iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Gga-040997

Ensembl Protein ID

ENSGALP00000000634.4

UniProt Accession

F1NP54; F1NP54_CHICK

Genbank Protein ID

ENSGALP00000000634

Protein Name

Tyrosine-protein kinase

Genbank Nucleotide ID

AADN04000227

Gene Name

LCK

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGALG00000000466.6	ENSGALT00000000635.6	ENSGALP00000000634.4

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	2.10e-19	69.6	61	119

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 2    skekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           ++++v +lydye+++d++L lk+G++++v+   e++++W+++++ ++g++Gl+P+nFv+ ++
   Q: 61   QDKLVVALYDYEPTHDGDLGLKQGEKLRVL---EESGEWWRAQSLTTGQEGLIPHNFVAMVN 119
           5789**************************...99***********************9987 PP

Organism

Gallus gallus

Protein Sequence
(Fasta)

MGCCCSSDYD EDWIENIDIC EHCNYPIDPD SKRQQLIRNV SEVRDPLVSY EAMSPPCSPL 60
QDKLVVALYD YEPTHDGDLG LKQGEKLRVL EESGEWWRAQ SLTTGQEGLI PHNFVAMVNS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCTGCGAACC AGCTCCTCTA GAGTTTGCTC AGGAGGCAGG AAACCGGGGC AGGCGGCGAG 60
CAAGAGCGAA CGGCGGCGGT GGGGAGCGCG CCCGTGTGCG GGGGGCTCAG CTGCACTGCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0001772--C:immunological synapse
GO:0045121--C:membrane raft
GO:0000242--C:pericentriolar material
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0004722--F:protein serine/threonine phosphatase activity
GO:0006919--P:activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006882--P:cellular zinc ion homeostasis
GO:2001244--P:positive regulation of intrinsic apoptotic signaling pathway
GO:0050870--P:positive regulation of T cell activation
GO:0042493--P:response to drug
GO:0030217--P:T cell differentiation

KEGG

gga:396460

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001315	Ailuropoda melanoleuca	78.11	0.00e+00	887.00
IUUC-Apl-004134	Anas platyrhynchos	89.24	0.00e+00	801.00
IUUC-Bta-013264	Bos taurus	82.51	0.00e+00	900.00
IUUC-Cfa-021161	Canis familiaris	77.37	0.00e+00	879.00
IUUC-Cpo-022492	Cavia porcellus	82.51	0.00e+00	900.00
IUUC-Dre-028005	Danio rerio	68.43	0.00e+00	717.00
IUUC-Dno-029365	Dasypus novemcinctus	79.17	0.00e+00	854.00
IUUC-Dor-030892	Dipodomys ordii	80.20	0.00e+00	848.00
IUUC-Eca-033325	Equus caballus	80.00	0.00e+00	864.00
IUUC-Eeu-035004	Erinaceus europaeus	74.38	0.00e+00	690.00
IUUC-Fca-035908	Felis catus	82.32	0.00e+00	900.00
IUUC-Fal-036804	Ficedula albicollis	78.35	0.00e+00	811.00
IUUC-Gmo-038984	Gadus morhua	63.88	0.00e+00	697.00
IUUC-Gac-041854	Gasterosteus aculeatus	71.96	0.00e+00	761.00
IUUC-Gma-043426	Glycine max	32.57	1.00e-22	101.00
IUUC-Ggo-045238	Gorilla gorilla	78.11	0.00e+00	887.00
IUUC-Hsa-047039	Homo sapiens	82.71	0.00e+00	902.00
IUUC-Itr-048479	Ictidomys tridecemlineatus	83.10	0.00e+00	910.00
IUUC-Lch-049568	Latimeria chalumnae	81.45	0.00e+00	889.00
IUUC-Loc-052222	Lepisosteus oculatus	68.09	0.00e+00	704.00
IUUC-Laf-054499	Loxodonta africana	77.37	0.00e+00	882.00
IUUC-Meu-056879	Macropus eugenii	80.51	0.00e+00	880.00
IUUC-Mtr-058765	Medicago truncatula	29.41	3.00e-21	97.10
IUUC-Mga-059971	Meleagris gallopavo	96.65	0.00e+00	1028.00
IUUC-Mmr-060740	Microcebus murinus	82.32	0.00e+00	901.00
IUUC-Mdo-062192	Monodelphis domestica	82.51	0.00e+00	904.00
IUUC-Mmu-064241	Mus musculus	82.32	0.00e+00	903.00
IUUC-Mpu-066595	Mustela putorius furo	82.32	0.00e+00	897.00
IUUC-Mlu-067069	Myotis lucifugus	80.98	0.00e+00	883.00
IUUC-Opr-070472	Ochotona princeps	78.09	0.00e+00	879.00
IUUC-Ont-071711	Oreochromis niloticus	72.16	0.00e+00	746.00
IUUC-Ocu-074221	Oryctolagus cuniculus	81.18	0.00e+00	884.00
IUUC-Ola-087000	Oryzias latipes	69.09	0.00e+00	743.00
IUUC-Oga-088225	Otolemur garnettii	81.73	0.00e+00	891.00
IUUC-Oar-090244	Ovis aries	72.81	0.00e+00	843.00
IUUC-Pan-091804	Papio anubis	82.91	0.00e+00	905.00
IUUC-Psi-093252	Pelodiscus sinensis	81.71	0.00e+00	859.00
IUUC-Pma-094311	Petromyzon marinus	64.53	0.00e+00	692.00
IUUC-Pfo-096542	Poecilia formosa	70.16	0.00e+00	759.00
IUUC-Pab-098168	Pongo abelii	83.78	0.00e+00	868.00
IUUC-Rno-105542	Rattus norvegicus	81.93	0.00e+00	900.00
IUUC-Sha-107524	Sarcophilus harrisii	80.75	0.00e+00	888.00
IUUC-Sly-111528	Solanum lycopersicum	31.25	3.00e-24	107.00
IUUC-Stu-112331	Solanum tuberosum	31.21	9.00e-25	108.00
IUUC-Sar-113235	Sorex araneus	76.65	0.00e+00	753.00
IUUC-Ssc-115624	Sus scrofa	82.32	0.00e+00	897.00
IUUC-Tru-118559	Takifugu rubripes	68.22	0.00e+00	734.00
IUUC-Ttr-129002	Tursiops truncatus	74.77	0.00e+00	831.00
IUUC-Vvi-131057	Vitis vinifera	33.79	8.00e-24	105.00
IUUC-Xtr-132224	Xenopus tropicalis	76.42	0.00e+00	840.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence