iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ptr-091240

UUCD1 version

UUC-PaT-00941

Ensembl Protein ID

ENSPTRP00000054619.3

UniProt Accession

Q1XHT8; Q1XHT9; TRI40_PANTR

Genbank Protein ID

BAE92831.1; BAE92832.1

Protein Name

Tripartite motif-containing protein 40; Probable E3 NEDD8-protein ligase

Genbank Nucleotide ID

AB210209; AB210210

Gene Name

TRIM40

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPTRG00000017918.6	ENSPTRT00000062068.3	ENSPTRP00000054619.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	1.20e-09	38.5	14	57

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadCl.qkwpglknssskefrCPlCr 46
           C+iC+e++k+  ++++CgH+f++ Cl q++   k s+s+ f CPlCr
   Q: 14   CPICQESLKE-AVSTNCGHLFCRVCLtQHV--EKASASGVFCCPLCR 57
           ********99.999************8888..8889**********8 PP

Organism

Pan troglodytes

Functional Description
(View)

May function as an E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway. Promotes neddylation of IKBKG/NEMO, stabilizing NFKBIA, and inhibiting of NF-kappaB nuclear translocation and activity (By similarity).

Protein Sequence
(Fasta)

MIPLQKDNQE EGVCPICQES LKEAVSTNCG HLFCRVCLTQ HVEKASASGV FCCPLCRKPC 60
SEEVLGTGYI CPNHQKRVCR FCEESRLLLC VECLVSPEHM SHHELTIENA LSHYKERLNR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTGTATGAAA AATAATTTCA AGTTTAACAA ATACAAGGAA ACCGCAGGGT CCATGTCAAA 60
GTTGATGAGC TATTTCTGAA ACTCGTGCAG AATTGTGGTT TGTGTGGTCT ATGTCACGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR000315--Znf_B-box
IPR018957--Znf_C3HC4_RING-type
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00097--zf-C3HC4

SMART

SM00184--RING

Gene Ontology

GO:0008385--C:IkappaB kinase complex
GO:0008270--F:zinc ion binding
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:0042177--P:negative regulation of protein catabolic process
GO:1900181--P:negative regulation of protein localization to nucleus
GO:0045116--P:protein neddylation

KEGG

ptr:742243

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001427	Ailuropoda melanoleuca	51.81	2.00e-56	212.00
IUUC-Bta-012543	Bos taurus	54.39	7.00e-58	216.00
IUUC-Cja-018793	Callithrix jacchus	72.91	3.00e-84	304.00
IUUC-Csa-023101	Chlorocebus sabaeus	95.11	9.00e-124	435.00
IUUC-Cho-024926	Choloepus hoffmanni	69.01	9.00e-26	110.00
IUUC-Dno-029338	Dasypus novemcinctus	48.58	8.00e-50	189.00
IUUC-Dor-030164	Dipodomys ordii	63.44	1.00e-66	246.00
IUUC-Dse-031337	Dothistroma septosporum	37.04	7.00e-09	54.70
IUUC-Ete-032446	Echinops telfairi	46.50	1.00e-43	169.00
IUUC-Eca-034042	Equus caballus	66.52	5.00e-82	296.00
IUUC-Eeu-034444	Erinaceus europaeus	52.86	2.00e-55	208.00
IUUC-Ggo-044410	Gorilla gorilla	86.05	1.00e-119	422.00
IUUC-Hsa-045978	Homo sapiens	85.66	7.00e-119	419.00
IUUC-Itr-048126	Ictidomys tridecemlineatus	59.15	5.00e-69	253.00
IUUC-Laf-054019	Loxodonta africana	68.06	2.00e-66	244.00
IUUC-Mcc-054616	Macaca mulatta	86.22	4.00e-122	430.00
IUUC-Meu-055981	Macropus eugenii	39.64	1.00e-36	145.00
IUUC-Mdo-062958	Monodelphis domestica	36.89	1.00e-36	146.00
IUUC-Mmu-063571	Mus musculus	61.28	3.00e-73	267.00
IUUC-Nle-069843	Nomascus leucogenys	72.14	3.00e-46	177.00
IUUC-Opr-071083	Ochotona princeps	55.73	7.00e-73	266.00
IUUC-Ocu-073939	Oryctolagus cuniculus	64.57	2.00e-76	278.00
IUUC-Oga-088040	Otolemur garnettii	70.47	3.00e-87	314.00
IUUC-Oar-089914	Ovis aries	65.40	3.00e-81	295.00
IUUC-Pan-092095	Papio anubis	84.96	2.00e-106	377.00
IUUC-Pab-098406	Pongo abelii	84.50	2.00e-118	417.00
IUUC-Pca-101043	Procavia capensis	55.46	7.00e-62	229.00
IUUC-Pva-102651	Pteropus vampyrus	64.34	3.00e-90	324.00
IUUC-Rno-106090	Rattus norvegicus	59.27	7.00e-77	280.00
IUUC-Smo-109224	Selaginella moellendorffii	46.81	4.00e-06	45.80
IUUC-Ssc-115942	Sus scrofa	63.97	2.00e-81	295.00
IUUC-Tsy-119497	Tarsius syrichta	68.92	6.00e-92	330.00
IUUC-Tbe-127279	Tupaia belangeri	64.90	3.00e-68	251.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence