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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046683
UUCD1 version UUC-HoS-00413
Ensembl Protein ID ENSP00000351933.4
UniProt Accession Q9P2J3; Q8TCQ2; KLHL9_HUMAN
Genbank Protein ID BAA92592.1; CAD28475.1
Protein Name Kelch-like protein 9
Genbank Nucleotide ID AB037775; AL713669
Gene Name KLHL9; KIAA1354
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000198642.6 ENST00000359039.4 ENSP00000351933.4
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
miRWalkTargetScanRepTarmiRcode
RAID2
Protein-protein Interaction
IIDPINAHINTMentha
InWeb_IM
Disease-associated Information
ClinVarOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/BCR/BTB_3-box BTB_3-box 17543862; 15772280
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB 2.20e-15 58.4 50 118
E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box 6.50e-08 31.8 151 182
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB
   S: 1    aDvilvvg..geeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgklden 68
           +Dv+lv g  +e f++h++++a++S++F+a+f+++++e++   ++++++v    ++ +++F+Yt kl++n
   Q: 50   CDVTLVPGdgDEIFPVHRAMMASASDYFKAMFTGGMKEQD-LMCIKLHGVNKVGLKKIIDFIYTAKLSLN 118
           8******998999**************************9.**************************987 PP
   

   E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box
   S: 1    leNclgilrfAdlydcpdLkdaaldfilkhFk 32
           l+Nc+++ r+A++y++ ++ +++++filk+F+
   Q: 151  LDNCVEVGRIANTYNLIEVDKYVNNFILKNFP 182
           69*****************************6 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis.
 Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis.
Protein Sequence
(Fasta)
MKVSLGNGEM GVSAHLQPCK AGTTRFFTSN THSSVVLQGF DQLRIEGLLC DVTLVPGDGD 60
EIFPVHRAMM ASASDYFKAM FTGGMKEQDL MCIKLHGVNK VGLKKIIDFI YTAKLSLNMD 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046683|E3,BTB_3-box|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGAAGGAGCG GCTCGGTGTT GGGGCTAGGC CGGTATTCTA GGCCCAAGCC CAGGCCCAGG 60
CCTGTGTTCC CGGCCCTTGC TCAAAGACAG GCCGGTGGCC GCTGCGACAC TCTAGGTACA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046683|E3,BTB_3-box|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0880--Kelch repeat
KW-0498--Mitosis
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
Interpro

IPR011705--BACK
IPR017096--BTB-kelch_protein
IPR000210--BTB/POZ_dom
IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR011333--SKP1/BTB/POZ
PROSITE

PS50097--BTB
Pfam

PF07707--BACK
PF00651--BTB
PF01344--Kelch_1
SMART

SM00875--BACK
SM00225--BTB
SM00612--Kelch
Gene Ontology

GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0030496--C:midbody
GO:0000910--P:cytokinesis
GO:0007067--P:mitotic nuclear division
GO:0016567--P:protein ubiquitination
KEGG hsa:55958
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Apl-003784 Anas platyrhynchos 95.92 0.00e+00 1217.00
IUUC-Bta-013439 Bos taurus 99.35 0.00e+00 1257.00
IUUC-Cho-024873 Choloepus hoffmanni 99.03 0.00e+00 1259.00
IUUC-Cin-025654 Ciona intestinalis 64.37 0.00e+00 807.00
IUUC-Fca-036091 Felis catus 95.92 0.00e+00 1192.00
IUUC-Gmo-039422 Gadus morhua 84.36 0.00e+00 1048.00
IUUC-Gga-040612 Gallus gallus 95.76 0.00e+00 1213.00
IUUC-Ggo-044475 Gorilla gorilla 96.60 0.00e+00 1210.00
IUUC-Itr-048813 Ictidomys tridecemlineatus 99.51 0.00e+00 1261.00
IUUC-Mcc-054723 Macaca mulatta 99.83 0.00e+00 1236.00
IUUC-Meu-056474 Macropus eugenii 91.52 0.00e+00 1157.00
IUUC-Mor-057229 Magnaporthe oryzae 37.68 3.00e-07 48.90
IUUC-Mmr-061352 Microcebus murinus 99.34 0.00e+00 1229.00
IUUC-Mdo-061869 Monodelphis domestica 90.76 0.00e+00 1174.00
IUUC-Mmu-063519 Mus musculus 98.70 0.00e+00 1254.00
IUUC-Mpu-065703 Mustela putorius furo 99.51 0.00e+00 1262.00
IUUC-Mlu-067082 Myotis lucifugus 98.38 0.00e+00 1248.00
IUUC-Opr-070825 Ochotona princeps 99.18 0.00e+00 1239.00
IUUC-Ont-071620 Oreochromis niloticus 92.01 0.00e+00 1168.00
IUUC-Oan-073694 Ornithorhynchus anatinus 87.72 0.00e+00 1023.00
IUUC-Ocu-074027 Oryctolagus cuniculus 99.68 0.00e+00 1262.00
IUUC-Oga-088341 Otolemur garnettii 99.51 0.00e+00 1251.00
IUUC-Ptr-091283 Pan troglodytes 100.00 0.00e+00 1126.00
IUUC-Pan-092737 Papio anubis 96.57 0.00e+00 1202.00
IUUC-Psi-094003 Pelodiscus sinensis 95.76 0.00e+00 1213.00
IUUC-Pab-098052 Pongo abelii 100.00 0.00e+00 1266.00
IUUC-Rno-105991 Rattus norvegicus 99.19 0.00e+00 1258.00
IUUC-Ssc-116052 Sus scrofa 99.68 0.00e+00 1263.00
IUUC-Tru-117586 Takifugu rubripes 91.22 0.00e+00 1165.00
IUUC-Tsy-119119 Tarsius syrichta 99.51 0.00e+00 1257.00
IUUC-Ttr-128192 Tursiops truncatus 99.68 0.00e+00 1262.00
Created Date 25-Jun-2017

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