0.00e+00 2471.00
IUUC-Pfo-097486 Poecilia formosa 74.16 0.00e+00 1844.00
IUUC-Pab-098281 Pongo abelii 88.25 0.00e+00 2132.00
IUUC-Pca-100270 Procavia capensis 79.88 0.00e+00 1348.00
IUUC-Pva-102335 Pteropus vampyrus 93.57 0.00e+00 2358.00
IUUC-Rno-106122 Rattus norvegicus 93.27 0.00e+00 2382.00
IUUC-Sha-106851 Sarcophilus harrisii 92.78 0.00e+00 2265.00
IUUC-Sit-110414 Setaria italica 40.48 4.00e-14 74.30
IUUC-Sbi-114170 Sorghum bicolor 38.89 3.00e-14 74.70
IUUC-Tgu-117028 Taeniopygia guttata 90.33 0.00e+00 2295.00
IUUC-Tru-117789 Takifugu rubripes 75.51 0.00e+00 1868.00
IUUC-Tsy-119039 Tarsius syrichta 94.69 0.00e+00 1410.00
IUUC-Tni-119952 Tetraodon nigroviridis 73.94 0.00e+00 1736.00
IUUC-Tae-123242 Triticum aestivum 41.67 5.00e-14 73.90
IUUC-Tur-126623 Triticum urartu 40.00 3.00e-14 74.30
IUUC-Tbe-127754 Tupaia belangeri 86.51 0.00e+00 1778.00
IUUC-Ttr-129178 Tursiops truncatus 96.90 0.00e+00 2408.00
IUUC-Uma-129456 Ustilago maydis 31.66 3.00e-32 135.00
IUUC-Vpa-130687 Vicugna pacos 92.65 0.00e+00 1202.00
IUUC-Xtr-132905 Xenopus tropicalis 86.14 0.00e+00 2179.00
Created Date 25-Jun-2017

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