iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Aml-002249

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ACTA01115295

Gene Name

TRIM59

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAMEG00000018682.1	ENSAMET00000020505.1	ENSAMEP00000019736.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/U-box	3.50e-06	27.1	6	89
E3 activity/RING/RING	7.60e-10	39.3	10	60

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 4    eeflCpIslelMrdPvvlpsGitydrssIekwlasggk...........tcPvtrqpl.....teedlvPnltlrrliqawcee 71
           +e+ CpI + +++dP vlp+ +t+ r+++e  l+ +g+           +cP +r+ +       e+l  n +l+++i+++ +e
   Q: 6    DELTCPICYSIFEDPRVLPCSHTFCRNCLENVLQASGNfyiwrplriplKCPSCRSIIeiaptGIESLPVNFALKAIIEKYQQE 89
           7899*****************************999999**********99999986533321456677788999999998776 PP

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefr..........CPlCr 46
           C+iC++ f+d p+vlpC H+f+++Cl+++     ++s++f+          CP Cr
   Q: 10   CPICYSIFED-PRVLPCSHTFCRNCLENV----LQASGNFYiwrplriplkCPSCR 60
           **********.***************999....667777766777777777****8 PP

Organism

Ailuropoda melanoleuca

Protein Sequence
(Fasta)

MHNFEDELTC PICYSIFEDP RVLPCSHTFC RNCLENVLQA SGNFYIWRPL RIPLKCPSCR 60
SIIEIAPTGI ESLPVNFALK AIIEKYQQED HRDIVTCPEH YRQPLNVYCL LDKKLVCGHC 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGCACAATT TTGAGGACGA GTTAACATGT CCCATTTGTT ACAGTATTTT TGAAGATCCT 60
CGTGTGCTAC CGTGCTCTCA TACATTTTGT AGAAATTGCT TGGAAAACGT TCTTCAAGCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0472--Membrane
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR027370--Znf-RING_LisH
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00643--zf-B_box
PF13445--zf-RING_UBOX

SMART

SM00184--RING

Gene Ontology

GO:0005783--C:endoplasmic reticulum
GO:0016021--C:integral component of membrane
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0045087--P:innate immune response
GO:0043124--P:negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0046597--P:negative regulation of viral entry into host cell

KEGG

aml:100481642

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Apl-003996	Anas platyrhynchos	56.54	8.00e-122	430.00
IUUC-Aca-005141	Anolis carolinensis	56.35	5.00e-131	460.00
IUUC-Ame-011353	Astyanax mexicanus	50.80	1.00e-96	346.00
IUUC-Bta-013440	Bos taurus	91.44	0.00e+00	683.00
IUUC-Cja-019076	Callithrix jacchus	89.94	2.00e-174	606.00
IUUC-Cfa-021168	Canis familiaris	94.55	0.00e+00	778.00
IUUC-Cpo-021702	Cavia porcellus	77.36	3.00e-179	620.00
IUUC-Csa-024141	Chlorocebus sabaeus	89.05	0.00e+00	678.00
IUUC-Dre-028408	Danio rerio	47.12	6.00e-88	317.00
IUUC-Dno-029180	Dasypus novemcinctus	89.55	0.00e+00	735.00
IUUC-Ete-033028	Echinops telfairi	88.05	6.00e-169	588.00
IUUC-Eca-034357	Equus caballus	91.04	0.00e+00	726.00
IUUC-Eeu-034909	Erinaceus europaeus	81.90	2.00e-154	539.00
IUUC-Fca-036287	Felis catus	95.02	0.00e+00	780.00
IUUC-Gga-040739	Gallus gallus	57.88	7.00e-135	473.00
IUUC-Ggo-045307	Gorilla gorilla	87.81	0.00e+00	711.00
IUUC-Hsa-045690	Homo sapiens	88.56	0.00e+00	712.00
IUUC-Itr-048230	Ictidomys tridecemlineatus	92.54	0.00e+00	770.00
IUUC-Laf-054522	Loxodonta africana	88.59	0.00e+00	737.00
IUUC-Mcc-055145	Macaca mulatta	89.80	0.00e+00	720.00
IUUC-Meu-056214	Macropus eugenii	47.77	5.00e-62	231.00
IUUC-Mmr-061197	Microcebus murinus	93.03	0.00e+00	775.00
IUUC-Mdo-062631	Monodelphis domestica	59.01	1.00e-133	469.00
IUUC-Mmu-064217	Mus musculus	85.86	0.00e+00	693.00
IUUC-Mpu-065691	Mustela putorius furo	95.77	0.00e+00	789.00
IUUC-Mlu-067742	Myotis lucifugus	88.83	0.00e+00	710.00
IUUC-Nle-069722	Nomascus leucogenys	89.05	0.00e+00	745.00
IUUC-Oan-073382	Ornithorhynchus anatinus	58.96	1.00e-133	469.00
IUUC-Olu-087666	Ostreococcus lucimarinus	35.71	4.00e-10	59.70
IUUC-Oar-089206	Ovis aries	90.05	0.00e+00	749.00
IUUC-Pan-092189	Papio anubis	90.05	0.00e+00	722.00
IUUC-Psi-093523	Pelodiscus sinensis	61.82	4.00e-141	494.00
IUUC-Pma-094162	Petromyzon marinus	34.57	2.00e-48	186.00
IUUC-Pfo-096032	Poecilia formosa	45.66	5.00e-87	314.00
IUUC-Pva-103089	Pteropus vampyrus	91.07	0.00e+00	730.00
IUUC-Pgr-103338	Puccinia graminis	38.71	1.00e-06	46.20
IUUC-Rno-105440	Rattus norvegicus	88.06	0.00e+00	709.00
IUUC-Sly-111770	Solanum lycopersicum	36.67	1.00e-05	43.90
IUUC-Ssc-115809	Sus scrofa	90.80	0.00e+00	721.00
IUUC-Tru-118402	Takifugu rubripes	43.22	1.00e-90	326.00
IUUC-Tni-119737	Tetraodon nigroviridis	44.05	1.00e-83	302.00
IUUC-Tbe-127434	Tupaia belangeri	88.96	1.00e-164	573.00
IUUC-Ttr-128921	Tursiops truncatus	89.78	0.00e+00	724.00
IUUC-Vpa-130397	Vicugna pacos	92.31	0.00e+00	766.00
IUUC-Xtr-132752	Xenopus tropicalis	45.53	5.00e-85	307.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence