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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-063766
Ensembl Protein ID ENSMUSP00000026865.8
UniProt Accession Q6ZPI0; Q6IE84; Q8C7S6; Q8CFM2; Q8R362; JADE1_MOUSE
Genbank Protein ID BAC98255.1; BAC33688.1; BAE27932.1; AAH20316.1; AAH26471.1; CAE30497.1; CAE30496.1
Protein Name Protein Jade-1; Jade family PHD finger protein 1; PHD finger protein 17
Genbank Nucleotide ID AK129445; AK049332; AK147466; BC020316; BC026471; BN000282; BN000281
Gene Name Jade1; Kiaa1807; Phf17
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000025764.14 ENSMUST00000026865.14 ENSMUSP00000026865.8
ENSMUSG00000025764.14 ENSMUST00000195846.5 ENSMUSP00000141711.1
ENSMUSG00000025764.14 ENSMUST00000191952.1 ENSMUSP00000141499.1
ENSMUSG00000025764.14 ENSMUST00000192451.1 ENSMUSP00000142142.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
RepTarmiRNAMapRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Mentha
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
UniProt
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/PHD 1.70e-10 42.0 205 252
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/PHD
   S: 2    kvClvCgeggedek.slveCekCrewfHpaClklsveeelpnsekwiCpkCr 52
           +vC vC++++ ++  ++v C+kC+ ++H+aC ++    ++p+ + w C+ C 
   Q: 205  VVCDVCQSPDGEDGnEMVFCDKCNICVHQACYGIL---KVPEGS-WLCRTCA 252
           69******99887569*******************...*****8.******5 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Transcriptional coactivator, it may also promote acetylation of nucleosomal histone H4 by KAT5. Promotes apoptosis. May act as a renal tumor suppressor. Negatively regulates canonical Wnt signaling; at least in part, cooperates with NPHP4 in this function (By similarity).
 Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Transcriptional coactivator, it may also promote acetylation of nucleosomal histone H4 by KAT5. Promotes apoptosis. May act as a renal tumor suppressor. Negatively regulates canonical Wnt signaling; at least in part, cooperates with NPHP4 in this function (By similarity).
Protein Sequence
(Fasta)
MKRGRLPSSS EDSDDNGSLS TTWSQHSRSQ HGRSSTCSRP EDRKPSEVFR TDLITAMKLH 60
DSYQLNPDDY YVLADPWRQE WEKGVQVPVS PGTIPQPVAR VVSEEKSLMF IRPKKYIASS 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063766|E3,PHD|Mus musculus
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Nucleotide Sequence
(Fasta)
TGCTCTTTGG GTTCTAGAAG GCAGAAGACA TCCTTGTCCG CTCGCCTGCT ACCTCTGAGG 60
AAACTCGGGG CTCTACTCAA AGTGCTGAGG TAGGTGGTCC ACCTTGGAGA TAGGTCTCGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063766|E3,PHD|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0010--Activator
KW-0025--Alternative splicing
KW-0053--Apoptosis
KW-0966--Cell projection
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR019542--Enhancer_polycomb-like_N
IPR034732--EPHD
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS51805--EPHD
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
Pfam

PF10513--EPL1
SMART

SM00249--PHD
Gene Ontology

GO:0036064--C:ciliary basal body
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0000123--C:histone acetyltransferase complex
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0001105--F:RNA polymerase II transcription coactivator activity
GO:0008270--F:zinc ion binding
GO:0006915--P:apoptotic process
GO:0043966--P:histone H3 acetylation
GO:0043983--P:histone H4-K12 acetylation
GO:0043981--P:histone H4-K5 acetylation
GO:0043982--P:histone H4-K8 acetylation
GO:0090090--P:negative regulation of canonical Wnt signaling pathway
GO:2000134--P:negative regulation of G1/S transition of mitotic cell cycle
KEGG mmu:269424
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001854 Ailuropoda melanoleuca 90.06 0.00e+00 1528.00
IUUC-Apl-003904 Anas platyrhynchos 77.09 0.00e+00 1268.00
IUUC-Aca-004650 Anolis carolinensis 77.29 0.00e+00 1278.00
IUUC-Bta-013212 Bos taurus 89.70 0.00e+00 1465.00
IUUC-Bci-013740 Botrytis cinerea 47.83 1.00e-11 65.90
IUUC-Cja-019342 Callithrix jacchus 90.80 0.00e+00 1521.00
IUUC-Cfa-021159 Canis familiaris 89.01 0.00e+00 1501.00
IUUC-Cpo-022179 Cavia porcellus 90.77 0.00e+00 1522.00
IUUC-Csa-024123 Chlorocebus sabaeus 91.53 0.00e+00 1528.00
IUUC-Dno-028951 Dasypus novemcinctus 89.94 0.00e+00 1540.00
IUUC-Dor-030376 Dipodomys ordii 89.94 4.00e-164 571.00
IUUC-Fca-035825 Felis catus 89.94 0.00e+00 1557.00
IUUC-Fal-037191 Ficedula albicollis 76.71 0.00e+00 1315.00
IUUC-Gga-040453 Gallus gallus 82.14 0.00e+00 1095.00
IUUC-Ggo-044730 Gorilla gorilla 91.52 0.00e+00 1528.00
IUUC-Hsa-045954 Homo sapiens 91.64 0.00e+00 1529.00
IUUC-Itr-047942 Ictidomys tridecemlineatus 88.52 0.00e+00 1429.00
IUUC-Lch-050370 Latimeria chalumnae 63.93 0.00e+00 1021.00
IUUC-Loc-052824 Lepisosteus oculatus 59.62 0.00e+00 965.00
IUUC-Laf-053741 Loxodonta africana 90.96 0.00e+00 1541.00
IUUC-Mcc-055206 Macaca mulatta 91.40 0.00e+00 1528.00
IUUC-Meu-055951 Macropus eugenii 75.42 0.00e+00 755.00
IUUC-Mga-059286 Meleagris gallopavo 77.71 0.00e+00 1222.00
IUUC-Mvi-060566 Microbotryum violaceum 30.77 4.00e-15 78.20
IUUC-Mmr-061461 Microcebus murinus 89.59 0.00e+00 1488.00
IUUC-Mdo-062145 Monodelphis domestica 78.06 0.00e+00 1303.00
IUUC-Mpu-066859 Mustela putorius furo 89.74 0.00e+00 1424.00
IUUC-Mlu-068114 Myotis lucifugus 86.95 0.00e+00 1254.00
IUUC-Nle-069678 Nomascus leucogenys 91.39 0.00e+00 1528.00
IUUC-Ont-072674 Oreochromis niloticus 68.48 0.00e+00 745.00
IUUC-Ocu-074755 Oryctolagus cuniculus 90.06 0.00e+00 1537.00
IUUC-Ola-086618 Oryzias latipes 54.46 0.00e+00 739.00
IUUC-Olu-087752 Ostreococcus lucimarinus 46.94 2.00e-38 151.00
IUUC-Oga-089141 Otolemur garnettii 90.19 0.00e+00 1508.00
IUUC-Oar-089329 Ovis aries 89.70 0.00e+00 1495.00
IUUC-Ptr-091632 Pan troglodytes 91.64 0.00e+00 1529.00
IUUC-Pan-091906 Papio anubis 91.53 0.00e+00 1529.00
IUUC-Pfo-096495 Poecilia formosa 70.67 0.00e+00 725.00
IUUC-Pab-098033 Pongo abelii 91.15 0.00e+00 1520.00
IUUC-Pva-102586 Pteropus vampyrus 88.07 0.00e+00 1394.00
IUUC-Sha-106818 Sarcophilus harrisii 84.22 0.00e+00 1113.00
IUUC-Ssl-108594 Sclerotinia sclerotiorum 40.54 2.00e-07 52.40
IUUC-Smo-109236 Selaginella moellendorffii 39.62 2.00e-39 158.00
IUUC-Sre-115128 Sporisorium reilianum 34.18 2.00e-11 65.50
IUUC-Ssc-116244 Sus scrofa 89.70 0.00e+00 1526.00
IUUC-Tgu-117051 Taeniopygia guttata 77.18 0.00e+00 1288.00
IUUC-Tru-118032 Takifugu rubripes 69.87 0.00e+00 666.00
IUUC-Tni-120429 Tetraodon nigroviridis 68.11 0.00e+00 728.00
IUUC-Tre-122041 Trichoderma reesei 42.86 8.00e-14 73.60
IUUC-Ttr-129299 Tursiops truncatus 90.04 0.00e+00 1538.00
IUUC-Uma-129405 Ustilago maydis 32.65 1.00e-11 66.20
IUUC-Xtr-132813 Xenopus tropicalis 65.26 0.00e+00 1033.00
IUUC-Xma-133556 Xiphophorus maculatus 53.26 0.00e+00 777.00
Created Date 25-Jun-2017

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