iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	microRNA	TRANSFAC	RepTar
RAID2
Protein-protein Interaction
IID
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/U-box	4.70e-06	27.7	6	89
E3 activity/RING/RING	3.10e-09	38.3	10	60

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 4    eeflCpIslelMrdPvvlpsGitydrssIekwlasggk...........tcPvtrqpl.....teedlvPnltlrrliqawcee 71
           ee+ CpI + +++dP vlp+ +t+ r+++e  l+ +g+           +cP +r+ +       e+l  n +lr++i+++ +e
   Q: 6    EELTCPICYSIFEDPRVLPCSHTFCRNCLENVLQASGNfyiwrplriplKCPNCRSIIeiastGIESLPVNFALRAIIEKYQQE 89
           7999*****************************999999**************9998743321234555688999999999776 PP

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefr..........CPlCr 46
           C+iC++ f+d p+vlpC H+f+++Cl+++     ++s++f+          CP Cr
   Q: 10   CPICYSIFED-PRVLPCSHTFCRNCLENV----LQASGNFYiwrplriplkCPNCR 60
           **********.***************999....667777766667777777****8 PP

Organism

Mus musculus

Functional Description
(View)

May serve as a multifunctional regulator for innate immune signaling pathways.

Protein Sequence
(Fasta)

MHNFEEELTC PICYSIFEDP RVLPCSHTFC RNCLENVLQA SGNFYIWRPL RIPLKCPNCR 60
SIIEIASTGI ESLPVNFALR AIIEKYQQED HPDVVTCPEH YRQPLNVYCL LDKKLVCGHC 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCCCCCGCCG GGCACCTGAA GACTCGGGCG AGCGCCTCGC AGTGTCCGCA CCAGGCTGCC 60
CGGGAGCCCT CGCCGTGCGC GCCGTCGCCC GCCTCGCCCG CCTCGCCCGC CTCGCCCGCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0472--Membrane
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR027370--Znf-RING_LisH
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00643--zf-B_box
PF13445--zf-RING_UBOX

SMART

SM00184--RING

Gene Ontology

GO:0005813--C:centrosome
GO:0005929--C:cilium
GO:0005783--C:endoplasmic reticulum
GO:0005789--C:endoplasmic reticulum membrane
GO:0016021--C:integral component of membrane
GO:0030992--C:intraciliary transport particle B
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0060271--P:cilium assembly
GO:0045087--P:innate immune response
GO:0043124--P:negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0046597--P:negative regulation of viral entry into host cell

KEGG

mmu:66949

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002249	Ailuropoda melanoleuca	85.86	0.00e+00	726.00
IUUC-Apl-003996	Anas platyrhynchos	56.30	2.00e-122	432.00
IUUC-Aca-005141	Anolis carolinensis	56.69	1.00e-129	456.00
IUUC-Ame-011353	Astyanax mexicanus	51.77	8.00e-99	353.00
IUUC-Bta-013440	Bos taurus	86.74	0.00e+00	656.00
IUUC-Cfa-021168	Canis familiaris	86.39	0.00e+00	730.00
IUUC-Cpo-021702	Cavia porcellus	75.37	3.00e-174	604.00
IUUC-Csa-024141	Chlorocebus sabaeus	84.58	0.00e+00	648.00
IUUC-Dre-028408	Danio rerio	47.12	6.00e-90	324.00
IUUC-Dno-029180	Dasypus novemcinctus	84.33	0.00e+00	703.00
IUUC-Ete-033028	Echinops telfairi	86.03	5.00e-164	572.00
IUUC-Eca-034357	Equus caballus	86.32	0.00e+00	695.00
IUUC-Fca-036287	Felis catus	86.82	0.00e+00	726.00
IUUC-Gga-040739	Gallus gallus	57.84	2.00e-135	475.00
IUUC-Ggo-045307	Gorilla gorilla	82.34	0.00e+00	669.00
IUUC-Hsa-045690	Homo sapiens	82.84	0.00e+00	669.00
IUUC-Itr-048230	Ictidomys tridecemlineatus	89.80	0.00e+00	753.00
IUUC-Laf-054522	Loxodonta africana	83.62	0.00e+00	709.00
IUUC-Mcc-055145	Macaca mulatta	85.07	0.00e+00	689.00
IUUC-Meu-056214	Macropus eugenii	45.70	2.00e-57	216.00
IUUC-Mmr-061197	Microcebus murinus	89.05	0.00e+00	748.00
IUUC-Mdo-062631	Monodelphis domestica	60.34	5.00e-132	464.00
IUUC-Mpu-065691	Mustela putorius furo	87.56	0.00e+00	736.00
IUUC-Mlu-067742	Myotis lucifugus	83.87	0.00e+00	676.00
IUUC-Nle-069722	Nomascus leucogenys	83.83	0.00e+00	704.00
IUUC-Oan-073382	Ornithorhynchus anatinus	58.96	5.00e-135	474.00
IUUC-Oar-089206	Ovis aries	85.32	0.00e+00	721.00
IUUC-Pan-092189	Papio anubis	85.32	0.00e+00	691.00
IUUC-Psi-093523	Pelodiscus sinensis	60.10	1.00e-139	489.00
IUUC-Pma-094162	Petromyzon marinus	34.67	3.00e-50	192.00
IUUC-Pfo-096032	Poecilia formosa	45.98	4.00e-88	318.00
IUUC-Pva-103089	Pteropus vampyrus	86.35	0.00e+00	695.00
IUUC-Pgr-103338	Puccinia graminis	36.23	1.00e-06	47.00
IUUC-Rno-105440	Rattus norvegicus	95.77	0.00e+00	754.00
IUUC-Ssc-115809	Sus scrofa	83.83	0.00e+00	676.00
IUUC-Tru-118402	Takifugu rubripes	43.79	1.00e-92	333.00
IUUC-Tni-119737	Tetraodon nigroviridis	45.34	8.00e-87	313.00
IUUC-Ttr-128921	Tursiops truncatus	85.54	0.00e+00	697.00
IUUC-Vpa-130397	Vicugna pacos	86.60	0.00e+00	732.00
IUUC-Xtr-132752	Xenopus tropicalis	45.94	8.00e-83	300.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence