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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-046180
UUCD1 version UUC-HoS-01039
Ensembl Protein ID ENSP00000432786.1
UniProt Accession Q9Y2K7; D4QA03; E9PIL6; I3VM55; Q49A21; Q4G0M3; Q69YY8; Q9BVH5; Q9H7H5; Q9UK66; KDM2A_HUMAN
Genbank Protein ID BAA76848.2; BAJ05817.1; AFK81542.1; AFK81543.1; BAB15795.1; AAH01203.1; AAH47371.1; AAH47486.1; AAH64360.1; AAD56012.1; CAH10721.1
Protein Name Lysine-specific demethylase 2A; CXXC-type zinc finger protein 8; F-box and leucine-rich repeat protein 11; F-box protein FBL7; F-box protein Lilina; F-box/LRR-repeat protein 11; JmjC domain-containing histone demethylation protein 1A; [Histone-H3]-lysine-36 demethylase 1A
Genbank Nucleotide ID AB023221; AB490246; JQ710743; JQ710744; AK024505; AP000729; BC047371; BC047486; BC064360; AF179221; AL117517
Gene Name KDM2A; CXXC8; FBL7; FBXL11; JHDM1A; KIAA1004
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000173120.14 ENST00000398645.6 ENSP00000381640.2
ENSG00000173120.14 ENST00000529006.6 ENSP00000432786.1
ENSG00000173120.14 ENST00000530342.2 ENSP00000435776.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDPINAMentha
Protein 3D Structure
PDBMMDB
Disease-associated Variation
OMIM
Drug and target
TTDGRAC
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtBioGRID
mUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/PHD 1.00e-09 40.1 619 677
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/PHD
   S: 3    vClvCgeggedek......slveCekCrewfHpaClkls....veeelpnsekwiCpkCrs 53
            C +Cge +++e+      +l+eC++C+e++Hp+Cl++      +eelpn+  w+CpkC +
   Q: 619  TCSLCGEVDQNEEtqdfekKLMECCICNEIVHPGCLQMDgeglLNEELPNC--WECPKCYQ 677
           7*********995555666***********************99*******..******76 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at the centromere. Required to sustain centromeric integrity and genomic stability, particularly during mitosis.
 Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at the centromere. Required to sustain centromeric integrity and genomic stability, particularly during mitosis.
Protein Sequence
(Fasta)
MEPEEERIRY SQRLRGTMRR RYEDDGISDD EIEGKRTFDL EEKLHTNKYN ANFVTFMEGK 60
DFNVEYIQRG GLRDPLIFKN SDGLGIKMPD PDFTVNDVKM CVGSRRMVDV MDVNTQKGIE 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046180|E3,PHD|Homo sapiens
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Nucleotide Sequence
(Fasta)
GAGTCTGACG GGTTCAAAAT GGCGGCGGCT GCTTCAGCGG CTCCTCCTGT GTGAGGGAAA 60
CAACACCCCT CCCCGGCAGC GGCGGCGGCG GCGGCGGCTC TCGGAGCACC TTCCCAGCGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046180|E3,PHD|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0223--Dioxygenase
KW-0238--DNA-binding
KW-0408--Iron
KW-0433--Leucine-rich repeat
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0560--Oxidoreductase
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001810--F-box_dom
IPR003347--JmjC_dom
IPR032675--L_dom-like
IPR006553--Leu-rich_rpt_Cys-con_subtyp
IPR019786--Zinc_finger_PHD-type_CS
IPR002857--Znf_CXXC
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS51184--JMJC
PS51058--ZF_CXXC
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
Pfam

PF00646--F-box
PF02373--JmjC
PF16866--PHD_4
PF02008--zf-CXXC
SMART

SM00558--JmjC
SM00367--LRR_CC
SM00249--PHD
Gene Ontology

GO:0005654--C:nucleoplasm
GO:0003677--F:DNA binding
GO:0032452--F:histone demethylase activity
GO:0051864--F:histone demethylase activity (H3-K36 specific)
GO:0008270--F:zinc ion binding
GO:0006303--P:double-strand break repair via nonhomologous end joining
GO:0070544--P:histone H3-K36 demethylation
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
KEGG hsa:22992
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002052 Ailuropoda melanoleuca 88.68 0.00e+00 1149.00
IUUC-Apl-003192 Anas platyrhynchos 77.56 0.00e+00 1052.00
IUUC-Aca-004576 Anolis carolinensis 84.02 0.00e+00 1914.00
IUUC-Ago-007912 Ashbya gossypii 37.24 3.00e-52 199.00
IUUC-Ame-011753 Astyanax mexicanus 57.30 0.00e+00 781.00
IUUC-Bta-012730 Bos taurus 87.44 0.00e+00 1871.00
IUUC-Cja-019030 Callithrix jacchus 98.80 0.00e+00 2141.00
IUUC-Cfa-020644 Canis familiaris 99.48 0.00e+00 2175.00
IUUC-Cpo-022055 Cavia porcellus 97.85 0.00e+00 2120.00
IUUC-Csa-023379 Chlorocebus sabaeus 99.74 0.00e+00 2112.00
IUUC-Cho-024541 Choloepus hoffmanni 77.48 0.00e+00 1431.00
IUUC-Cin-025140 Ciona intestinalis 61.09 3.00e-107 383.00
IUUC-Csv-025861 Ciona savignyi 45.14 2.00e-134 473.00
IUUC-Cne-026797 Cryptococcus neoformans 38.51 6.00e-59 222.00
IUUC-Dno-029268 Dasypus novemcinctus 98.71 0.00e+00 2122.00
IUUC-Dor-031142 Dipodomys ordii 98.91 0.00e+00 1025.00
IUUC-Dme-032039 Drosophila melanogaster 60.36 1.00e-124 441.00
IUUC-Ete-032467 Echinops telfairi 89.15 0.00e+00 1898.00
IUUC-Eca-033526 Equus caballus 98.97 0.00e+00 2137.00
IUUC-Eeu-035273 Erinaceus europaeus 84.05 0.00e+00 1425.00
IUUC-Fca-035532 Felis catus 99.48 0.00e+00 2106.00
IUUC-Fal-037140 Ficedula albicollis 86.87 0.00e+00 1929.00
IUUC-Gmo-038932 Gadus morhua 58.95 0.00e+00 793.00
IUUC-Gga-040418 Gallus gallus 83.26 0.00e+00 1097.00
IUUC-Gac-041674 Gasterosteus aculeatus 55.98 0.00e+00 1196.00
IUUC-Ggo-045330 Gorilla gorilla 94.33 0.00e+00 802.00
IUUC-Itr-048198 Ictidomys tridecemlineatus 98.98 0.00e+00 1424.00
IUUC-Lch-049730 Latimeria chalumnae 60.19 0.00e+00 983.00
IUUC-Laf-053939 Loxodonta africana 98.43 0.00e+00 2139.00
IUUC-Mcc-054600 Macaca mulatta 99.57 0.00e+00 2139.00
IUUC-Meu-056314 Macropus eugenii 92.41 0.00e+00 1198.00
IUUC-Mga-059549 Meleagris gallopavo 78.70 0.00e+00 1132.00
IUUC-Mmr-060865 Microcebus murinus 99.57 0.00e+00 2156.00
IUUC-Mdo-062567 Monodelphis domestica 95.44 0.00e+00 2083.00
IUUC-Mmu-063782 Mus musculus 96.90 0.00e+00 2131.00
IUUC-Mpu-066055 Mustela putorius furo 99.23 0.00e+00 2178.00
IUUC-Mlu-067228 Myotis lucifugus 90.70 0.00e+00 1144.00
IUUC-Nle-069668 Nomascus leucogenys 99.74 0.00e+00 2142.00
IUUC-Opr-070225 Ochotona princeps 96.28 0.00e+00 2079.00
IUUC-Ont-071349 Oreochromis niloticus 52.67 0.00e+00 1086.00
IUUC-Oan-073668 Ornithorhynchus anatinus 79.19 0.00e+00 670.00
IUUC-Ocu-074710 Oryctolagus cuniculus 98.71 0.00e+00 2102.00
IUUC-Ola-087410 Oryzias latipes 57.81 0.00e+00 770.00
IUUC-Oga-088644 Otolemur garnettii 99.27 0.00e+00 2053.00
IUUC-Oar-089193 Ovis aries 98.09 0.00e+00 2078.00
IUUC-Ptr-091523 Pan troglodytes 100.00 0.00e+00 2189.00
IUUC-Pan-092415 Papio anubis 99.74 0.00e+00 2148.00
IUUC-Psi-093607 Pelodiscus sinensis 90.94 0.00e+00 1051.00
IUUC-Ppa-095609 Physcomitrella patens 37.58 5.00e-58 218.00
IUUC-Pfo-096695 Poecilia formosa 51.11 0.00e+00 1087.00
IUUC-Pab-098580 Pongo abelii 100.00 0.00e+00 1244.00
IUUC-Pca-100670 Procavia capensis 94.43 0.00e+00 1533.00
IUUC-Pva-102416 Pteropus vampyrus 91.83 0.00e+00 1924.00
IUUC-Pgr-103554 Puccinia graminis 44.67 3.00e-74 272.00
IUUC-Rno-105814 Rattus norvegicus 97.33 0.00e+00 2152.00
IUUC-Sce-106445 Saccharomyces cerevisiae 43.46 6.00e-50 191.00
IUUC-Sha-106693 Sarcophilus harrisii 95.00 0.00e+00 1962.00
IUUC-Sar-113568 Sorex araneus 95.38 0.00e+00 2031.00
IUUC-Sre-115112 Sporisorium reilianum 40.94 1.00e-59 224.00
IUUC-Ssc-116337 Sus scrofa 98.12 0.00e+00 1569.00
IUUC-Tgu-117298 Taeniopygia guttata 87.37 0.00e+00 1927.00
IUUC-Tru-118423 Takifugu rubripes 53.26 0.00e+00 1129.00
IUUC-Tsy-119293 Tarsius syrichta 97.93 0.00e+00 2051.00
IUUC-Tni-120020 Tetraodon nigroviridis 56.95 0.00e+00 764.00
IUUC-Tbe-127450 Tupaia belangeri 86.39 0.00e+00 1766.00
IUUC-Ttr-128837 Tursiops truncatus 89.47 0.00e+00 924.00
IUUC-Uma-129458 Ustilago maydis 40.31 4.00e-60 226.00
IUUC-Vpa-130655 Vicugna pacos 93.45 0.00e+00 1498.00
Created Date 25-Jun-2017

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